プロフィール詳細

プロジェクトを作成

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Dr. Abhimanyu S.に依頼

India

PhD Structural Biologist | Scientific Evaluation, Biophysics & Research Consulting

プロフィール概要

I am a PhD-trained structural molecular biologist and biophysicist with over 10 years of international research and academic experience across Europe and India. My primary expertise is in structural biology and biophysics, including protein structure–function analysis, macromolecular interactions, and interpretation of structure-derived biological insights. I work with academic groups, startups, and industry clients on scientific evaluation, research consulting, literature analysis, and content validation. I have extensive experience reviewing experimental data, mechanistic explanations, and scientific documents for accuracy, clarity, and conceptual consistency. In addition to research consulting, I provide expert support for literature reviews, manuscript and report evaluation, proposal review, and interpretation of complex biological data. I am comfortable working remotely on both short-term and ongoing projects and value clear communication, scientific rigor, and confidentiality.

専門分野

• ☆ X-Ray Crystallography
• ☆ Structural Biology
• ☆ Biophysics
• ☆ Recombinant Protein Expression
• ☆ Electron Microscopy
• ☆ Bioinformatics
• ☆ Structural Bioinformatics
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review

サービス

• Writing
• Research
• Consulting

Writing Technical Writing

Research Feasibility Study, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Assistant Professor

Sri Balaji Vidyapeeth University

8月 2023 - 現在

Post doctoral scientist

Rega Institute for Medical Research

9月 2018 - 7月 2023

Post doctoral scientist

University of Kent

2月 2015 - 6月 2018

学歴

Ph.D. Structural Biology

Centro Nacional de Biotecnología

10月 2010 - 10月 2014

M.Sc. Bioinformatics

Birla Institute of Technology, Mesra

2007 - 2009

B.Sc.(Honours) Biotechnology

Ranchi University

2004 - 2007

認定資格

• NA

  NA

  1月 2025 - 1月 2025

出版物

JOURNAL ARTICLE

Benjamin Van Loy, Eugènia Pujol, Kenichi Kamata, Xiao Yin Lee, Nikolai Bakirtzoglou, Ria Van Berwaer, Julie Vandeput, Cato Mestdagh, Leentje Persoons, Brent De Wijngaert, et al. (2025). A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses . PLOS Pathogens.

Maria Infant Majula Shifani Mahendran, Vinoj Gopalakrishnan, Vaijayanthi Saravanan, Ramasamy Dhamodharan, Pradeep Jothimani, M. Balasubramanian, Abhimanyu Kumar Singh, Rajan Vaithianathan (2024). Managing drug therapy-related problems and assessment of chronic diabetic wounds . Current Medical Research and Opinion.

Antoni R. Blaazer, Abhimanyu K. Singh, Lorena Zara, Pierre Boronat, Lady J. Bautista, Steve Irving, Maciej Majewski, Xavier Barril, Maikel Wijtmans, U. Helena Danielson, et al. (2024). The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity . ChemMedChem.

Abhimanyu K. Singh, Brent De Wijngaert, Marc Bijnens, Kris Uyttersprot, Hoai Nguyen, Sergio E. Martinez, Dominique Schols, Piet Herdewijn, Christophe Pannecouque, Eddy Arnold, et al. (2022). Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine . Proceedings of the National Academy of Sciences.

Abhimanyu K. Singh, Kalyan Das (2022). Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies . Viruses.

Abhimanyu K. Singh, Sergio E. Martinez, Weijie Gu, Hoai Nguyen, Dominique Schols, Piet Herdewijn, Steven De Jonghe, Kalyan Das (2021). Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening . Nature Communications.

Weijie Gu, Sergio Martinez, Abhimanyu K. Singh, Hoai Nguyen, Jef Rozenski, Dominique Schols, Piet Herdewijn, Kalyan Das, Steven De Jonghe (2021). Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design . European Journal of Medicinal Chemistry.

Alana R. Cowell, Guillaume Jacquemet, Abhimanyu K. Singh, Lorena Varela, Anna S. Nylund, York-Christoph Ammon, David G. Brown, Anna Akhmanova, Johanna Ivaska, Benjamin T. Goult (2021). Talin rod domain–containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation . Journal of Cell Biology.

Abhimanyu Singh, Arnaud Boonen, Anneleen Hout, Kalyan Das, Tom Loy, Sam Noppen, Dominique Schols (2020). Development of a Novel SPR Assay to Study CXCR4–Ligand Interactions . Biosensors.

Irene G. Salado, Abhimanyu K. Singh, Carlos Moreno-Cinos, Guna Sakaine, Marco Siderius, Pieter Van der Veken, An Matheeussen, Tiffany van der Meer, Payman Sadek, Sheraz Gul, et al. (2020). Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds . Journal of Medicinal Chemistry.

Erik de Heuvel, Abhimanyu K. Singh, Ewald Edink, Tiffany van der Meer, Melanie van der Woude, Payman Sadek, Mikkel P. Krell-Jørgensen, Toine van den Bergh, Johan Veerman, Guy Caljon, et al. (2019). Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors . Bioorganic & Medicinal Chemistry.

Erik de Heuvel, Abhimanyu K. Singh, Pierre Boronat, Albert J. Kooistra, Tiffany van der Meer, Payman Sadek, Antoni R. Blaazer, Nathan C. Shaner, Daphne S. Bindels, Guy Caljon, et al. (2019). Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2) . Bioorganic & Medicinal Chemistry.

