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プロフィール詳細
Dr. Anwar H.に依頼
United States
Medicinal Chemist | Expert in small molecule drug design and discovery | Expert in drug metabolism and disposition
プロフィール概要
専門分野
サービス
Writing
Non-Medical Regulatory Writing,
Technical Writing,
Creative Writing
Research
Fact Checking,
Scientific and Technical Research,
Systematic Literature Review,
Secondary Data Collection
Consulting
Healthcare Consulting,
Scientific and Technical Consulting
Data & AI
Statistical Analysis,
Data Processing,
Data Insights
Product Development
Concept Development
職務経験
Research Assistant Professor
University of North Carolina at Chapel Hill
3月 2025 - 現在 
Postdoctoral Research Associate
The University of North Carolina at Chapel Hill
3月 2020 - 3月 2025
Research Assistant
Texas Tech University Health Sciences Center
1月 2015 - 3月 2020
学歴
Ph.D. (Pharmaceutical Sciences)
Texas Tech University Health Sciences Center
1月 2015 - 12月 2019
M. Pharm
University of Dhaka
1月 2009 - 12月 2010
認定資格
出版物
JOURNAL ARTICLE
Hans J. Oh, John D. Sears, Bose Muthu Ramalingam, Rahman Shah Zaib Saleem, Zachary W. Davis-Gilbert, Mohammed Anwar Hossain, Stella R. Moorman, Durbadal Ohja, Sabian A. Martinez, Jane E. Burdick, et al. (2026). Identification of spirodioxolane nsP2 helicase inhibitors with antialphaviral activity . RSC Medicinal Chemistry.
Tao Yang, Hasi Huhe, Sean‐Paul Williams, Sukhneet Kaur, Yeonglong Albert Ay, Zachary W. Davis‐Gilbert, Gregory A. Cary, Carolyn Paisie, Robert R. Butler, Jesse Wiley, et al. (2025). PAK1 inhibitor NVS‐PAK1‐1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice . Alzheimer's & Dementia.
Anirban Ghoshal, John D. Sears, Mohammad Anwar Hossain, Edwin G. Tse, Stefanie Howell, Jane E. Burdick, Noah L. Morales, Sabian A. Martinez, Isabella Law, Zachary J. Streblow, et al. (2025). N-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity . Journal of Medicinal Chemistry.
Bose Muthu Ramalingam, Hans J. Oh, John D. Sears, Chun-Hsing Chen, Anand Vala, Shubin Liu, Kacey M. Talbot, Mohammed Anwar Hossain, Peter J. Brown, Scott Houliston, et al. (2025). Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity . ACS Infectious Diseases.
Bose Muthu Ramalingam, John D. Sears, Kacey M. Talbot, Yuan-Wei Norman Su, Scott Houliston, Mohammed Anwar Hossain, Zachary W. Davis-Gilbert, Chunqing Zhao, Hans J. Oh, Peter J. Brown, et al. (2025). Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity . Journal of Medicinal Chemistry.
Holli-Joi Martin, Mohammad Anwar Hossain, James Wellnitz, Enes Kelestemur, Joshua E. Hochuli, Sumera Perveen, Cheryl Arrowsmith, Timothy M. Willson, Eugene N. Muratov, Alexander Tropsha (2025). Chemical arsenal for helicase Hunters: Striking the toughest targets in antiviral research . Antiviral Research.
Mohammad Anwar Hossain, Abigail K. Mayo, Anirban Ghoshal, Sharon Taft-Benz, Elizabeth Anderson, Noah L. Morales, Katia D. Pressey, Ava Vargason, Kim L. R. Brouwer, Nathaniel J. Moorman, et al. (2025). Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity . Journal of Medicinal Chemistry.
Anirban Ghoshal, Edwin G. Tse, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Eric M. Merten, John D. Sears, Stefanie Howell, Sumera Perveen, Jane Burdick, Noah L. Morales, et al. (2025). A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity . Scientific Reports.
Joseph A. Newman, Angeline E. Gavard, Nergis Imprachim, Hazel Aitkenhead, Hadley E. Sheppard, Robert te Poele, Paul A. Clarke, Mohammad Anwar Hossain, Louisa Temme, Hans J. Oh, et al. (2025). Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy . Nature Communications.
Tamanna Islam, Jacob Hooper, Xiaojun Zhang, Clarissa Garcia, Md Mahedi Hasan, David H. Drewry, Mohammad Anwar Hossain, Taslim A. Al-Hilal (2025). A soft-stiff patterned bioengineering model reveals kinase pathways driving directional cell migration in pulmonary arterial hypertension . Biomaterials Science.
Eric M. Merten, John D. Sears, Tina M. Leisner, P. Brian Hardy, Anirban Ghoshal, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Peter J. Brown, Edwin G. Tse, Michael A. Stashko, et al. (2024). Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach . Proceedings of the National Academy of Sciences.
Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J. Brown, Meganathan Nandakumar, Anand Vala, Eric M. Merten, John D. Sears, Isabella Law, Jane E. Burdick, et al. (2024). Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity . Journal of Medicinal Chemistry.
Anirban Ghoshal, Álvaro F. Magalhães, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Matthew H. Todd, Timothy M. Willson (2024). Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors . Pharmaceuticals.
Anirban Ghoshal, Álvaro F. Magalhães, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Matthew H. Todd, Timothy M. Willson (2024). Identification of Dihydropyrazolo[1,5-<i>a</i>]pyrazin-4(5<i>H</i>)-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors . Pharmaceuticals.
Siavash Shahbazi Nia, Yuma T. Ortiz, Julio D. Zuarth Gonzalez, Leila Shamir, Kofi Frimpong-Manson, Mohammad Anwar Hossain, Sadisna Shahi, Rayna Bandy, Anoushka Bhat, Dhavalkumar Patel, et al. (2024). Characterization of a Nonselective Opioid Receptor Functional Antagonist: Implications for Development as a Novel Opioid Dependence Medication . ACS Pharmacology & Translational Science.
Brian Anderson, Peter Rosston, Han Wee Ong, Mohammad Anwar Hossain, Zachary W. Davis-Gilbert, David H. Drewry (2023). How many kinases are druggable? A review of our current understanding . Biochemical Journal.
Florentina Negoita, Alex B. Addinsall, Kristina Hellberg, Conchita Fraguas Bringas, Paul S. Hafen, Tyler J. Sermersheim, Marianne Agerholm, Christopher T.A. Lewis, Danial Ahwazi, Naomi X.Y. Ling, et al. (2023). CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle . Molecular Metabolism.
Zachary W. Davis-Gilbert, Andreas Krämer, James E. Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I. Wells, Frances M. Bashore, Tammy M. Havener, Jeffery L. Smith, Mohammad A. Hossain, et al. (2023). Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2 . ACS Medicinal Chemistry Letters.
Thaila Fernanda dos Reis, Patrícia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro F. N. Souza, Suzanne Ackloo, Mohammad Anwar Hossain, David Harold Drewry, Sondus Alkhazraji, Ashraf S. Ibrahim, et al. (2023). A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi . Nature Communications.
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, et al. (2023). SGC-CAMKK2-1: A Chemical Probe for CAMKK2 . Cells.
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, et al. (2023). SGC-CAMKK2-1: A Chemical Probe for CAMKK2 . Cells.
David H. Drewry, Frances M. Potjewyd, Armin Bayati, Jeffery L. Smith, Rebekah J. Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M. Min, Mohammad Anwar Hossain, Mark Heise, et al. (2022). Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses . Journal of Medicinal Chemistry.
Mohammad Anwar Hossain(2022). Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses . Journal of Medicinal Chemistry. American Chemical Society ({ACS})
Update on modulators of quorum sensing pathways in Pseudomonas Aeruginosa. Hossain Anwar Mohammad and German A. Nadezhda *, Update on Modulators of Quorum Sensing Pathways in Pseudomonas aeruginosa, Current Topics in Medicinal Chemistry 2021; 21(23) . https://dx.doi.org/10.2174/1568026621666210924160004 . Current topics in medicinal chemistry.
Benjamin J. Eduful, Sean N. O’Byrne, Louisa Temme, Christopher R. M. Asquith, Yi Liang, Alfredo Picado, Joseph R. Pilotte, Mohammad Anwar Hossain, Carrow I. Wells, William J. Zuercher, et al. (2021). Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes . Journal of Medicinal Chemistry.
Benjamin J. Eduful and Sean N. O'Byrne and Louisa Temme and Christopher R. M. Asquith and Yi Liang and Alfredo Picado and Joseph R. Pilotte and Mohammad Anwar Hossain and Carrow I. Wells and William J. Zuercher and Carolina M. C. Catta-Preta and Priscila Zonzini Ramos and Andr{\'{e}} de S. Santiago and Rafael M. Cou{\~{n}}ago and Christopher G. Langendorf and K{\'{e}}vin Nay and Jonathan S. Oakhill and Thomas L. Pulliam and Chenchu Lin and Dominik Awad and Timothy M. Willson and Daniel E. Frigo and John W. Scott and David H. Drewry(2021). Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes . Journal of Medicinal Chemistry. American Chemical Society ({ACS})
(2021). Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects . Journal of controlled release : official journal of the Controlled Release Society.
(2019). Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence . European Journal of Medicinal Chemistry.
Patel, R., Hossain, M.A., German, N., Al-Ahmad, A.J.(2018). Gliotoxin penetrates and impairs the integrity of the human blood-brain barrier in vitro . Mycotoxin Research. 34. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 257-268.
PREPRINT
Hans Oh, John Sears, Muthu Bose Ramalingam, Rahman Shah Zaib Saleem, Zachary Davis-Gilbert, Mohammed Anwar Hossain, Stella Moorman, Durbadal Ojha, Sabian Martinez, Jane Burdick, et al. (2025). Identification of Spirodioxolane nsP2 Helicase Inhibitors with Antialphaviral Activity .
Anirban Ghoshal, John D. Sears, Mohammad Anwar Hossain, Edwin G. Tse, Stefanie Howell, Jane E. Burdick, Noah L. Morales, Sabian A. Martinez, Isabella Law, Zachary J. Streblow, et al. (2025). N-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad Spectrum Antialphaviral Activity .
John D. Sears, Durbadal Ojha, Sharon Taft-Benz, Paul Sylvester, Zachary Streblow, Amanda J. Gramm, Adam M. Drobish, Bose Muthu Ramalingam, Mohammad Anwar Hossain, Kacey Talbot, et al. (2025). Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase .
Bose Muthu Ramalingam, Hans J. Oh, John D. Sears, Chun-Hsing Chen, Anand Vala, Shubin Liu, Kacey M. Talbot, Mohammed Anwar Hossain, Peter J. Brown, Scott Houliston, et al. (2025). An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity .
Muthu Ramalingam Bose, John D. Sears, Kacey M. Talbot, Yuan-Wei Norman Su, Scott Houliston, Mohammed Anwar Hossain, Zachary W. Davis-Gilbert, Chunqing Zhao, Hans J. Oh, Peter J. Brown, et al. (2025). Identification of Direct-acting nsP2 Helicase Inhibitors with Antialphaviral Activity .
Mohammad Anwar Hossain, Abigail K. Mayo, Anirban Ghoshal, Sharon A. Taft-Benz, Elizabeth J. Anderson, Noah L. Morales, Katia D. Pressey, Ava M. Vargason, Kim L. R. Brouwer, Nathaniel J. Moorman, et al. (2025). Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with in Vivo Anti-alphaviral Activity .
Hernan Navarro, John E. Scott, Ginger R. Smith, Pegah Ghiabi, Elisa Gibson, Peter Loppnau, Rachel J. Harding, Mohammad Anwar Hossain, Muthu Ramalingam Bose, Kenneth H. Pearce, et al. (2024). Identification of Inhibitors of Chikungunya virus nsP2 ATPase .
Holli-Joi Martin, Mohammad A. Hossain, James Wellnitz, Enes Kelestemur, Joshua E. Hochuli, Sumera Parveen, Cheryl Arrowsmith, Timothy M. Willson, Eugene Muratov, Alexander Tropsha (2024). Heli-SMACC: Helicase-targeting SMAll Molecule Compound Collection .
Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J. Brown, Eric M. Merten, John D. Sears, Sumera Perveen, Kenneth H. Pearce, Konstantin I. Popov, Nathaniel J. Moorman, et al. (2024). Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors ofChikungunyansP2 Cysteine Protease with Anti-alphavirus Activity .
Joseph A Newman, Angeline E Gavard, Nergis Imprachim, Hazel Aitkenhead, Hadley E. Sheppard, Paul A. Clarke, Mohammad Anwar Hossain, Louisa Temme, Hans J. Oh, Carrow I. Wells, et al. (2024). Structures of the human transcription factor brachyury offer insights into DNA recognition, and identify small molecule binders for the development of degraders for cancer therapy .
Anirban Ghoshal, Álvaro Magalhães, Kesatebrhan Asressu, Mohammad Hossain, Matthew Todd, Timothy Willson (2024). Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of Beta-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors .
Eric M. Merten, John D. Sears, Tina M. Leisner, Paul B. Hardy, Anirban Ghoshal, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Peter J. Brown, Michael A. Stashko, Laura Herring, et al. (2024). Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach .
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Catta-Preta, Priscila Zonzini Ramos, et al.(2022). SGC-CAMKK2-1: A chemical probe for CAMKK2 . biorxiv. Cold Spring Harbor Laboratory
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, et al. (2022). SGC-CAMKK2-1: A chemical probe for CAMKK2 .
PATENT
German Nadezhda, Neugebauer Volker, Hossain Mohammad Anwar, Abbruscatto Thomas(2024). SELECTIVE AND NON-SELECTIVE OPIOID RECEPTOR FUNCTIONAL ANTAGONISTS AND METHODS RELATED THERETO FOR TREATMENT OF ADDICTION, OPIOD DEPENDENCE, AND NEUROPATHIC PAIN . US 2024/0165110 A1
German Nadezhda, Hossain Mohammad(2020). NOVEL OPIOID ANTAGONISTS AND METHODS RELATED THERETO . WO 2020/092603 A1
German Nadezhda, Neugebauer Volker, Hossain Mohammad, Abbruscatto Thomas(2020). NOVEL SELECTIVE KAPPA OPIOID RECEPTOR ANTAGONISTS AND METHODS RELATED THERETO FOR TREATMENT OF ADDICTION AND NEUROPATHIC PAIN . WO 2020/092996 A1
DATA SET
Davis-Gilbert, Zachary and Drewry, David H. and Hossain, Mohammad Anwar(2022). LMW Binding Affinity Screen for TBXT . Zenodo
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