Abhimanyu K. Singh, Thanh H. Nguyen, Márton Z. Vidovszky, Balázs Harrach, Mária Benkő, Alan Kirwan, Lokesh Joshi, Michelle Kilcoyne, M. Álvaro Berbis, F. Javier Cañada, et al. (2018). Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre . Journal of General Virology.

Antoni R. Blaazer, Abhimanyu K. Singh, Erik de Heuvel, Ewald Edink, Kristina M. Orrling, Johan J. N. Veerman, Toine van den Bergh, Chimed Jansen, Erin Balasubramaniam, Wouter J. Mooij, et al. (2018). Targeting a Subpocket in <i>Trypanosoma brucei</i> Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity . Journal of Medicinal Chemistry.

Austin J. Whitewood, Abhimanyu K. Singh, David G. Brown, Benjamin T. Goult (2018). Chlamydial virulence factor TarP mimics talin to disrupt the talin‐vinculin complex . FEBS Letters.

Andriy Kryshtafovych, Reinhard Albrecht, Arnaud Basl&#233;, Pedro Bule, Alessandro T. Caputo, Ana Luisa Carvalho, Kinlin L. Chao, Ron Diskin, Krzysztof Fidelis, Carlos M. G. A. Fontes, et al. (2018). Target highlights from the first post‐PSI CASP experiment (CASP12, May–August 2016) . Proteins: Structure, Function, and Bioinformatics.

Rosa Men&#233;ndez-Conejero, Thanh H. Nguyen, Abhimanyu K. Singh, Gabriela N. Condezo, Rachel E. Marschang, Mark J. van Raaij, Carmen San Mart&#237;n (2017). Structure of a Reptilian Adenovirus Reveals a Phage Tailspike Fold Stabilizing a Vertebrate Virus Capsid . Structure.

Andriy Kryshtafovych, John Moult, Arnaud Basl&#233;, Alex Burgin, Timothy K. Craig, Robert A. Edwards, Deborah Fass, Marcus D. Hartmann, Mateusz Korycinski, Richard J. Lewis, et al. (2016). Some of the most interesting CASP 11 targets through the eyes of their authors . Proteins: Structure, Function, and Bioinformatics.

Thanh H. Nguyen, M&#225;rton Z. Vidovszky, M&#243;nika Z. Ballmann, Marta Sanz-Gaitero, Abhimanyu K. Singh, Bal&#225;zs Harrach, M&#225;ria Benkő, Mark J. van Raaij (2015). Crystal structure of the fibre head domain of bovine adenovirus 4, a ruminant atadenovirus . Virology Journal.

Abhimanyu K. Singh, M. &#193;lvaro Berb&#237;s, M&#243;nika Z. Ballmann, Michelle Kilcoyne, Margarita Men&#233;ndez, Thanh H. Nguyen, Lokesh Joshi, F. Javier Ca&#241;ada, Jes&#250;s Jim&#233;nez-Barbero, M&#225;ria Benkő, et al. (2015). Structure and Sialyllactose Binding of the Carboxy-Terminal Head Domain of the Fibre from a Siadenovirus, Turkey Adenovirus 3 . PLOS ONE.

Abhimanyu K. Singh, Rosa Men&#233;ndez-Conejero, Carmen San Mart&#237;n, Mark J. van Raaij (2014). Crystal Structure of the Fibre Head Domain of the Atadenovirus Snake Adenovirus 1 . PLoS ONE.

Kumar Nikhil, Shruti Sharan, Abhimanyu K. Singh, Ajanta Chakraborty, Partha Roy (2014). Anticancer Activities of Pterostilbene-Isothiocyanate Conjugate in Breast Cancer Cells: Involvement of PPARγ . PLoS ONE.

Meritxell Granell, Mikiyoshi Namura, Sara Alvira, Carmela Garcia-Doval, Abhimanyu K. Singh, Irina Gutsche, Mark J. van Raaij, Shuji Kanamaru (2014). Crystallization of the carboxy-terminal region of the bacteriophage T4 proximal long tail fibre protein gp34 . Acta Crystallographica Section F Structural Biology Communications.

Abhimanyu K. Singh, Rosa Men&#233;ndez-Conejero, Carmen San Mart&#237;n, Mark J. van Raaij (2013). Crystallization of the C-terminal domain of the fibre protein from snake adenovirus 1, an atadenovirus . Acta Crystallographica Section F Structural Biology and Crystallization Communications.

Abhimanyu K. Singh, M&#243;nika Z. Ballmann, M&#225;ria Benkő, Bal&#225;zs Harrach, Mark J. van Raaij (2013). Crystallization of the C-terminal head domain of the fibre protein from a siadenovirus, turkey adenovirus 3 . Acta Crystallographica Section F Structural Biology and Crystallization Communications.

Abhimanyu Kumar Singh, A. S. Vidyarthi, Shankaracharya (2011). Codon usage pattern of differentially expressed genes in Leishmania species . Indian Journal of Biotechnology.

PREPRINT

Abhimanyu K. Singh, Brent De Wijngaert, Marc Bijnens, Kris Uyttersprot, Hoai Nguyen, Sergio E. Martinez, Dominique Schols, Piet Herdewijn, Christophe Pannecouque, Eddy Arnold, et al. (2022). Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer – Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations .

Abhimanyu Singh, Sergio Martinez, Weijie Gu, Hoai Nguyen, Dominique Schols, Piet Herdewijn, Steven De Jonghe, Kalyan Das (2021). Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – Targeting P-pocket by fragment screening .

Alana R Cowell, Guillaume Jacquemet, Abhimanyu K Singh, York-Christoph Ammon, David G Brown, Anna Akhmanova, Johanna Ivaska, Benjamin T. Goult (2020). Talin Rod Domain Containing Protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation .