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Adomas B. に連絡

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プロフィール詳細

プロジェクトを作成

★★★★★

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Dr. Adomas B.に依頼

United States

Neuro-oncologist at Columbia NYC

プロフィール概要

専門分野

サービス

Writing

Writing Clinical Trial Documentation

職務経験

Columbia University Columbia College

- 現在

NewYork–Presbyterian Hospital

- 現在

Harvard University

7月 2018 - 7月 2019

Image Guided Neurosurgery Fellow

Brigham and Women's Hospital

7月 2018 - 7月 2019

Neurosurgeon, Assistant Professor

Hospital of Lithuanian University of Health Sciences Kaunas Clinics

8月 2017 - 7月 2018

Senior researcher, Lab head

Lithuanian University of Health Sciences

6月 2016 - 7月 2018

学歴

(Neuro-oncology fellowship)

Columbia University in the City of New York

7月 2025 - 7月 2026

Neurology residency (Neurology)

Columbia University Columbia College

7月 2021 - 7月 2025

Radiosurgery fellowship (Neurosurgery)

University of Virginia

7月 2019 - 7月 2021

(Neurosurgery)

Harvard Medical School

7月 2018 - 7月 2019

Image Guided Neurosurgery Fellow (Neurosurgery)

Brigham and Women's Hospital

7月 2018 - 7月 2019

Neurosurgery residency (Department of Neurosurgery)

Lithuanian University of Health Sciences

8月 2009 - 8月 2017

Postdoctoral research fellowship in neuroimaging (Department of Neurology and Biomedical Research Imaging Center)

University of North Carolina at Chapel Hill

8月 2012 - 6月 2013

Ph.D. (Department of Medical Psychology and Neuropsychology/ Center of Research on Psychology in Somatic diseases (CoRPS))

Tilburg University

1月 2008 - 11月 2012

Postdoctoral research fellowship (Department of Psychiatry)

University of North Carolina at Chapel Hill

8月 2010 - 8月 2012

M.D.

Lithuanian University of Health Sciences

9月 2002 - 7月 2008

認定資格

The American Board of Psychiatry and Neurology

The American Board of Psychiatry and Neurology

9月 2025 - 現在

出版物

JOURNAL ARTICLE

Gabrielė Dargė, Gabrielė Kasputytė, Paulius Savickas, Adomas Bunevičius, Inesa Bunevičienė, Erika Korobeinikova, Domas Vaitiekus, Arturas Inčiūra, Laimonas Jaruševičius, Romas Bunevičius, et al. (2025). Machine Learning Methods for Predicting Cancer Complications Using Smartphone Sensor Data: A Prospective Study . Applied Sciences.

Thirugnanam A, Donthineni K, Mammi M, Hundel J, Munteh D, D'Amore F, Bunevicius A, Mekary RA (2025). Chimeric antigen receptor T-cell therapy and immune effector cell-associated neurotoxicity syndrome: A meta-analysis . Critical reviews in oncology/hematology.

Woodworth GF, Anastasiadis P, Ozair A, Chabros J, Bettegowda C, Chen C, Gerstl JVE, Douville C, Mekary RA, Smith TR, et al. (2025). Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial . The Lancet. Oncology.

Krithara A, Nentidis A, Vandorou E, Katsimpras G, Almirantis Y, Arnal M, Bunevicius A, Farre-Maduell E, Kassiss M, Konstantakos V, et al. (2024). BioASQ Synergy: a dialogue between question-answering systems and biomedical experts for promoting COVID-19 research . Journal of the American Medical Informatics Association : JAMIA.

Sheehan JP, Mantziaris G, Bunevicius A (2024). Stereotactic radiosurgery and bevacizumab for recurrent glioblastoma . Journal of neuro-oncology.

Kasputytė G, Jenciūtė G, Šakinis N, Bunevičienė I, Korobeinikova E, Vaitiekus D, Inčiūra A, Jaruševičius L, Bunevičius R, Krikštolaitis R, et al. (2024). Smartphone sensors for evaluating COVID-19 fear in patients with cancer: a prospective study . Frontiers in public health.

Jenciūtė G, Kasputytė G, Bunevičienė I, Korobeinikova E, Vaitiekus D, Inčiūra A, Jaruševičius L, Bunevičius R, Krikštolaitis R, Krilavičius T, et al. (2023). Digital Phenotyping for Monitoring and Disease Trajectory Prediction of Patients With Cancer: Protocol for a Prospective Observational Cohort Study . JMIR research protocols.

Adomas Bunevicius, Maha Alkazemi, Yu Tung Lo, Helweh Hussein, Marco Mammi, Serag Saleh, Lita Araujo-Lama, Shannon Mommsen, Alessandra Pisano, Nayan Lamba, et al. (2023). Laser Interstitial Thermal Therapy for the Treatment of Primary and Metastatic Brain Tumors: A Systematic Review and Meta-Analysis . World Neurosurgery.

Associations of miR-181a with Health-Related Quality of Life, Cognitive Functioning, and Clinical Data of Patients with Different Grade Glioma Tumors <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . International Journal of Molecular Sciences.

Adomas Bunevicius, Indre Valiulyte, Aiste Pranckeviciene, Arimantas Tamasauskas, Hanna Svitina, Inessa Skrypkina, Paulina Vaitkiene (2022). Associations of <i>miR-181a</i> with Health-Related Quality of Life, Cognitive Functioning, and Clinical Data of Patients with Different Grade Glioma Tumors . International Journal of Molecular Sciences.

Adomas Bunevicius, Laura Donovan, Jason Sheehan(2022). Health related quality of life trajectories after stereotactic radiosurgery for brain metastases: a systematic review . Journal of Neuro-Oncology. Springer Science and Business Media {LLC}

Adomas Bunevicius, Inesa Buneviciene, Romas Bunevicius, Sarunas Bagdonas (2022). Psychometric properties of The COVID‐19 Fears Questionnaire for Chronic Medical Conditions in patients with pre‐existing medical conditions . Health & Social Care in the Community.

Adomas Bunevicius, Mindaugas Urbonas, Nijole Raskauskiene, Vytenis Pranas Deltuva (2022). Thyroid Hormones and Health-Related Quality of Life in Normal Pressure Hydrocephalus Patients before and after the Ventriculoperitoneal Shunt Surgery: A Longitudinal Study . Journal of Clinical Medicine.

Adomas Bunevicius, Nijole Kazukauskiene, Naomi A Fineberg, Nicolás Francisco Narvaez Linares, Marilou Poitras, Helene Plamondon, Aiste Pranckeviciene, Julija Gecaite-Stonciene, Julija Brozaitiene, Giedrius Varoneckas, et al.(2022). Predictive value of baseline cognitive functioning on health-related quality of life in individuals with coronary artery disease: a 5-year longitudinal study . European Journal of Cardiovascular Nursing. Oxford University Press ({OUP})

Adomas Bunevicius, Inesa Buneviciene, Romas Bunevicius, Sarunas Bagdonas(2022). The impact of pre-existing conditions and perceived health status on mental health during the COVID-19 pandemic . Journal of Public Health. Oxford University Press ({OUP})

Adomas Bunevicius, Stylianos Pikis, Frederic Padilla, Francesco Prada, Jason Sheehan (2022). Sonodynamic therapy for gliomas . Journal of Neuro-Oncology.

Adomas Bunevicius, Stylianos Pikis, Douglas Kondziolka, Dev N. Patel, Kenneth Bernstein, Erik P. Sulman, Cheng-chia Lee, Huai-che Yang, Violaine Delabar, David Mathieu, et al.(2021). Stereotactic radiosurgery for IDH wild type glioblastoma: an international, multicenter study . Journal of Neuro-Oncology. Springer Science and Business Media {LLC}

Adomas Bunevicius, Jungeun Ahn, Sarah Fribance, Selcuk Peker, Batu Hergunsel, Darrah Sheehan, Kimball Sheehan, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, et al. (2021). Stereotactic Radiosurgery for Olfactory Groove Meningiomas: An International, Multicenter Study . Neurosurgery.

Adomas Bunevicius, Stylianos Pikis, Rithika Kormath Anand, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Tomas Chytka, et al.(2021). Stereotactic radiosurgery for clinoid meningiomas: a multi-institutional study . Acta Neurochirurgica. 163. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2861--2869. Springer Science and Business Media {LLC}

Adomas Bunevicius, Stylianons Pikis, Joseph Donahue, Karen Lavezzo, Greg Patterson, Zhiyuan Xu, Jason Sheehan(2021). Diffusivity Metrics Three Months After Upfront Gamma Knife Radiosurgery for Trigeminal Neuralgia May Be Correlated with Pain Relief . World Neurosurgery. Elsevier {BV}

Adomas Bunevicius, Inesa Buneviciene (2021). Prevalence of internet addiction in healthcare professionals: Systematic review and meta-analysis . International Journal of Social Psychiatry.

Adomas Bunevicius, Karen Lavezzo, Philip W. Smith, Mary Lee Vance, Jason Sheehan(2021). Stereotactic radiosurgery before bilateral adrenalectomy is associated with lowered risk of Nelson’s syndrome in refractory Cushing’s disease patients . Acta Neurochirurgica. 163. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1949--1956. Springer Science and Business Media {LLC}

I. Buneviciene, R. Bunevicius, S. Bagdonas, A. Bunevicius(2021). COVID-19 media fatigue: predictors of decreasing interest and avoidance of COVID-19–related news . Public Health. 196. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 124--128. Elsevier {BV}

Adomas Bunevicius, Rithika Kormath Anand, Mohanad Suleiman, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, Khaled Abdelkarim, Amr M N El-Shehaby, Reem M Emad, Tomas Chytka, et al. (2021). Stereotactic Radiosurgery for Perioptic Meningiomas: An International, Multicenter Study . Neurosurgery.

Adomas Bunevicius, David A. Joyner, Thomas Eluvathingal Muttikkal, Jungeun Ahn, Jason Sheehan(2021). Magnetic Resonance Perfusion Changes of Arteriovenous Malformations Treated with Stereotactic Radiosurgery . World Neurosurgery. 146. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e1003--e1011. Elsevier {BV}

Multidimensional Structure of the Alcohol Use Disorders Identification Test: Factorial Validity and Reliability in Patients With Anxiety and Mood Disorders in Lithuania @article{PMID:33191431, Title= {Multidimensional Structure of the Alcohol Use Disorders Identification Test: Factorial Validity and Reliability in Patients With Anxiety and Mood Disorders in Lithuania}, Author= {Gecaite-Stonciene, Julija and Steibliene, Vesta and Fineberg, Naomi Anne and Podlipskyte, Aurelija and Bunevicius, Adomas and Liaugaudaite, Vilma and Juskiene, Alicja and Mickuviene, Narseta and Burkauskas, Julius}, DOI= {10.1093/alcalc/agaa118}, Number= {1}, Volume= {56}, Month= {January}, Year= {2021}, Journal= {Alcohol and alcoholism (Oxford, Oxfordshire)}, ISSN= {0735-0414}, Pages= {109—115}, Abstract= {<h4>Aims</h4>The current study aimed to evaluate the factorial structure of the Lithuanian version of the Alcohol Use Disorders Identification Test (AUDIT) in patients with anxiety and mood disorders (AMD).<h4>Methods</h4>The AUDIT was completed by 199 consecutive outpatients with AMD (21% men, mean age 39 ± 12 years), as defined by AMD criteria in DSM-5. The MINI International Neuropsychiatric Interview was used for current diagnosis of alcohol use disorder (AUD). Sociodemographic and clinical data were also collected.<h4>Results</h4>In patients with AMD, the AUDIT showed high internal consistency (Cronbach's alpha = 0.88) and good psychometric characteristics for identifying current AUD at a cut-off value of ≥9 (positive predictive value = 83.7%, sensitivity = 94.7%, specificity = 95.7%). The confirmatory factor analysis suggested a three-factor ('consumption', 'dependence' and 'related consequences') structure and indicated adequate fit to the model (comparative fit index = 0.966, normed fit index = 0.936, root mean square error of approximation = 0.072).<h4>Conclusions</h4>The findings are in line with increasing evidence suggesting that the AUDIT measures three separate factors related to alcohol misuse level of consumption, dependence and alcohol-related consequences and support the utility of AUDIT as a screening instrument for AUD in AMD patients in Lithuania.}, URL= {https://doi.org/10.1093/alcalc/agaa118}} . Alcohol and alcoholism (Oxford, Oxfordshire).

Stereotactic radiosurgery for treatment of radiation-induced meningiomas: a multiinstitutional study @article{PMID:33385995, Title= {Stereotactic radiosurgery for treatment of radiation-induced meningiomas: a multiinstitutional study}, Author= {Bunevicius, Adomas and Suleiman, Mohand and Patel, Samir and Martínez Álvarez, Roberto and Martinez Moreno, Nuria E and Liscak, Roman and Hanuska, Jaromir and Langlois, Anne-Marie and Mathieu, David and Mau, Christine and Caldwell, Catherine and Tuanquin, Leonard C and Zacharia, Brad E and McInerney, James and Lee, Cheng-Chia and Yang, Huai-Che and Peterson, Jennifer L and Trifiletti, Daniel M and Ogino, Akiyoshi and Kano, Hideyuki and Warnick, Ronald E and Saylany, Anissa and Buch, Love Y and Lee, John Y K and Strickland, Ben A and Zada, Gabriel and Chang, Eric L and Lunsford, L Dade and Sheehan, Jason}, DOI= {10.3171/2020.7.jns202064}, Month= {January}, Year= {2021}, Journal= {Journal of neurosurgery}, ISSN= {0022-3085}, Pages= {1—9}, Abstract= {<h4>Objective</h4>Radiation-induced meningiomas (RIMs) are associated with aggressive clinical behavior. Stereotactic radiosurgery (SRS) is sometimes considered for selected RIMs. The authors investigated the effectiveness and safety of SRS for the management of RIMs.<h4>Methods</h4>From 12 institutions participating in the International Radiosurgery Research Foundation, the authors pooled patients who had prior cranial irradiation and were subsequently clinically diagnosed with WHO grade I meningiomas that were managed with SRS.<h4>Results</h4>Fifty-two patients underwent 60 SRS procedures for histologically confirmed or radiologically suspected WHO grade I RIMs. The median ages at initial cranial radiation therapy and SRS for RIM were 5.5 years and 39 years, respectively. The most common reasons for cranial radiation therapy were leukemia (21%) and medulloblastoma (17%). There were 39 multiple RIMs (35%), the mean target volume was 8.61 ± 7.80 cm3, and the median prescription dose was 14 Gy. The median imaging follow-up duration was 48 months (range 4-195 months). RIM progressed in 9 patients (17%) at a median duration of 30 months (range 3-45 months) after SRS. Progression-free survival at 5 years post-SRS was 83%. Treatment volume ≥ 5 cm3 predicted progression (HR 8.226, 95% CI 1.028-65.857, p = 0.047). Seven patients (14%) developed new neurological symptoms or experienced SRS-related complications or T2 signal change from 1 to 72 months after SRS.<h4>Conclusions</h4>SRS is associated with durable local control of RIMs in the majority of patients and has an acceptable safety profile. SRS can be considered for patients and tumors that are deemed suboptimal, poor surgical candidates, and those whose tumor again progresses after removal.}, URL= {https://doi.org/10.3171/2020.7.JNS202064}} . Journal of neurosurgery.

(2021). Editorial: Radiosurgical induced malignancy associated with stereotactic radiosurgery . Acta neurochirurgica.

(2021). Epistatic effect of Ankyrin repeat and kinase domain containing 1 - Dopamine receptor D2 and catechol-o-methyltransferase single nucleotide polymorphisms on the risk for hazardous use of alcohol in Lithuanian population . Gene.

Probability of Major Depression Classification Based on the SCID, CIDI, and MINI Diagnostic Interviews: A Synthesis of Three Individual Participant Data Meta-Analyses @article{PMID:32814337, Title= {Probability of Major Depression Classification Based on the SCID, CIDI, and MINI Diagnostic Interviews: A Synthesis of Three Individual Participant Data Meta-Analyses}, Author= {Wu, Yin and Levis, Brooke and Ioannidis, John P A and Benedetti, Andrea and Thombs, Brett D and {DEPRESsion Screening Data (DEPRESSD) Collaboration}}, DOI= {10.1159/000509283}, Number= {1}, Volume= {90}, Year= {2021}, Journal= {Psychotherapy and psychosomatics}, ISSN= {0033-3190}, Pages= {28—40}, Abstract= {<h4>Introduction</h4>Three previous individual participant data meta-analyses (IPDMAs) reported that, compared to the Structured Clinical Interview for the DSM (SCID), alternative reference standards, primarily the Composite International Diagnostic Interview (CIDI) and the Mini International Neuropsychiatric Interview (MINI), tended to misclassify major depression status, when controlling for depression symptom severity. However, there was an important lack of precision in the results.<h4>Objective</h4>To compare the odds of the major depression classification based on the SCID, CIDI, and MINI.<h4>Methods</h4>We included and standardized data from 3 IPDMA databases. For each IPDMA, separately, we fitted binomial generalized linear mixed models to compare the adjusted odds ratios (aORs) of major depression classification, controlling for symptom severity and characteristics of participants, and the interaction between interview and symptom severity. Next, we synthesized results using a DerSimonian-Laird random-effects meta-analysis.<h4>Results</h4>In total, 69,405 participants (7,574 [11%] with major depression) from 212 studies were included. Controlling for symptom severity and participant characteristics, the MINI (74 studies; 25,749 participants) classified major depression more often than the SCID (108 studies; 21,953 participants; aOR 1.46; 95% confidence interval [CI] 1.11-1.92]). Classification odds for the CIDI (30 studies; 21,703 participants) and the SCID did not differ overall (aOR 1.19; 95% CI 0.79-1.75); however, as screening scores increased, the aOR increased less for the CIDI than the SCID (interaction aOR 0.64; 95% CI 0.52-0.80).<h4>Conclusions</h4>Compared to the SCID, the MINI classified major depression more often. The odds of the depression classification with the CIDI increased less as symptom levels increased. Interpretation of research that uses diagnostic interviews to classify depression should consider the interview characteristics.}, URL= {https://doi.org/10.1159/000509283}} . Psychotherapy and psychosomatics.

Outcomes from treatment of asymptomatic skull base meningioma with stereotactic radiosurgery @article{PMID:33211178, Title= {Outcomes from treatment of asymptomatic skull base meningioma with stereotactic radiosurgery}, Author= {Pikis, Stylianos and Bunevicius, Adomas and Sheehan, Jason}, DOI= {10.1007/s00701-020-04648-4}, Number= {1}, Volume= {163}, Month= {January}, Year= {2021}, Journal= {Acta neurochirurgica}, ISSN= {0001-6268}, Pages= {83—88}, Abstract= {<h4>Background</h4>Optimal management of asymptomatic skull base meningiomas is controversial. We evaluated the safety and efficiency of Gamma Knife radiosurgery (GKRS) for the management of asymptomatic skull base meningiomas.<h4>Methods</h4>This retrospective study involved patients managed with GKRS for asymptomatic, skull base meningiomas from 1997 to 2019. Patient clinico-radiologic data, tumor characteristics, and procedural details were analyzed. Favorable outcome was defined as lack of procedure-related mortality or permanent neurologic morbidity and radiologic evidence of tumor control. Tumor progression and regression were defined as an increase or decrease of > 20% in volume from baseline to the last neuroimaging study respectively. Tumor volumes within ± 20% of baseline volume were considered stable.<h4>Results</h4>Thirty-seven patients (30 women), median age 68 years old (range 42-83 months) were managed with a single-session GKRS for 40 asymptomatic, skull base meningiomas. At a median clinical follow-up of 58.5 months (range 14-150 months), no mortality associated with the procedure or the treated tumor was noted. Permanent neurologic morbidity was 2.75%. There was a statistically significant decrease in mean tumor volume (p < 0.001) from 4.04 cc (SD 3.09 cc) prior to radiosurgery to 2.73 cc (SD 2.24 cc) at last follow-up. Higher margin dose was associated with tumor regression at last follow-up (HR = 1.351; 95%CI [1.094-1.669]; p = 0.05).<h4>Conclusion</h4>As compared to natural history studies, GKRS affords long-standing tumor control and neurologic preservation in the vast majority of patients treated for asymptomatic, skull base meningiomas. Further study is necessary to identify the optimal management of asymptomatic skull base meningiomas.}, URL= {https://doi.org/10.1007/s00701-020-04648-4}} . Acta neurochirurgica.

Radiosurgery for Glioblastoma @article{PMID:33223020, Title= {Radiosurgery for Glioblastoma}, Author= {Bunevicius, Adomas and Sheehan, Jason P}, DOI= {10.1016/j.nec.2020.08.007}, Number= {1}, Volume= {32}, Month= {January}, Year= {2021}, Journal= {Neurosurgery clinics of North America}, ISSN= {1042-3680}, Pages= {117—128}, Abstract= {Glioblastoma (GBM) is infiltrative neoplasm with limited treatment options and poor overall survival. Stereotactic radiosurgery (SRS) allows spatially precise and conformal delivery of high doses of radiation. Salvage SRS for locally recurrent GBM was shown to improve patient survival and have more favorable safety profile than repeated surgical resection. Boost SRS after fractionated radiation therapy is sometimes attempted; however, Radiation Therapy Oncology Group 93-05 randomized clinical trial did not demonstrate benefits of upfront SRS that was administered before fractionated radiation. Administration of bevacizumab with SRS is associated with improved survival and can allow SRS dose escalation.}, URL= {https://doi.org/10.1016/j.nec.2020.08.007}} . Neurosurgery clinics of North America.

Adomas Bunevicius, Julie Miller, Michael Parsons(2020). Isocitrate Dehydrogenase, Patient-Reported Outcomes, and Cognitive Functioning of Glioma Patients: a Systematic Review . Current Oncology Reports. 22. (12). Springer Science and Business Media {LLC}

Adomas Bunevicius, Julija Gecaite-Stonciene, Julius Burkauskas, Julija Brozaitiene, Julius Neverauskas, Narseta Mickuviene, Nijole Kazukauskiene(2020). Validation of the Multidimensional Fatigue Inventory with Coronary Artery Disease Patients . International Journal of Environmental Research and Public Health. 17. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 8003. {MDPI} {AG}

Adomas Bunevicius, Rytis Stakaitis, Aiste Pranckeviciene, Giedrius Steponaitis, Arimantas Tamasauskas, Paulina Vaitkiene(2020). Unique Interplay between Molecular miR-181b/d Biomarkers and Health Related Quality of Life Score in the Predictive Glioma Models . International Journal of Molecular Sciences. 21. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7450. {MDPI} {AG}

Adomas Bunevicius, Julija Gecaite-Stonciene, Julius Burkauskas, Julija Brozaitiene, Julius Neverauskas, Narseta Mickuviene, Nijole Kazukauskiene (2020). Validation of the Multidimensional Fatigue Inventory with Coronary Artery Disease Patients . International Journal of Environmental Research and Public Health.

Adomas Bunevicius, Rytis Stakaitis, Aiste Pranckeviciene, Giedrius Steponaitis, Arimantas Tamasauskas, Paulina Vaitkiene (2020). Unique Interplay Between Molecular miR-181b/d Biomarkers and Health Related Quality of Life Score in the Predictive Glioma Models . International Journal of Molecular Sciences.

Adomas Bunevicius, Nathan Judson McDannold, Alexandra J Golby (2020). Focused Ultrasound Strategies for Brain Tumor Therapy . Operative Neurosurgery.

Adomas Bunevicius, Ashley Vernon, Alexandra Golby (2020). Abdominal Insufflation Is Associated With Increase of Intracranial Pressure in Patients With Normal Pressure Hydrocephalus . Operative Neurosurgery.

Adomas Bunevicius, Inesa Buneviciene(2020). Academic Productivity of Neurosurgeons Practicing in Joint Residency Advisory and Accreditation Committee Accredited Programs . World Neurosurgery. 138. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e620--e626. Elsevier {BV}

Adomas Bunevicius(2020). Academic productivity of neurosurgery residents in Europe . Acta Neurochirurgica. 162. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 245--246. Springer Science and Business Media {LLC}

Adomas Bunevicius, Aiste Pranckeviciene, Vytenis P. Deltuva, Arimantas Tamasauskas, Jurate Zegliene, Gelin Xu (2020). Clinical and Biological Correlates of Preoperative Cognitive Functioning of Glioma and Meningioma Patients . BioMed Research International.

Anita Lyubenova and Dipika Neupane and Brooke Levis and Yin Wu and Ying Sun and Chen He and Ankur Krishnan and Parash Mani Bhandari and Zelalem Negeri and Mahrukh Imran and Danielle B. Rice and Marleine Azar and Matthew J. Chiovitti and Nazanin Saadat and Kira E. Riehm and Jill Boruff and John P. A. Ioannidis and Pim Cuijpers and Simon Gilbody and Lorie A. Kloda and Scott B. Patten and Ian Shrier and Roy C. Ziegelstein and Liane Comeau and Nicholas D. Mitchell and Marcello Tonelli and Simone N. Vigod and Franca Aceti and Jacqueline Barnes and Amar D. Bavle and Cheryl Tatano Beck and Carola Bindt and Philip Boyce and Adomas Bunevicius and Linda H. Chaudron and Nicolas Favez and Bárbara Figueiredo and Lluïsa Garcia-Esteve and Lisa Giardinelli and Nadine Helle and Louise M. Howard and Jane Kohlhoff and Laima Kusminskas and Zoltán Kozinszky and Lorenzo Lelli and Angeliki A. Leonardou and Valentina Meuti and Sandra Nakić Radoš and Purificación Navarro García and Susan J. Pawlby and Chantal Quispel and Emma Robertson-Blackmore and Tamsen J. Rochat and Deborah Sharp and Bonnie W.M. Siu and Alan Stein and Robert C. Stewart and Meri Tadinac and S. Darius Tandon and Iva Alexandra Barbosa Tendais and Annamária Töreki and Anna Torres-Giménez and Thach Duc Tran and Kylee Trevillion and Katherine Turner and Johann M. Vega-Dienstmaier and Andrea Benedetti and Brett D. Thombs(2020). Depression prevalence based on the Edinburgh Postnatal Depression Scale compared to Structured Clinical Interview for DSM DIsorders classification: Systematic review and individual participant data meta-analysis . International journal of methods in psychiatric research. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e1860--.

(2020). Endoscopic third ventriculostomy versus ventriculoperitoneal shunt in pediatric and adult population: a systematic review and meta-analysis . Neurosurgical review.

Nasser Mohammed and Adomas Bunevicius and Eluvathingal Muttikkal Thomas and Jason Druzgal and Jason P Sheehan(2020). Gamma Knife radiosurgery associated worsening of superficial siderosis due to a foramen magnum tumor - A case report . Journal of radiosurgery and SBRT. 7. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 169--.

(2020). Isocitrate Dehydrogenase, Patient-Reported Outcomes, and Cognitive Functioning of Glioma Patients: a Systematic Review . Current oncology reports.

Adomas Bunevicius and Julie J. Miller and Michael W. Parsons(2020). Isocitrate Dehydrogenase, Patient-Reported Outcomes, and Cognitive Functioning of Glioma Patients: a Systematic Review . Current oncology reports. 22. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 120--.

Bunevicius, A.(2020). Academic productivity of neurosurgery residents in Europe . Acta Neurochirurgica. 162. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 245-246.

(2020). Accuracy of the Edinburgh Postnatal Depression Scale (EPDS) for screening to detect major depression among pregnant and postpartum women: systematic review and meta-analysis of individual participant data . BMJ (Clinical research ed.).

(2020). Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis . Critical reviews in oncology/hematology.

Lok Wa Laura Leung and Prashin Unadkat and Melina More Bertotti and Wenya Linda Bi and Walid I. Essayed and Adomas Bunevicius and Vamsidhar Chavakula and Laura Rigolo and Luca Fumagalli and Ziyun Tie and Alexandra J. Golby and Yanmei Tie(2020). Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors . Journal of neuroimaging : official journal of the American Society of Neuroimaging. 30. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 175--183.

(2020). Clinical and Biological Correlates of Preoperative Cognitive Functioning of Glioma and Meningioma Patients . BioMed research international.

Buneviciene, I., Bunevicius, A.(2020). Academic Productivity of Neurosurgeons Practicing in Joint Residency Advisory and Accreditation Committee Accredited Programs . World Neurosurgery.

Julija Gecaite-Stonciene and Vesta Steibliene and Naomi A. Fineberg and A. Podlipskyte and Adomas Bunevicius and V. Liaugaudaite and A. Juskiene and Narseta Mickuviene and Julius Burkauskas(2020). Multidimensional Structure of the Alcohol Use Disorders Identification Test: Factorial Validity and Reliability in Patients With Anxiety and Mood Disorders in Lithuania . Alcohol and alcoholism (Oxford, Oxfordshire). 56. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 109--115.

Stylianos Pikis and Adomas Bunevicius and Jason P. Sheehan(2020). Outcomes from treatment of asymptomatic skull base meningioma with stereotactic radiosurgery . Acta neurochirurgica. 163. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--6.

Adomas Bunevicius and Jason P. Sheehan(2020). Radiosurgery for Glioblastoma . Neurosurgery clinics of North America. 32. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 117--128.

(2020). Validation of the Multidimensional Fatigue Inventory with Coronary Artery Disease Patients . International journal of environmental research and public health.

(2020). Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale - Depression subscale scores: An individual participant data meta-analysis of 73 primary studies . Journal of psychosomatic research.

Wu, Y., Levis, B., Sun, Y., Krishnan, A., He, C., Riehm, K.E., Rice, D.B., Azar, M., Yan, X.W., Neupane, D., et al.(2020). Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale – Depression subscale scores: An individual participant data meta-analysis of 73 primary studies . Journal of Psychosomatic Research. 129.

Adomas Bunevicius and Karen Lavezzo and Leah Shabo and Jesse McClure and Jason P. Sheehan(2020). Quality-of-life trajectories after stereotactic radiosurgery for brain metastases . Journal of neurosurgery. -1. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--9.

(2020). Magnetic Resonance Perfusion Changes of Arteriovenous Malformations Treated with Stereotactic Radiosurgery . World neurosurgery.

Leung, L.W.L., Unadkat, P., Bertotti, M.M., Bi, W.L., Essayed, W.I., Bunevicius, A., Chavakula, V., Rigolo, L., Fumagalli, L., Tie, Z., et al.(2020). Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors . Journal of Neuroimaging. 30. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 175-183.

(2020). Depression prevalence based on the Edinburgh Postnatal Depression Scale compared to Structured Clinical Interview for DSM DIsorders classification: Systematic review and individual participant data meta-analysis . International journal of methods in psychiatric research.

Radziunas, A., Deltuva, V.P., Tamasauskas, A., Gleizniene, R., Pranckeviciene, A., Surkiene, D., Bunevicius, A.(2020). Neuropsychiatric complications and neuroimaging characteristics after deep brain stimulation surgery for Parkinson’s disease . Brain Imaging and Behavior. 14. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 62-71.

Adomas Bunevicius and Darrah E. Sheehan and Mary Lee Vance and David Schlesinger and Jason P. Sheehan(2020). Outcomes of Cushing's disease following Gamma Knife radiosurgery: effect of a center's growing experience and era of treatment . Journal of neurosurgery. -1. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--8.

(2020). Prevalence of internet addiction in healthcare professionals: Systematic review and meta-analysis . The International journal of social psychiatry.

(2020). REVIEW: MR elastography of brain tumors . NeuroImage. Clinical.

Adomas Bunevicius, Katharina Schregel, Ralph Sinkus, Alexandra Golby, Samuel Patz(2020). REVIEW: MR elastography of brain tumors . NeuroImage: Clinical. 25. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 102109. Elsevier {BV}

Bunevicius, A., Schregel, K., Sinkus, R., Golby, A., Patz, S.(2020). REVIEW: MR elastography of brain tumors . NeuroImage. Clinical. 25. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 102109.

(2020). Safety and efficacy of prothrombin complex concentrate (PCC) for anticoagulation reversal in patients undergoing urgent neurosurgical procedures: a systematic review and metaanalysis . Neurosurgical review.

(2020). Sex Effect on Presurgical Language Mapping in Patients With a Brain Tumor . Frontiers in neuroscience.

Yao, S., Liebenthal, E., Juvekar, P., Bunevicius, A., Vera, M., Rigolo, L., Golby, A.J., Tie, Y.(2020). Sex Effect on Presurgical Language Mapping in Patients With a Brain Tumor . Frontiers in Neuroscience. 14.

Suleiman, M., Bunevicius, A., Sheehan, J.(2020). Stereotactic radiosurgery for management of recurring Choroid Plexus Metastases from Non-Small Cell Lung Carcinoma . Journal of Neuro-Oncology.

(2020). Unique Interplay Between Molecular miR-181b/d Biomarkers and Health Related Quality of Life Score in the Predictive Glioma Models . International journal of molecular sciences.

Neuropsychiatric complications and neuroimaging characteristics after deep brain stimulation surgery for Parkinson's disease @article{PMID:30267364, Title= {Neuropsychiatric complications and neuroimaging characteristics after deep brain stimulation surgery for Parkinson's disease}, Author= {Radziunas, Andrius and Deltuva, Vytenis Pranas and Tamasauskas, Arimantas and Gleizniene, Rymante and Pranckeviciene, Aiste and Surkiene, Danguole and Bunevicius, Adomas}, DOI= {10.1007/s11682-018-9971-4}, Number= {1}, Volume= {14}, Month= {February}, Year= {2020}, Journal= {Brain imaging and behavior}, ISSN= {1931-7557}, Pages= {62—71}, Abstract= {Psychiatric complications after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease patients are common. The aim of this study was to evaluate a possible role of cortical thickness, cortical and subcortical volume for neuropsychiatric complications after STN-DBS implantation surgery. Twenty-two Parkinson's disease patients underwent STN-DBS. Control group consisted of 18 healthy volunteers who were matched by age and gender. All Parkinson's disease patients and control subjects underwent neuropsychological assessment and brain MRI. Control group subjects had normal MRI and neurocognitive testing results. Seven (31.8%) Parkinson's disease patients developed neuropsychiatric complications (psychosis and delirium) after STN-DBS implantation surgery with full recovery in short follow up. Two Parkinson's disease patients were excluded from further analysis, because they did not match image processing and analysis quality control. Volumetric analysis showed significant differences in cortical thickness between STN-DBS patients with and without postoperative neuropsychiatric complications in 13 gyruses on the right hemisphere (superior frontal, caudal middle frontal, pars triangularis and opercularis, temporal lobe, superior and inferior parietal, supramarginal) and in 7 gyruses on the left hemisphere (caudal middle frontal, inferior and middle temporal, pre and postcentral, superior parietal and supramarginal). White matter volume analysis showed also its reduction in the left caudal middle frontal area. Moreover, white matter volume and surface area reduction implicating that this area can be the most important for postoperative neuropsychiatric complication risk. Study results suggest that neuropsychiatric complications are common in Parkinson's disease patients after STN-DBS implantation and can be associated with excitation of frontal-striatum-thalamus and temporal-parietal circuits.}, URL= {https://doi.org/10.1007/s11682-018-9971-4}} . Brain imaging and behavior.

Focused Ultrasound Strategies for Brain Tumor Therapy @article{PMID:31853548, Title= {Focused Ultrasound Strategies for Brain Tumor Therapy}, Author= {Bunevicius, Adomas and McDannold, Nathan Judson and Golby, Alexandra J}, DOI= {10.1093/ons/opz374}, Number= {1}, Volume= {19}, Month= {July}, Year= {2020}, Journal= {Operative neurosurgery (Hagerstown, Md.)}, ISSN= {2332-4252}, Pages= {9—18}, Abstract= {BACKGROUND:A key challenge in the medical treatment of brain tumors is the limited penetration of most chemotherapeutic agents across the blood-brain barrier (BBB) into the tumor and the infiltrative margin around the tumor. Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising tool to enhance the delivery of chemotherapeutic agents into brain tumors. OBJECTIVE:To review the mechanism of FUS, preclinical evidence, and clinical studies that used low-frequency FUS for a BBB opening in gliomas. METHODS:Literature review. RESULTS:The potential of externally delivered low-intensity ultrasound for a temporally and spatially precise and predictable disruption of the BBB has been investigated for over a decade, yielding extensive preclinical literature demonstrating that FUS can disrupt the BBB in a spatially targeted and temporally reversible manner. Studies in animal models documented that FUS enhanced the delivery of numerous chemotherapeutic and investigational agents across the BBB and into brain tumors, including temozolomide, bevacizumab, 1,3-bis (2-chloroethyl)-1-nitrosourea, doxorubicin, viral vectors, and cells. Chemotherapeutic interventions combined with FUS slowed tumor progression and improved animal survival. Recent advances of MRgFUS systems allow precise, temporally and spatially controllable, and safe transcranial delivery of ultrasound energy. Initial clinical evidence in glioma patients has shown the efficacy of MRgFUS in disrupting the BBB, as demonstrated by an enhanced gadolinium penetration. CONCLUSION:Thus far, a temporary disruption of the BBB followed by the administration of chemotherapy has been both feasible and safe. Further studies are needed to determine the actual drug delivery, including the drug distribution at a tissue-level scale, as well as effects on tumor growth and patient prognosis.}, URL= {https://doi.org/10.1093/ons/opz374}} . Operative neurosurgery (Hagerstown, Md.).

Academic Productivity of Neurosurgeons Practicing in Joint Residency Advisory and Accreditation Committee Accredited Programs @article{PMID:32171931, Title= {Academic Productivity of Neurosurgeons Practicing in Joint Residency Advisory and Accreditation Committee Accredited Programs}, Author= {Buneviciene, Inesa and Bunevicius, Adomas}, DOI= {10.1016/j.wneu.2020.03.020}, Volume= {138}, Month= {June}, Year= {2020}, Journal= {World neurosurgery}, ISSN= {1878-8750}, Pages= {e620—e626}, Abstract= {BACKGROUND:Bibliometric indexes are often used to evaluate and compare neurosurgeons and departments, and they have been shown to correlate with academic rank and department reputation. We evaluated academic productivity of neurosurgeons practicing in departments accredited by the Joint Residency Advisory and Accreditation Committee and European Association of Neurological Surgeons. METHODS:In a cross-sectional study, we calculated number of publications, citations, h-index, and m-quotient from PubMed and Web of Science databases for 285 neurosurgeons affiliated with 19 departments that are accredited or in progress of accreditation by the Joint residency Advisory and Accreditation Committee. Academic productivity was compared as a function of academic rank and research degree. RESULTS:Median number of publications in PubMed and Web of Science indexed journals were 13 (range, 0-352) and 15 (range, 0-323), respectively. Median h-index was 4 (range, 0-41), and median m-quotient was 0.56 (range, 0-2.86). There was a significant variability between the studied departments in median number of publications and h-index (P = 0.001). Professors and associate professors had significantly higher bibliometric indexes than neurosurgeons without academic rank (all P values < 0.001). Department chairmen had higher bibliometric indexes than other faculty members (all P values < 0.001). Neurosurgeons holding a research degree authored more publications and had higher bibliometric indexes than faculty members not holding a research degree (P < 0.001). CONCLUSIONS:This is the first study to evaluate academic productivity of neurosurgeons practicing in Europe and Turkey. Higher academic rank and advanced research degree were associated with greater academic productivity. Further studies exploring regional differences in academic productivity of European neurosurgeons are encouraged.}, URL= {https://doi.org/10.1016/j.wneu.2020.03.020}} . World neurosurgery.

Academic productivity of neurosurgery residents in Europe @article{PMID:31863298, Title= {Academic productivity of neurosurgery residents in Europe}, Author= {Bunevicius, Adomas}, DOI= {10.1007/s00701-019-04181-z}, Number= {2}, Volume= {162}, Month= {February}, Year= {2020}, Journal= {Acta neurochirurgica}, ISSN= {0001-6268}, Pages= {245—246}, URL= {https://doi.org/10.1007/s00701-019-04181-z}} . Acta neurochirurgica.

Abdominal Insufflation Is Associated With Increase of Intracranial Pressure in Patients With Normal Pressure Hydrocephalus @article{PMID:31620775, Title= {Abdominal Insufflation Is Associated With Increase of Intracranial Pressure in Patients With Normal Pressure Hydrocephalus}, Author= {Bunevicius, Adomas and Vernon, Ashley and Golby, Alexandra}, DOI= {10.1093/ons/opz319}, Number= {1}, Volume= {19}, Month= {July}, Year= {2020}, Journal= {Operative neurosurgery (Hagerstown, Md.)}, ISSN= {2332-4252}, Pages= {53—56}, Abstract= {BACKGROUND:Ventriculoperitoneal shunting (VPS) is effective for the treatment of normal-pressure hydrocephalus (NPH) and sometimes requires laparoscopic assistance with abdominal insufflation. OBJECTIVE:To evaluate the association of abdominal insufflation with opening pressure (OP) in NPH patients undergoing VPS implantation. METHODS:Between March 2016 and April 2019, 52 consecutive patients who underwent first-time VPS implantation surgery were retrospectively identified by reviewing electronic health records. OP during the large volume lumbar tap test (OPLP) and VPS implantation surgery (OPSURGERY) were measured in 29 patients. RESULTS:Laparoscopic assistance with abdominal insufflation was used in 20 (69%) cases. There were no differences in patient age (P = .589), gender (P = .822), body mass index (P = .289), weight (P = .789), height (P = .542), and OPLP (P = .476) in patients operated with and without laparoscopic assistance. When compared to patients operated without laparoscopic assistance, laparoscopic assistance was associated with a greater rate of OP increase during surgery relative to OPLP (40% vs 100%, P = .002), a greater increase in OPSURGERY relative to OPLP (-0.40 ± 5.38 vs 10.17 ± 5.53 cm H2O, P < .001), and a greater proportion of patients with OPSURGERY of ≥25 cm H2O during the VPS surgery (0% vs 78%, P < .001). CONCLUSION:Abdominal insufflation is associated with an increase in intracranial pressure with OPs often exceeding 25 cm H2O. This should be considered when selecting optimal VPS pressure settings.}, URL= {https://doi.org/10.1093/ons/opz319}} . Operative neurosurgery (Hagerstown, Md.).

A comparison of thin-plate spline deformation and finite element modeling to compensate for brain shift during tumor resection @article{PMID:31444624, Title= {A comparison of thin-plate spline deformation and finite element modeling to compensate for brain shift during tumor resection}, Author= {Frisken, Sarah and Luo, Ma and Juvekar, Parikshit and Bunevicius, Adomas and Machado, Ines and Unadkat, Prashin and Bertotti, Melina M and Toews, Matt and Wells, William M and Miga, Michael I and Golby, Alexandra J}, DOI= {10.1007/s11548-019-02057-2}, Number= {1}, Volume= {15}, Month= {January}, Year= {2020}, Journal= {International journal of computer assisted radiology and surgery}, ISSN= {1861-6410}, Pages= {75—85}, Abstract= {PURPOSE:Brain shift during tumor resection can progressively invalidate the accuracy of neuronavigation systems and affect neurosurgeons' ability to achieve optimal resections. This paper compares two methods that have been presented in the literature to compensate for brain shift: a thin-plate spline deformation model and a finite element method (FEM). For this comparison, both methods are driven by identical sparse data. Specifically, both methods are driven by displacements between automatically detected and matched feature points from intraoperative 3D ultrasound (iUS). Both methods have been shown to be fast enough for intraoperative brain shift correction (Machado et al. in Int J Comput Assist Radiol Surg 13(10):1525-1538, 2018; Luo et al. in J Med Imaging (Bellingham) 4(3):035003, 2017). However, the spline method requires no preprocessing and ignores physical properties of the brain while the FEM method requires significant preprocessing and incorporates patient-specific physical and geometric constraints. The goal of this work was to explore the relative merits of these methods on recent clinical data. METHODS:Data acquired during 19 sequential tumor resections in Brigham and Women's Hospital's Advanced Multi-modal Image-Guided Operating Suite between December 2017 and October 2018 were considered for this retrospective study. Of these, 15 cases and a total of 24 iUS to iUS image pairs met inclusion requirements. Automatic feature detection (Machado et al. in Int J Comput Assist Radiol Surg 13(10):1525-1538, 2018) was used to detect and match features in each pair of iUS images. Displacements between matched features were then used to drive both the spline model and the FEM method to compensate for brain shift between image acquisitions. The accuracies of the resultant deformation models were measured by comparing the displacements of manually identified landmarks before and after deformation. RESULTS:The mean initial subcortical registration error between preoperative MRI and the first iUS image averaged 5.3 ± 0.75 mm. The mean subcortical brain shift, measured using displacements between manually identified landmarks in pairs of iUS images, was 2.5 ± 1.3 mm. Our results showed that FEM was able to reduce subcortical registration error by a small but statistically significant amount (from 2.46 to 2.02 mm). A large variability in the results of the spline method prevented us from demonstrating either a statistically significant reduction in subcortical registration error after applying the spline method or a statistically significant difference between the results of the two methods. CONCLUSIONS:In this study, we observed less subcortical brain shift than has previously been reported in the literature (Frisken et al., in: Miller (ed) Biomechanics of the brain, Springer, Cham, 2019). This may be due to the fact that we separated out the initial misregistration between preoperative MRI and the first iUS image from our brain shift measurements or it may be due to modern neurosurgical practices designed to reduce brain shift, including reduced craniotomy sizes and better control of intracranial pressure with the use of mannitol and other medications. It appears that the FEM method and its use of geometric and biomechanical constraints provided more consistent brain shift correction and better correction farther from the driving feature displacements than the simple spline model. The spline-based method was simpler and tended to give better results for small deformations. However, large variability in the spline results and relatively small brain shift prevented this study from demonstrating a statistically significant difference between the results of the two methods.}, URL= {https://europepmc.org/articles/PMC6952552}} . International journal of computer assisted radiology and surgery.

Frisken, S., Luo, M., Juvekar, P., Bunevicius, A., Machado, I., Unadkat, P., Bertotti, M.M., Toews, M., Wells, W.M., Miga, M.I., et al.(2020). A comparison of thin-plate spline deformation and finite element modeling to compensate for brain shift during tumor resection . International Journal of Computer Assisted Radiology and Surgery. 15. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 75-85.

Validation of the Substance Use Risk Profile Scale in Lithuanian population @article{PMID:32787865, Title= {Validation of the Substance Use Risk Profile Scale in Lithuanian population}, Author= {Kaminskaite, Migle and Pranckeviciene, Aiste and Bunevicius, Adomas and Janaviciute, Jovita and Jokubonis, Darius and Plioplyte, Aistė and Lelyte, Inesa and Sinkariova, Liuda and Jokubka, Ramunas}, DOI= {10.1186/s12955-020-01527-5}, Number= {1}, Volume= {18}, Month= {August}, Year= {2020}, Journal= {Health and quality of life outcomes}, ISSN= {1477-7525}, Pages= {276}, Abstract= {BACKGROUND:Personality traits are related with risk of hazardous alcohol use and alcohol dependence. The Substance Use Risk Profile Scale (SURPS) measures personality traits associated with addictive substance abuse. We examined psychometric properties of the SURPS in Lithuanian population. MATERIALS AND METHODS:Two hundred forty-seven participants (mean age 37.22 ± 0.78 years), were recruited from the local community and from an inpatient addiction treatment centre. Internal consistency, stability, factor structure, content validity, and external validity of the SURPS were examined. Hazardous alcohol use was evaluated by Alcohol Use Disorder Identification Test (AUDIT). Alcohol dependence diagnosis was established by International Classification of Diseases - 10 (ICD - 10). We also performed gender analyses for associations of personality traits with alcohol dependence and hazardous use of alcohol. RESULTS:The SURPS scale demonstrated appropriate internal validity, good temporal stability, and adequate criterion validity and construct validity. The SURPS scores of hopelessness, anxiety sensitivity and impulsivity were higher in the alcohol dependence group than in the control group for both males and females. Impulsivity and sensation seeking were associated with hazardous alcohol use and these associations were more prevalent in females. CONCLUSIONS:Lithuanian translation of the SURPS scale was appropriate. The SURPS demonstrated good sensitivity for discriminating on alcohol dependence and was more sensitive for discriminating on hazardous alcohol use for females.}, URL= {https://europepmc.org/articles/PMC7425129}} . Health and quality of life outcomes.

Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors @article{PMID:32037662, Title= {Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors}, Author= {Leung, Lok Wa Laura and Unadkat, Prashin and Bertotti, Melina More and Bi, Wenya Linda and Essayed, Walid Ibn and Bunevicius, Adomas and Chavakula, Vamsidhar and Rigolo, Laura and Fumagalli, Luca and Tie, Ziyun and Golby, Alexandra J and Tie, Yanmei}, DOI= {10.1111/jon.12690}, Number= {2}, Volume= {30}, Month= {March}, Year= {2020}, Journal= {Journal of neuroimaging : official journal of the American Society of Neuroimaging}, ISSN= {1051-2284}, Pages= {175—183}, Abstract= {BACKGROUND AND PURPOSE:Previous literature has demonstrated disparity in the postoperative recovery of first and second language function of bilingual neurosurgical patients. However, it is unclear to whether preoperative brain mapping of both languages is needed. In this study, we aimed to evaluate the clinical utility of language task functional MRI (fMRI) implemented in both languages in bilingual patients. METHODS:We retrospectively examined fMRI data of 13 bilingual brain tumor patients (age: 23 to 59 years) who performed antonym generation task-based fMRIs in English and non-English language. The usefulness of bilingual language mapping was evaluated using a structured survey administered to 5 neurosurgeons. Additionally, quantitative comparison between the brain activation maps of both languages was performed. RESULTS:Survey responses revealed differences in raters' surgical approach, including asleep versus awake surgery and extent of resection, after viewing the language fMRI maps. Additional non-English fMRI led to changes in surgical decision-making and bettered localization of language areas. Quantitative analysis revealed an increase in laterality index (LI) in non-English fMRI compared to English fMRI. The Dice coefficient demonstrated fair overlap (.458 ± .160) between the activation maps. CONCLUSION:Bilingual fMRI mapping of bilingual patients allows to better appreciate functionally active language areas that may be neglected in single language mapping. Utility of bilingual mapping was supported by changes in both surgical approach and LI measurements, suggesting its benefit on preoperative language mapping.}, URL= {https://doi.org/10.1111/jon.12690}} . Journal of neuroimaging : official journal of the American Society of Neuroimaging.

Early versus late Gamma Knife radiosurgery for Cushing's disease after prior resection: results of an international, multicenter study @article{PMID:32084634, Title= {Early versus late Gamma Knife radiosurgery for Cushing's disease after prior resection: results of an international, multicenter study}, Author= {Bunevicius, Adomas and Kano, Hideyuki and Lee, Cheng-Chia and Krsek, Michal and Nabeel, Ahmed M and El-Shehaby, Amr and Abdel Karim, Khaled and Martinez-Moreno, Nuria and Mathieu, David and Lee, John Y K and Grills, Inga and Kondziolka, Douglas and Martinez-Alvarez, Roberto and Reda, Wael A and Liscak, Roman and Su, Yan-Hua and Lunsford, L Dade and Lee Vance, Mary and Sheehan, Jason P}, DOI= {10.3171/2019.12.jns192836}, Month= {February}, Year= {2020}, Journal= {Journal of neurosurgery}, ISSN= {0022-3085}, Pages= {1—9}, Abstract= {OBJECTIVE:The optimal time to perform stereotactic radiosurgery after incomplete resection of adrenocorticotropic hormone (ACTH)-producing pituitary adenoma in patients with Cushing's disease (CD) remains unclear. In patients with persistent CD after resection of ACTH-producing pituitary adenoma, the authors evaluated the association of the interval between resection and Gamma Knife radiosurgery (GKRS) with outcomes. METHODS:Pooled data from 10 institutions participating in the International Radiosurgery Research Foundation were used in this study. RESULTS:Data from 255 patients with a mean follow-up of 65.59 ± 49.01 months (mean ± SD) were analyzed. Seventy-seven patients (30%) underwent GKRS within 3 months; 46 (18%) from 4 to 6 months; 34 (13%) from 7 to 12 months; and 98 (38%) at > 12 months after the resection. Actuarial endocrine remission rates were higher in patients who underwent GKRS ≤ 3 months than when treatment was > 3 months after the resection (78% and 65%, respectively; p = 0.017). Endocrine remission rates were lower in patients who underwent GKRS at > 12 months versus ≤ 12 months after the resection (57% vs 76%, respectively; p = 0.006). In multivariate Cox regression analyses adjusted for clinical and treatment characteristics, early GKRS was associated with increased probability of endocrine remission (hazard ratio [HR] 1.518, 95% CI 1.039-2.218; p = 0.031), whereas late GKRS (HR 0.641, 95% CI 0.448-0.919; p = 0.015) was associated with reduced probability of endocrine remission. The incidence of some degree of new pituitary deficiency (p = 0.922), new visual deficits (p = 0.740), and other cranial nerve deficits (p = 0.610) was not significantly related to time from resection to GKRS. CONCLUSIONS:Early GKRS is associated with an improved endocrine remission rate, whereas later GKRS is associated with a lower rate of endocrine remission after pituitary adenoma resection. Early GKRS should be considered for patients with CD after incomplete pituitary adenoma resection.}, URL= {https://doi.org/10.3171/2019.12.JNS192836}} . Journal of neurosurgery.

Gamma Knife radiosurgery associated worsening of superficial siderosis due to a foramen magnum tumor - A case report @article{PMID:33282471, Title= {Gamma Knife radiosurgery associated worsening of superficial siderosis due to a foramen magnum tumor - A case report}, Author= {Mohammed, Nasser and Bunevicius, Adomas and Muttikkal Thomas, Eluvathingal and Druzgal, Jason and P Sheehan, Jason}, Number= {2}, Volume= {7}, Year= {2020}, Journal= {Journal of radiosurgery and SBRT}, ISSN= {2156-4639}, Pages= {169—172}, Abstract= {Superficial siderosis (SS) of the brain results from a chronic iron toxicity due to repeated microscopic leakage of blood products into the subarachnoid space. We report on Gamma Knife Radiosurgery (GKRS) associated worsening of superficial siderosis in a patient with skull-base tumor. A 73 year-old male patient presented with clumsiness and gait ataxia and was diagnosed with foramen magnum meningioma. He was also noted to have superficial siderosis involving the mainly the infratentorial compartment. After a thorough evaluation of craniospinal axis, no other cause of bleeding was identified. Patient was treated with the GKRS. After GKRS, there was an initial radiological and clinical worsening of SS starting at 6 months and peaking at 2 years. The disease stabilized and showed mild reduction at 3 years. GKRS lead to an initial progression of superficial siderosis. However, over a longer period, tumor control and improvement of the siderosis was observed.}, URL= {https://europepmc.org/articles/PMC7717088}} . Journal of radiosurgery and SBRT.

Outcomes of Cushing's disease following Gamma Knife radiosurgery: effect of a center's growing experience and era of treatment @article{PMID:32005023, Title= {Outcomes of Cushing's disease following Gamma Knife radiosurgery: effect of a center's growing experience and era of treatment}, Author= {Bunevicius, Adomas and Sheehan, Darrah and Lee Vance, Mary and Schlesinger, David and Sheehan, Jason P}, DOI= {10.3171/2019.12.jns192743}, Month= {January}, Year= {2020}, Journal= {Journal of neurosurgery}, ISSN= {0022-3085}, Pages= {1—8}, Abstract= {OBJECTIVE:Stereotactic radiosurgery (SRS) is used for the management of residual or recurrent Cushing's disease (CD). Increasing experience and technological advancements of Gamma Knife radiosurgery (GKRS) systems can impact the outcomes of CD patients. The authors evaluated the association of their center's growing experience and the era in which GKRS was performed with treatment success and adverse events in patients with CD. METHODS:The authors studied consecutive patients with CD treated with GKRS at the University of Virginia since installation of the first Gamma Knife system in March 1989 through August 2019. They compared endocrine remission and complication rates between patients treated before 2000 (early cohort) and those who were treated in 2000 and later (contemporary cohort). RESULTS:One hundred thirty-four patients with CD underwent GKRS during the study period: 55 patients (41%) comprised the early cohort, and 79 patients (59%) comprised the contemporary cohort. The contemporary cohort, compared with the early cohort, had a significantly greater treatment volume, radiation prescription dose, maximal dose to the optic chiasm, and number of isocenters, and they more often had cavernous sinus involvement. Endocrine remission rates were higher in the contemporary cohort when compared with the early cohort (82% vs 66%, respectively; p = 0.01). In a Cox regression analysis adjusted for demographic, clinical, and SRS characteristics, the contemporary GKRS cohort had a higher probability of endocrine remission than the early cohort (HR 1.987, 95% CI 1.234-3.199; p = 0.005). The tumor control rate, incidence of cranial nerve neuropathy, and new anterior pituitary deficiency were similar between the two groups. CONCLUSIONS:Technological advancements over the years and growing center experience were important factors for improved endocrine remission rates in patients with CD. Technological aspects and results of contemporary Gamma Knife systems should be considered when counseling patients, planning treatment, and reporting treatment results. Studies exploring the learning curve for GKRS are warranted.}, URL= {https://doi.org/10.3171/2019.12.JNS192743}} . Journal of neurosurgery.

Stereotactic radiosurgery for management of recurring Choroid Plexus Metastases from Non-Small Cell Lung Carcinoma @article{PMID:32297093, Title= {Stereotactic radiosurgery for management of recurring Choroid Plexus Metastases from Non-Small Cell Lung Carcinoma}, Author= {Suleiman, Mohanad and Bunevicius, Adomas and Sheehan, Jason}, DOI= {10.1007/s11060-020-03498-5}, Number= {1}, Volume= {148}, Month= {May}, Year= {2020}, Journal= {Journal of neuro-oncology}, ISSN= {0167-594X}, Pages= {207—209}, URL= {https://doi.org/10.1007/s11060-020-03498-5}} . Journal of neuro-oncology.

Quality-of-life trajectories after stereotactic radiosurgery for brain metastases @article{PMID:32650308, Title= {Quality-of-life trajectories after stereotactic radiosurgery for brain metastases}, Author= {Bunevicius, Adomas and Lavezzo, Karen and Shabo, Leah and McClure, Jesse and Sheehan, Jason P}, DOI= {10.3171/2020.4.jns20788}, Month= {July}, Year= {2020}, Journal= {Journal of neurosurgery}, ISSN= {0022-3085}, Pages= {1—9}, Abstract= {OBJECTIVE:Quality of life (QOL) is an important endpoint measure of cancer treatment. The authors' goal was to evaluate QOL trajectories and prognostic value in cancer patients treated with stereotactic radiosurgery (SRS) for brain metastases. METHODS:Patients who underwent Gamma Knife radiosurgery (GKRS) between January 2016 and November 2019 were prospectively evaluated for QOL using the EQ-5D-3L questionnaire before SRS and at follow-up visits. Only patients who had pre-SRS and at least 1 post-SRS QOL assessment were considered. RESULTS:Fifty-four cancer patients underwent 109 GKRS procedures. The first post-SRS visit was at a median of 2.59 months (range 0.13-21.08 months), and the last post-SRS visit was at 14.72 months (range 2.52-45.21 months) after SRS. There was no statistically significant change in the EQ-5D index score (p = 0.539) at the first compared with last post-SRS visit. The proportion of patients reporting some problems on the EQ-5D dimension of self-care increased during the course of follow-up from 9% (pre-SRS visit) to 18% (last post-SRS visit; p = 0.03). The proportion of patients reporting problems on the EQ-5D dimensions of mobility, usual activities, pain/discomfort, and anxiety/depression remained stable during the course of follow-up (p ≥ 0.106). After adjusting for clinical variables, a higher recursive partitioning analysis (RPA) class (i.e., worse prognostic category) was independently associated with greater odds for EQ-5D index score deterioration (p = 0.050). Upfront whole-brain radiation therapy predicted deterioration of the EQ-5D self-care (p = 0.03) and usual activities (p = 0.024) dimensions, while a greater number of lesions predicted deterioration of the EQ-5D anxiety/depression dimension (p = 0.008). A lower pre-SRS EQ-5D index was associated with shorter survival independently from clinical and demographic variables (OR 18.956, 95% CI 2.793-128.64; p = 0.003). CONCLUSIONS:QOL is largely preserved in brain metastasis patients treated with SRS. Higher RPA class, upfront whole-brain radiation therapy, and greater intracranial disease burden are independent predictors of post-SRS QOL deterioration. Worse pre-SRS QOL predicts shorter survival. Assessment of QOL is recommended in brain metastasis patients managed with SRS.}, URL= {https://doi.org/10.3171/2020.4.JNS20788}} . Journal of neurosurgery.

Adomas Bunevicius, Edward R. Laws, Ausra Saudargiene, Arimantas Tamasauskas, Giorgio Iervasi, Vytenis Deltuva, Timothy R. Smith, Robertas Bunevicius(2019). Common genetic variations of deiodinase genes and prognosis of brain tumor patients . Endocrine. 66. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 563--572. Springer Science and Business Media {LLC}

Adomas Bunevicius(2019). Comments: “Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome” . Revista da Associação Médica Brasileira. 65. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 993--994. {FapUNIFESP} ({SciELO})

Adomas Bunevicius(2019). Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma . Radiotherapy and Oncology. 135. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 197. Elsevier {BV}

Bunevicius, A.(2019). Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma . Radiotherapy and Oncology. 135. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 197.

Bunevicius, A., Laws, E.R., Saudargiene, A., Tamasauskas, A., Iervasi, G., Deltuva, V., Smith, T.R., Bunevicius, R.(2019). Common genetic variations of deiodinase genes and prognosis of brain tumor patients . Endocrine. 66. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 563-572.

(2019). Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta-analysis . International journal of methods in psychiatric research.

Levis, B., McMillan, D., Sun, Y., He, C., Rice, D.B., Krishnan, A., Wu, Y., Azar, M., Sanchez, T.A., Chiovitti, M.J., et al.(2019). Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta-analysis . International Journal of Methods in Psychiatric Research. 28. (4).

Julius Burkauskas and Adomas Bunevicius and Naomi A. Fineberg and Julija Brozaitiene and Nijole Kazukauskiene and Narseta Mickuviene(2019). Pilot study of neurocognitive functioning and health-related quality of life in coronary artery disease patients . European Neuropsychopharmacology. 29. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S317--S318.

(2019). Preliminary Results Comparing Thin Plate Splines with Finite Element Methods for Modeling Brain Deformation during Neurosurgery using Intraoperative Ultrasound . Proceedings of SPIE--the International Society for Optical Engineering.

(2019). Management of glioblastoma: a perspective from Lithuania . Chinese clinical oncology.

Adomas Bunevicius and Jurgita Usinskiene and Inesa Buneviciene and Ieva Vincerzevskiene(2019). Management of glioblastoma: a perspective from Lithuania . Chinese clinical oncology.

Pop, V.J., Ormindean, V., Mocan, A., Meems, M., Broeren, M., Denollet, J.K., Wiersinga, W.M., Bunevicius, A.(2019). Maternal cognitive function during pregnancy in relation to hypo- and hyperthyroxinemia . Clinical Endocrinology. 91. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 824-833.

Adomas Bunevicius(2019). Reader response: Depressed TSH level as a predictor of poststroke fatigue in patients with acute ischemic stroke . Neurology. 93. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 563--564.

Pranckevičienė, A., Jurkuvėnas, V., Deltuva, V.P., Tamašauskas, A., Bunevičius, A.(2019). Preoperative verbal memory problems and their clinical prognostic value in meningioma patients: A prospective study . Applied Neuropsychology:Adult. 26. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 503-512.

Michael W. Parsons and Adomas Bunevicius and Jorg Dietrich(2019). QOLP-38. PATIENT REPORTED OUTCOMES IN GLIOMA: THE ROLE OF IDH MUTATION ON QUALITY OF LIFE AND MOOD . Neuro-Oncology. 21. (Supplement_6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString vi206--vi206.

Bunevicius, A.(2019). Reader response: Depressed TSH level as a predictor of poststroke fatigue in patients with acute ischemic stroke . Neurology. 93. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 563-564.

Liaugaudaite, V., Naginiene, R., Raskauskiene, N., Mickuviene, N., Bunevicius, A., Sher, L.(2019). Relationship between Lithium Levels in Drinking Water and Suicide Rates: A Nationwide Study in Lithuania . Archives of Suicide Research.

Alonso, C.E., Bunevicius, A., Trifiletti, D.M., Larner, J., Lee, C.-C., Pai, F.-Y., Liscak, R., Kosak, M., Kano, H., Sisterson, N.D., et al.(2019). Safety and efficacy of repeat radiosurgery for acromegaly: an International Multi-Institutional Study . Journal of Neuro-Oncology. 145. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 301-307.

Bunevicius, A., Tamasauskas, A., Ambrozaitis, K.V.(2019). Spontaneous thoracic subdural hematoma associated with warfarin therapy: Case report with serial MRI . Surgical Neurology International. 10. (1).

Bunevicius, A., Laws, E.R., Vance, M.L., Iuliano, S., Sheehan, J.(2019). Surgical and radiosurgical treatment strategies for Cushing’s disease . Journal of Neuro-Oncology. 145. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 403-413.

Shun Yao and Einat Liebenthal and Parikshit Juvekar and Adomas Bunevicius and Matthew Vera and Laura Rigolo and Alexandra J. Golby and Yanmei Tie(2019). Sex Difference in Language Processing in Patients With Malignant Brain Tumors . Neurosurgery. 66. (Supplement_1).

Julija Gecaite and Julius Burkauskas and Adomas Bunevicius and Julija Brozaitiene and Nijole Kazukauskiene and Narseta Mickuviene(2019). The association of cardiovascular reactivity during the Trier Social Stress Test with quality of life in coronary artery disease patients . Journal of psychosomatic research. 126. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 109824--.

(2019). Spontaneous thoracic subdural hematoma associated with warfarin therapy: Case report with serial MRI . Surgical neurology international.

Gecaite, J., Burkauskas, J., Bunevicius, A., Brozaitiene, J., Kazukauskiene, N., Mickuviene, N.(2019). The association of cardiovascular reactivity during the Trier Social Stress Test with quality of life in coronary artery disease patients . Journal of Psychosomatic Research. 126.

Adomas Bunevicius and A. Tamasauskas and Kazys Vytautas Ambrozaitis(2019). Spontaneous thoracic subdural hematoma associated with warfarin therapy: Case report with serial MRI . Surgical neurology international. 10. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 28--.

A. Juskiene and G. Varoneckas and A. Podlipskyte and Adomas Bunevicius and Narseta Mickuviene(2019). Thyroid hormones and personality in coronary artery disease patients with and without sleep apnea . European Neuropsychopharmacology. 29. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S512--S513.

Aiste Pranckeviciene and Ausra Saudargiene and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Adomas Bunevicius(2019). QOLP-16. DISTRESSED (D TYPE) PERSONALITY, PREOPERATIVE PSYCHOLOGICAL DISTRESS, COGNITIVE FUNCTIONING, QUALITY OF LIFE, AND TREATMENT OUTCOMES OF GLIOMA PATIENTS: PROSPECTIVE STUDY . Neuro-Oncology. 21. (Supplement_6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString vi201--vi201.

(2019). Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma . Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Adomas Bunevicius(2019). Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma . Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 135. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 197--.

Deividas Nekrosius and Migle Kaminskaite and Ramunas Jokubka and Aiste Pranckeviciene and Karolis Lideikis and Arimantas Tamasauskas and Adomas Bunevicius(2019). Association of COMT Val158Met Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury . The Journal of neuropsychiatry and clinical neurosciences. 31. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 298--305.

Nekrosius, D., Kaminskaite, M., Jokubka, R., Pranckeviciene, A., Lideikis, K., Tamasauskas, A., Bunevicius, A.(2019). Association of comt val<sup>158</sup>met polymorphism with delirium risk and outcomes after traumatic brain injury . Journal of Neuropsychiatry and Clinical Neurosciences. 31. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 298-305.

(2019). Association of miR-34a Expression with Quality of Life of Glioblastoma Patients: A Prospective Study . Cancers.

Vaitkiene, P., Pranckeviciene, A., Stakaitis, R., Steponaitis, G., Tamasauskas, A., Bunevicius, A.(2019). Association of miR-34a expression with quality of life of glioblastoma patients: A prospective study . Cancers. 11. (3).

Adomas Bunevicius(2019). Comments: "Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome" . Revista da Associacao Medica Brasileira (1992). 65. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 993--994.

Bunevicius, A.(2019). Comments: “Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome” . Revista da Associacao Medica Brasileira. 68. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 993-994.

Adomas Bunevicius and Edward R. Laws and Ausra Saudargiene and Arimantas Tamasauskas and Giorgio Iervasi and Vytenis Pranas Deltuva and Timothy R. Smith and Robertas Bunevicius(2019). Common genetic variations of deiodinase genes and prognosis of brain tumor patients . Endocrine. 66. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 563--572.

Sarah F. Frisken and Ma Luo and Parikshit Juvekar and Adomas Bunevicius and Inês Machado and Prashin Unadkat and Melina More Bertotti and Matthew Toews and William M. Wells and Michael I. Miga and Alexandra J. Golby(2019). A comparison of thin-plate spline deformation and finite element modeling to compensate for brain shift during tumor resection . International journal of computer assisted radiology and surgery. 15. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 75--85.

Adomas Bunevicius(2019). Academic productivity of neurosurgery residents in Europe . Acta neurochirurgica. 162. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 245--246.

Association of COMT Val158Met Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury @article{PMID:31046593, Title= {Association of COMT Val158Met Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury}, Author= {Nekrosius, Deividas and Kaminskaite, Migle and Jokubka, Ramunas and Pranckeviciene, Aiste and Lideikis, Karolis and Tamasauskas, Arimantas and Bunevicius, Adomas}, DOI= {10.1176/appi.neuropsych.18080195}, Number= {4}, Volume= {31}, Year= {2019}, Journal= {The Journal of neuropsychiatry and clinical neurosciences}, ISSN= {0895-0172}, Pages= {298—305}, Abstract= {OBJECTIVE:The authors investigated the association of the catechol-o-methyltransferase (COMT) gene Val158Met polymorphism with delirium risk and functional and cognitive outcomes among patients with complicated mild to moderate traumatic brain injury (TBI). METHODS:In a prospective observational cohort study, patients were monitored for occurrence of delirium during the first 4 days of admission by using the Confusion Assessment Method. Functional and cognitive outcomes were evaluated with the Glasgow Outcome on Discharge Scale and the Montreal Cognitive Assessment test, respectively. Eighty-nine patients were included in the study; of these, 17 (19%) were diagnosed with delirium. RESULTS:The COMT Val158/Val158 polymorphism was associated with increased risk of delirium in multivariable regression analyses adjusted for alcohol misuse, history of neurological disorder, age, and admission Glasgow Coma Scale score (odds ratio=4.57, 95% CI=1.11, 18.9, p=0.036). The COMT Met158 allele was associated with better functional outcomes in univariate analysis (odds ratio=2.82, 95% CI=1.10, 7.27, p=0.031) but not in multivariable analysis (odds ratio=2.33, 95% CI=0.89, 6.12, p=0.085). Cognitive outcomes were not associated with the COMT Val158Met polymorphism in univariate regression analysis (p=0.390). Delirium was a significant predictor of worse functional and cognitive outcomes in multivariable regression analyses adjusted for other risk factors (odds ratio=0.04, 95% CI=0.01, 0.16, p<0.001, and β=-3.889, 95% CI=-7.55, -0.23, p=0.038, respectively). CONCLUSIONS:The COMT genotype is important in delirium risk and functional outcomes of patients with mild to moderate TBI. Whether the COMT genotype is associated with outcomes through incident delirium remains to be determined in larger studies.}, URL= {https://doi.org/10.1176/appi.neuropsych.18080195}} . The Journal of neuropsychiatry and clinical neurosciences.

Preoperative verbal memory problems and their clinical prognostic value in meningioma patients: A prospective study @article{PMID:29617166, Title= {Preoperative verbal memory problems and their clinical prognostic value in meningioma patients: A prospective study}, Author= {Pranckevičienė, Aistė and Jurkuvėnas, Vytautas and Deltuva, Vytenis Pranas and Tamašauskas, Arimantas and Bunevičius, Adomas}, DOI= {10.1080/23279095.2018.1450750}, Number= {6}, Volume= {26}, Year= {2019}, Journal= {Applied neuropsychology. Adult}, ISSN= {2327-9095}, Pages= {503—512}, Abstract= {This study aimed to evaluate clinical utility of The Hopkins Verbal Learning Test-Revised (HVLT-R) for assessment of preoperative memory function in meningioma patients and to investigate prognostic value of memory assessment in predicting outcomes after meningioma excision surgery. A total of 93 meningioma patients were assessed 2-3 days preoperatively using HVLT-R, and EORTC QLQ-30 and QLQ-BN20. Functional outcome at discharge was evaluated using The Glasgow Outcome Scale. A sample of 95 healthy controls was matched to patients according to age, gender, and education. Meningioma patients demonstrated impaired working memory, delayed recall and recognition, flatter learning slope, and less effective acquisition. Location of meningioma was not related to any of the studied memory scores. Patients with left sided meningiomas more often produced false positive recognitions and demonstrated worse delayed recall when compared to patients with right sided, but not bilateral meningiomas. Verbal memory impairment was not associated with perceived health status. Functional outcome at discharge was predicted by tumor side, global health status score, and HVLT-R Cumulative learning score. Cumulative verbal learning impairment was associated with greater risk for poor functional outcome, indicating that cognitive impairment has added prognostic value beyond established prognostic indicators of meningioma patients.}, URL= {https://doi.org/10.1080/23279095.2018.1450750}} . Applied neuropsychology. Adult.

QOLP-16. DISTRESSED (D TYPE) PERSONALITY, PREOPERATIVE PSYCHOLOGICAL DISTRESS, COGNITIVE FUNCTIONING, QUALITY OF LIFE, AND TREATMENT OUTCOMES OF GLIOMA PATIENTS: PROSPECTIVE STUDY @article{PMCID:PMC6847316, Title= {QOLP-16. DISTRESSED (D TYPE) PERSONALITY, PREOPERATIVE PSYCHOLOGICAL DISTRESS, COGNITIVE FUNCTIONING, QUALITY OF LIFE, AND TREATMENT OUTCOMES OF GLIOMA PATIENTS: PROSPECTIVE STUDY}, Author= {Pranckeviciene, Aiste and Saudargiene, Ausra and Deltuva, Vytenis and Tamasauskas, Arimantas and Bunevicius, Adomas}, Number= {Suppl 6}, Volume= {21}, Month= {November}, Year= {2019}, Journal= {Neuro-oncology}, ISSN= {1522-8517}, Pages= {vi201—vi201}, Abstract= {Abstract BACKGROUND This study aimed to evaluate impact of distressed (D type) personality on preoperative psychological distress, cognitive functioning and quality of life (QoL) as well as short-term and long-term treatment outcomes of glioma patients. METHOD One-hundred and seventy patients (93 men, mean age=51.1±14.5 years) participated in the study. Fifty-four (31.8%) patients were diagnosed with low grade (WHO grade I-II), and 116 (68.2%) with high grade (WHO grade III-IV) tumors. Psychological assessment was performed 2–3 days before surgery using a set of self-report questionnaires (NCCN Distress thermometer, EORTC-QLQ-C30, EORTCQLQ-BN20, HADS, DS-14) and a short battery of neuropsychological tests. Functional status at the discharge was assessed using the GOS. Follow-up period was 40 months. RESULTS Thirty-nine (22.9%) of patients met criteria for D type personality. D-type patients relative to non D-type patients reported significantly worse QoL, higher number tumor related symptoms, greater depression and anxiety symptoms, and demonstrated slowing of psychomotor speed in neuropsychological tests. However, no personality related differences were observed in level of functioning at time of discharge as well as long-term patients’ survival. Path analysis using SEM revealed non-direct impact of D-type personality traits on patients QoL (Chi-square value=16.73, df=13, p=0.212). The model indicated statistically significant indirect effects of D-type Negative Affectivity on QoL (IPC -0.285, 95% CI [-0.386; -0.178], p=0.003) and tumor related symptoms (IPC 0.196, 95% CI [0.117; 0.296], p=0.002) mediated via depression and anxiety. Social Inhibition was also indirectly associated with QoL (IPC -0.047, 95% CI [-0.120; -0.002], p=0.035) and symptoms (IPC 0.033, 95% CI [0.002; 0.097], p=0.032) through depression and anxiety. CONCLUSION D-type personality contributes to impairment of QoL and higher number of reported symptoms in glioma patients via increased susceptibility for depression and anxiety.}, URL= {https://europepmc.org/articles/PMC6847316}} . Neuro-oncology.

The association of cardiovascular reactivity during the Trier Social Stress Test with quality of life in coronary artery disease patients @article{PMID:31522009, Title= {The association of cardiovascular reactivity during the Trier Social Stress Test with quality of life in coronary artery disease patients}, Author= {Gecaite, Julija and Burkauskas, Julius and Bunevicius, Adomas and Brozaitiene, Julija and Kazukauskiene, Nijole and Mickuviene, Narseta}, DOI= {10.1016/j.jpsychores.2019.109824}, Volume= {126}, Month= {November}, Year= {2019}, Journal= {Journal of psychosomatic research}, ISSN= {0022-3999}, Pages= {109824}, Abstract= {OBJECTIVE:Knowledge of objective psychophysiological stress parameters and its relationship to health-related quality of life (HRQoL) is limited in patients with coronary artery disease (CAD). The aim was to investigate the association of cardiovascular reaction to psychosocial stress with HRQoL in patients with CAD. METHODS:One-hundred and thirty-six patients (84.6% men, age 52 ± 8) within 2-3 weeks after acute coronary syndromes (ACS) during cardiac rehabilitation were recruited in this cross-sectional study. Patients were evaluated for HRQoL (SF-36 questionnaire), symptoms of anxiety and depression (Hospital Anxiety and Depression scale) and Type D personality (DS14 scale). Trier Social Stress Test (TSST) was employed to evaluate cardiovascular reactivity (systolic and diastolic blood pressure [BP], and heart rate [HR]) to psychosocial stress. Multiple linear regression analyses were performed to test for the associations between cardiovascular reactivity and HRQoL, while controlling for possible confounders. RESULTS:After controlling for baseline levels of HR, gender, age, NYHA functional class, AH, Type D personality, symptoms of anxiety and depression, use of beta-blockers, and history of smoking, the SF-36 Social functioning scale (β = -0.182; p = .03) and SF-36 Vitality scale (β = -0.203; p = .03) was associated with prolonged HR recovery following stress evoking tasks. No associations were found between HRQoL and BP measures during the TSST. CONCLUSION:In CAD patients who have experienced ACS, HRQoL was associated with prolonged HR recovery after mental stress, even after controlling for potential confounder. Future studies should investigate the possible role of mediating factors involved in the mechanisms relating cardiovascular stress response and HRQoL.}, URL= {https://doi.org/10.1016/j.jpsychores.2019.109824}} . Journal of psychosomatic research.

Maternal cognitive function during pregnancy in relation to hypo- and hyperthyroxinemia @article{PMID:31614008, Title= {Maternal cognitive function during pregnancy in relation to hypo- and hyperthyroxinemia}, Author= {Pop, Victor J and Ormindean, Vlad and Mocan, Andreia and Meems, Margreet and Broeren, Maarten and Denollet, Johan K and Wiersinga, Wilmar M and Bunevicius, Adomas}, DOI= {10.1111/cen.14107}, Number= {6}, Volume= {91}, Month= {December}, Year= {2019}, Journal= {Clinical endocrinology}, ISSN= {0300-0664}, Pages= {824—833}, Abstract= {<h4>Objective</h4>To assess a possible relationship between maternal cognitive dysfunction during pregnancy and hypothyroxinemia, adjusted for major confounders.<h4>Background</h4>Thyroid dysfunction in general is associated with cognitive dysfunction. Cognitive dysfunction is common during pregnancy.<h4>Design</h4>Prospective follow-up study from 12 to 32 weeks of pregnancy.<h4>Participants</h4>2082 healthy pregnant women.<h4>Measurements</h4>Cognitive function, depression and sleeping problems were assessed by self-report questionnaires at 12, 22 and 32 weeks of gestation, higher scores reflecting more symptoms. FT4, TSH and TPO-Ab were assessed at 12 weeks of gestation.<h4>Definitions</h4>healthy (euthyroxinemia) control group: FT4 within 10-90th percentiles, without elevated TPO-Ab titres and TSH within first trimester-specific reference range (0.23-4.0 mU/L). Hypothyroxinemia: FT4 <2.5th percentile with TSH within first trimester-specific reference range. Poor cognitive function: a score >1 SD > mean on the cognitive function scale.<h4>Results</h4>A total of 54 women showed hypothyroxinemia and 1476 women had euthyroxinemia. At 12 weeks, multiple logistic regression showed that poor cognitive function was independently related to hypothyroxinemia: OR: 2.9 (95% CI: 1.6-5.4), adjusted for depression (OR: 3.1; 95% CI: 2.7-4.6) and sleeping problems (OR: 2.8, 95% CI: 1.9-3.9). TPO-Ab + women with hypothyroxinemia had the highest levels of cognitive dysfunction. Other cut-offs of hypothyroxinemia (<5th or <10th percentile with normal TSH) showed similar results. GLM-ANOVA showed that throughout pregnancy women with hypothyroxinemia at 12 weeks had significantly higher cognitive dysfunction scores compared with the healthy controls: F = 12.1, P = .001.<h4>Conclusions</h4>Women with hypothyroxinemia during early gestation are at risk for poor cognitive function throughout gestation, adjusted for depression and sleeping problems.}, URL= {https://europepmc.org/articles/PMC6900117}} . Clinical endocrinology.

Comments: "Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome" @article{PMID:31389511, Title= {Comments: "Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome"}, Author= {Bunevicius, Adomas}, DOI= {10.1590/1806-9282.65.7.993}, Number= {7}, Volume= {65}, Month= {August}, Year= {2019}, Journal= {Revista da Associacao Medica Brasileira (1992)}, ISSN= {0104-4230}, Pages= {993—994}, URL= {https://doi.org/10.1590/1806-9282.65.7.993}} . Revista da Associacao Medica Brasileira (1992).

Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta‐analysis @article{lens.org/044-257-916-999-986, author= {Brooke Levis and Dean McMillan and Ying Sun and Chen He and Danielle B. Rice and Ankur Krishnan and Yin Wu and Marleine Azar and Tatiana A. Sanchez and Matthew J. Chiovitti and Parash Mani Bhandari and Dipika Neupane and Nazanin Saadat and Kira E. Riehm and Mahrukh Imran and Jill Boruff and Pim Cuijpers and Simon Gilbody and John P. A. Ioannidis and Lorie A. Kloda and Scott B. Patten and Ian Shrier and Roy C. Ziegelstein and Liane Comeau and Nicholas D. Mitchell and Marcello Tonelli and Simone N. Vigod and Franca Aceti and Rubén Alvarado and Cosme Alvarado-Esquivel and Muideen O. Bakare and Jacqueline Barnes and Cheryl Tatano Beck and Carola Bindt and Philip Boyce and Adomas Bunevicius and Tiago Castro e Couto and Linda H. Chaudron and Humberto Correa and Felipe Pinheiro de Figueiredo and Valsamma Eapen and Michelle Fernandes and Bárbara Figueiredo and Jane Fisher and Lluïsa Garcia-Esteve and Lisa Giardinelli and Nadine Helle and Louise M. Howard and Dina Mohammed Sami Khalifa and Jane Kohlhoff and Laima Kusminskas and Zoltán Kozinszky and Lorenzo Lelli and Angeliki A. Leonardou and Beth A. Lewis and Michael Maes and Valentina Meuti and Sandra Nakić Radoš and Purificación Navarro García and Daisuke Nishi and Daniel Okitundu Luwa E-Andjafono and Emma Robertson-Blackmore and Tamsen J. Rochat and Heather Rowe and Bonnie W.M. Siu and Alkistis Skalkidou and Alan Stein and Robert C. Stewart and Kuan-Pin Su and Inger Sundström-Poromaa and Meri Tadinac and S. Darius Tandon and Iva Alexandra Barbosa Tendais and Pavaani Thiagayson and Annamária Töreki and Anna Torres-Giménez and Thach Duc Tran and Kylee Trevillion and Katherine Turner and Johann M. Vega-Dienstmaier and Karen Wynter and Kimberly A. Yonkers and Andrea Benedetti and Brett D. Thombs}, title= {Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta‐analysis}, journal= {International journal of methods in psychiatric research}, year= {2019}, volume= {28}, number= {4}, pages= {1--11}, month= {September}, doi= {10.1002/mpr.1803}, date= {2019-09-30}, note= {\url{http://dro.deakin.edu.au/view/DU:30130680} ; \url{https://kclpure.kcl.ac.uk/portal/en/publications/comparison-of-major-depression-diagnostic-classification-probability-using-the-scid-cidi-and-mini-diagnostic-interviews-among-women-in-pregnancy-or-postpartum(6386945f-81d7-4415-9480-54792fed7051).html} ; \url{https://ro.uow.edu.au/cgi/viewcontent.cgi?article=5638&context=sspapers} ; \url{https://research.vu.nl/en/publications/comparison-of-major-depression-diagnostic-classification-probabil} ; \url{https://repositorium.sdum.uminho.pt/bitstream/1822/61631/1/2019%20Comparison%20of%20major%20depression%20diagnostic%20classification.pdf} ; \url{https://www.ncbi.nlm.nih.gov/pubmed/31568624} ; \url{http://repositorium.sdum.uminho.pt/handle/1822/61631} ; \url{https://repozitorij.unizg.hr/islandora/object/ffzg%3A3234} ; \url{https://ro.uow.edu.au/sspapers/4565/} ; \url{https://research.monash.edu/en/publications/comparison-of-major-depression-diagnostic-classification-probabil} ; \url{https://www.psych.ox.ac.uk/publications/1053314} ; \url{http://eprints.whiterose.ac.uk/149968/} ; \url{https://onlinelibrary.wiley.com/doi/full/10.1002/mpr.1803} ; \url{https://experts.umn.edu/en/publications/comparison-of-major-depression-diagnostic-classification-probabil} ; \url{https://www.research.ed.ac.uk/portal/files/114015773/Levis_et_al_2019_International_Journal_of_Methods_in_Psychiatric_Research.pdf} ; \url{https://repozitorij.ffzg.unizg.hr/islandora/object/ffzg%3A3234} ; \url{https://www.research.ed.ac.uk/portal/en/publications/comparison-of-major-depression-diagnostic-classification-probability-using-the-scid-cidi-and-mini-diagnostic-interviews-among-women-in-pregnancy-or-postpartum-an-individual-participant-data-metaanalysis(d3d377a6-6cea-48f9-a365-0b7be78723c7).html} ; \url{https://www.narcis.nl/publication/RecordID/oai%3Aresearch.vu.nl%3Apublications%2Fb7fc04c3-ca6d-41f4-ba22-234704793403} ; \url{http://www.diva-portal.org/smash/record.jsf?pid=diva2:1423929} ; \url{https://www.scholars.northwestern.edu/en/publications/comparison-of-major-depression-diagnostic-classification-probabil} ; \url{https://www.neuroscience.ox.ac.uk/publications/1053314} ; \url{https://pubmed.ncbi.nlm.nih.gov/31568624/}}, url= {https://lens.org/044-257-916-999-986}} . International journal of methods in psychiatric research.

Common genetic variations of deiodinase genes and prognosis of brain tumor patients @article{PMID:31452060, Title= {Common genetic variations of deiodinase genes and prognosis of brain tumor patients}, Author= {Bunevicius, Adomas and Laws, Edward R and Saudargiene, Ausra and Tamasauskas, Arimantas and Iervasi, Giorgio and Deltuva, Vytenis and Smith, Timothy R and Bunevicius, Robertas}, DOI= {10.1007/s12020-019-02016-6}, Number= {3}, Volume= {66}, Month= {December}, Year= {2019}, Journal= {Endocrine}, ISSN= {1355-008X}, Pages= {563—572}, Abstract= {BACKGROUND:Thyroid hormone (TH) metabolism can have prognostic significance in brain tumors. We studied the association of common variations in three deiodinase gene single-nucleotide polymorphisms (SNPs) with circulating TH concentrations and prognosis of brain tumor patients. METHODS:Patients admitted for glioma and meningioma surgery between January, 2010 and September, 2011 were evaluated for functional status (Barthel Index or BI) and circulating free tri-iodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) concentrations. Ten common SNPs in the DIO1 gene; five SNPs in the DIO2 gene; and one SNP in the DIO3 gene were genotyped. Follow-up continued until November, 2017. RESULTS:In glioblastoma patients, the DIO1 SNP rs2235544 CC genotype was associated with significantly lower risk of death at 2 years when compared to AA + CA genotypes after adjusting for patient gender, age, pre-operative functional status, adjuvant therapy, and extent of resection (HR = 0.34, 95% CI: 0.13-0.84, p = 0.019). The TT genotype vs. CC + TC genotypes of the DI02 SNP rs12885300 was associated with increased mortality risk after adjusting for patient gender, age, pre-operative functional status, adjuvant therapy, extent of resection, and FT3/FT4 (HR = 3.13, 95% CI: 1.20-8.16, p < 0.019). The C-allele of the DI01 SNP rs2235544 was related to increased circulating free T3/ free T4 ratio in glioma and meningioma patients, indicating greater T4 to T3 conversion. CONCLUSIONS:SNPs of DIO1 gene (rs2235544) and DIO2 gene (rs12885300) have independent prognostic significance in glioblastoma patients. The C-allele of the DIO1 (rs2235544) is associated with greater T4 to T3 conversion.}, URL= {https://doi.org/10.1007/s12020-019-02016-6}} . Endocrine.

Reader response: Depressed TSH level as a predictor of poststroke fatigue in patients with acute ischemic stroke @article{PMID:31527103, Title= {Reader response: Depressed TSH level as a predictor of poststroke fatigue in patients with acute ischemic stroke}, Author= {Bunevicius, Adomas}, DOI= {10.1212/wnl.0000000000008142}, Number= {12}, Volume= {93}, Month= {September}, Year= {2019}, Journal= {Neurology}, ISSN= {0028-3878}, Pages= {563—564}, URL= {https://doi.org/10.1212/WNL.0000000000008142}} . Neurology.

Relationship between Lithium Levels in Drinking Water and Suicide Rates: A Nationwide Study in Lithuania @article{PMID:31596179, Title= {Relationship between Lithium Levels in Drinking Water and Suicide Rates: A Nationwide Study in Lithuania}, Author= {Liaugaudaite, Vilma and Naginiene, Rima and Raskauskiene, Nijole and Mickuviene, Narseta and Bunevicius, Adomas and Sher, Leo}, DOI= {10.1080/13811118.2019.1674226}, Month= {October}, Year= {2019}, Journal= {Archives of suicide research : official journal of the International Academy for Suicide Research}, ISSN= {1381-1118}, Pages= {1—13}, Abstract= {OBJECTIVE:To investigate an association of lithium levels in the drinking water with suicide mortality rates in Lithuania. METHODS:Samples from public drinking water systems were taken in all districts of Lithuania. Lithium levels were determined using the ion chromatography method. For the statistical calculations, lithium levels were averaged per district municipality and plotted against suicide standardized mortality rates (SMR) per 100,000 populations, within the 5-year period from 2012 to 2016. RESULTS:We found that lithium concentrations in drinking water were significantly negatively associated with total suicide rates in a nonlinear way. CONCLUSION:Lithium intake with drinking water may affect suicide rates in some geographical areas.}, URL= {https://doi.org/10.1080/13811118.2019.1674226}} . Archives of suicide research : official journal of the International Academy for Suicide Research.

Safety and efficacy of repeat radiosurgery for acromegaly: an International Multi-Institutional Study @article{PMID:31541405, Title= {Safety and efficacy of repeat radiosurgery for acromegaly: an International Multi-Institutional Study}, Author= {Alonso, Clayton E and Bunevicius, Adomas and Trifiletti, Daniel M and Larner, James and Lee, Cheng-Chia and Pai, Fu-Yuan and Liscak, Roman and Kosak, Mikulas and Kano, Hideyuki and Sisterson, Nathaniel D and Mathieu, David and Lunsford, L Dade and Sheehan, Jason P}, DOI= {10.1007/s11060-019-03296-8}, Number= {2}, Volume= {145}, Month= {November}, Year= {2019}, Journal= {Journal of neuro-oncology}, ISSN= {0167-594X}, Pages= {301—307}, Abstract= {<h4>Purpose</h4>Surgical resection is the first line treatment for growth hormone (GH) secreting tumors. Stereotactic radiosurgery (SRS) is recommended for patients who do not achieve endocrine remission after resection. The purpose of this study was to evaluate safety and efficacy of repeat radiosurgery for acromegaly.<h4>Methods</h4>Three hundred and ninety-eight patients with acromegaly treated with the Gamma Knife radiosurgery (Elekta AB, Stockholm) were identified from the International Gamma Knife Research Foundation database. Among these, 21 patients underwent repeated SRS with sufficient endocrine follow-up and 18 patients had sufficient imaging follow-up. Tumor control was defined as lack of adenoma progression on imaging. Endocrine remission was defined as a normal IGF-1 concentration while off medical therapy.<h4>Results</h4>Median time from initial SRS to repeat SRS was 5.0 years. The median imaging and endocrine follow-up duration after repeat SRS was 3.4 and 3.8 years, respectively. The median initial marginal dose was 17 Gy, and the median repeat marginal dose was 23 Gy. Of the 18 patients with adequate imaging follow up, 15 (83.3%) patients had tumor control and of 21 patients with endocrine follow-up, 9 (42.9%) patients had endocrine remission at last follow-up visit. Four patients (19.0%) developed new deficits after repeat radiosurgery. Of these, 3 patients had neurologic deficits and 1 patient had endocrine deficit.<h4>Conclusions</h4>Repeat radiosurgery for persistent acromegaly offers a reasonable benefit to risk profile for this challenging patient cohort. Further studies are needed to identify patients best suited for this type of approach.}, URL= {https://doi.org/10.1007/s11060-019-03296-8}} . Journal of neuro-oncology.

QOLP-38. PATIENT REPORTED OUTCOMES IN GLIOMA: THE ROLE OF IDH MUTATION ON QUALITY OF LIFE AND MOOD @article{PMCID:PMC6847005, Title= {QOLP-38. PATIENT REPORTED OUTCOMES IN GLIOMA: THE ROLE OF IDH MUTATION ON QUALITY OF LIFE AND MOOD}, Author= {Parsons, Michael and Bunevicius, Adomas and Dietrich, Jorg}, Number= {Suppl 6}, Volume= {21}, Month= {November}, Year= {2019}, Journal= {Neuro-oncology}, ISSN= {1522-8517}, Pages= {vi206—vi206}, Abstract= {Abstract Isocitrate dehydrogenase 1 (IDH) mutation has important clinical prognostic value in glioma patients conferring improved survival and better neurocognitive function (NCF) compared to IDH wild type (IDH-WT) patients. It is not known whether IDH mutation status has an impact on patient reported outcomes (PRO). The goal of this single institution retrospective study was to examine the impact of IDH-mutation status on PRO’s in patients who also completed neuropsychological evaluation. METHODS Out of 101 glioma patients referred for neuropsychological evaluation between 2018–2019, 73 completed the Functional Assessment of Cancer Therapy-Brain (FACT-Br; non-completion due to severe cognitive impairment, poor English). In addition to the total score, the FACT-Br includes 5 subscales of wellbeing (Physical, Social, Emotional, Functional, and Brain specific symptoms). 69 patients completed the Beck Depression Inventory (BDI) and 61 completed the Beck Anxiety Inventory (BAI). Self-reported symptoms were compared between those with IDH-Mut vs IDH-WT by ANOVA. RESULTS Diagnoses included glioblastoma (20), diffuse astrocytoma grade II/III (29) and oligodendroglioma grade II/III (24). 29/73 (40%) patients were IDH-mut. FACT-Br total scores did not differ between IDH-WT and IDH-Mut glioma patients (F=2.685; p=ns). Separate analyses of the 5 FACT-Br subscales showed that only the emotional functioning subscale differed significantly, with IDH-Mut patients reporting better emotional functioning than IDH-WT patients (F=7.4; p< 0.05). BDI and BAI scores did not differ by group (F= 2.2 and 1.9, respectively; p=NS). CONCLUSIONS IDH mutation was related to patient reported emotional status on the FACT-Br in this mixed clinical sample of glioma patients. Analysis is complicated by the heterogeneity of the sample and retrospective nature of the study. Routine inclusion of PRO’s as standard of care may allow a more comprehensive understanding of the impact of IDH throughout the natural history of glioma.}, URL= {https://europepmc.org/articles/PMC6847005}} . Neuro-oncology.

Surgical and radiosurgical treatment strategies for Cushing's disease @article{PMID:31677031, Title= {Surgical and radiosurgical treatment strategies for Cushing's disease}, Author= {Bunevicius, Adomas and Laws, Edward R and Vance, Mary Lee and Iuliano, Sherry and Sheehan, Jason}, DOI= {10.1007/s11060-019-03325-6}, Number= {3}, Volume= {145}, Month= {December}, Year= {2019}, Journal= {Journal of neuro-oncology}, ISSN= {0167-594X}, Pages= {403—413}, Abstract= {INTRODUCTION:Cushing's disease (CD) is rare disorder that should be adequately managed to optimize long-term prognosis. Treatment of CD is multidisciplinary and often includes surgical resection, adjuvant stereotactic radiosurgery (SRS), and medical treatment. Here we review surgical and radiosurgical treatment strategies for ACTH producing pituitary adenomas. METHODS:A comprehensive literature review was carried out to review remission and recurrence rates, and complications of surgical and SRS treatments of ACTH producing pituitary adenomas. RESULTS:Surgical resection plays a central role in the management of ACTH secreting pituitary adenomas and usually allows rapid endocrine remission that ranges from 69 to 90%. The most common complications after resection include some degree of new hypopituitarism, diabetes insipidus and CSF leak. Devastating complications, such as injury of vascular and neural structures, are very rare. Surgeon experience and adequate pre-operative imaging are important for safe and successful surgery. Endocrine recurrence rates after resection range from 9 to 30%. SRS is often employed for incompletely resected adenomas. Endocrine remission after SRS ranges from 35 to 72%. The most common complication of SRS is new anterior pituitary gland deficiency. Recurrence rates after GKRS range from 18 to 24%. CONCLUSIONS:Transsphenoidal resection of ACTH producing pituitary adenoma is a safe and highly effective procedure for CD in experienced hands. Radiosurgery is more frequently used as treatment of residual and recurrent adenoma and persistent CD. Long-term endocrine and imaging follow-up is important as delayed recurrences and hypopituitarism are not infrequent.}, URL= {https://doi.org/10.1007/s11060-019-03325-6}} . Journal of neuro-oncology.

Antanas Budėnas, Šarūnas Tamašauskas, Albertas Šliaužys, Ieva Navickaitė, Miglė Sidaraitė, Aistė Pranckevičienė, Vytenis Pranas Deltuva, Arimantas Tamašauskas, Adomas Bunevičius(2018). Incidence and clinical significance of postoperative delirium after brain tumor surgery . Acta Neurochirurgica. 160. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2327--2337. Springer Nature

Adomas Bunevicius, Andrius Radziunas, Sarunas Tamasauskas, Arimantas Tamasauskas, Edwards R. Laws, Giorgio Iervasi, Robertas Bunevicius, Vytenis Deltuva(2018). Prognostic role of high sensitivity C-reactive protein and interleukin-6 in glioma and meningioma patients . Journal of Neuro-Oncology. 138. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 351--358. Springer Nature

Adomas Bunevicius(2018). Personality traits, patient-centered health status and prognosis of brain tumor patients . Journal of Neuro-Oncology. Springer Nature

Adomas Bunevicius, Algimantas Matukevicius, Vytenis Deltuva, Inga Gudinaviciene, Darius Pranys, Arimantas Tamasauskas(2018). Atypical Teratoid/Rhabdoid Tumor After In Vitro Fertilization: Illustrative Case Report and Systematic Literature Review . World Neurosurgery. 113. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 129--134. Elsevier {BV}

Adomas Bunevicius, Arimantas Tamasauskas, Kazys Ambrozaitis (2018). Sudden onset paraplegia . Emergency Medicine Journal.

Bunevicius, A., Tamasauskas, A., Ambrozaitis, K.(2018). Sudden onset paraplegia . Emergency medicine journal : EMJ. 35. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 315-316.

(2018). Prothrombin Complex Concentrate for Warfarin-Associated Intracranial Bleeding in Neurosurgical Patients: A Single-Center Experience . Medicina (Kaunas, Lithuania).

Jomantė Mačiukaitienė and Diana Bilskienė and Arimantas Tamasauskas and Adomas Bunevicius(2018). Prothrombin Complex Concentrate for Warfarin-Associated Intracranial Bleeding in Neurosurgical Patients: A Single-Center Experience . Medicina (Kaunas, Lithuania). 54. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 22--.

Mačiukaitienė, J., Bilskienė, D., Tamašauskas, A., Bunevičius, A.(2018). Prothrombin complex concentrate for warfarin-associated intracranial bleeding in neurosurgical patients: A single-center experience . Medicina (Lithuania). 54. (2).

Adomas Bunevicius and Arimantas Tamasauskas and Kazys Vytautas Ambrozaitis(2018). Sudden onset paraplegia . Emergency medicine journal : EMJ. 35. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 315--316.

(2018). The Association of Digit Ratio (2D : 4D) with Cancer: A Systematic Review and Meta-Analysis . Disease markers.

Adomas Bunevicius(2018). The Association of Digit Ratio (2D : 4D) with Cancer: A Systematic Review and Meta-Analysis . Disease markers. 2018. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7698193--9.

Adomas Bunevicius (2018). The Association of Digit Ratio (2D : 4D) with Cancer: A Systematic Review and Meta-Analysis . Disease Markers.

Bunevicius, A.(2018). The Association of Digit Ratio (2D: 4D) with Cancer: A Systematic Review and Meta-Analysis . Disease Markers. 2018.

Adomas Bunevicius(2018). The Association of Digit Ratio (2D : 4D) with Cancer: A Systematic Review and Meta-Analysis . {Hindawi Limited}

Juskiene, A., Podlipskyte, A., Bunevicius, A., Varoneckas, G.(2018). Type D Personality and Sleep Quality in Coronary Artery Disease Patients With and Without Obstructive Sleep Apnea: Mediating Effects of Anxiety and Depression . International Journal of Behavioral Medicine. 25. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 171-182.

Bunevicius, A., Matukevicius, A., Deltuva, V., Gudinaviciene, I., Pranys, D., Tamasauskas, A.(2018). Atypical Teratoid/Rhabdoid Tumor After In Vitro Fertilization: Illustrative Case Report and Systematic Literature Review . World Neurosurgery. 113. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 129-134.

Bunevicius, A.(2018). Personality traits, patient-centered health status and prognosis of brain tumor patients . Journal of Neuro-Oncology. 137. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 593-600.

Adomas Bunevicius(2018). Personality traits, patient-centered health status and prognosis of brain tumor patients . Journal of neuro-oncology. 137. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 593--600.

Bunevicius, A., Radziunas, A., Tamasauskas, S., Tamasauskas, A., Laws, E.R., Iervasi, G., Bunevicius, R., Deltuva, V.(2018). Prognostic role of high sensitivity C-reactive protein and interleukin-6 in glioma and meningioma patients . Journal of Neuro-Oncology. 138. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 351-358.

(2018). Brain MRI morphometric analysis in Parkinson's disease patients with sleep disturbances . BMC neurology.

Andrius Radziunas and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Rymante Gleizniene and Aiste Pranckeviciene and Kęstutis Petrikonis and Adomas Bunevicius(2018). Brain MRI morphometric analysis in Parkinson's disease patients with sleep disturbances . BMC neurology. 18. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 88--88.

Radziunas, A., Deltuva, V.P., Tamasauskas, A., Gleizniene, R., Pranckeviciene, A., Petrikonis, K., Bunevicius, A.(2018). Brain MRI morphometric analysis in Parkinson's disease patients with sleep disturbances . BMC Neurology. 18. (1).

Burkauskas, J., Lang, P., Bunevičius, A., Neverauskas, J., Bučiūtė-Jankauskienė, M., Mickuvienė, N.(2018). Cognitive function in patients with coronary artery disease: A literature review . Journal of International Medical Research. 46. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4019-4031.

Jurate Butnoriene and Vesta Steibliene and Ausra Saudargiene and Adomas Bunevicius(2018). Does presence of metabolic syndrome impact anxiety and depressive disorder screening results in middle aged and elderly individuals? A population based study . BMC psychiatry. 18. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--10.

Butnoriene, J., Steibliene, V., Saudargiene, A., Bunevicius, A.(2018). Does presence of metabolic syndrome impact anxiety and depressive disorder screening results in middle aged and elderly individuals? A population based study . BMC Psychiatry. 18. (1).

Antanas Budėnas and Šarūnas Tamašauskas and Albertas Šliaužys and Ieva Navickaitė and Miglė Sidaraitė and Aistė Pranckevičienė and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Adomas Bunevicius(2018). Incidence and clinical significance of postoperative delirium after brain tumor surgery . Acta neurochirurgica. 160. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2327--2337.

Budėnas, A., Tamašauskas, Š., Šliaužys, A., Navickaitė, I., Sidaraitė, M., Pranckevičienė, A., Deltuva, V.P., Tamašauskas, A., Bunevičius, A.(2018). Incidence and clinical significance of postoperative delirium after brain tumor surgery . Acta Neurochirurgica. 160. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2327-2337.

Bunevicius, A.(2018). Letter: Simple preoperative patient-reported factors predict adverse outcome after elective cranial neurosurgery . Neurosurgery. 82. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString E21-E22.

Aistė Pranckevičienė and Vytautas Jurkuvėnas and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Adomas Bunevicius(2018). Preoperative verbal memory problems and their clinical prognostic value in meningioma patients: A prospective study . Applied neuropsychology. Adult. 26. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 503--512.

Nayan Lamba and Chunming Liu and Hasan A. Zaidi and Marike L. D. Broekman and Thomas Simjian and Chen Shi and Joanne Doucette and Steven Ren and Timothy R. Smith and Rania A. Mekary and Adomas Bunevicius(2018). A prognostic role for Low tri-iodothyronine syndrome in acute stroke patients: A systematic review and meta-analysis . Clinical neurology and neurosurgery. 169. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 55--63.

Lamba, N., Liu, C., Zaidi, H., Broekman, M.L.D., Simjian, T., Shi, C., Doucette, J., Ren, S., Smith, T.R., Mekary, R.A., et al.(2018). A prognostic role for Low tri-iodothyronine syndrome in acute stroke patients: A systematic review and meta-analysis . Clinical Neurology and Neurosurgery. 169. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 55-63.

Adomas Bunevicius and Algimantas Matukevičius and Vytenis Pranas Deltuva and Inga Gudinaviciene and Darius Pranys and Arimantas Tamasauskas(2018). Atypical Teratoid/Rhabdoid Tumor After In Vitro Fertilization: Illustrative Case Report and Systematic Literature Review . World neurosurgery. 113. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 129--134.

Letter: Simple Preoperative Patient-Reported Factors Predict Adverse Outcome After Elective Cranial Neurosurgery @article{PMID:29040699, Title= {Letter: Simple Preoperative Patient-Reported Factors Predict Adverse Outcome After Elective Cranial Neurosurgery}, Author= {Bunevicius, Adomas}, DOI= {10.1093/neuros/nyx503}, Number= {1}, Volume= {82}, Month= {January}, Year= {2018}, Journal= {Neurosurgery}, ISSN= {0148-396X}, Pages= {E21—E22}, URL= {https://doi.org/10.1093/neuros/nyx503}} . Neurosurgery.

Incidence and clinical significance of postoperative delirium after brain tumor surgery @article{PMID:30406871, Title= {Incidence and clinical significance of postoperative delirium after brain tumor surgery}, Author= {Budėnas, Antanas and Tamašauskas, Šarūnas and Šliaužys, Albertas and Navickaitė, Ieva and Sidaraitė, Miglė and Pranckevičienė, Aistė and Deltuva, Vytenis Pranas and Tamašauskas, Arimantas and Bunevičius, Adomas}, DOI= {10.1007/s00701-018-3718-2}, Number= {12}, Volume= {160}, Month= {December}, Year= {2018}, Journal= {Acta neurochirurgica}, ISSN= {0001-6268}, Pages= {2327—2337}, Abstract= {BACKGROUND:Delirium is an acute and reversible deterioration of mental state. Postoperative delirium (POD) can develop after surgical procedures and is associated with impaired health status and worse recovery. So far, there is little data about postoperative delirium after brain surgery. The aim of this study was to evaluate frequency, risk factors, and prognostic value of POD in predicting short-term postoperative outcomes after brain tumor surgery. METHODS:Five-hundred and twenty-two patients who underwent elective brain tumor surgery in 2010-2017 were included in this prospective study. Patients were monitored for POD using the Confusion Assessment Method for the ICU (CAM-ICU) for 2 to 7 days after the surgery. At hospital discharge, outcomes were evaluated using the Glasgow Outcome Scale (GOS). RESULTS:POD was diagnosed in 22 (4.2%) patients. Risk factors of POD were low level of hemoglobin, poor functional status at time of admission, low education level and older age (65 years and older). POD incidence was not associated with brain tumor laterality, location, extent of resection, histological diagnosis, or affected brain lobe. POD was associated with greater risk for unfavorable outcomes at hospital discharge (OR = 5.3; 95% CI [2.1-13.4], p = 0.001). CONCLUSIONS:POD is not a common complication after elective brain tumor surgery. Older age, poor functional status, low education level and anemia are associated with greater POD risk. Extent of surgical intervention and brain tumor location are not associated with POD risk. POD is associated with worse outcome at hospital discharge.}, URL= {https://doi.org/10.1007/s00701-018-3718-2}} . Acta neurochirurgica.

A prognostic role for Low tri-iodothyronine syndrome in acute stroke patients: A systematic review and meta-analysis @article{PMID:29627642, Title= {A prognostic role for Low tri-iodothyronine syndrome in acute stroke patients: A systematic review and meta-analysis}, Author= {Lamba, Nayan and Liu, Chunming and Zaidi, Hasan and Broekman, MLD and Simjian, Thomas and Shi, Chen and Doucette, Joanne and Ren, Steven and Smith, Timothy R and Mekary, Rania A and Bunevicius, Adomas}, DOI= {10.1016/j.clineuro.2018.03.025}, Volume= {169}, Month= {June}, Year= {2018}, Journal= {Clinical neurology and neurosurgery}, ISSN= {0303-8467}, Pages= {55—63}, Abstract= {BACKGROUND:Low triiodothyronine (T3) syndrome could be a powerful prognostic factor for acute stroke; yet, a prognostic role for low T3 has not been given enough importance in stroke management. This meta-analysis aimed to evaluate whether low T3 among acute stroke patients could be used as a prognostic biomarker for stroke severity, functional outcome, and mortality. METHODS:Studies that investigated low T3 prognostic roles in acute stroke patients were sought from PubMed/Medline, Embase, and Cochrane databases through 11/23/2016. Pooled estimates of baseline stroke severity, mortality, and functional outcomes were assessed from fixed-effect (FE) and random-effects (RE) models. RESULTS:Eighteen studies met the inclusion criteria. Six studies (1,203 patients) provided data for low-T3 and normal-T3 patients and were meta-analyzed. Using the FE model, pooled results revealed low-T3 patients exhibited a significantly higher stroke severity, as assessed by the National Institutes of Health Stroke Scale (NIHSS) score at admission (mean difference = 3.18; 95%CI = 2.74, 3.63; I2 = 61.9%), had 57% higher risk of developing poor functional outcome (RR = 1.57; 95%CI = 1.33,1.8), and had 83% higher odds of mortality (Peto-OR = 1.83; 95%CI = 1.21, 1.99) compared to normal-T3 patients. In a univariate meta-regression analysis, the low-T3 and stroke severity association was reduced in studies with higher smokers% (slope = -0.11; P = 0.02), higher hypertension% (slope = -0.11; P = 0.047), older age (slope = -0.54; P = 0.02), or longer follow-up (slope = -0/17, P < 0.01). RE models yielded similar results. No significant publication bias was observed for either outcome using Begg's and Egger's tests. CONCLUSIONS:Low-T3 syndrome in acute stroke patients is an effective prognostic factor for predicting greater baseline stroke severity, poorer functional outcome, and higher overall mortality risk.}, URL= {https://doi.org/10.1016/j.clineuro.2018.03.025}} . Clinical neurology and neurosurgery.

Atypical Teratoid/Rhabdoid Tumor After In Vitro Fertilization: Illustrative Case Report and Systematic Literature Review @article{PMID:29452330, Title= {Atypical Teratoid/Rhabdoid Tumor After In Vitro Fertilization: Illustrative Case Report and Systematic Literature Review}, Author= {Bunevicius, Adomas and Matukevicius, Algimantas and Deltuva, Vytenis and Gudinaviciene, Inga and Pranys, Darius and Tamasauskas, Arimantas}, DOI= {10.1016/j.wneu.2018.02.012}, Volume= {113}, Month= {May}, Year= {2018}, Journal= {World neurosurgery}, ISSN= {1878-8750}, Pages= {129—134}, Abstract= {In vitro fertilization (IVF) is increasingly used for the treatment of infertile couples worldwide. The association between IVF and cancer risk in offspring is conflicting. We present a case of atypical teratoid/rhabdoid tumor (AT/RT) in a girl conceived by IVF and present results of systematic review of literature of primary intracranial neoplasms diagnosed in children conceived by IVF.A systematic review of literature was conducted on April 12, 2017, to identify previously published reports of intracranial brain tumors in patients conceived after IVF.A 21-month-old girl born after IVF and uneventful pregnancy presented with progressive nausea, vomiting, irritability, and right-side weakness. Magnetic resonance imaging demonstrated large heterogeneous contrast enhancing left frontotemporoparietal tumor. The operation was aborted due to asystole after subtotal tumor removal. The patient passed away on postoperative day 3. Histologic examination demonstrated AT/RT. We identified 7 previously published case reports of intracranial neoplasms in children conceived by IVF. Patient age at brain tumor diagnosis ranged from 31st week of gestation to 3 years of age. The most common histological diagnosis was AT/RT (3 cases), followed by glioblastoma multiforme, gliosarcoma, medulloblastoma, craniopharyngioma, and choroid plexus papilloma. Three of five operated patients died during perioperative period. Outcomes were dismal in 7 patients.IVF-associated brain tumors are usually malignant and associated with high mortality. Future studies investigating possible causal relationship between IVF and brain tumor risk are encouraged.}, URL= {https://doi.org/10.1016/j.wneu.2018.02.012}} . World neurosurgery.

Type D Personality and Sleep Quality in Coronary Artery Disease Patients With and Without Obstructive Sleep Apnea: Mediating Effects of Anxiety and Depression @article{PMID:29327226, Title= {Type D Personality and Sleep Quality in Coronary Artery Disease Patients With and Without Obstructive Sleep Apnea: Mediating Effects of Anxiety and Depression}, Author= {Juskiene, Alicja and Podlipskyte, Aurelija and Bunevicius, Adomas and Varoneckas, Giedrius}, DOI= {10.1007/s12529-017-9708-6}, Number= {2}, Volume= {25}, Month= {April}, Year= {2018}, Journal= {International journal of behavioral medicine}, ISSN= {1070-5503}, Pages= {171—182}, Abstract= {PURPOSE:The study aimed to examine the association between type D personality trait and sleep quality in coronary artery disease (CAD) patients with and without obstructive sleep apnea (OSA) and to explore the mediating effects of anxiety and depression symptoms. METHOD:A cross-sectional study was performed in 879 CAD patients attending cardiac rehabilitation program (mean age 57.8 years; SD = 9.0; 75% men). Participants underwent full-night polysomnography and were classified in OSA (n = 349) and no OSA (n = 530) groups. Patients were evaluated for type D personality, subjective sleep quality (Pittsburgh sleep quality index), and symptoms of anxiety and depression (hospital anxiety and depression scale). RESULTS:Patients with type D personality reported poorer subjective sleep quality than non-type D patients irrespective of the presence of OSA. Type D and negative affectivity (NA) were associated with worse subjective sleep quality in patients with OSA and without OSA. The mediational analysis revealed that type D and NA were indirectly associated with Pittsburgh sleep quality index through anxiety and depression symptoms in no OSA and OSA patients. CONCLUSION:In CAD patients, type D personality and NA are associated with worse subjective sleep quality and this association is mediated by depression and anxiety symptoms irrespective of OSA presence.}, URL= {https://doi.org/10.1007/s12529-017-9708-6}} . International journal of behavioral medicine.

Sudden onset paraplegia @article{PMID:29674381, Title= {Sudden onset paraplegia}, Author= {Bunevicius, Adomas and Tamasauskas, Arimantas and Ambrozaitis, Kazys}, DOI= {10.1136/emermed-2017-206830}, Number= {5}, Volume= {35}, Month= {May}, Year= {2018}, Journal= {Emergency medicine journal : EMJ}, ISSN= {1472-0205}, Pages= {315—316}, URL= {https://doi.org/10.1136/emermed-2017-206830}} . Emergency medicine journal : EMJ.

Prognostic role of high sensitivity C-reactive protein and interleukin-6 in glioma and meningioma patients @article{PMID:29460097, Title= {Prognostic role of high sensitivity C-reactive protein and interleukin-6 in glioma and meningioma patients}, Author= {Bunevicius, Adomas and Radziunas, Andrius and Tamasauskas, Sarunas and Tamasauskas, Arimantas and Laws, Edwards R and Iervasi, Giorgio and Bunevicius, Robertas and Deltuva, Vytenis}, DOI= {10.1007/s11060-018-2803-y}, Number= {2}, Volume= {138}, Month= {June}, Year= {2018}, Journal= {Journal of neuro-oncology}, ISSN= {0167-594X}, Pages= {351—358}, Abstract= {High sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) can be important prognostic indicators of brain tumor patients. We investigated the association of circulating IL-6 and hsCRP concentrations with discharge outcomes and survival of glioma and meningioma patients. One-hundred and sixty-three (115 women; median age 57 years) patients admitted for meningioma (n = 94), high-grade glioma (n = 48) and low-grade glioma (n = 21) surgery were enrolled in this prospective cohort study. Serum samples were collected within 24 h of admission. Discharge outcome was evaluated using the Glasgow Outcome Scale (unfavorable outcome = score from 1 to 3). Follow-up continued until November, 2016. Elevated IL-6 (≥ 2 pg/ml) and hsCRP (≥ 1 mg/l) concentrations were present in 25 and 35% of brain tumor patients, respectively. Elevated IL-6 concentrations were associated with unfavorable outcome at hospital discharge, adjusting for brain tumor histological diagnosis, patient age and gender (OR 2.39, 95% CI 0.97-5.91, p = 0.05). Elevated hsCRP concentrations were not associated with discharge outcome (p = 0.13). In multivariate Cox regression analyses adjusted for patient age, gender, extent of tumor resection and adjuvant treatment, elevated IL-6 concentration was associated with greater mortality risk in high-grade glioma patients (OR 2.623; 95% CI 1.129-5.597; p = 0.01), while elevated hsCRP concentration was associated with greater mortality risk in meningioma patients (OR 3.650; 95% CI 1.038-12.831; p = 0.04). Elevated IL-6 concentration is associated with greater unfavorable outcome risk in brain tumor patients and with greater mortality in high-grade glioma patients, while elevated hsCRP concentration is associated with greater mortality in meningioma patients.}, URL= {https://doi.org/10.1007/s11060-018-2803-y}} . Journal of neuro-oncology.

Personality traits, patient-centered health status and prognosis of brain tumor patients @article{PMID:29327173, Title= {Personality traits, patient-centered health status and prognosis of brain tumor patients}, Author= {Bunevicius, Adomas}, DOI= {10.1007/s11060-018-2751-6}, Number= {3}, Volume= {137}, Month= {May}, Year= {2018}, Journal= {Journal of neuro-oncology}, ISSN= {0167-594X}, Pages= {593—600}, Abstract= {Personality traits can be related to prognosis of cancer patients. The study aimed to evaluate the association of big-five personality dimensions with emotional and cognitive health status, and prognosis of brain tumor patients. A total of 178 patients admitted for brain tumor surgery were evaluated for personality traits (Tem item Personality Inventory), depressive/anxiety symptoms (Hospital Anxiety and Depression Scale or HADS) and cognitive functioning (Mini Mental State Examination or MMSE) on admission. One-hundred and forty-three patients were re-evaluated (HADS and MMSE scales) at hospital discharge. Follow-up continued until November, 2015. Thirty-five patients were diagnosed with high-grade glioma, 15 with low-grade glioma and 128 with benign brain tumors (meningioma, pituitary adenoma and vestibular schwannoma). In multivariate regression analyses adjusted for age, gender, past brain tumor treatment, psychiatric histories and medication use, and education, greater TIPI-Extroversion score was associated with greater admission MMSE score (β = 0.159); TIPI-Emotional stability score, with lower HADS-Depression and HADS-Anxiety scores on admission (β = - 0.407 and β = - 0.404, respectively) and at discharge (β = - 0.404 and β = - 0.319, respectively); and greater TIPI-Openness score, with lower admission HADS-D score (β = - 0.255, p = 0.001). In benign brain tumor patients, greater TIPI-Openness score was associated with reduced mortality risk [HR = 0.554 95% CI (0.376-0.814) p = 0.003)] independently from age, gender and histological diagnosis. Personality traits were not associated with survival of high-grade and low-grade glioma patients. Emotional stability and openness are associated with lower depressive/anxiety symptom severity, and extroversion with better cognitive functioning independently from demographic and clinical risk factors. Openness predicts lower mortality risk of low-grade/benign brain tumor patients.}, URL= {https://doi.org/10.1007/s11060-018-2751-6}} . Journal of neuro-oncology.

Burkauskas, J., Bunevičius, A., Brozaitiene, J., Neverauskas, J., Fineberg, N.A., Wellsted, D., Bunevičius, R., Mickuvienė, N.(2018). Exploring cognitive concomitants of mental fatigue in patients with coronary artery disease . Neuropsychobiology. 76. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 151-160.

Cognitive function in patients with coronary artery disease: A literature review @article{PMID:30157691, Title= {Cognitive function in patients with coronary artery disease: A literature review}, Author= {Burkauskas, J and Lang, P and Bunevičius, A and Neverauskas, J and Bučiūtė-Jankauskienė, M and Mickuvienė, N}, DOI= {10.1177/0300060517751452}, Number= {10}, Volume= {46}, Month= {October}, Year= {2018}, Journal= {The Journal of international medical research}, ISSN= {0300-0605}, Pages= {4019—4031}, Abstract= {Objective Cognitive function impairment is a well-documented complication of cerebrovascular disease (CBVD). Less is known about what factors affect the deterioration of cognitive function in patients with coronary artery disease (CAD). The aim of this review is to explore recent studies investigating factors associated with cognitive function in patients with CAD. Methods Studies published from 2010 to 2016 were identified through a systematic search of MEDLINE/PubMed and were included if they addressed factors affecting cognitive function in the CAD population. Results Of the 227 publications identified, 32 were selected for the review. Five factors tentatively affecting cognitive function in patients with CAD were identified: coronary artery bypass grafting (CABG) surgery, apolipoprotein E4 (APOE4) genotype, left ventricular ejection fraction (LVEF), medication use, and various hormones and biomarkers. Conclusion New techniques in CABG surgery have proven to alleviate postoperative cognitive decline. Researchers are still debating the effects of APOE4 genotype, LVEF, and the use of cardiovascular medications on cognitive function. Thyroid hormones and biomarkers are associated with cognitive function, but the exact nature of the association is debatable. Longitudinal studies should clarify those associations. In addition, cross-sectional studies addressing other causes of cognitive decline in patients with CAD are warranted.}, URL= {https://europepmc.org/articles/PMC6166352}} . The Journal of international medical research.

Does presence of metabolic syndrome impact anxiety and depressive disorder screening results in middle aged and elderly individuals? A population based study @article{PMID:29310620, Title= {Does presence of metabolic syndrome impact anxiety and depressive disorder screening results in middle aged and elderly individuals? A population based study}, Author= {Butnoriene, Jurate and Steibliene, Vesta and Saudargiene, Ausra and Bunevicius, Adomas}, DOI= {10.1186/s12888-017-1576-8}, Number= {1}, Volume= {18}, Month= {January}, Year= {2018}, Journal= {BMC psychiatry}, ISSN= {1471-244X}, Pages= {5}, Abstract= {Depressive and anxiety disorders are common in primary care setting but often remain undiagnosed. Metabolic syndrome (MetS) is also prevalent in the general population and can impair recognition of common mental disorders due to significant co-morbidity and overlap with psychiatric symptoms included in self-reported depression/anxiety screening tools. We investigated if MetS has an impact on the accuracy of current major depressive disorder (MDD) and generalized anxiety disorder (GAD) screening results using the Hospital Anxiety and Depression scale (HADS).A total of 1115 (562 men; mean age 62.0 ± 9.6 years) individuals of 45+ years of age were randomly selected from the general population and evaluated for current MetS; depressive and anxiety symptoms (HADS); and current MDD and GAD (Mini International Neuropsychiatric Interview [MINI]).The MetS was diagnosed in 34.4% of the study participants. Current MDD and GAD were more common in individuals with MetS relative to individuals without MetS (25.3% vs 14.2%, respectively, p < 0.001; and 30.2% vs 20.9%, respectively, p < 0.001). The ROC analyses demonstrated that optimal thresholds of the HADS-Depression subscale for current MDE were ≥9 in individuals with MetS (sensitivity = 87%, specificity = 73% and PPV = 52%) and ≥8 in individuals without MetS (sensitivity = 81%, specificity = 78% and PPV = 38%). At threshold of ≥9 the HADS-Anxiety subscale demonstrated optimal psychometric properties for current GAD screening in individuals with MetS (sensitivity = 91%, specificity = 85% and PPV = 72%) and without MetS (sensitivity = 84%, specificity = 83% and PPV = 56%).The HADS is a reliable screening tool for current MDE and GAD in middle aged and elderly population with and without MetS. Optimal thresholds of the HADS-Depression subscale for current MDD is ≥9 for individuals with MetS and ≥8 - without MetS. Optimal threshold of the HADS-Anxiety subscale is ≥9 for current GAD in individuals with and without MetS. The presence of MetS should be considered when interpreting depression screening results.}, URL= {https://europepmc.org/articles/PMC5759833}} . BMC psychiatry.

Adomas Bunevicius (2017). Re: Impact of pre‐operative health‐related quality of life on outcomes after heart surgery . ANZ Journal of Surgery.

Adomas Bunevicius, Vytenis Deltuva, Edward R. Laws, Giorgio Iervasi, Arimantas Tamsauskas, Robertas Bunevicius (2017). Preoperative N-terminal pro-B-type natriuretic peptide concertation and prognosis of brain tumor patients: a 5-year follow up study . Scientific Reports.

Adomas Bunevicius(2017). Re: Impact of pre-operative health-related quality of life on outcomes after heart surgery . ANZ journal of surgery. 87. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1061--1062.

Bunevicius, A.(2017). Re: Impact of pre-operative health-related quality of life on outcomes after heart surgery . ANZ Journal of Surgery. 87. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1061-1062.

Bunevicius, A., Deltuva, V., Laws, E.R., Iervasi, G., Tamsauskas, A., Bunevicius, R.(2017). Preoperative N-Terminal pro-B-Type natriuretic peptide concertation and prognosis of brain tumor patients: A 5-year follow up study . Scientific Reports. 7. (1).

Julius Burkauskas and Adomas Bunevicius and Julija Brozaitiene and Julius Neverauskas and Peter Lang and Robert Duwors and Narseta Mickuviene and Robertas Bunevicius(2017). Cognitive Functioning in Coronary Artery Disease Patients: Associations with Thyroid Hormones, N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein . Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 32. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 245--251.

Burkauskas, J., Bunevicius, A., Brozaitiene, J., Neverauskas, J., Lang, P., Duwors, R., Mickuviene, N., Bunevicius, R.(2017). Cognitive functioning in coronary artery disease patients: Associations with thyroid hormones, N-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive protein . Archives of Clinical Neuropsychology. 32. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 245-251.

Adomas Bunevicius(2017). Commentary . Journal of neurosciences in rural practice. 8. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 132--133.

Bunevicius, A.(2017). Commentary . Journal of Neurosciences in Rural Practice. 8. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 132-133.

Adomas Bunevicius(2017). Commentary . {Thieme Medical and Scientific Publishers Pvt. Ltd.}

Bunevicius, A.(2017). Reliability and validity of the SF-36 Health Survey Questionnaire in patients with brain tumors: A cross-sectional study . Health and Quality of Life Outcomes. 15. (1).

Giedrimantas Bernotas and Karolis Simaitis and Adomas Bunevicius and Arimantas Tamasauskas(2017). Safety and efficacy of stereotactic aspiration with fibrinolysis for deep-seated spontaneous intracerebral hemorrhages: A single-center experience . Medicina (Kaunas, Lithuania). 53. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 303--309.

Bernotas, G., Simaitis, K., Bunevičius, A., Tamašauskas, A.(2017). Safety and efficacy of stereotactic aspiration with fibrinolysis for deep-seated spontaneous intracerebral hemorrhages: A single-center experience . Medicina (Lithuania).

Rimantas Vilcinis and Adomas Bunevicius and Arimantas Tamasauskas(2017). The Association of Surgical Method with Outcomes of Acute Subdural Hematoma Patients: Experience with 643 Consecutive Patients . World neurosurgery. 101. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 335--342.

Vilcinis, R., Bunevicius, A., Tamasauskas, A.(2017). The Association of Surgical Method with Outcomes of Acute Subdural Hematoma Patients: Experience with 643 Consecutive Patients . World Neurosurgery. 101. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 335-342.

(2017). The association between lunar phase and intracranial aneurysm rupture: Myth or reality? Own data and systematic review . BMC neurology.

Adomas Bunevicius and Agne Gendvilaite and Vytenis Pranas Deltuva and Arimantas Tamasauskas(2017). The association between lunar phase and intracranial aneurysm rupture: Myth or reality? Own data and systematic review . BMC neurology. 17. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 99--.

Bunevicius, A., Gendvilaite, A., Deltuva, V.P., Tamasauskas, A.(2017). The association between lunar phase and intracranial aneurysm rupture: Myth or reality? Own data and systematic review . BMC Neurology. 17. (1).

Adomas Bunevicius(2017). Reliability and validity of the SF-36 Health Survey Questionnaire in patients with brain tumors: a cross-sectional study . {BMC}

Adomas Bunevicius(2017). Reliability and validity of the SF-36 Health Survey Questionnaire in patients with brain tumors: a cross-sectional study . Health and quality of life outcomes. 15. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 92--92.

Commentary @article{PMID:28149100, Title= {Commentary}, Author= {Bunevicius, Adomas}, DOI= {10.4103/0976-3147.193563}, Number= {1}, Volume= {8}, Year= {2017}, Journal= {Journal of neurosciences in rural practice}, ISSN= {0976-3147}, Pages= {132—133}, URL= {https://europepmc.org/articles/PMC5225698}} . Journal of neurosciences in rural practice.

Association of pre-operative depressive and anxiety symptoms with five-year survival of glioma and meningioma patients: a prospective cohort study @article{PMID:28915694, Title= {Association of pre-operative depressive and anxiety symptoms with five-year survival of glioma and meningioma patients: a prospective cohort study}, Author= {Bunevicius, Adomas and Deltuva, Vytenis Pranas and Tamasauskas, Arimantas}, DOI= {10.18632/oncotarget.15743}, Number= {34}, Volume= {8}, Month= {August}, Year= {2017}, Journal= {Oncotarget}, ISSN= {1949-2553}, Pages= {57543—57551}, Abstract= {BACKGROUND:Mental symptoms are common and associated with worse health status of brain tumor patients. We evaluated the association of pre-operative depressive and anxiety symptoms with 5-year mortality of glioma and meningioma patients. METHODS:One-hundred and fifty-two patients (mean age 56.9±14.7 years, 69% women) were evaluated for functional status (Barthel index), and depressive and anxiety symptom severity (Hospital Anxiety and Depression scale or HADS). Patients were categorized as having mild, moderate or severe depressive/anxiety symptoms if they scored ≤7, 8-10 or ≥11 on the HADS, respectively. Information pertaining to histological diagnosis, extent of resection and adjuvant therapies were obtained from medical records. Follow-up continued through November, 2015. RESULTS:Forty-three patients were diagnosed with high-grade glioma, 20 with low-grade glioma and 89 with meningioma. Moderate to severe depressive and anxiety symptoms were diagnosed in 28% and 36% of patients, respectively. In meningioma patients, survival was the shortest in patients with severe depressive symptoms (40.32±7.92 months) followed by patients with moderate (46.66±6.05 months) and mild (55.68±1.77 months) depressive symptoms (Log-Rank = 6.211, p = 0.045). After adjusting for patients' age, gender, functional status, extent of resection, history of depression, and tumor location, laterality and grade, severe depressive symptoms were associated with increased 5-year mortality risk of meningioma patients (HR = 7.083 [95%CI: 1.755-28.588], p = 0.006). Depressive and anxiety symptoms were not associated with mortality of glioma patients. CONCLUSIONS:Depressive and anxiety symptoms are common in glioma and meningioma patients. Pre-operative depressive symptoms are associated with shorter survival of meningioma patients independently from clinical prognostic indicators.}, URL= {https://europepmc.org/articles/PMC5593666}} . Oncotarget.

Aiste Pranckeviciene and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Adomas Bunevicius(2017). Association between psychological distress, subjective cognitive complaints and objective neuropsychological functioning in brain tumor patients . Clinical neurology and neurosurgery. 163. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 18--23.

Pranckeviciene, A., Deltuva, V.P., Tamasauskas, A., Bunevicius, A.(2017). Association between psychological distress, subjective cognitive complaints and objective neuropsychological functioning in brain tumor patients . Clinical Neurology and Neurosurgery. 163. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 18-23.

Adomas Bunevicius and Vytenis Pranas Deltuva and Arimantas Tamasauskas(2017). Association of pre-operative depressive and anxiety symptoms with five-year survival of glioma and meningioma patients: a prospective cohort study . Oncotarget. 8. (34). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 57543--57551.

Bunevicius, A., Deltuva, V.P., Tamasauskas, A.(2017). Association of pre-operative depressive and anxiety symptoms with five-year survival of glioma and meningioma patients: A prospective cohort study . Oncotarget. 8. (34). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 57543-57551.

Bunevicius, A., Laws, E.R., Deltuva, V., Tamasauskas, A.(2017). Association of thyroid hormone concentrations with quality of life of primary brain tumor patients: a pilot study . Journal of Neuro-Oncology. 131. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 385-391.

Safety and efficacy of stereotactic aspiration with fibrinolysis for deep-seated spontaneous intracerebral hemorrhages: A single-center experience @article{PMID:28838850, Title= {Safety and efficacy of stereotactic aspiration with fibrinolysis for deep-seated spontaneous intracerebral hemorrhages: A single-center experience}, Author= {Bernotas, Giedrimantas and Simaitis, Karolis and Bunevičius, Adomas and Tamašauskas, Arimantas}, DOI= {10.1016/j.medici.2017.07.006}, Number= {5}, Volume= {53}, Month= {December}, Year= {2017}, Journal= {Medicina (Kaunas, Lithuania)}, ISSN= {1010-660X}, Pages= {303—309}, Abstract= {OBJECTIVE:The aim of this study was to evaluate feasibility and safety of stereotactic aspiration with fibrinolysis of deep-seated intracerebral hemorrhages (ICH). MATERIALS AND METHODS:From March 1995 until December 2016, 58 adult patients (34 men and 24 women; mean age of 56.8±11.8 years) presenting with deep-seated spontaneous supratentorial ICH were treated using a minimally invasive technique. Intracerebral hematomas were aspirated until obvious resistance to free-hand suction and subsequent clot fibrinolysis was done using either streptokinase or recombinant tissue-type plasminogen activator. CT scans were performed at intervals ranging from 24 to 72h. At discharge, functional outcomes were evaluated using the Glasgow outcome scale (GOS). The 30-day mortality rate was evaluated in all patients. RESULTS:The average ICH volume on initial CT scan was 34.7±11.1cm3 (range, 20-90cm3). Mean residual hematoma volume after the treatment was 8.0±5.1cm3 (range, 3-32cm3). There was statistically significant reduction of ICH volume after the treatment (P<0.001). Median ICH reduction rate was 5cm3/d (range, 1.5-16.0cm3/d) and 17.2%/d (range, 5.27-40.0%/d). Median discharge GOS score was 3 (range, 1-4). Six (10.9%) patients died during the 30-day follow-up period. Treatment related complications were observed in three (5.5%) patients. In two patients asymptomatic increase of ICH volume occurred and one patient was diagnosed with CNS infection. CONCLUSIONS:Stereotactic clot aspiration with subsequent fibrinolytic therapy is safe and feasible treatment procedure associated with significant hematoma resolution rates and acceptable patient outcomes.}, URL= {https://doi.org/10.1016/j.medici.2017.07.006}} . Medicina (Kaunas, Lithuania).

Association of thyroid hormone concentrations with quality of life of primary brain tumor patients: a pilot study @article{PMID:27830477, Title= {Association of thyroid hormone concentrations with quality of life of primary brain tumor patients: a pilot study}, Author= {Bunevicius, Adomas and Laws, Edward R and Deltuva, Vytenis and Tamasauskas, Arimantas}, DOI= {10.1007/s11060-016-2311-x}, Number= {2}, Volume= {131}, Month= {January}, Year= {2017}, Journal= {Journal of neuro-oncology}, ISSN= {0167-594X}, Pages= {385—391}, Abstract= {Reduced triiodothyronine (T3) concentrations were implicated in worse prognosis of brain tumor patients. In this study we investigated the association of normal and abnormal thyroid hormone concentrations with health-related quality of life (HRQoL) of patients with primary brain tumors. Sixty-three patients (67% women and a mean age of 55.5 ± 13.8 years) before brain tumor surgery were evaluated for: (1) HRQoL using the EORTC questionnaire for cancer patients (QLQ-C30) and the Brain Cancer-Specific Quality of Life Questionnaire (QLQ-BN20); (2) functional status (Barthel Index); and (3) clinical disease severity. Blood samples were obtained for assessment of thyroid hormone concentrations before surgery. After adjusting for the brain tumor histological diagnosis, patients' age, gender and functional status, lower thyroid stimulating hormone (TSH) concentrations were associated with poor levels of functioning on the QLQ-C30 scales: physical functioning (β = 0.395, p < 0.001), role functioning (β = 0.334, p = 0.003) and cognitive functioning (β = 0.327, p = 0.009), and with greater QLQ-BN20 fatigue symptom severity (β = -0.406, p < 0.001). Lower free T3 concentrations were associated with worse HRQOL on the QLQ-C30 global health status (β = 0.302, p = 0.017), emotional functioning (β= 0.422, p < 0.001) and cognitive functioning (β= 0.259, p = 0.042) domains, and with greater symptom severity on the QLQ-BN20 fatigue (β = -0.238, p = 0.041), motor dysfunction (β = -0.283, p = 0.013) and weakness of legs (β = -0.269. p = 0.027) domains. In conclusion, reduced T3 and TSH hormone concentrations are associated with impaired emotional and physical aspects of HRQoL of primary brain tumor patients independent of brain tumor histological diagnosis, patients' age, gender and functional status. Assessment for thyroid axis dysfunction should be addressed and appropriately managed in neuro-oncology patient care.}, URL= {https://doi.org/10.1007/s11060-016-2311-x}} . Journal of neuro-oncology.

Cognitive Functioning in Coronary Artery Disease Patients: Associations with Thyroid Hormones, N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein @article{PMID:28119302, Title= {Cognitive Functioning in Coronary Artery Disease Patients: Associations with Thyroid Hormones, N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein}, Author= {Burkauskas, Julius and Bunevicius, Adomas and Brozaitiene, Julija and Neverauskas, Julius and Lang, Peter and Duwors, Robert and Mickuviene, Narseta and Bunevicius, Robertas}, DOI= {10.1093/arclin/acx004}, Number= {2}, Volume= {32}, Month= {March}, Year= {2017}, Journal= {Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists}, ISSN= {0887-6177}, Pages= {245—251}, Abstract= {To determine whether biomarkers of health such as serum levels of free triiodothyronine (fT3), total triiodothyronine (TT3), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hsCRP) impact the cognitive functioning of coronary artery disease (CAD) patients.About 278 patients were evaluated for socio-demographic and clinical risk factors as well as fT3, TT3, NT-proBNP, and hsCRP serum levels. Cognitive functioning measures included the Mini-Mental State Examination, Digit Span Test, Digit Symbol Substitution Test (DSST), and Trail Making Test A (TMTA). Depressive symptoms were assessed with the Hospital Anxiety and Depression Scale.Lower fT3 concentrations were associated with longer completion time of the DSST and TMTA. Elevated levels of NT-proBNP were also associated with inferior performance on TMTA independently of socio-demographic characteristics, clinical risk factors, and depression symptoms.Lower fT3 concentrations and higher levels of NT-proBNP were associated with worse cognitive functioning in CAD patients.}, URL= {https://doi.org/10.1093/arclin/acx004}} . Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

Preoperative N-terminal pro-B-type natriuretic peptide concertation and prognosis of brain tumor patients: a 5-year follow up study @article{PMID:29116209, Title= {Preoperative N-terminal pro-B-type natriuretic peptide concertation and prognosis of brain tumor patients: a 5-year follow up study}, Author= {Bunevicius, Adomas and Deltuva, Vytenis and Laws, Edward R and Iervasi, Giorgio and Tamsauskas, Arimantas and Bunevicius, Robertas}, DOI= {10.1038/s41598-017-15394-6}, Number= {1}, Volume= {7}, Month= {November}, Year= {2017}, Journal= {Scientific reports}, ISSN= {2045-2322}, Pages= {14775}, Abstract= {Increased N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration predicts poor prognosis of non-CNS cancer patients. We evaluated the association of NT-proBNP concentration with disease severity, discharge outcomes and prognosis of patients undergoing craniotomy for brain tumor. From January, 2010 until September, 2011 two-hundred and forty-five patients (age 55.05 ± 14.62 years) admitted for brain tumor surgery were evaluated for NT-proBNP serum concentration. Outcome at hospital discharge was evaluated with the Glasgow Outcome Scale (GOS). Most common diagnoses were meningioma (37%) and high-grade glioma (20%). Greater NT-proBNP concentration was associated with lower Barthel index (rho = -0.305, p = 0.001) and Mini Mental State Examination scores (rho = -0.314, p = 0.001) and with greater Hospital Anxiety and Depression scale Depression score (rho = 0.240, p = 0.026). Greater admission NT-proBNP concentration was associated with lower discharge GOS score after adjusting for patient age, gender and histological brain tumor diagnosis (β = -0.253, p < 0.001). Greater NT-proBNP concentration was also associated with greater 5-year mortality risk (HR = 1.845; 95%CI [1.166-2.920], p = 0.009) controlling for patient age, gender, history of cardiovascular disease, histological diagnosis and adjuvant therapy. In sum, greater pre-operative NT-proBNP concentration is associated with worse health status, unfavorable discharge outcome and shorter survival of brain tumor patients.}, URL= {https://europepmc.org/articles/PMC5677015}} . Scientific reports.

Re: Impact of pre-operative health-related quality of life on outcomes after heart surgery @article{PMID:29205821, Title= {Re: Impact of pre-operative health-related quality of life on outcomes after heart surgery}, Author= {Bunevicius, Adomas}, DOI= {10.1111/ans.14205}, Number= {12}, Volume= {87}, Month= {December}, Year= {2017}, Journal= {ANZ journal of surgery}, ISSN= {1445-1433}, Pages= {1061—1062}, URL= {https://doi.org/10.1111/ans.14205}} . ANZ journal of surgery.

Preoperative low tri-iodothyronine concentration is associated with worse health status and shorter five year survival of primary brain tumor patients @article{PMID:28055959, Title= {Preoperative low tri-iodothyronine concentration is associated with worse health status and shorter five year survival of primary brain tumor patients}, Author= {Bunevicius, Adomas and Deltuva, Vytenis Pranas and Tamasauskas, Sarunas and Smith, Timothy and Laws, Edward R and Bunevicius, Robertas and Iervasi, Giorgio and Tamasauskas, Arimantas}, DOI= {10.18632/oncotarget.14376}, Number= {5}, Volume= {8}, Month= {January}, Year= {2017}, Journal= {Oncotarget}, ISSN= {1949-2553}, Pages= {8648—8656}, Abstract= {Low tri-iodothyronine syndrome is associated with worse prognosis of severely ill patients. We investigated the association of thyroid hormone levels with discharge outcomes and 5-year mortality in primary brain tumor patients.From January, 2010 until September, 2011, 230 patients (70% women) before brain tumor surgery were evaluated for cognitive (Mini mental State Examination; MMSE) and functional (Barthel index; BI) status, and thyroid function profile. The Low triiodothyronine syndrome was defined as triiodothyronine concentration below the reference range. Unfavorable discharge outcomes were Glasgow outcome scale score of ≤3. Follow-up continued until November, 2015.Seventy-four percent of patients had Low triiodothyronine syndrome. Lower total tri-iodothyronine concentrations were associated with lower MMSE (p=.013) and BI (p=.023) scores independent of age, gender and histological diagnosis. Preoperative Low tri-iodothyronine syndrome increased risk for unfavorable discharge outcomes adjusting for age, gender and histological diagnosis (OR=2.944, 95%CI [1.314-6.597], p=.009). In all patients, lower tri-iodothyronine concentrations were associated with greater mortality risk (p≤.038) adjusting for age, gender, extent of resection, adjuvant treatment and histological diagnosis. The Low tri-iodothyronine syndrome was associated with greater 5-year mortality for glioma patients (HR=2.197; 95%CI [1.160-4.163], p=.016) and with shorter survival (249 [260] vs. 352 [399] days; p=.029) of high grade glioma patients independent of age, gender, extent of resection and adjuvant treatment.The Low tri-iodothyronine syndrome is common in brain tumor patients and is associated with poor functional and cognitive status, and with worse discharge outcomes. The Low tri-iodothyronine syndrome is associated with shorter survival of glioma patients.}, URL= {https://europepmc.org/articles/PMC5352429}} . Oncotarget.

Exploring Cognitive Concomitants of Mental Fatigue in Patients with Coronary Artery Disease @article{PMID:29940561, Title= {Exploring Cognitive Concomitants of Mental Fatigue in Patients with Coronary Artery Disease}, Author= {Burkauskas, Julius and Bunevičius, Adomas and Brožaitienė, Julija and Neverauskas, Julius and Fineberg, Naomi A and Wellsted, David and Bunevičius, Robertas and Mickuvienė, Narseta}, DOI= {10.1159/000489713}, Number= {3}, Volume= {76}, Year= {2017}, Journal= {Neuropsychobiology}, ISSN= {0302-282X}, Pages= {151—160}, Abstract= {Fatigue and reduced exercise capacity are common concomitants of coronary artery disease (CAD). They are known to be associated with the deterioration in mental health, including emotional and cognitive status. However, the precise nature of the inter-relationship is poorly understood. The aim of this study was to investigate the relationship between fatigue and exercise capacity on the one hand and changes in cognitive functioning on the other, to generate new heuristics for clinical management and outcome prediction of CAD.A cross-sectional study included 827 in-patients (58 ± 9 years, 75% men) with CAD. Patients were evaluated for demographic, cardiac characteristics, and exercise capacity. The Multidimensional Fatigue Inventory-20 was used to assess fatigue, the Mini Mental State Examination for global cognitive function, the Digit Span Test, Digit Symbol Test, and Trail Making Test for executive aspects of cognitive functioning, and the Hospital Anxiety and Depression Scale for anxiety and depression symptom severity.Using multiple regression analysis, after adjusting for possible confounders such as anxiety and depression, mental fatigue was associated with several executive aspects of cognitive function including short-term memory (Digit Symbol Test pairs recalled correctly [β = -0.127, p < 0.005]), psychomotor performance (time to complete the Digit Symbol Test [β = 0.089, p < 0.03]), and cognitive processing speed (Trail Making Test A [β = 0.081, p < 0.05]).In rehabilitating CAD patients, certain aspects of executive functioning were independently associated with mental fatigue. These findings suggest that the subjective experience of mental fatigue, rather than reduced exercise capacity, is significantly associated with cognitive function.}, URL= {https://doi.org/10.1159/000489713}} . Neuropsychobiology.

Reliability and validity of the SF-36 Health Survey Questionnaire in patients with brain tumors: a cross-sectional study @article{PMID:28472964, Title= {Reliability and validity of the SF-36 Health Survey Questionnaire in patients with brain tumors: a cross-sectional study}, Author= {Bunevicius, Adomas}, DOI= {10.1186/s12955-017-0665-1}, Number= {1}, Volume= {15}, Month= {May}, Year= {2017}, Journal= {Health and quality of life outcomes}, ISSN= {1477-7525}, Pages= {92}, Abstract= {Deterioration of health related quality of life (HRQoL) is common in brain tumor patients. This study evaluated validity and reliability of the Medical Outcomes Study 36-Item Short Form (SF-36) in patients with brain tumors.Two hundred and seventy-seven patients admitted for brain tumor surgery were evaluated for HRQoL (SF-36 questionnaire); depressive symptoms (Beck Depression Inventory-II or BDI-II); and functional status (Barthel index or BI). Final histological diagnosis was obtained from pathology reports.Two-hundred and twenty-seven (completion rate of 82%) patients (69% women; mean age 55.8 ± 14.4 years) completed the SF-36 questionnaire. The most common brain tumor diagnosis was meningioma (40%), followed high-grade glioma (19%). Missing data rates were ≤4%. Internal consistency was adequate for all (Cronbach α ≥ .728) but Social Functioning (Cronbach α = .527) and General Health (Cronbach α = .693) subscales. Ceiling (≥36%) and floor (≥22%) effect rates were the greatest for the Role Limitations subscales. The SF-36 subscales pertaining physical health correlated the strongest with the BI score, while the SF-36 subscales pertaining emotional health correlated the strongest with the BDI-II score. Patients with mild-moderate depressive symptoms (BDI-II score ≥20) scored lower across all SF-36 subscales, and handicap patients (BI score <90) scored the lower across all, but Mental Health, subscales.The SF-36 is a valid and reliable instrument in brain tumor patients and therefore can be reliably applied for evaluation of HRQoL in neuro-oncology setting. Further studies exploring other psychometric properties of the SF-36 in brain tumor patients across disease progression stages are warranted.}, URL= {https://europepmc.org/articles/PMC5418840}} . Health and quality of life outcomes.

The Association of Surgical Method with Outcomes of Acute Subdural Hematoma Patients: Experience with 643 Consecutive Patients @article{PMID:28216211, Title= {The Association of Surgical Method with Outcomes of Acute Subdural Hematoma Patients: Experience with 643 Consecutive Patients}, Author= {Vilcinis, Rimantas and Bunevicius, Adomas and Tamasauskas, Arimantas}, DOI= {10.1016/j.wneu.2017.02.010}, Volume= {101}, Month= {May}, Year= {2017}, Journal= {World neurosurgery}, ISSN= {1878-8750}, Pages= {335—342}, Abstract= {We investigated the association of decompressive craniectomy (DC) and osteoplastic craniotomy (OC) with outcomes in consecutive patients undergoing surgical evacuation of acute subdural hematoma (ASDH) and analyzed prognostic indicators to determine optimal surgical management strategy for patients with ASDH.We performed a prospective review of all adult patients with ASDH operated on by craniotomy from January 2009 to January 2016. Mortality and discharge outcomes (Glasgow Outcome Scale) were analyzed as a function of surgical method adjusting for age, admission Glasgow Coma Scale score, ASDH thickness and midline shift.OC was performed in 394 (61%) patients, and DC was performed in 249 (39%) patients. Patients undergoing DC were younger, with lower Glasgow Coma Scale score, greater ASDH thickness, and greater midline shift (P < 0.001). Mortality rate (54% vs. 20%; P < 0.001) and proportion of patients with poor discharge outcomes (85% and 45%; P < 0.001) were greater in DC patients versus OC patients. Glasgow Outcome Scale score was lower and mortality rate was greater (P ≤ 0.048) in DC patients versus OC patients across all patient subgroups. Outcomes were similar between the 2 groups in patients with Glasgow Coma Scale score of 3 and midline shift of ≥2 cm. Adjusting for disease severity, DC remained associated with greater risk for in-hospital mortality (odds ratio = 3.442 [95% confidence interval 2.196-5.396], P < 0.001) and unfavorable discharge outcome (odds ratio = 5.277 [95% confidence interval 3.030-9.191], P < 0.001).DC was performed more often in younger and more severely injured patients. DC is associated with greater mortality and handicap rates independent of disease severity. Clinical trials investigating optimal surgical management strategy of patients with ASDH are needed.}, URL= {https://doi.org/10.1016/j.wneu.2017.02.010}} . World neurosurgery.

Beta-1-Selective Beta-Blockers and Cognitive Functions in Patients With Coronary Artery Disease: A Cross-Sectional Study @article{PMID:26715033, Title= {Beta-1-Selective Beta-Blockers and Cognitive Functions in Patients With Coronary Artery Disease: A Cross-Sectional Study}, Author= {Burkauskas, Julius and Noreikaite, Aurelija and Bunevicius, Adomas and Brozaitiene, Julija and Neverauskas, Julius and Mickuviene, Narseta and Bunevicius, Robertas}, DOI= {10.1176/appi.neuropsych.15040088}, Number= {2}, Volume= {28}, Year= {2016}, Journal= {The Journal of neuropsychiatry and clinical neurosciences}, ISSN= {0895-0172}, Pages= {143—146}, Abstract= {The association between current beta-1-selective beta-blocker use and cognitive function was evaluated in 722 patients with coronary artery disease without dementia. Beta-1-selective beta-blocker use was associated with worse incidental learning independently of sociodemographic characteristics, clinical coronary artery disease severity, and depression/anxiety.}, URL= {https://doi.org/10.1176/appi.neuropsych.15040088}} . The Journal of neuropsychiatry and clinical neurosciences.

Digit ratio (2D:4D) in primary brain tumor patients: A case-control study @article{PMID:27750190, Title= {Digit ratio (2D:4D) in primary brain tumor patients: A case-control study}, Author= {Bunevicius, Adomas and Tamasauskas, Sarunas and Deltuva, Vytenis Pranas and Tamasauskas, Arimantas and Sliauzys, Albertas and Bunevicius, Robertas}, DOI= {10.1016/j.earlhumdev.2016.10.003}, Volume= {103}, Month= {December}, Year= {2016}, Journal= {Early human development}, ISSN= {0378-3782}, Pages= {205—208}, Abstract= {The second-to-fourth digit ratio (2D:4D) reflects prenatal estrogen and testosterone exposure, and is established in utero. Sex steroids are implicated in development and progression of primary brain tumors.To investigate whether there is a link between 2D:4D ratio and primary brain tumors, and age at presentation.Digital images of the right and left palms of 85 primary brain tumor patients (age 56.96±13.68years; 71% women) and 106 (age 54.31±13.68years; 68% women) gender and age matched controls were obtained. The most common brain tumor diagnoses were meningioma (41%), glioblastoma (20%) and pituitary adenoma (16%). Right and left 2D:4D ratios, and right minus left 2D:4D (Dr-l) were compared between patients and controls, and were correlated with age.Right and left 2D:4D ratios were significantly lower in primary brain tumor patients relative to controls (t=-4.28, p<0.001 and t=-3.69, p<0.001, respectively). The Dr-l was not different between brain tumor patients and controls (p=0.27). In meningioma and glioma patients, age at presentation correlated negatively with left 2D:4D ratio (rho=-0.42, p=0.01 and rho=-0.36, p=0.02, respectively) and positively with Dr-l (rho=0.45, p=0.009 and rho=0.65, p=0.04, respectively).Right and left hand 2D:4D ratios are lower in primary brain tumor patients relative to healthy individuals suggesting greater prenatal testosterone and lower prenatal estrogen exposure in brain tumor patients. Greater age at presentation is associated with greater Dr-l and with lower left 2D:4D ratio of meningioma and glioma patients. Due to small sample size our results should be considered preliminary and interpreted with caution.}, URL= {https://doi.org/10.1016/j.earlhumdev.2016.10.003}} . Early human development.

Association of Depression, Anxiety, and Type D Personality with Cognitive Function in Patients with Coronary Artery Disease @article{PMID:27336806, Title= {Association of Depression, Anxiety, and Type D Personality with Cognitive Function in Patients with Coronary Artery Disease}, Author= {Burkauskas, Julius and Brozaitiene, Julija and Bunevicius, Adomas and Neverauskas, Julius and Zaliunaite, Violeta and Bunevicius, Robertas}, DOI= {10.1097/wnn.0000000000000093}, Number= {2}, Volume= {29}, Month= {June}, Year= {2016}, Journal= {Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology}, ISSN= {1543-3633}, Pages= {91—99}, Abstract= {Cognitive impairment predicts poor outcomes in patients with coronary artery disease (CAD), but much remains to be learned about these patients' cognitive function. We investigated how depression, anxiety, and Type D personality relate to cognitive function in patients with CAD, adjusting for sociodemographic factors and clinical markers of CAD severity.We evaluated 510 consecutive patients with CAD (364 men, 146 women; mean age 58±9 years) but no history of coronary artery bypass graft surgery or cognitive impairment who were attending a cardiac rehabilitation program. We assessed the patients' cognitive function (Mini-Mental State Examination, Digit Span Test, Digit Symbol Test, and Trail Making Test Part A), depressive symptoms (Beck Depression Inventory-II), anxiety (State-Trait Anxiety Inventory), Type D personality (14-item Type D Scale), and clinical markers of CAD severity.After adjusting for sex, age, education, New York Heart Association functional class, and left ventricular ejection fraction, we found that higher depression symptom scores correlated with longer Digit Symbol Test completion time (β=0.158, P<0.004). Higher state anxiety scores correlated with worse Digit Span Test backward recall (β=-0.117, P<0.008) and Trail Making Test Part A scores (β=0.182, P<0.004). Type D personality correlated with lower Mini-Mental State Examination scores (β=-0.148, P=0.001).For patients with CAD undergoing a cardiac rehabilitation program, depression, anxiety, and Type D personality were associated with worse cognitive performance independent of clinical CAD severity and sociodemographic characteristics.}, URL= {https://doi.org/10.1097/WNN.0000000000000093}} . Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

Suicidal ideation in patients undergoing brain tumor surgery: prevalence and risk factors @article{PMID:26868951, Title= {Suicidal ideation in patients undergoing brain tumor surgery: prevalence and risk factors}, Author= {Pranckeviciene, Aiste and Tamasauskas, Sarunas and Deltuva, Vytenis Pranas and Bunevicius, Robertas and Tamasauskas, Arimantas and Bunevicius, Adomas}, DOI= {10.1007/s00520-016-3117-2}, Number= {7}, Volume= {24}, Month= {July}, Year= {2016}, Journal= {Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer}, ISSN= {0941-4355}, Pages= {2963—2970}, Abstract= {Suicidal ideation (SI) is an important complication in cancer patients that should be promptly recognized and adequately managed. We investigated the prevalence rate and correlates of pre-operative SI in brain tumor (BT) patients admitted for elective BT surgery.Two hundred and eleven consecutive patients (70 % women; mean age 55.9 ± 15.4 years) scheduled for BT surgery were evaluated for SI ("suicidal thought" item from the Beck Depression Inventory-II), depressive/anxiety symptom severity (Hospital Anxiety and Depression scale (HADS)), health-related quality of life (SF-36 scale), functional status (Barthel Index), and psychiatric histories and treatments. The majority of patients were diagnosed with meningioma (39 %) and high-grade glioma (17 %).SI was self-reported by 12 (6 %) patients. Patients expressing SI were most commonly diagnosed with meningioma (50 %). Patients with SI were more likely to have a past history of psychiatric disorders, scored higher on the HADS anxiety subscale, and reported worse health-related quality of life across physical and mental health domains. In multivariate regression analyses, worse perceived mental health was associated with increased risk for SI independently from clinical, sociodemographic, and other patient-oriented variables considered in the study.SI was self-reported by 6 % of BT patients before surgical intervention and was associated with a past history of psychiatric disorders and worse perceived health status. Poor mental health was an independent correlate of SI. The perception of health status by a patient should be considered as an important determinant of poor mental health in BT patients.}, URL= {https://doi.org/10.1007/s00520-016-3117-2}} . Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.

Olfactory Fossa Meningioma Presenting as Depressive Disorder: A Case Report @article{PMID:27336808, Title= {Olfactory Fossa Meningioma Presenting as Depressive Disorder: A Case Report}, Author= {Pranckeviciene, Aiste and Bunevicius, Adomas and Deltuva, Vytenis Pranas and Tamasauskas, Arimantas}, DOI= {10.1097/wnn.0000000000000090}, Number= {2}, Volume= {29}, Month= {June}, Year= {2016}, Journal= {Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology}, ISSN= {1543-3633}, Pages= {107—112}, Abstract= {Meningiomas are common, usually benign intracranial tumors. They grow slowly and can remain asymptomatic for many years. Meningiomas can present as mental disorders rather than with neurologic signs or symptoms. In this case report we describe a middle-aged man with a 2-year history of depressive disorder who was diagnosed with a large olfactory fossa meningioma after he developed mental status changes and urinary incontinence. After the tumor was removed, the patient's depressive symptoms resolved and his neurocognitive functions improved. We discuss the patient's neuropsychological and psychiatric profiles to identify symptoms and other clues that could expedite identification of meningiomas in patients with psychiatric disorders. Because olfactory fossa meningiomas can present as depressive disorder, we recommend brain imaging to rule out organic brain lesions in middle-aged and older patients with new-onset psychiatric symptoms. Although tumor removal brought improvement of our patient's mental state and neurocognitive functions, patients may not be able to recover their cognitive functions completely.}, URL= {https://doi.org/10.1097/WNN.0000000000000090}} . Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

Penetrating Anterior Skull Base Fracture Inflicted by a Cow’s Horn @article{lens.org/025-885-372-641-967, author= {Adomas Bunevicius and Karolis Bareikis and Laimutis Kalasauskas and Arimantas Tamasauskas}, title= {Penetrating Anterior Skull Base Fracture Inflicted by a Cow’s Horn}, journal= {Journal of Neurosciences in Rural Practice}, year= {2016}, volume= {7}, number= {S 01}, pages= {S106--S108}, doi= {10.4103/0976-3147.196443}, url= {https://lens.org/025-885-372-641-967}} . Journal of Neurosciences in Rural Practice.

Hemodynamic response during aneurysm clipping surgery among experienced neurosurgeons @article{PMID:26711287, Title= {Hemodynamic response during aneurysm clipping surgery among experienced neurosurgeons}, Author= {Bunevicius, Adomas and Bilskiene, Diana and Macas, Andrius and Tamasauskas, Arimantas}, DOI= {10.1007/s00701-015-2682-3}, Number= {2}, Volume= {158}, Month= {February}, Year= {2016}, Journal= {Acta neurochirurgica}, ISSN= {0001-6268}, Pages= {221—227}, Abstract= {Neurosurgery is a challenging field associated with high levels of mental stress. The goal of this study was to investigate the hemodynamic response of experienced neurosurgeons during aneurysm clipping surgery and to evaluate whether neurosurgeons' hemodynamic responses are associated with patients' clinical statuses.Four vascular neurosurgeons (all male; mean age 51 ± 10 years; post-residency experience ≥7 years) were studied during 42 aneurysm clipping procedures. Blood pressure (BP) and heart rate (HR) were assessed at rest and during seven phases of surgery: before the skin incision, after craniotomy, after dural opening, after aneurysm neck dissection, after aneurysm clipping, after dural closure and after skin closure.HR and BP were significantly greater during surgery relative to the rest situation (p ≤ 0.03). There was a statistically significant increase in neurosurgeons' HR (F [6, 41] = 10.88, p < 0.001), systolic BP (F [6, 41] = 2.97, p = 0.01), diastolic BP (F [6, 41] = 2.49, p = 0.02) and mean BP (F [6, 41] = 3.36, p = 0.003) during surgery. The greatest mean HR was after aneurysm clipping, and the greatest BP was after aneurysm neck dissection. Systolic, diastolic and mean BPs were significantly greater during surgical clipping for unruptured aneurysms compared to ruptured aneurysms across all stages of surgery (p ≤ 0.002); however, after adjusting for neurosurgeon experience, the difference in BP as a function of aneurysm rupture was not significant (p > 0.08). Aneurysm location, intraoperative aneurysm rupture, admission WFNS score, admission Glasgow Coma Scale scores and Fisher grade were not associated with neurosurgeons' intraoperative HR and BP (all p > 0.07).Aneurysm clipping surgery is associated with significant hemodynamic system activation among experienced neurosurgeons. The greatest HR and BP were after aneurysm neck dissection and clipping. Aneurysm location and patient clinical status were not associated with intraoperative changes of neurosurgeons' HR and BP.}, URL= {https://doi.org/10.1007/s00701-015-2682-3}} . Acta neurochirurgica.

Low Tri-Iodothyronine Syndrome in Neurosurgical Patients: A Systematic Review of Literature @article{PMID:27450974, Title= {Low Tri-Iodothyronine Syndrome in Neurosurgical Patients: A Systematic Review of Literature}, Author= {Bunevicius, Adomas and Smith, Timothy and Laws, Edward R}, DOI= {10.1016/j.wneu.2016.07.035}, Volume= {95}, Month= {November}, Year= {2016}, Journal= {World neurosurgery}, ISSN= {1878-8750}, Pages= {197—207}, Abstract= {Intracranial neurosurgical disorders are important causes of mortality and disability worldwide. Low tri-iodothyronine (T3) syndrome is a common complication in critically ill patients and is associated with a poor prognosis.We performed a systematic review of clinical studies analyzing the prevalence of low T3 syndrome and the association of serum T3 concentrations with disease severity and outcomes in patients with traumatic brain injury (TBI), hydrocephalus, aneurysmal subarachnoid hemorrhage (SAH), and brain tumors.The greatest prevalence rate of low T3 syndrome was reported in severe TBI patients (up to 67%), followed by patients with brain tumors (54%), aneurysmal SAH (up to 43%), and hydrocephalus (33%). A lower than normal serum T3 concentration was associated with greater disease severity, worse health status, complicated clinical course, and worse hospital discharge outcomes for TBI, aneurysmal SAH, and brain tumor patients. Lower T3 concentrations were also associated with greater long-term mortality and increased disability in TBI and aneurysmal SAH patients.Low T3 syndrome is a common complication in patients suffering from intracranial neurosurgical disorders and is associated with greater disease severity, complicated clinical course, and greater mortality and handicap rates. However, it remains unclear if low T3 syndrome can impact the findings of currently available clinical prognostic models and if management of low T3 syndrome can improve outcomes in neurosurgical patients.}, URL= {https://doi.org/10.1016/j.wneu.2016.07.035}} . World neurosurgery.

Professional burnout and its correlates in Lithuanian neurosurgeons @article{PMID:27339267, Title= {Professional burnout and its correlates in Lithuanian neurosurgeons}, Author= {Pranckeviciene, Aiste and Tamasauskas, Arimantas and Deltuva, Vytenis Pranas and Bunevicius, Adomas}, DOI= {10.1007/s00701-016-2869-2}, Number= {8}, Volume= {158}, Month= {August}, Year= {2016}, Journal= {Acta neurochirurgica}, ISSN= {0001-6268}, Pages= {1437—1445}, Abstract= {This study aimed to evaluate prevalence and severity of professional burnout in a sample of Lithuanian neurosurgeons and to analyze its personal, interpersonal, and organizational correlates.Thirty-one out of 79 (response rate 39 %) Lithuanian neurosurgeons participated in the study. Professional burnout was evaluated using the Maslach Burnout Inventory - General Survey. Participants also answered questions about professional stressors, sources of professional dissatisfaction, life-style factors, sickness absenteeism/presenteeism, and professional practice.The majority of neurosurgeons were between 41 and 60 years of age (48 %), were married (97 %), had children (84 %). Most neurosurgeons had 20 or more years of professional experience (54.9 %), worked from 41 to 60 h per week (58 %), and performed up to 150 surgeries per year (77.4 %). Eight (26 %) neurosurgeons reported a high level of emotional exhaustion, five (16 %) reported high level of cynicism, and eight (26 %) reported low professional efficacy. Correlation analyses revealed that higher number of surgeries per year, more hours devoted to clinical work, opportunities for professional development, intellectual challenges at work, appreciation by the patients and prestige of the profession were related to lower level of burnout. Greater general workload, unpredictability of the work schedule, lack of necessary technical equipment, dissatisfaction with colleagues, and uncertainty about the future were related to a higher level of burnout.Burnout was reported by one-quarter of neurosurgeons who chose to participate in the study. Personal, interpersonal, and organizational factors arising while fulfilling professional duties were important correlates of neurosurgeons' burnout. Due to the moderate response rate, our results should be interpreted with caution. Larger studies evaluating burnout among European neurosurgeons are needed.}, URL= {https://doi.org/10.1007/s00701-016-2869-2}} . Acta neurochirurgica.

Stress during neurosurgery: no need to worry? @article{PMID:26852035, Title= {Stress during neurosurgery: no need to worry?}, Author= {Bunevicius, Adomas and Tamasauskas, Arimantas}, DOI= {10.1007/s00701-016-2729-0}, Number= {4}, Volume= {158}, Month= {April}, Year= {2016}, Journal= {Acta neurochirurgica}, ISSN= {0001-6268}, Pages= {623—624}, URL= {https://doi.org/10.1007/s00701-016-2729-0}} . Acta neurochirurgica.

Triiodothyronine accelerates and enhances the antipsychotic effect of risperidone in acute schizophrenia @article{PMID:26679760, Title= {Triiodothyronine accelerates and enhances the antipsychotic effect of risperidone in acute schizophrenia}, Author= {Steibliene, Vesta and Bunevicius, Adomas and Savickas, Arunas and Prange, Arthur J and Nemeroff, Charles B and Bunevicius, Robertas}, DOI= {10.1016/j.jpsychires.2015.11.007}, Volume= {73}, Month= {February}, Year= {2016}, Journal= {Journal of psychiatric research}, ISSN= {0022-3956}, Pages= {9—16}, Abstract= {In acute psychotic schizophrenia patients we investigated if the combination of triiodothyronine (T3) plus risperidone was more effective when compared to risperidone monotherapy. Thirty-two in-patients meeting the DSM-IV-TR diagnostic criteria for schizophrenia and without thyroid disease received risperidone (flexibly adjusted dose for tolerability) and were randomized to additionally receive either T3 (25 μg daily; risperidone plus T3 group) or placebo (risperidone plus placebo group). Treatment lasted until meeting the response to treatment criteria defined as score of ≤ 3 on the Clinical Global Impression Severity and Improvement scales. Acute psychotic episode symptom severity was evaluated using the Brief Psychiatric Rating Scale (BPRS) at treatment initiation and at the final study assessment. Fourteen patients were randomized to receive risperidone plus T3 and eighteen to receive risperidone plus placebo. The time until treatment response was shorter in the risperidone plus T3 group relative to the risperidone plus placebo group (25.5 ± 4.4 days vs 32.2 ± 8.2 days, respectively; p = 0.001). Moreover, there was a greater reduction of BPRS-total score (p = 0.01) in the risperidone plus T3 group relative to the risperidone plus placebo group. Treatment with T3 was associated with shorter time to treatment response (β = -0.440, p = 0.022) and with greater improvement in BPRS score (β = 0.240, p = 0.053), independent of patients' gender, age, baseline BPRS score and mean risperidone dose. The study confirms that addition of T3 to risperidone was associated with accelerated and enhanced treatment response in acutely psychotic schizophrenic patients.}, URL= {https://doi.org/10.1016/j.jpsychires.2015.11.007}} . Journal of psychiatric research.

Penetrating Anterior Skull Base Fracture Inflicted by a Cow's Horn @article{PMID:28163520, Title= {Penetrating Anterior Skull Base Fracture Inflicted by a Cow's Horn}, Author= {Bunevicius, Adomas and Bareikis, Karolis and Kalasauskas, Laimutis and Tamasauskas, Arimantas}, DOI= {10.4103/0976-3147.196443}, Number= {Suppl 1}, Volume= {7}, Month= {December}, Year= {2016}, Journal= {Journal of neurosciences in rural practice}, ISSN= {0976-3147}, Pages= {S106—S108}, Abstract= {Farm workers are at increased risk for animal-inflicted head injuries that are associated with significant morbidity and occasionally may be fatal. These injuries may cause permanent eye damage with or without concomitant skull base fracture. Here, we present a male farmer who suffered a cow attack that resulted in perforating orbital injury with comminuted frontobasal cranial fracture caused by a cow's horn. The next day, the patient developed nasal and orbital cerebrospinal fluid (CSF) leak. Computed Tomography cisternography revealed CSF leakage to frontal and maxillary sinuses. The patient was treated using prophylactic antibiotic therapy, lumbar drainage, and underwent craniotomy for debridement and dural tear plastic. Post operative course was uneventful and there were no signs of CSF leak 1 year after the surgery. The case illustrates unusual injury inflicted by a cow's horn and underscores the importance of careful investigation for underlying skull base fracture and CSF leakage in patients sustaining perforating orbital injuries. Adequate and timely management of dural tears is associated with favorable outcomes.}, URL= {https://europepmc.org/articles/PMC5244038}} . Journal of neurosciences in rural practice.

Unruptured anterior communicating artery aneurysm presenting as depression: A case report and review of literature @article{PMID:27583172, Title= {Unruptured anterior communicating artery aneurysm presenting as depression: A case report and review of literature}, Author= {Bunevicius, Adomas and Cikotas, Paulius and Steibliene, Vesta and Deltuva, Vytenis P and Tamsauskas, Arimantas}, DOI= {10.4103/2152-7806.187489}, Number= {Suppl 18}, Volume= {7}, Year= {2016}, Journal= {Surgical neurology international}, ISSN= {2229-5097}, Pages= {S495—8}, Abstract= {BACKGROUND:Intracranial aneurysms most commonly present following rupture causing subarachnoid hemorrhage. Mental disorders are common among patients with unruptured intracranial aneurysms and in aneurysmal subarachnoid hemorrhage survivors. However, to the best of our knowledge, there is no published report of unruptured intracranial aneurysm presenting as a mental disorder. CASE DESCRIPTION:A 69-year-old male without a past history of mental disorders and neurological symptoms presented with a 2-month history of anxiety, sadness, lack of pleasure in usual activities, fatigue, difficulties falling asleep and waking up early in the morning, reduced appetite, and weight loss. The patient was diagnosed with major depressive disorder and antidepressant treatment was initiated. Subsequent non-contrast computed tomography (CT) of the head demonstrated hypointense oval-shaped lesion within the projection of the anterior communicating artery. CT angiography confirmed the diagnosis of a 0.8 × 0.6 cm saccular aneurysm originating from the anterior communicating artery and anterior cerebral artery. The patient underwent microsurgical clipping of the aneurysm. On psychiatric assessment 1 month after the surgery, there were no signs of depressive disorder and antidepressive treatment was discontinued. On follow-up visit 1 year after the surgery, the patient did not have any mood symptoms. CONCLUSIONS:The case indicates that organic brain lesions, including intracranial aneurysms, should be suspected in elderly patients presenting with their first episode of mental disorder.}, URL= {https://europepmc.org/articles/PMC4982348}} . Surgical neurology international.

Adomas Bunevicius and Arimantas Tamasauskas(2016). Stress during neurosurgery: no need to worry? . Acta neurochirurgica. 158. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 623--624.

Bunevicius, A., Bareikis, K., Kalasauskas, L., Tamasauskas, A.(2016). Penetrating anterior skull base fracture inflicted by a cow's horn . Journal of Neurosciences in Rural Practice. 7. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S106-S108.

Pranckeviciene, A., Tamasauskas, A., Deltuva, V.P., Bunevicius, A.(2016). Professional burnout and its correlates in Lithuanian neurosurgeons . Acta Neurochirurgica. 158. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1437-1445.

Karolis Bareikis and Adomas Bunevicius and Vytenis Pranas Deltuva and Arimantas Tamasauskas(2016). Safety and Efficacy of Surgical Treatment of Small Petroclival Meningiomas . Journal of Neurological Surgery Part B: Skull Base. 77. (S 02).

Bunevicius, A., Tamasauskas, A.(2016). Stress during neurosurgery: no need to worry? . Acta Neurochirurgica. 158. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 623-624.

Aiste Pranckeviciene and Sarunas Tamasauskas and Vytenis Pranas Deltuva and Robertas Bunevicius and Arimantas Tamasauskas and Adomas Bunevicius(2016). Suicidal ideation in patients undergoing brain tumor surgery: prevalence and risk factors . Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 24. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2963--2970.

Steibliene, V., Bunevicius, A., Savickas, A., Prange, A.J., Nemeroff, C.B., Bunevicius, R.(2016). Triiodothyronine accelerates and enhances the antipsychotic effect of risperidone in acute schizophrenia . Journal of Psychiatric Research. 73. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9-16.

Bunevicius, A., Cikotas, P., Steibliene, V., Deltuva, V., Tamsauskas, A.(2016). Unruptured anterior communicating artery aneurysm presenting as depression: A case report and review of literature . Surgical Neurology International. 7. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S495-S498.

Adomas Bunevicius and Paulius Cikotas and Vesta Steibliene and Vytenis Pranas Deltuva and Arimantas Tamsauskas(2016). Unruptured anterior communicating artery aneurysm presenting as depression: A case report and review of literature . Surgical Neurology International. 7. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 495--.

Pranckeviciene, A., Tamasauskas, S., Deltuva, V.P., Bunevicius, R., Tamasauskas, A., Bunevicius, A.(2016). Suicidal ideation in patients undergoing brain tumor surgery: prevalence and risk factors . Supportive Care in Cancer. 24. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2963-2970.

Julius Burkauskas and Julija Brozaitiene and Adomas Bunevicius and Julius Neverauskas and Violeta Zaliunaite and Robertas Bunevicius(2016). Association of Depression, Anxiety, and Type D Personality with Cognitive Function in Patients with Coronary Artery Disease . Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. 29. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 91--99.

Burkauskas, J., Brozaitiene, J., Bunevicius, A., Neverauskas, J., Zaliunaite, V., Bunevicius, R.(2016). Association of depression, anxiety, and type D personality with cognitive function in patients with coronary artery disease . Cognitive and Behavioral Neurology. 29. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 91-99.

Burkauskas, J., Noreikaite, A., Bunevicius, A., Brozaitiene, J., Neverauskas, J., Mickuviene, N., Bunevicius, R.(2016). Beta-1-selective beta-blockers and cognitive functions in patients with coronary artery disease: A cross-sectional study . Journal of Neuropsychiatry and Clinical Neurosciences. 28. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 143-146.

Adomas Bunevicius and Sarunas Tamasauskas and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Albertas Sliauzys and Robertas Bunevicius(2016). Digit ratio (2D:4D) in primary brain tumor patients: A case-control study . Early human development. 103. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 205--208.

Bunevicius, A., Tamasauskas, S., Deltuva, V.P., Tamasauskas, A., Sliauzys, A., Bunevicius, R.(2016). Digit ratio (2D:4D) in primary brain tumor patients: A case-control study . Early Human Development. 103. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 205-208.

Andrius Radziunas and Sarunas Tamasauskas and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Adomas Bunevicius(2016). Greater High-Sensitivity C-Reactive Protein and Interleukin-6 Concentrations Are Associated with Greater Mood and Anxiety Symptoms and Worse Cognitive Functioning of Acoustic Neuroma Patients . Journal of Neurological Surgery Part B: Skull Base. 77. (S 02).

Bunevicius, A., Bilskiene, D., Macas, A., Tamasauskas, A.(2016). Hemodynamic response during aneurysm clipping surgery among experienced neurosurgeons . Acta Neurochirurgica. 158. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 221-227.

Adomas Bunevicius and Edward R. Laws and Vytenis Pranas Deltuva and Arimantas Tamasauskas(2016). Association of thyroid hormone concentrations with quality of life of primary brain tumor patients: a pilot study . Journal of neuro-oncology. 131. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 385--391.

Bunevicius, A., Smith, T., Laws, E.R.(2016). Low Tri-Iodothyronine Syndrome in Neurosurgical Patients: A Systematic Review of Literature . World Neurosurgery. 95. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 197-207.

Pranckeviciene, A., Bunevicius, A., Deltuva, V.P., Tamasauskas, A.(2016). Olfactory fossa meningioma presenting as depressive disorder: A case report . Cognitive and Behavioral Neurology. 29. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 107-112.

Aiste Pranckeviciene and Adomas Bunevicius and Vytenis Pranas Deltuva and Arimantas Tamasauskas(2016). Olfactory Fossa Meningioma Presenting as Depressive Disorder: A Case Report . Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. 29. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 107--112.

A Bunevicius(2015). The Need for Open-access, Structured Data in Clinical Brain Research . Biomed Data J. 01. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 27--32. Procon, Ltd.

Adomas Bunevicius(2015). The Need for Open-access, Structured Data in Clinical Brain Research . {Procon Ltd.}

Vesta Steibliene and Adomas Bunevicius and Arunas Savickas and Arthur J. Prange and Charles B. Nemeroff and Robertas Bunevicius(2015). Triiodothyronine accelerates and enhances the antipsychotic effect of risperidone in acute schizophrenia . Journal of psychiatric research. 73. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9--16.

Adomas Bunevicius and Henrikas Kazlauskas and Nijole Raskauskiene and Narseta Mickuviene and Rudina Ndreu and Elena Corsano and Robertas Bunevicius(2015). Role of N-Terminal Pro-B-Type Natriuretic Peptide, High-Sensitivity C-Reactive Protein, and Inteleukin-6 in Predicting a Poor Outcome after a Stroke . Neuroimmunomodulation. 22. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 365--372.

Bunevicius, A., Kazlauskas, H., Raskauskiene, N., Mickuviene, N., Ndreu, R., Corsano, E., Bunevicius, R.(2015). Role of N-Terminal Pro-B-Type Natriuretic Peptide, High-Sensitivity C-Reactive Protein, and Inteleukin-6 in Predicting a Poor Outcome after a Stroke . NeuroImmunoModulation. 22. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 365-372.

Butnoriene, J., Bunevicius, A., Saudargiene, A., Nemeroff, C.B., Norkus, A., Ciceniene, V., Bunevicius, R.(2015). Metabolic syndrome, major depression, generalized anxiety disorder, and ten-year all-cause and cardiovascular mortality in middle aged and elderly patients . International Journal of Cardiology. 190. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 360-366.

Bluth, K., Gaylord, S., Nguyen, K., Bunevicius, A., Girdler, S.(2015). Mindfulness-Based Stress Reduction as a Promising Intervention for Amelioration of Premenstrual Dysphoric Disorder Symptoms . Mindfulness. 6. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1292-1302.

Karen Bluth and Susan Gaylord and Khanh Nguyen and Adomas Bunevicius and Susan S. Girdler(2015). Mindfulness-Based Stress Reduction as a Promising Intervention for Amelioration of Premenstrual Dysphoric Disorder Symptoms . Mindfulness. 6. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1292--1302.

Bunevicius, A., Iervasi, G., Bunevicius, R.(2015). Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders . Expert Review of Neurotherapeutics. 15. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 315-326.

Adomas Bunevicius and Giorgio Iervasi and Robertas Bunevicius(2015). Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders . Expert review of neurotherapeutics. 15. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 315--326.

Adomas Bunevicius, Henrikas Kazlauskas, Nijole Raskauskiene, Vinsas Janusonis, Robertas Bunevicius(2015). Thyroid Hormone and C-Reactive Protein Serum Concentrations, Disease Severity and Discharge Outcomes of Ischemic Stroke Patients: A Dataset . Biomed Data Journal. 1. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 13--18. Procon, Ltd.

Nafiseh Toghianifar and Fereshteh Ashtari and Sayyed Hamid Zarkesh-Esfahani and Marjan Mansourian and Joseph Weidenfeld and Anna Itzik and Haim Ovadia and Zahida Taibi-Djennah and Marie-France Matin-Eauclaire and Fatima Laraba-Djebari and Soraia K.P. Costa and Livia L. Camargo and Alexandre Denadai-Souza and Lidia M. Yshii and Filiphe P.N. Mesquita and Antonio G. Soares and Carla Lima and André Almeida Schenka and Andrew D. Grant and Elizabeth S. Fernandes and Marcelo Nicolas Muscará and Avinash Chandra and Nassima Behairi and Mourad Belkhelfa and Hamida Mesbah-Amroun and Hayet Rafa and Soreya Belarbi and Meriem Tazir and Chafia Touil-Boukoffa and Adomas Bunevicius and Henrikas Kazlauskas and Nijole Raskauskiene and Narseta Mickuviene and Rudina Ndreu and Elena Corsano and Robertas Bunevicius and Gabriela Laste and Joanna Ripoll Rozisky and Wolnei Caumo and Iraci Lucena da Silva Torres and Satz Mengensatzproduktion and Druckerei Stückle(2015). Contents Vol. 22, 2015 . Neuroimmunomodulation. 22. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString I--IV.

Pranckeviciene, A., Bunevicius, A.(2015). Depression screening in patients with brain tumors: a review . CNS oncology. 4. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 71-78.

J. Peceliuniene and Narseta Mickuviene and Adomas Bunevicius and Robertas Bunevicius(2015). Mental Disorders and General Medical Conditions in Primary Care . European Psychiatry. 30. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1866--.

Mindfulness-based Stress Reduction as a Promising Intervention for Amelioration of Premenstrual Dysphoric Disorder Symptoms @article{PMID:26594254, Title= {Mindfulness-based Stress Reduction as a Promising Intervention for Amelioration of Premenstrual Dysphoric Disorder Symptoms}, Author= {Bluth, Karen and Gaylord, Susan and Nguyen, Khanh and Bunevicius, Adomas and Girdler, Susan}, DOI= {10.1007/s12671-015-0397-4}, Number= {6}, Volume= {6}, Month= {December}, Year= {2015}, Journal= {Mindfulness}, ISSN= {1868-8527}, Pages= {1292—1302}, URL= {https://europepmc.org/articles/PMC4651211}} . Mindfulness.

Metabolic syndrome, major depression, generalized anxiety disorder, and ten-year all-cause and cardiovascular mortality in middle aged and elderly patients @article{PMID:25939128, Title= {Metabolic syndrome, major depression, generalized anxiety disorder, and ten-year all-cause and cardiovascular mortality in middle aged and elderly patients}, Author= {Butnoriene, Jurate and Bunevicius, Adomas and Saudargiene, Ausra and Nemeroff, Charles B and Norkus, Antanas and Ciceniene, Vile and Bunevicius, Robertas}, DOI= {10.1016/j.ijcard.2015.04.122}, Volume= {190}, Year= {2015}, Journal= {International journal of cardiology}, ISSN= {0167-5273}, Pages= {360—366}, Abstract= {Studies investigating specifically whether metabolic syndrome (MetS) and common psychiatric disorders are independently associated with mortality are lacking. In a middle-aged general population, we investigated the association of the MetS, current major depressive episode (MDE), lifetime MDE, and generalized anxiety disorder (GAD) with ten-year all-cause and cardiovascular disease mortality.From February 2003 until January 2004, 1115 individuals aged 45 years and older were randomly selected from a primary care practice and prospectively evaluated for: (1) MetS (The World Health Organization [WHO], National Cholesterol Education Program/Adult Treatment Panel III and International Diabetes Federation [IDF] definitions); (2) current MDE and GAD, and lifetime MDE (Mini International Neuropsychiatric Interview); and (3) conventional cardiovascular risk factors. Follow-up continued through January, 2013.During the 9.32 ± 0.47 years of follow-up, there were 248 deaths, of which 148 deaths were attributed to cardiovascular causes. In women, WHO-MetS and IDF-MetS were associated with greater all-cause (HR-values range from 1.77 to 1.91; p-values ≤ 0.012) and cardiovascular (HR-values range from 1.83 to 2.77; p-values ≤ 0.013) mortality independent of cardiovascular risk factors and MDE/GAD. Current GAD predicted greater cardiovascular mortality (HR-values range from 1.86 to 1.99; p-values ≤ 0.025) independently from MetS and cardiovascular risk factors. In men, the MetS and MDE/GAD were not associated with mortality.In middle aged women, the MetS and GAD predicted greater 10-year cardiovascular mortality independently from each other; 10-year all-cause mortality was independently predicted by the MetS. MetS and GAD should be considered important and independent mortality risk factors in women.}, URL= {https://doi.org/10.1016/j.ijcard.2015.04.122}} . International journal of cardiology.

Depression screening in patients with brain tumors: a review @article{PMID:25768331, Title= {Depression screening in patients with brain tumors: a review}, Author= {Pranckeviciene, Aiste and Bunevicius, Adomas}, DOI= {10.2217/cns.14.60}, Number= {2}, Volume= {4}, Year= {2015}, Journal= {CNS oncology}, ISSN= {2045-0907}, Pages= {71—78}, Abstract= {Brain tumor (BT) is often a devastating disease associated with poor prognosis. Depression is a common complication in BT patients that often remains under-recognized and untreated. Implementation of reliable depression screening algorithms in routine neuro-oncology setting could potentially improve recognition of depression. The Hospital Anxiety and Depression scale-Depression subscale and Patient Health Questionnaire-9 demonstrated adequate psychometric properties for depressive disorder screening in glioma patients. Patients screened positive for depression should be referred for detailed psychiatric assessment prior to initiating anti-depressive treatment. Further methodologically rigorous studies investigating psychometric properties of single-item and multiple-item depression scales are urgently warranted. Studies evaluating anti-depressive treatments' efficacy and clinical value of depression biomarkers are important avenues for future research endeavors in BT patients.}, URL= {https://europepmc.org/articles/PMC6093018}} . CNS oncology.

Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders @article{PMID:25673072, Title= {Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders}, Author= {Bunevicius, Adomas and Iervasi, Giorgio and Bunevicius, Robertas}, DOI= {10.1586/14737175.2015.1013465}, Number= {3}, Volume= {15}, Month= {March}, Year= {2015}, Journal= {Expert review of neurotherapeutics}, ISSN= {1473-7175}, Pages= {315—326}, Abstract= {Acute cerebrovascular disorders are common causes of death and disability worldwide. Prognostication of stroke victims rests mainly on admission clinical and radiological indexes of disease severity. Preclinical studies strongly suggest that thyroid hormones have a capacity to exert neuroprotective actions in the central nervous system under ischemic conditions via genomic and nongenomic actions. Low triiodothyronine (T3) syndrome affects 32-62% of patients following acute cerebrovascular events. Lower serum T3 concentrations are associated with greater stroke severity, more complicated clinical course, greater mortality rates and elevated risk for poor functional outcomes at discharge and long term. Further studies should address whether T3 can improve clinical stroke prognostication models. Studies investigating the neuroprotective role of thyroid hormone administration in acute cerebrovascular disease victims are encouraged.}, URL= {https://doi.org/10.1586/14737175.2015.1013465}} . Expert review of neurotherapeutics.

Role of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and inteleukin-6 in predicting a poor outcome after a stroke @article{PMID:25967464, Title= {Role of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and inteleukin-6 in predicting a poor outcome after a stroke}, Author= {Bunevicius, Adomas and Kazlauskas, Henrikas and Raskauskiene, Nijole and Mickuviene, Narseta and Ndreu, Rudina and Corsano, Elena and Bunevicius, Robertas}, DOI= {10.1159/000381218}, Number= {6}, Volume= {22}, Year= {2015}, Journal= {Neuroimmunomodulation}, ISSN= {1021-7401}, Pages= {365—372}, Abstract= {N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP), and interleukin-6 (IL-6) concentrations can be important biomarkers in the acute stroke setting. In acute ischemic and hemorrhagic stroke patients, we investigated the association of NT-proBNP, hsCRP, and IL-6 serum concentrations with stroke severity and functional and cognitive outcomes at discharge.Seventy-eight patients (53 men; median age 72 years) admitted with ischemic or hemorrhagic stroke within 48 h of symptom onset were evaluated for clinical stroke severity (Scandinavian stroke scale; SSS), functional status before the stroke (modified Rankin scale; mRS), and cerebrovascular disease risk factors. Cognitive (Mini Mental State Examination) and functional (mRS) outcomes were evaluated at hospital discharge. Blood samples were drawn for the assessment of NT-proBNP, hsCRP, and IL-6 concentrations within 24 h of admission.Greater NT-proBNP and hsCRP serum concentrations were associated with greater clinical stroke severity, adjusting for the patients' gender, age, stroke type, mRS score on admission, and presence of heart failure (β = -0.292, p = 0.012; β = -0.303, p = 0.009). In multivariate adjusted regression models with IL-6, hsCRP, and NT-proBNP considered together, IL-6 and hsCRP remained associated with worse functional (β = 0.210, p = 0.022) and cognitive (β = -0.269, p = 0.014) outcomes at discharge, respectively. In receiver operating characteristic analyses, the investigated blood biomarkers produced a minimal increase in predictive values for outcomes at discharge above the SSS score, age, and gender.In acute stroke patients, greater NT-proBNP and hsCRP serum concentrations are independently associated with greater clinical stroke severity. Elevated concentrations of IL-6 and hsCRP are associated with worse functional and cognitive outcomes at discharge, respectively.}, URL= {https://doi.org/10.1159/000381218}} . Neuroimmunomodulation.

A. Bunevicius, S. Tamasauskas, V. P. Deltuva, A. Tamasauskas, R. Bunevicius(2014). BI-04 * PRE-OPERATIVE LOW TRI-IODOTHYRONINE SYNDROME IS ASSOCIATED WITH GREATER 6-MONTH MORTALITY RATE OF NEUROSURGICAL BRAIN TUMOR PATIENTS . Neuro-Oncology. 16. (suppl 5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString v23--v23. Oxford University Press ({OUP})

A. Bunevicius, S. Tamasauskas, V. P. Deltuva, A. Tamasauskas, R. Bunevicius(2014). QL-06 * RELIABILITY OF THE SF-36 QUESTIONNAIRE FOR ASSESSMENT OF HEALTH RELATED QUALITY OF LIFE IN NEUROSURGICAL BRAIN TUMOR PATIENTS . Neuro-Oncology. 16. (suppl 5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString v179--v179. Oxford University Press ({OUP})

A. Bunevicius, J. Butnoriene, A. Norkus, A. Saudargiene, R. Bunevicius(2014). P.1.k.006 The association of metabolic syndrome and depression with mortality in a primary care population sample . European Neuropsychopharmacology. 24. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S344. Elsevier {BV}

A. Bunevicius, A. Tamasauskas, V.P. Deltuva, R. Bunevicius(2014). P.1.e.004 Low tri-iodothyronine concentration is associated with greater depressive and anxiety symptoms in brain tumor patients . European Neuropsychopharmacology. 24. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S192. Elsevier {BV}

Adomas Bunevicius, Robertas Bunevicius, Vilma Liaugaudaite, Jurate Peceliuniene, Nijole Raskauskiene, Narseta Mickuviene(2014). Factors affecting the presence of depression, anxiety disorders, and suicidal ideation in patients attending primary health care service in Lithuania . Scand J Prim Health Care. 32. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 24--29. Informa Healthcare

Bunevicius, A., Kazlauskas, H., Raskauskiene, N., Janusonis, V., Bunevicius, R.(2014). Ischemic stroke functional outcomes are independently associated with C-reactive protein concentrations and cognitive outcomes with triiodothyronine concentrations: A pilot study . Endocrine. 45. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 213-220.

Adomas Bunevicius, Diana S. Fleischman, Jane Leserman, Susan S. Girdler(2014). Menstrually related mood disorders and a history of abuse: Moderators of pain sensitivity . Health Psychology. 33. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 147--154. American Psychological Association ({APA})

Bunevicius, R., Liaugaudaite, V., Peceliuniene, J., Raskauskiene, N., Bunevicius, A., Mickuviene, N.(2014). Factors affecting the presence of depression, anxiety disorders, and suicidal ideation in patients attending primary health care service in Lithuania . Scandinavian Journal of Primary Health Care. 32. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 24-29.

Tamasauskas, A., Bunevicius, A., Matukevicius, A., Radziunas, A., Urbonas, M., Deltuva, V.(2014). Extended pterional approach for initial surgical management of craniopharyngiomas: A case series . Turkish Neurosurgery. 24. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 174-183.

Adomas Bunevicius and Sarunas Tamasauskas and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Robertas Bunevicius(2014). BI-04PRE-OPERATIVE LOW TRI-IODOTHYRONINE SYNDROME IS ASSOCIATED WITH GREATER 6-MONTH MORTALITY RATE OF NEUROSURGICAL BRAIN TUMOR PATIENTS . Neuro-Oncology. 16. (suppl 5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString v23--v23.

Bunevicius, A., Tamasauskas, A., Deltuva, V.P., Bunevicius, R.(2014). Regarding paper "Somatotropic and thyroid hormones in the acute phase of subarachnoid haemorrhage" .

Staniute, M., Bunevicius, A., Brozaitiene, J., Bunevicius, R.(2014). Relationship of health-related quality of life with fatigue and exercise capacity in patients with coronary artery disease . European Journal of Cardiovascular Nursing. 13. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 338-344.

Klatzkin, R.R., Bunevicius, A., Forneris, C.A., Girdler, S.(2014). Menstrual mood disorders are associated with blunted sympathetic reactivity to stress . Journal of Psychosomatic Research. 76. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 46-55.

Bunevicius, A., Tamasauskas, S., Deltuva, V., Tamasauskas, A., Radziunas, A., Bunevicius, R.(2014). Predictors of health-related quality of life in neurosurgical brain tumor patients: Focus on patient-centered perspective . Acta Neurochirurgica. 156. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 367-374.

Fleischman, D.S., Bunevicius, A., Leserman, J., Girdler, S.S.(2014). Menstrually related mood disorders and a history of abuse: Moderators of pain sensitivity . Health Psychology. 33. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 147-154.

(2014). Authors' response: Patient Health Questionnaire-2 as a screening tool for psychological distress in brain tumor patients . Psycho-oncology.

Bunevicius, A., Bunevicius, R.(2014). Authors' response: Patient Health Questionnaire-2 as a screening tool for psychological distress in brain tumor patients . Psycho-Oncology. 23. (3).

Bunevicius, A., Brozaitiene, J., Staniute, M., Gelziniene, V., Duoneliene, I., Pop, V.J.M., Bunevicius, R., Denollet, J.(2014). Decreased physical effort, fatigue, and mental distress in patients with coronary artery disease: Importance of personality-related differences . International Journal of Behavioral Medicine. 21. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 240-247.

Butnoriene, J., Bunevicius, A., Norkus, A., Bunevicius, R.(2014). Depression but not anxiety is associated with metabolic syndrome in primary care based community sample . Psychoneuroendocrinology. 40. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 269-276.

Depression but not anxiety is associated with metabolic syndrome in primary care based community sample @article{PMID:24485498, Title= {Depression but not anxiety is associated with metabolic syndrome in primary care based community sample}, Author= {Butnoriene, Jurate and Bunevicius, Adomas and Norkus, Antanas and Bunevicius, Robertas}, DOI= {10.1016/j.psyneuen.2013.11.002}, Volume= {40}, Month= {February}, Year= {2014}, Journal= {Psychoneuroendocrinology}, ISSN= {0306-4530}, Pages= {269—276}, Abstract= {INTRODUCTION: Metabolic syndrome (MetS) and depression are considered important risk factors for diabetes and cardiovascular disease. Recent evidence suggests that depression can be an important predictor of MetS. Data on the association between anxiety and MetS remain mixed. In a large primary care based community sample we investigated an association of depressive and anxiety disorders and symptoms with MetS. METHODS: A total of 1115 (51% men, mean age 62.0 ± 9.6 years) randomly selected individuals of 45 years and older were evaluated for: (i) MetS using the World Health Organization (WHO), National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) and International Diabetes Federation (IDF) criteria; (ii) current major depressive episode (MDE) and current generalized anxiety disorder (GAD), the Mini International Neuropsychiatric interview; (iii) lifetime MDE; and (iv) symptoms of depression and anxiety, the Hospital Anxiety and Depression scale (HADS). Socio-demographic characteristics (education, residence, marital status and social status) and medical histories (physical activity, smoking status, alcohol consumption and histories of myocardial infarction and stroke) were also evaluated. RESULTS: After adjusting for socio-demographic status, medical histories and current GAD, current MDE and lifetime MDE were associated with greater prevalence of MetS according to the WHO criteria (OR=1.7, 95%CI [1.1-2.7] and OR=3.7, 95%CI [2.4-5.7], respectively, p ≤ 0.001). Lifetime MDE was also associated with MetS according to the IDF and NCEP/ATP III criteria. On the other hand, current GAD was not associated with MetS in multivariate regression models when adjusted for current MDE. Similar results were obtained when evaluating an association between depression/anxiety symptoms and MetS, since elevated depressive, but not anxiety, symptoms were independently associated with MetS. CONCLUSIONS: Depressive, but not anxiety, disorders and symptoms are associated with greater prevalence rate of MetS. Assessment and management of MetS risk factors should be considered in depressed individuals.}, URL= {https://doi.org/10.1016/j.psyneuen.2013.11.002}} . Psychoneuroendocrinology.

QL-06RELIABILITY OF THE SF-36 QUESTIONNAIRE FOR ASSESSMENT OF HEALTH RELATED QUALITY OF LIFE IN NEUROSURGICAL BRAIN TUMOR PATIENTS @article{PMCID:PMC4218513, Title= {QL-06RELIABILITY OF THE SF-36 QUESTIONNAIRE FOR ASSESSMENT OF HEALTH RELATED QUALITY OF LIFE IN NEUROSURGICAL BRAIN TUMOR PATIENTS}, Author= {Bunevicius, Adomas and Tamasauskas, Sarunas and Deltuva, Vytenis Pranas and Tamasauskas, Arimantas and Bunevicius, Robertas}, Number= {Suppl 5}, Volume= {16}, Month= {November}, Year= {2014}, Journal= {Neuro-oncology}, ISSN= {1522-8517}, Pages= {v179—v179}, Abstract= {BACKGROUND: Brain tumor is often a devastating disease associated with significant impairment of health-related quality of life (HRQoL). We evaluated reliability of the SF-36 questionnaire for assessment of HRQoL in neurosurgical brain tumor patients. METHODS: Consecutive patients admitted for primary brain tumor surgery were considered for this prospective study. On admission, patients were evaluated for HRQoL (SF-36 scale), functional status (Barthel index or BI) and depressive symptom severity (Beck depression inventory-II or BDI-II). RESULTS: Two-hundred and fourteen patients (70% women and 30% men; mean age 55.8 ± 14.4 years) completed the study. The most common brain tumor diagnoses were meningioma (40%), high-grade glioma (18%) and pituitary adenoma (13%). The lowest scores were on the SF-36 General health (48.3 ± 20.0), Role limitations due to physical problems (53.2 ± 42.5) and Energy/vitality (53.7 ± 21.5) subscales. Internal consistency of individual SF-36 subscales was acceptable for all but Social functioning subscale of the SF-36 questionnaire with Cronbach's coefficients alpha ranging from 0.92 for Physical functioning subscale to 0.69 for General health subscale of the SF-36. There was a moderate-to-strong correlation of the Role limitations due to emotional problems, Energy/vitality and Emotional well-being SF-36 subscales with the BDI-II scores (Pearson's correlation coefficients r range from -0.30 to -0.66; p-values <0.001). Scores on the SF-36 Physical functioning and Role limitations due to physical problems correlated with BI scores (0.49 and 0.25, p-values <0.001). CONCLUSIONS: In neurosurgical brain tumor patients, the greatest impairment was found in General health, Role limitations due to physical problems and Energy/vitality domains of HRQoL. The SF-36 subscales had acceptable internal consistency with an exception of Social functioning subscale. The SF-36 subscales pertaining to physical health and emotional health aspects of HRQoL demonstrated adequate construct validity. The SF-36 is a reliable measure of HRQoL in neurosurgical brain tumor patients.}, URL= {https://europepmc.org/articles/PMC4218513}} . Neuro-oncology.

Factors affecting the presence of depression, anxiety disorders, and suicidal ideation in patients attending primary health care service in Lithuania @article{PMID:24533847, Title= {Factors affecting the presence of depression, anxiety disorders, and suicidal ideation in patients attending primary health care service in Lithuania}, Author= {Bunevicius, Robertas and Liaugaudaite, Vilma and Peceliuniene, Jurate and Raskauskiene, Nijole and Bunevicius, Adomas and Mickuviene, Narseta}, DOI= {10.3109/02813432.2013.873604}, Number= {1}, Volume= {32}, Month= {March}, Year= {2014}, Journal= {Scandinavian journal of primary health care}, ISSN= {0281-3432}, Pages= {24—29}, Abstract= {OBJECTIVE: The aim of this study was to establish prevalence, recognition, and risk factors for mental disorders and suicidal ideation in PC patients. DESIGN: A cross-sectional survey based on standard mental health evaluation. SETTING: Lithuanian primary care. SUBJECTS: 998 patients from four urban PC clinics. MAIN OUTCOME MEASURES: Current mental disorders and suicidal ideation assessed using the Mini International Neuropsychiatric Interview (MINI). RESULTS: According to the MINI, 27% of patients were diagnosed with at least one current mental disorder. The most common mental disorders were generalized anxiety disorder (18%) and major depressive episode (MDE) (15%), followed by social phobia (3%), panic disorder (3%), and post-traumatic stress disorder (2%). Some 6% of patients reported suicidal ideation. About 70% of patients with current mental disorder had no documented psychiatric diagnosis and about 60% received no psychiatric treatment. Greater adjusted odds for current MDE were associated with being widowed or divorced patients (odds ratio, OR = 1.8, 95% CI 1.2-2.8) and with lower education (OR = 1.6, 95% CI 1.1-2.3), while greater adjusted odds for any current anxiety disorder were found for women (OR = 1.9, 95% CI 1.3-2.8) and for patients with documented insomnia (OR = 2.2, 95% CI 1.2-4.2). Suicidal ideation was independently associated with use of antidepressants (OR = 5.4, 95% CI 1.7-16.9), with current MDE (OR = 2.9, 95% CI 1.5-5.8), and with excessive alcohol consumption (OR = 2.0, 95% CI 1.1-3.8). CONCLUSIONS: Depression, anxiety disorders, and suicidal ideation are prevalent but poorly recognized among PC patients. The presence of current MDE is independently associated with marital status and with lower education, while current anxiety disorder is associated with female gender and insomnia. Suicidal ideation is associated with current MDE, and with antidepressants and alcohol use.}, URL= {https://europepmc.org/articles/PMC4137898}} . Scandinavian journal of primary health care.

Regarding paper "Somatotropic and thyroid hormones in the acute phase of subarachnoid haemorrhage" @article{PMID:24477557, Title= {Regarding paper "Somatotropic and thyroid hormones in the acute phase of subarachnoid haemorrhage"}, Author= {Bunevicius, Adomas and Tamasauskas, Arimtantas and Deltuva, Vytenis Pranas and Bunevicius, Robertas}, DOI= {10.1007/s00701-014-2012-1}, Number= {5}, Volume= {156}, Month= {May}, Year= {2014}, Journal= {Acta neurochirurgica}, ISSN= {0001-6268}, Pages= {979—980}, URL= {https://doi.org/10.1007/s00701-014-2012-1}} . Acta neurochirurgica.

Predictors of health-related quality of life in neurosurgical brain tumor patients: focus on patient-centered perspective @article{PMID:24254135, Title= {Predictors of health-related quality of life in neurosurgical brain tumor patients: focus on patient-centered perspective}, Author= {Bunevicius, Adomas and Tamasauskas, Sarunas and Deltuva, Vytenis and Tamasauskas, Arimantas and Radziunas, Andrius and Bunevicius, Robertas}, DOI= {10.1007/s00701-013-1930-7}, Number= {2}, Volume= {156}, Month= {February}, Year= {2014}, Journal= {Acta neurochirurgica}, ISSN= {0001-6268}, Pages= {367—374}, Abstract= {BACKGROUND: In brain tumor (BT) patients, the association between health-related quality of life (HRQoL) and psychological characteristics remains largely unknown. We evaluated the association of personality traits, clinical factors, psychological distress symptoms, and cognitive state with HRQoL in BT patients. METHODS: On admission for BT surgery, 200 patients (69 % women; age 55.8 ± 14.5 years) were evaluated for HRQoL (SF-36 scale), Big-Five personality traits (Ten-Item Personality Inventory), psychological distress symptoms (Hospital Anxiety and Depression Scale or HADS), cognitive function (Mini-Mental State Examination or MMSE) and clinical characteristics, including functional status (Barthel index or BI). The most common BT diagnoses were meningioma (39 %) and high-grade glioma (18 %). RESULTS: Only factors significantly associated with SF-36 domains in univariable regression analyses were included in their respective multivariable models and predicted from 6 %-49 % of the total variance of SF-36 scores. Greater TIPI emotional stability score was independently associated with greater SF-36 emotional well-being (β = 0.23, p < 0.001) and general health (β = 0.18, p = 0.01) scores, and greater TIPI consciousness score, with greater SF-36 emotional well-being score (β = 0.13, p = 0.02). HADS-anxiety and HADS-depression scores were the strongest independent determinants of all, except physical functioning, SF-36 scores (β-values range from 0.14 to 0.56; p values ≤ 0.03). BI score was the strongest independent determinant of SF-36 physical functioning score (β = 0.36, p < 0.001). MMSE score was associated with all but emotional well-being and social functioning SF-36 scores. CONCLUSIONS: Consciousness and emotional stability should be considered important personality-related determinants of HRQoL in BT patients. Psychological distress, functional disability, and cognitive impairment are also important predictors of HRQoL.}, URL= {https://doi.org/10.1007/s00701-013-1930-7}} . Acta neurochirurgica.

Relationship of health-related quality of life with fatigue and exercise capacity in patients with coronary artery disease @article{PMID:23818215, Title= {Relationship of health-related quality of life with fatigue and exercise capacity in patients with coronary artery disease}, Author= {Staniute, Margarita and Bunevicius, Adomas and Brozaitiene, Julija and Bunevicius, Robertas}, DOI= {10.1177/1474515113496942}, Number= {4}, Volume= {13}, Month= {August}, Year= {2014}, Journal= {European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology}, ISSN= {1474-5151}, Pages= {338—344}, Abstract= {The study objective was to evaluate the relationship of health-related quality of life (HRQoL) with fatigue and exercise capacity in coronary artery disease (CAD) patients.A total of 1072 consecutive CAD patients on admission to a cardiac rehabilitation program were evaluated for HRQoL (36-item Short Form Medical Outcome Questionnaire; SF-36), body mass index, clinical characteristics (New York Heart Association (NYHA) class, angina pectoris class, coronary interventions, treatment with beta blockers, hypertension and diabetes), symptoms of depression and anxiety (Hospital Anxiety and Depression Scale), fatigue (Multidimensional Fatigue Inventory-20; MFI-20), and exercise capacity (bicycle ergometer test).In univariate regression analyses lower scores on all SF-36 domains were associated with greater scores on all MFI-20 subscales. Exercise capacity was associated with all SF-36 domains, except for social functioning and mental health domains. In multivariate regression analyses, after adjusting for age, gender, body mass index, NYHA class, angina pectoris class, hypertension, diabetes, coronary interventions, treatment with betablockers, and symptoms of depression and anxiety, greater limitation due to physical and due to emotional problems, poor social functioning, decreased energy/vitality, worse general health perception, reduced mental component summary and lower global SF-36 score were independently associated with higher MFI-20 general fatigue score. Reduced physical functioning, greater pain, and reduced physical component summary SF-36 scores were associated with greater MFI-20 physical fatigue score. Lower SF-36 mental health score was associated, with greater MFI-20 mental fatigue score.In CAD patients undergoing rehabilitation, poor HRQoL is associated with greater fatigue and decreased exercise capacity independently from mental distress and CAD severity score.}, URL= {https://doi.org/10.1177/1474515113496942}} . European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology.

Ischemic stroke functional outcomes are independently associated with C-reactive protein concentrations and cognitive outcomes with triiodothyronine concentrations: a pilot study @article{PMID:23605905, Title= {Ischemic stroke functional outcomes are independently associated with C-reactive protein concentrations and cognitive outcomes with triiodothyronine concentrations: a pilot study}, Author= {Bunevicius, Adomas and Kazlauskas, Henrikas and Raskauskiene, Nijole and Janusonis, Vinsas and Bunevicius, Robertas}, DOI= {10.1007/s12020-013-9958-2}, Number= {2}, Volume= {45}, Month= {March}, Year= {2014}, Journal= {Endocrine}, ISSN= {1355-008X}, Pages= {213—220}, Abstract= {Elevated concentrations of C-reactive protein (CRP) and decreased concentrations of triiodothyronine (T3) were shown to predict poor outcomes in patients with stroke. However, the prognostic value of CRP and T3 has not been studied simultaneously in relation to stroke functional and cognitive outcomes despite of close interaction between inflammatory markers and thyroid function. We evaluated the association of thyroid hormone and CRP concentrations with immediate outcomes after ischemic stroke. Eighty-eight ischemic stroke patients on admission to the stroke unit were evaluated for clinical stroke severity (Scandinavian stroke scale or SSS) and concentrations of thyroid-stimulating hormone, free thyroxin, free T3, and CRP. Functional outcome (modified Rankin scale) and cognitive outcome (Mini mental state examination) were evaluated at discharge. Greater ln CRP concentrations (r = -0.35, p = 0.001), but not thyroid hormone concentrations, correlated with score on the SSS. In univariate analyses lower free T3 concentrations and higher CRP concentrations were associated with poor functional and poor cognitive outcomes. After adjustment for clinical stroke severity, higher CRP concentrations (β = 0.18, p = 0.04) remained associated with worse functional outcome and lower free T3 concentrations with worse cognitive outcome (β = 0.23, p = 0.03). In sum, clinical stroke severity is associated with elevated CRP concentration. Higher CRP concentration is independently associated with worse functional outcomes and lower free T3 concentration with worse cognitive outcomes at discharge. T3 and CRP can be important biomarkers in patients with acute ischemic stroke.}, URL= {https://doi.org/10.1007/s12020-013-9958-2}} . Endocrine.

BI-04PRE-OPERATIVE LOW TRI-IODOTHYRONINE SYNDROME IS ASSOCIATED WITH GREATER 6-MONTH MORTALITY RATE OF NEUROSURGICAL BRAIN TUMOR PATIENTS @article{PMCID:PMC4217903, Title= {BI-04PRE-OPERATIVE LOW TRI-IODOTHYRONINE SYNDROME IS ASSOCIATED WITH GREATER 6-MONTH MORTALITY RATE OF NEUROSURGICAL BRAIN TUMOR PATIENTS}, Author= {Bunevicius, Adomas and Tamasauskas, Sarunas and Deltuva, Vytenis Pranas and Tamasauskas, Arimantas and Bunevicius, Robertas}, Number= {Suppl 5}, Volume= {16}, Month= {November}, Year= {2014}, Journal= {Neuro-oncology}, ISSN= {1522-8517}, Pages= {v23—v23}, Abstract= {BACKGROUND: We have previously demonstrated that pre-operative low tri-iodothyronine (T3) syndrome is a significant predictor of poor discharge outcomes in patients admitted for scheduled brain tumor surgery. In the present study we investigated an association of pre-operative low T3 syndrome with 6-month survival rate in neurosurgical brain tumor patients. METHODS: Two-hundred and forty-nine consecutive patients (166 women; age 55.6 ± 15.2 years) admitted for scheduled brain tumor surgery at the Department of Neurosurgery of the Lithuanian University of Health Sciences agreed to participate in the study. On admission, blood samples were drawn for evaluation of thyroid hormone concentrations. Low T3 syndrome was defined as free T3 concentrations of 1.1 pg/ml or lower. Final histological diagnoses of brain tumor were evaluated according to the pathology reports. Survival data were obtained from the national death registry. RESULTS: Ninety-three (37%) patients were diagnosed with meningioma, 48 (19%) – glioblastoma, 36 (15%) – pituitary adenoma, 19 (8%) – low grade glioma, 14 (6%) acoustic nerve neurinoma, and 10 (4%) – metastatic brain tumor. There were 28 (12%) deaths within a 6-month period following brain tumor surgery. Six-month mortality rate was the greatest in metastatic brain tumor patients (n = 6; 60%), followed by glioblastoma (n = 12; 25%) and meningioma (n = 7; 7.5%) patients. Pre-operative low T3 syndrome was associated with greater 6-month mortality rate (HR = 3.46, 95%CI 1.51 to 7.87, p = 0.003) in a total sample of patients. In subgroup analyses we have found that pre-operative low T3 syndrome was associated with greater 6-month mortality rate in glioblastoma patients (HR = 3.57 95%CI 1.07 to 11.90), p = 0.039) and in meningioma patients (HR = 5.59 95%CI 1.25 to 25.0, p = 0.025). CONCLUSIONS: Our findings suggest that pre-operative low T3 syndrome is associated with greater 6-month mortality rate of neurosurgical brain tumor patients. Low T3 syndrome can be an important prognostic biomarker of patients with brain tumors.}, URL= {https://europepmc.org/articles/PMC4217903}} . Neuro-oncology.

Decreased physical effort, fatigue, and mental distress in patients with coronary artery disease: importance of personality-related differences @article{PMID:23456184, Title= {Decreased physical effort, fatigue, and mental distress in patients with coronary artery disease: importance of personality-related differences}, Author= {Bunevicius, Adomas and Brozaitiene, Julija and Staniute, Margarita and Gelziniene, Vaidute and Duoneliene, Inga and Pop, Victor J M and Bunevicius, Robertas and Denollet, Johan}, DOI= {10.1007/s12529-013-9299-9}, Number= {2}, Volume= {21}, Month= {April}, Year= {2014}, Journal= {International journal of behavioral medicine}, ISSN= {1070-5503}, Pages= {240—247}, Abstract= {Identification of cardio-toxic psychological symptoms in coronary artery disease (CAD) patients is important.We examined the association of negative affectivity (NA), social inhibition (SI), and their combination in the distressed (Type D) personality with functional status, fatigue, and mental distress in CAD patients.Following acute coronary syndrome, 690 consecutive CAD patients agreed to participate in this cross-sectional study and were evaluated for clinical characteristics, including left ventricular ejection fraction (LVEF), and for NA, SI, and Type D personality (i.e., NA and SI; DS14 scale) when they entered a cardiac rehabilitation program in Lithuania. Patient-centered outcomes included functional status (bicycle ergometer), symptoms of fatigue (Multidimensional Fatigue Inventory-20), and mental distress (Beck Depression Inventory-II and Hospital Anxiety and Depression Scale).The reference subgroup (neither NA nor SI) included 34 % of patients; 13 % had NA only, 19 % had SI only, and 34 % had Type D profile. Type D patients had worse functional status, and Type D patients and NA-only patients had higher symptom levels of fatigue and mental distress. In multivariate regression models that included LVEF, clinical characteristics, and depressive symptoms, Type D personality was an independent predictor of decreased exercise capacity (OR = 1.77, 95 % CI 1.06-2.95, p = .03) and decreased motivation for activity (OR = 3.14, 95 % CI 1.73-5.73, p < .001). Type D, NA, and SI were also independent predictors of mental distress.Type D personality traits independently predicted poor functional status and worse patient-centered outcomes independently from LVEF and depression. Further studies exploring personality-related differences in cardiovascular outcomes are needed.}, URL= {https://doi.org/10.1007/s12529-013-9299-9}} . International journal of behavioral medicine.

Extended pterional approach for initial surgical management of craniopharyngiomas: a case series @article{PMID:24831357, Title= {Extended pterional approach for initial surgical management of craniopharyngiomas: a case series}, Author= {Tamasauskas, Arimantas and Bunevicius, Adomas and Matukevicius, Algimantas and Radziunas, Andrius and Urbonas, Mindaugas and Deltuva, Vytenis}, DOI= {10.5137/1019-5149.jtn.6995-12.2}, Number= {2}, Volume= {24}, Year= {2014}, Journal= {Turkish neurosurgery}, ISSN= {1019-5149}, Pages= {174—183}, Abstract= {AIM: Treatment of craniopharyngiomas remains challenging. The aim of this study was to evaluate results of initial surgical management of craniopharyngiomas via the extended pterional approach. MATERIAL AND METHODS: Nineteen patients (10 female; median age of 23 years; ranging from 10 months to 67 years) undergone initial surgery for craniopharyngiomas through the extended pterional approach. Data were retrospectively collected by reviewing medical records, operative reports and imaging results. RESULTS: The median size of craniopharyngiomas was 3.2 cm (range 1.3 - 4.8). Visual deterioration (n=12) and headache (n=10) were the most common symptoms on admission. After surgery, one patient died due to medical complications, 12 patients developed diabetes insipidus and eight patients developed anterior pituitary dysfunction. Median follow-up period was 9 years (range 2 - 13). Patients with progression of craniopharyngioma (n=5) when compared to patients without progression of craniopharyngioma (n=14) were significantly younger at the time of surgery, had less visual deterioration before surgery and had higher rates of not changed vision after surgery. Children had larger craniopharyngiomas when compared to adults. CONCLUSION: Initial surgery for craniopharyngioma via the extended pterional approach is a safe and effective treatment option with low postoperative mortality, and acceptable postoperative morbidity and recurrence rate.}, URL= {https://doi.org/10.5137/1019-5149.JTN.6995-12.2}} . Turkish neurosurgery.

Menstrual mood disorders are associated with blunted sympathetic reactivity to stress @article{PMID:24360141, Title= {Menstrual mood disorders are associated with blunted sympathetic reactivity to stress}, Author= {Klatzkin, Rebecca R and Bunevicius, Adomas and Forneris, Catherine A and Girdler, Susan}, DOI= {10.1016/j.jpsychores.2013.11.002}, Number= {1}, Volume= {76}, Month= {January}, Year= {2014}, Journal= {Journal of psychosomatic research}, ISSN= {0022-3999}, Pages= {46—55}, Abstract= {Few studies have directly compared women with a menstrually related mood disorder (MRMD) with women who have suffered from depression for stress reactivity phenotypes. It is unclear whether blunted responses to stress in women with a MRMD reflect a unique phenotype of MRMDs or may be explained by a history of depression.We assessed cardiovascular reactivity to stress in four groups: 1) Women with a MRMD without a history of depression (n=37); 2) women with a MRMD plus a history of depression (n=26); 3) women without a MRMD and without a history of depression (n=43); and 4) women without a MRMD but with a history of depression (n=20).Women with a MRMD showed blunted myocardial (heart rate and cardiac index) reactivity to mental stress compared to non-MRMD women, irrespective of histories of depression. Hypo-reactivity to stress predicted greater premenstrual symptom severity in the entire sample. Women with a MRMD showed blunted norepinephrine and diastolic blood pressure stress reactivity relative to women with no MRMD, but only when no history of depression was present. Both MRMD women and women with depression histories reported greater negative subjective responses to stress relative to their non-MRMD and never depressed counterparts.Our findings support the assertion that a blunted stress reactivity profile represents a unique phenotype of MRMDs and also underscore the importance of psychiatric histories to stress reactivity. Furthermore, our results emphasize the clinical relevance of myocardial hypo-reactivity to stress, since it predicts heightened premenstrual symptom severity.}, URL= {https://europepmc.org/articles/PMC3951307}} . Journal of psychosomatic research.

A. Bunevicius, S. Tamasauskas, A. Tamasauskas, V. Deltuva, R. Bunevicius(2013). P.2.h.006 Emotional stability and openness are associated with severity of depressive and anxiety symptoms in patients with brain tumors . European Neuropsychopharmacology. 23. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S418--S419. Elsevier {BV}

H. Yuan, J. E. Frank, Y. Hong, H. An, C. Eldeniz, J. Nie, A. Bunevicius, D. Shen, W. Lin(2013). Spatiotemporal Uptake Characteristics of [18]F-2-Fluoro-2-Deoxy-D-Glucose in a Rat Middle Cerebral Artery Occlusion Model . Stroke. 44. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2292--2299. Ovid Technologies (Wolters Kluwer Health)

Adomas Bunevicius, Vytenis Deltuva, Sarunas Tamasauskas, Arimantas Tamasauskas, Edward R. Laws, Robertas Bunevicius(2013). Low triiodothyronine syndrome as a predictor of poor outcomes in patients undergoing brain tumor surgery: a pilot study . Journal of Neurosurgery. 118. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1279--1287. Journal of Neurosurgery Publishing Group ({JNSPG})

(2013). Screening for anxiety disorders in patients with coronary artery disease . Health and quality of life outcomes.

Yuan, H., Frank, J.E., Hong, Y., An, H., Eldeniz, C., Nie, J., Bunevicius, A., Shen, D., Lin, W.(2013). Spatiotemporal uptake characteristics of [<sup>18</sup>]F-2-fluoro-2-deoxy- d-glucose in a rat middle cerebral artery occlusion model . Stroke. 44. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2292-2299.

Bunevicius, A., Yuan, H., Lin, W.(2013). The potential roles of <sup>18</sup>F-FDG-PET in management of acute stroke patients . BioMed Research International. 2013.

The association of migraine with menstrually related mood disorders and childhood sexual abuse @article{PMID:23930948, Title= {The association of migraine with menstrually related mood disorders and childhood sexual abuse}, Author= {Bunevicius, Adomas and Rubinow, David R and Calhoun, Anne and Leserman, Jane and Richardson, Erin and Rozanski, Kim and Girdler, Susan S}, DOI= {10.1089/jwh.2013.4279}, Number= {10}, Volume= {22}, Month= {October}, Year= {2013}, Journal= {Journal of women's health (2002)}, ISSN= {1540-9996}, Pages= {871—876}, Abstract= {Both female reproductive hormones and childhood sexual abuse (CSA) are implicated in migraine and in menstrually related mood disorders (MRMD). We examined the association of migraine, including migraine with aura (MA), and history of MRMD or CSA.A total of 174 women (mean age 33.9 ± 7.6 years) in this cross-sectional study were evaluated for (1) current MRMD using prospective daily ratings; (2) history of CSA using structured interview; and (3) MA and migraine without aura using the International Classification of Headaches Disorders II criteria.Ninety-six women met MRMD criteria (21 of whom had history of CSA) and 78 women were non-MRMD controls (16 with CSA histories). Migraine with aura was more prevalent in women with MRMD when compared to non-MRMD controls (11/88 and 0/86, respectively, p=0.001). In MRMD women only, a CSA history was associated with higher MA rates (6/21 and 5/67, respectively, p=0.019). A combination of current MRMD diagnosis and a history CSA was associated with increased risk for MA, even after adjusting for potential confounders (odds ratio=12.08, 95% confidence interval 2.98-48.90, p<0.001).Women with MRMD may be vulnerable to the development of MA, and a history of CSA in women with a MRMD appears to increase that vulnerability. MRMDs and MA should be included among other poor mental and physical health outcomes of an abuse history. Routine screening for abuse histories would potentially improve identification of women with increased risk of experiencing abuse-related disorders.}, URL= {https://europepmc.org/articles/PMC3787370}} . Journal of women's health (2002).

Adomas Bunevicius and Sarunas Tamasauskas and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Robertas Bunevicius(2013). Psychological distress symptoms' clusters in brain tumor patients: factor analysis of depression and anxiety scales . Psycho-oncology. 22. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2860--2863.

Bunevicius, A., Staniute, M., Brozaitiene, J., Stropute, D., Bunevicius, R., Denollet, J.(2013). Type D (distressed) personality and its assessment with the DS14 in Lithuanian patients with coronary artery disease . Journal of Health Psychology. 18. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1242-1251.

Low triiodothyronine syndrome as a predictor of poor outcomes in patients undergoing brain tumor surgery: a pilot study: clinical article @article{PMID:23480214, Title= {Low triiodothyronine syndrome as a predictor of poor outcomes in patients undergoing brain tumor surgery: a pilot study: clinical article}, Author= {Bunevicius, Adomas and Deltuva, Vytenis and Tamasauskas, Sarunas and Tamasauskas, Arimantas and Laws, Edward R and Bunevicius, Robertas}, DOI= {10.3171/2013.1.jns121696}, Number= {6}, Volume= {118}, Month= {June}, Year= {2013}, Journal= {Journal of neurosurgery}, ISSN= {0022-3085}, Pages= {1279—1287}, Abstract= {OBJECT: A low triiodothyronine (T3) state is highly prevalent and is associated with a poor prognosis in critically ill patients. The authors investigated, in patients undergoing brain tumor surgery, the direct association of a perioperative low T3 syndrome with clinical outcomes and also with symptoms of depression and anxiety. METHODS: Ninety consecutive patients (71% women, median age 55 years), on admission for brain tumor surgery, were evaluated for sociodemographic and clinical characteristics. Their thyroid function profile was assessed on the morning of brain tumor surgery and on the morning after brain tumor surgery. Patients with free T3 concentrations of 3.1 pmol/L or less were considered to have low T3 syndrome. The patients were evaluated for symptoms of depression and anxiety using the Hospital Anxiety and Depression Scale (HADS) before and after surgery and for clinical outcomes using the Glasgow Outcome Scale (GOS) at discharge. RESULTS: After brain tumor surgery, free T3 concentrations decreased (p < 0.001) and the proportion of patients with low T3 levels increased from 38% to 54% (p = 0.02). Lower preoperative (rho = 0.30, p = 0.004) and postoperative (rho = 0.33, p = 0.002) free T3 concentrations correlated with low GOS scores at discharge. Preoperative low T3 syndrome (OR 5.49, 95% CI 1.27-23.69, p = 0.02) and postoperative low T3 syndrome (OR 8.73, 95% CI 1.49-51.21, p = 0.02) both increased risk for unfavorable clinical outcomes (GOS scores < 5) at discharge, after adjusting for age, sex, histological diagnosis of brain tumor, preoperative functional impairment, previous treatment for brain tumor, and depressive symptoms. Preoperative low T3 syndrome increased the risk for preoperative (HADS-depression subscale score ≥ 11; OR 4.12, 95% CI 1.16-14.58, p = 0.03) but not postoperative depressive symptoms independently from sociodemographic and clinical factors. CONCLUSIONS: Low T3 syndrome is a strong independent predictor of unfavorable clinical outcomes and depressive symptoms, and its diagnosis and preoperative management should be considered in patients undergoing neurosurgery for the treatment of brain tumors.}, URL= {https://doi.org/10.3171/2013.1.JNS121696}} . Journal of neurosurgery.

Psychological distress symptoms' clusters in brain tumor patients: factor analysis of depression and anxiety scales @article{PMID:23913701, Title= {Psychological distress symptoms' clusters in brain tumor patients: factor analysis of depression and anxiety scales}, Author= {Bunevicius, Adomas and Tamasauskas, Sarunas and Deltuva, Vytenis and Tamasauskas, Arimantas and Bunevicius, Robertas}, DOI= {10.1002/pon.3354}, Number= {12}, Volume= {22}, Month= {December}, Year= {2013}, Journal= {Psycho-oncology}, ISSN= {1057-9249}, Pages= {2860—2863}, URL= {https://doi.org/10.1002/pon.3354}} . Psycho-oncology.

Beta-adrenergic receptor mechanisms and pain sensitivity in women with menstrually related mood disorders @article{PMID:23958279, Title= {Beta-adrenergic receptor mechanisms and pain sensitivity in women with menstrually related mood disorders}, Author= {Bunevicius, Adomas and Hinderliter, Alan and Klatzkin, Rebecca and Patel, Ankit and Arizmendi, Cara and Girdler, Susan S}, DOI= {10.1016/j.jpain.2013.05.014}, Number= {11}, Volume= {14}, Month= {November}, Year= {2013}, Journal= {The journal of pain : official journal of the American Pain Society}, ISSN= {1526-5900}, Pages= {1349—1360}, Abstract= {Somatic symptoms experienced by women with a menstrually related mood disorder (MRMD) during their premenstrual luteal phase contribute to functional impairment. Yet, investigations on pathophysiological mechanisms contributing to heightened pain sensitivity in MRMD are sparse. During the luteal phase, 61 women with an MRMD and 61 non-MRMD controls were evaluated for β-adrenergic receptor (β-AR) responsivity using the isoproterenol sensitivity test. A subset (43 MRMD and 50 non-MRMD) then entered a double-blind, placebo-controlled, crossover protocol to examine the effect of β-AR blockade with intravenous propranolol on sensitivity to experimental (cold pressor and ischemic) and clinical (McGill Pain Questionnaire score) pain. Women with an MRMD exhibited greater β1- and β2-AR responsivity, ischemic pain intensity, and affective clinical pain ratings than controls. Propranolol increased cold pressor pain tolerance in both groups, but it decreased cold pain intensity and ischemic pain unpleasantness ratings only in non-MRMD women. In contrast, propranolol decreased affective ratings of clinical pain in women with MRMD. Exploratory analyses indicated that only in MRMD women did greater β-AR responsivity predict greater sensitivity to cold pressor and ischemic pain. This study provides the first evidence for a role of β-AR mechanisms in the hyperalgesia and clinical pain experienced by women with MRMDs.This article describes the effects of β-adrenergic receptor stimulation and blockade on experimental and clinical pain sensitivity in women with an MRMD. The results of this study may have implications for the management of the substantial somatic premenstrual symptomatology experienced by women with an MRMD.}, URL= {https://doi.org/10.1016/j.jpain.2013.05.014}} . The journal of pain : official journal of the American Pain Society.

Type D (distressed) personality and its assessment with the DS14 in Lithuanian patients with coronary artery disease @article{PMID:23129829, Title= {Type D (distressed) personality and its assessment with the DS14 in Lithuanian patients with coronary artery disease}, Author= {Bunevicius, Adomas and Staniute, Margarita and Brozaitiene, Julija and Stropute, Dalia and Bunevicius, Robertas and Denollet, Johan}, DOI= {10.1177/1359105312459098}, Number= {9}, Volume= {18}, Month= {September}, Year= {2013}, Journal= {Journal of health psychology}, ISSN= {1359-1053}, Pages= {1242—1251}, Abstract= {We examined Type D personality (combination of negative affectivity with social inhibition) and its assessment with the DS14 in 543 Lithuanian coronary patients. Psychometric analyses confirmed the two-factor structure, internal consistency (α = 0.84/α = 0.75), and test-retest reliability (r = 0.69/0.81) of the DS14 negative affectivity and inhibition components. Negative affectivity correlated (r = -0.58) with emotional stability and social inhibition (r = -0.46) with extraversion; correlations with other Big-Five traits ranged between r = -0.11 and -0.19. Type D patients (34%) had a ninefold increased odds of depression (95% confidence interval = 5.01-17.36) and a fivefold increased odds of anxiety (95% confidence interval = 3.47-7.97). These findings support the validity of the Type D construct in Lithuania.}, URL= {https://doi.org/10.1177/1359105312459098}} . Journal of health psychology.

Spatiotemporal uptake characteristics of [18]F-2-fluoro-2-deoxy-D-glucose in a rat middle cerebral artery occlusion model @article{PMID:23743978, Title= {Spatiotemporal uptake characteristics of [18]F-2-fluoro-2-deoxy-D-glucose in a rat middle cerebral artery occlusion model}, Author= {Yuan, Hong and Frank, Jonathan E and Hong, Yonglong and An, Hongyu and Eldeniz, Cihat and Nie, Jingxin and Bunevicius, Adomas and Shen, Dinggang and Lin, Weili}, DOI= {10.1161/strokeaha.113.000903}, Number= {8}, Volume= {44}, Month= {August}, Year= {2013}, Journal= {Stroke}, ISSN= {0039-2499}, Pages= {2292—2299}, Abstract= {Alterations of cerebral glucose metabolism are well anticipated during cerebral ischemia. However, detailed spatiotemporal characteristics of disturbed cerebral glucose metabolism during acute ischemia remain largely elusive. This study aims to delineate spatiotemporal distributions of [18]F-2-fluoro-2-deoxy-D-glucose (FDG) uptake using positron emission tomography imaging, particularly at the peri-ischemic zone, and its correlation with tissue outcome.The intraluminal suture middle cerebral artery occlusion model was used to induce focal cerebral ischemia in rats (n=48). All animals underwent sequential MRI and FDG positron emission tomography imaging at different times (30-150 minutes) after middle cerebral artery occlusion. MR and positron emission tomography images were coregistered. FDG uptake in the peri-ischemic zone was assessed in relation to middle cerebral artery occlusion duration, cerebral blood flow, apparent diffusion coefficient, and 24-hour T2 lesions.Elevated FDG uptake was consistently observed at the peri-ischemic zone surrounding the presumed ischemic core with low FDG uptake. Both the spatial volume and the uptake level of the hyper-uptake region were inversely correlated with the duration of middle cerebral artery occlusion. The hyper-uptake regions exhibited a mild reduction of cerebral blood flow (28.2±3.2%) and apparent diffusion coefficient (9.1±1.4%) when compared with that in the contralateral hemisphere. Colocalization analysis revealed that, with reperfusion, an average of 12.1±1.7% of the hyper-uptake volume was recruited into final infarction.Elevated FDG uptake at the peri-ischemic zone is consistently observed during acute cerebral ischemia. The region with elevated FDG uptake likely reflects viable tissues that can be salvaged with reperfusion. Therefore, acute FDG positron emission tomography imaging might hold promise in the management of patients with acute stroke.}, URL= {https://europepmc.org/articles/PMC3885255}} . Stroke.

Bunevicius, A., Deltuva, V., Tamasauskas, S., Tamasauskas, A., Bunevicius, R.(2013). Screening for psychological distress in neurosurgical brain tumor patients using the Patient Health Questionnaire-2 . Psycho-Oncology. 22. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1895-1900.

Hong Yuan and Jonathan E. Frank and Yonglong Hong and Hongyu An and Cihat Eldeniz and Jingxin Nie and Adomas Bunevicius and Dinggang Shen and Weili Lin(2013). Spatiotemporal Uptake Characteristics of [18]F-2-Fluoro-2-Deoxy-d-Glucose in a Rat Middle Cerebral Artery Occlusion Model . Stroke. 44. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2292--2299.

Bunevicius, A., Deltuva, V., Tamasauskas, S., Tamasauskas, A., Laws Jr., E.R., Bunevicius, R.(2013). Low triiodothyronine syndrome as a predictor of poor outcomes in patients undergoing brain tumor surgery: A pilot study . Journal of Neurosurgery. 118. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1279-1287.

Adomas Bunevicius and Vytenis Pranas Deltuva and Sarunas Tamasauskas and Arimantas Tamasauskas and Edward R. Laws and Robertas Bunevicius(2013). Low triiodothyronine syndrome as a predictor of poor outcomes in patients undergoing brain tumor surgery: a pilot study: clinical article . Journal of neurosurgery. 118. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1279--1287.

Bunevicius, A., Tamasauskas, S., Deltuva, V., Tamasauskas, A., Bunevicius, R.(2013). Psychological distress symptoms' clusters in brain tumor patients: Factor analysis of depression and anxiety scales . Psycho-Oncology. 22. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2860-2863.

Adomas Bunevicius AND Hong Yuan AND Weili Lin(2013). The Potential Roles of 18F-FDG-PET in Management of Acute Stroke Patients . {Hindawi Limited}

Diana S. Fleischman and Adomas Bunevicius and Jane Leserman and Susan S. Girdler(2013). Menstrually related mood disorders and a history of abuse:moderators of pain sensitivity . Health psychology : official journal of the Division of Health Psychology, American Psychological Association. 33. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 147--154.

Adomas Bunevicius and Sarunas Tamasauskas and Vytenis Pranas Deltuva and Arimantas Tamasauskas and Andrius Radziunas and Robertas Bunevicius(2013). Predictors of health-related quality of life in neurosurgical brain tumor patients: focus on patient-centered perspective . Acta neurochirurgica. 156. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 367--374.

Rebecca R. Klatzkin and Adomas Bunevicius and Catherine A Forneris and Susan S. Girdler(2013). Menstrual mood disorders are associated with blunted sympathetic reactivity to stress . Journal of psychosomatic research. 76. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 46--55.

Jurate Butnoriene and Adomas Bunevicius and Antanas Norkus and Robertas Bunevicius(2013). Depression but not anxiety is associated with metabolic syndrome in primary care based community sample . Psychoneuroendocrinology. 40. (40). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 269--276.

Adomas Bunevicius and Henrikas Kazlauskas and Nijole Raskauskiene and Vinsas Janusonis and Robertas Bunevicius(2013). Ischemic stroke functional outcomes are independently associated with C-reactive protein concentrations and cognitive outcomes with triiodothyronine concentrations: a pilot study . Endocrine. 45. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 213--220.

(2013). The potential roles of 18F-FDG-PET in management of acute stroke patients . BioMed research international.

Bunevicius, A., Rubinow, D.R., Calhoun, A., Leserman, J., Richardson, E., Rozanski, K., Girdler, S.S.(2013). The association of migraine with menstrually related mood disorders and childhood sexual abuse . Journal of Women's Health. 22. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 871-876.

Bunevicius, A., Hinderliter, A., Klatzkin, R., Patel, A., Arizmendi, C., Girdler, S.S.(2013). Beta-adrenergic receptor mechanisms and pain sensitivity in women with menstrually related mood disorders . Journal of Pain. 14. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1349-1360.

Adomas Bunevicius and Alan L. Hinderliter and Rebecca R. Klatzkin and Ankit Patel and Cara Arizmendi and Susan S. Girdler(2013). Beta-Adrenergic Receptor Mechanisms and Pain Sensitivity in Women With Menstrually Related Mood Disorders . The journal of pain : official journal of the American Pain Society. 14. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1349--1360.

Adomas Bunevicius and Šarūnas Tamašauskas and Arimantas Tamasauskas and Vytenis Pranas Deltuva(2013). Evaluation of health-related quality of life in Lithuanian brain tumor patients using the EORTC brain cancer module . Medicina (Kaunas, Lithuania). 48. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 588--594.

Adomas Bunevicius and David R. Rubinow and Anne H. Calhoun and Jane Leserman and Erin Richardson and Kim Rozanski and Susan S. Girdler(2013). The Association of Migraine with Menstrually Related Mood Disorders and Childhood Sexual Abuse . Journal of women's health (2002). 22. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 871--876.

Adomas Bunevicius and Julija Brozaitiene and Margarita Staniute and Vaidute Gelziniene and Inga Duoneliene and Victor J. M. Pop and Robertas Bunevicius and Johan Denollet(2013). Decreased physical effort, fatigue, and mental distress in patients with coronary artery disease: importance of personality-related differences . International journal of behavioral medicine. 21. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 240--247.

A. Bunevicius, M. Staniute, J. Brozaitiene, R. Bunevicius(2012). P.4.e.001 Screening for anxiety disorders in patients with coronary artery disease using self-rating scales . European Neuropsychopharmacology. 22. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S372--S373. Elsevier {BV}

A. Bunevicius, S. Tamasauskas, R. Bunevicius, A. Tamasauskas, V. Deltuva(2012). P.2.g.010 Evaluation of mental distress in brain tumor patients using self-rating scales . European Neuropsychopharmacology. 22. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S301. Elsevier {BV}

A. Bunevicius, M. Staniute, J. Brozaitiene, R. Bunevicius(2012). P.2.g.001 Evaluation of the severity of depressive symptoms in coronary artery disease patients with and without current clinical depression . European Neuropsychopharmacology. 22. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S296. Elsevier {BV}

Bunevičius A, Tamašauskas Š, Tamašauskas A, Deltuva V, Medicina (Kaunas, Lithuania), 2012, vol. 48, no. 11, pp. 588-594 .

Bunevicius, A., Staniute, M., Brozaitiene, J., Pommer, A.M., Pop, V.J.M., Montgomery, S.A., Bunevicius, R.(2012). Evaluation of depressive symptoms in patients with coronary artery disease using the Montgomery Åsberg Depression Rating Scale . International Clinical Psychopharmacology. 27. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 249-255.

Bunevičius, A., Tamašauskas, S., Tamašauskas, A., Deltuva, V.(2012). Evaluation of health-related quality of life in lithuanian brain tumor patients using the EORTC brain cancer module . Medicina (Lithuania). 48. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 588-594.

Adomas Bunevicius and Margarita Staniute and Julija Brozaitiene and Robertas Bunevicius(2012). P.2.g.001 Evaluation of the severity of depressive symptoms in coronary artery disease patients with and without current clinical depression . European Neuropsychopharmacology. 22. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S296--.

Deltuva, V., Bunevicius, A., Jurkiene, N., Kulakiene, I., Tamasauskas, A.(2012). Perioperative single photon emission computed tomography in predicting survival of malignant glioma patients . Oncology Letters. 4. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 739-744.

Bunevicius, A., Gintauskiene, V., Podlipskyte, A., Zaliunas, R., Brozaitiene, J., Prange, A.J., Bunevicius, R.(2012). Fatigue in patients with coronary artery disease: Association with thyroid axis hormones and cortisol . Psychosomatic Medicine. 74. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 848-853.

Bunevicius, A., Staniute, M., Brozaitiene, J., Bunevicius, R.(2012). Diagnostic accuracy of self-rating scales for screening of depression in coronary artery disease patients . Journal of Psychosomatic Research. 72. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 22-25.

Bunevicius, A., Leserman, J., Girdler, S.S.(2012). Hypothalamic-pituitary-thyroid axis function in women with a menstrually related mood disorder: Association with histories of sexual abuse . Psychosomatic Medicine. 74. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 810-816.

Evaluation of health-related quality of life in Lithuanian brain tumor patients using the EORTC brain cancer module @article{PMID:23455894, Title= {Evaluation of health-related quality of life in Lithuanian brain tumor patients using the EORTC brain cancer module}, Author= {Bunevičius, Adomas and Tamašauskas, Šarūnas and Tamašauskas, Arimantas and Deltuva, Vytenis}, Number= {11}, Volume= {48}, Year= {2012}, Journal= {Medicina (Kaunas, Lithuania)}, ISSN= {1010-660X}, Pages= {588—594}, Abstract= {BACKGROUND AND OBJECTIVE. Health-related quality of life (HRQoL) is considered an important outcome measure in neuro-oncology. The aim of this study was to evaluate the psychometric properties of the brain cancer-specific Quality of Life Questionnaire (QLQ-BN20) of the European Organization for Research and Treatment of Cancer (EORTC) in Lithuanian brain tumor patients. MATERIAL AND METHODS. One hundred consecutive patients (71% of women; mean age, 58 ± 14 years) admitted for elective brain tumor surgery were evaluated for HRQoL using the QLQ-BN20, QLQ-C30 (a core EORTC questionnaire for cancer patients), and SF-36 scale; for motor dysfunction (clinical examination); for cognitive dysfunction (Mini-Mental State Examination); and for disability (Barthel Index). RESULTS. The QLQ-BN20 subscales had an adequate internal consistency (Cronbach α, 0.75-0.90). Motor dysfunction on neurological examination was associated with greater motor dysfunction on the QLQ-BN20; greater disability, with greater future uncertainty, motor dysfunction, communication deficits, headaches, seizures, drowsiness, itchy skin, weakness of legs, and poor bladder control on the QLQ-BN20; and cognitive dysfunction, with greater future uncertainty, visual deficits, motor dysfunction, communication deficits, headaches, drowsiness, and weakness of legs symptoms on the QLQ-BN20, suggesting an adequate clinical validity of the QLQ-BN20. A score for motor dysfunction on the QLQ-BN20 correlated with a score for motor dysfunction on the QLQ-C30 and SF-36 scales; a score for headache on the QLQ-BN20, with a score for pain on the QLQ-C30 and SF-36 scales; and a score for drowsiness symptoms on the QLQ-BN20, with a score for fatigue on the QLQ-C30. CONCLUSIONS. The Lithuanian version of the EORTC-QLQ-BN20 scale has acceptable psychometric properties and can be reliably used for the assessment of HRQoL in brain tumor patients.}, URL= {http://europepmc.org/abstract/MED/23455894}} . Medicina (Kaunas, Lithuania).

Perioperative single photon emission computed tomography in predicting survival of malignant glioma patients @article{PMID:23205093, Title= {Perioperative single photon emission computed tomography in predicting survival of malignant glioma patients}, Author= {Deltuva, Vytenis and Bunevicius, Adomas and Jurkiene, Nemira and Kulakiene, Ilona and Tamasauskas, Arimantas}, DOI= {10.3892/ol.2012.812}, Number= {4}, Volume= {4}, Month= {October}, Year= {2012}, Journal= {Oncology letters}, ISSN= {1792-1074}, Pages= {739—744}, Abstract= {Single photon emission computed tomography (SPECT) is widely used in the evaluation of glioma patients and has been demonstrated to correlate with glioma malignancy and proliferation indexes. The aim of this study was to evaluate the association between perioperative technetium-99m-methoxyisobutylisonitrile ((99m)Tc-MIBI) uptake on SPECT scans and survival of malignant glioma patients. A total of 17 patients (11 males and 6 women; mean age, 62.2±8.4 years) with histologically confirmed malignant gliomas (16 glioblastoma multiforme and 1 gliosarcoma) underwent (99m)Tc-MIBI SPECT scans 2.8±1.9 days before surgery and 9.8±1.5 days after surgery. The total intensity index (TII) that corresponds to the area and intensity of tracer uptake was calculated before and after surgery. In addition, the change of TII before versus after surgery (Δ TII) was calculated. The overall survival (OS) was defined as the period between the date of surgery and the date of death. The median overall survival time was 12.4 months, ranging from 1.4 to 88 months; there were nine (45%) 12-month survivors. In univariate analyses using a log-rank test, worse OS was significantly associated with higher preoperative TII (≥12), higher postoperative TII (≥6), lower Δ TII (<50%) and higher number of neurological symptoms prior to surgery (≥4). In multivariate analyses, higher postoperative TII, a greater number of neurological symptoms and female gender were found to be factors with independent prognostic value of OS. Patients who survived more than 12 months following surgery had a significantly lower postoperative TII, higher Δ TII and greater rate of gross total resection compared to patients who survived less than 12 months following surgery. Higher peri-operative tracer uptake and lower decrease of tracer uptake following surgery (suggesting less radical resection) were associated with worse OS of malignant glioma patients. Our results suggest that SPECT may be used to predict survival of malignant glioma patients; however, further studies using larger samples are required.}, URL= {https://europepmc.org/articles/PMC3506694}} . Oncology letters.

Evaluation of depressive symptoms in patients with coronary artery disease using the Montgomery Åsberg Depression Rating Scale @article{PMID:22869009, Title= {Evaluation of depressive symptoms in patients with coronary artery disease using the Montgomery Åsberg Depression Rating Scale}, Author= {Bunevicius, Adomas and Staniute, Margarita and Brozaitiene, Julija and Pommer, Antoinette M and Pop, Victor J M and Montgomery, Stuart A and Bunevicius, Robertas}, DOI= {10.1097/yic.0b013e328357670d}, Number= {5}, Volume= {27}, Month= {September}, Year= {2012}, Journal= {International clinical psychopharmacology}, ISSN= {0268-1315}, Pages= {249—255}, Abstract= {The aim of this study was to evaluate, in patients with coronary artery disease (CAD), factor structure and psychometric properties of the Montgomery Åsberg Depression Rating Scale (MADRS) to identify patients with current major depressive episode (MDE). The construct validity of the MADRS against self-rating scales was also evaluated. Consecutive 522 CAD patients at admission to the cardiac rehabilitation program were interviewed for the severity of depressive symptoms using the MADRS and for current MDE using the structured MINI International Neuropsychiatric Interview. Also, all patients completed the Hospital Anxiety and Depression Scale and the Beck Depression Inventory-II. The MADRS had one-factor structure and high internal consistency (Cronbach's coefficient α=0.82). Confirmative factor analysis indicated an adequate fit: comparative fit index=0.95, normed fit index=0.91, and root mean square error of approximation=0.07. At a cut-off value of 10 or higher, the MADRS had good psychometric properties for the identification of current MDE (positive predictive value=42%, with sensitivity=88% and specificity=85%). There was also a moderate to strong correlation of MADRS scores with scores on self-rating depression scales. In sum, in CAD patients undergoing rehabilitation, the MADRS is a unidimensional instrument with high internal consistency and can be used for the identification of depressed CAD patients. The association between MADRS and self-rating depression scores is moderate to strong.}, URL= {https://doi.org/10.1097/YIC.0b013e328357670d}} . International clinical psychopharmacology.

Fatigue in patients with coronary artery disease: association with thyroid axis hormones and cortisol @article{PMID:23023678, Title= {Fatigue in patients with coronary artery disease: association with thyroid axis hormones and cortisol}, Author= {Bunevicius, Adomas and Gintauskiene, Vilte and Podlipskyte, Aurelija and Zaliunas, Remigijus and Brozaitiene, Julija and Prange, Arthur J and Bunevicius, Robertas}, DOI= {10.1097/psy.0b013e318268e7f0}, Number= {8}, Volume= {74}, Month= {October}, Year= {2012}, Journal= {Psychosomatic medicine}, ISSN= {0033-3174}, Pages= {848—853}, Abstract= {OBJECTIVE: In people with coronary artery disease, the association between endocrine measures and fatigue is not well understood. We evaluated possible associations of fatigue and exercise capacity with function of adrenal axis and thyroid axis. METHODS: Sixty-five men and 18 women (mean age 55 years) attending a rehabilitation program were examined using the Multidimensional Fatigue Inventory, Dutch Exertion Fatigue Scale, and the Hospital Anxiety and Depression Scale. Exercise capacity was measured using a bicycle ergometer procedure. Serum concentrations of free triiodothyronine (T₃), free thyroxine (T₄), morning cortisol, afternoon cortisol, and change in cortisol concentrations (ΔCortisol) were measured. RESULTS: In univariate regression analysis, lower free T₄ concentrations were associated with general and exertion fatigue, lower free T₃ concentrations were associated with general and physical fatigue, and lower ΔCortisol was associated with mental fatigue. After adjusting for age, sex, body mass index, hypertension, previous myocardial infarction, heart failure, diabetes, New York Heart Association functional class, depressive symptoms, and anxiety symptoms, lower free T3 concentrations remained associated with physical fatigue (β = -.224, p = .03); lower free T₄ concentrations, with exertion fatigue (β = -.219, p = .03); and lower morning cortisol and lower ΔCortisol concentrations, with mental fatigue (β = -.193 [p = .03] and β = -.180 [p =.04], respectively). Exercise capacity was not associated with endocrine factors. CONCLUSIONS: In coronary artery disease patients, increased thyroid hormone concentrations are associated with decreased physical fatigue and decreased exertion fatigue, and increased cortisol concentrations with decreased mental fatigue. Exercise capacity is not associated with endocrine factors.}, URL= {https://doi.org/10.1097/PSY.0b013e318268e7f0}} . Psychosomatic medicine.

Transsphenoidal surgery for microprolactinomas in women: results and prognosis @article{PMID:22855071, Title= {Transsphenoidal surgery for microprolactinomas in women: results and prognosis}, Author= {Tamasauskas, Arimantas and Sinkunas, Kestutis and Bunevicius, Adomas and Radziunas, Andrius and Skiriute, Daina and Deltuva, Vytenis P}, DOI= {10.1007/s00701-012-1450-x}, Number= {10}, Volume= {154}, Month= {October}, Year= {2012}, Journal= {Acta neurochirurgica}, ISSN= {0001-6268}, Pages= {1889—1893}, Abstract= {BACKGROUND: Long-term dopamine agonist (DA) therapy is recommended as a first-line approach for the management of microprolactinomas. However, DA therapy may be poorly tolerated by some patients, and therefore some patients continue to prefer surgery over DA therapy. AIM: The aim of our study was to evaluate factors associated with favorable outcomes after surgical treatment of microprolactinomas in women. METHODS: Thirty-two women (mean age 31.0 ± 8.2 years) with confirmed microprolactinomas who were operated using transsphenoidal approach were included to the study. Twenty-two (61 %) women had previous DA therapy and ten (39 %) women preferred surgery as a first treatment. Mean follow-up was 4.2 ± 2.7 years. Surgery was considered to be effective and remission achieved if serum prolactin was normal without DA therapy and there were no signs of tumor re-growth on neuroimaging. RESULTS: Nine (47.4 %) patients in whom remission was achieved did not receive preoperative DA therapy when compared to one (7.7 %) patient in whom remission was not achieved (p = 0.02). Remission after operation was achieved in nine out of ten (90 %) patients who did not receive DA therapy compared to ten out of 22 patients (45.5 %) who were treated with DAs (p = 0.01). The independent factor associated with good outcome following surgical treatment was no preoperative DA therapy (RR = 14.57 (1.43-148.1), p = 0.02). Surgical complications were permanent diabetes insipidus in two patients (6.3 %) and transient DI in five (15.6 %) patients. CONCLUSIONS: The main factor associated with favorable microprolactinoma surgery outcome in women was the absence of preoperative DA therapy.}, URL= {https://doi.org/10.1007/s00701-012-1450-x}} . Acta neurochirurgica.

Hypothalamic-pituitary-thyroid axis function in women with a menstrually related mood disorder: association with histories of sexual abuse @article{PMID:23001392, Title= {Hypothalamic-pituitary-thyroid axis function in women with a menstrually related mood disorder: association with histories of sexual abuse}, Author= {Bunevicius, Adomas and Leserman, Jane and Girdler, Susan S}, DOI= {10.1097/psy.0b013e31826c3397}, Number= {8}, Volume= {74}, Month= {October}, Year= {2012}, Journal= {Psychosomatic medicine}, ISSN= {0033-3174}, Pages= {810—816}, Abstract= {We previously reported a unique hypothalamic-pituitary-thyroid (HPT) axis profile in women with a menstrually related mood disorder (MRMD) who also had a history of sexual abuse (SA). In the present study, we sought to extend that work by examining the association of an SA history with HPT-axis disturbance in both women with MRMD and women without MRMD.Fifty-seven women met the prospective criteria for MRMD (23 with an SA history), and 52 women were non-MRMD (18 with an SA history). Thyroid-stimulating hormone, thyroxin (T4; total and free), and triiodothyronine (T3; total and free) were evaluated in serum, together with thyroid hormone ratios reflecting T4 to T3 conversion.Women with MRMD, compared with women without MRMD, had elevated T3/T4 ratios (p values ≤ .01; reflecting increased conversion of T4 to T3) and lower free and total T4 concentrations (p values = .01). Higher T3/T4 ratios and lower T4 concentrations predicted more severe premenstrual symptoms in all women. An SA history, irrespective of MRMD status, was associated with elevated thyroid-stimulating hormone concentrations (p = .03). However, in women with MRMD, an SA history was associated with elevated T3 concentrations (p = .049), whereas in women without MRMD, an SA history was associated with decreased T3 concentrations (p = .02).An MRMD and an SA history are associated with independent and interactive effects on the HPT axis. The evidence that an MRMD moderates the influence of SA on T3 concentrations contributes to a growing body of work suggesting that an SA history may identify a distinct subgroup of women with MRMD.}, URL= {https://europepmc.org/articles/PMC3465520}} . Psychosomatic medicine.

Diagnostic accuracy of self-rating scales for screening of depression in coronary artery disease patients @article{PMID:22200518, Title= {Diagnostic accuracy of self-rating scales for screening of depression in coronary artery disease patients}, Author= {Bunevicius, Adomas and Staniute, Margarita and Brozaitiene, Julija and Bunevicius, Robertas}, DOI= {10.1016/j.jpsychores.2011.10.006}, Number= {1}, Volume= {72}, Month= {January}, Year= {2012}, Journal= {Journal of psychosomatic research}, ISSN= {0022-3999}, Pages= {22—25}, Abstract= {OBJECTIVE: We evaluated the internal consistency and psychometric properties of the Hospital Anxiety and Depression Scale (HADS) and the Beck Depression Inventory-II (BDI-II) for screening of major depressive episodes (MDE) in coronary artery disease (CAD) patients undergoing rehabilitation. METHODS: Five-hundred and twenty-two consecutive CAD patients (72% men; mean age 58±9 years) attending a rehabilitation program 2 weeks after inpatient treatment for acute ischemic cardiac events completed the HADS depression subscale (HADS-D), HADS anxiety subscale (HADS-A) and the BDI-II. Interview outcome using the Mini International Neuropsychiatric Interview (MINI) for current MDE according to the DSM-IV-TR criteria was considered as the gold standard. RESULTS: Fifty-six (11%) patients had a current MDE. The HADS-D, HADS-A, HADS-total and BDI-II had high internal consistency. Area under the ROC curve was the highest for the BDI-II followed by the HADS. Optimal cut-off values for screening of MDE were ≥5 for the HADS-D, ≥8 for the HADS-A and ≥14 for the HADS-total and for the BDI-II. At optimal cut-off values the BDI-II had slightly superior psychometric properties when compared to the HADS. However, positive predictive values were low for the HADS and for the BDI-II. CONCLUSIONS: In CAD patients undergoing rehabilitation, the HADS and BDI-II had high internal consistency. Screening for MDE at optimal cut-off values the BDI-II was slightly superior when compared to the HADS. Positive predictive values for the BDI-II and for the HADS were low indicating that a large proportion of patients with positive screening results did not meet criteria for MDE.}, URL= {https://doi.org/10.1016/j.jpsychores.2011.10.006}} . Journal of psychosomatic research.

Introduction of novel semiquantitative evaluation of (99m)Tc-MIBI SPECT before and after treatment of glioma @article{PMID:22481370, Title= {Introduction of novel semiquantitative evaluation of (99m)Tc-MIBI SPECT before and after treatment of glioma}, Author= {Deltuva, Vytenis Pranas and Jurkienė, Nemira and Kulakienė, Ilona and Bunevičius, Adomas and Matukevičius, Algimantas and Tamašauskas, Arimantas}, Number= {1}, Volume= {48}, Year= {2012}, Journal= {Medicina (Kaunas, Lithuania)}, ISSN= {1010-660X}, Pages= {15—21}, Abstract= {BACKGROUND AND OBJECTIVE. There is a need for objective semiquantitative indexes for the evaluation of results of single-photon emission tomography (SPECT) in patients with brain glioma. The aim of this study was to validate the total size index (TSI) and total intensity index (TII) based on technetium-99m-methoxyisobutylisonitrile ((99m)Tc-MIBI) SPECT scans to discriminate the patients with high-grade glioma versus low-grade glioma and to evaluate the changes of viable glioma tissue by the means of TSI and TII after surgery and after radiation treatment. MATERIAL AND METHODS. Thirty-two patients (mean age, 55 years [SD, 18]; 20 men) underwent a (99m)Tc-MIBI-SPECT scan before surgery. Of these patients, 27 underwent a postoperative (99m)Tc-MIBI-SPECT scan and 7 patients with grade IV glioma underwent a third (99m)Tc-MIBI-SPECT scan after radiation treatment. TII that corresponds to the area and intensity of tracer uptake and TSI that corresponds to the area of tracer uptake were calculated before surgery, after surgery, and after radiation treatment. RESULTS. The TII and TSI were found to be valid in discriminating the patients with high-grade versus low-grade glioma with optimal cutoff values of 3.0 and 2.5, respectively. Glioma grade correlated with the preoperative TSI score (r=0.76, P<0.001) and preoperative TII score (r=0.64, P<0.001). There was a significant decrease in the TII and TSI after surgery in patients with grade IV glioma. After radiation treatment, there was a significant increase in the TII in patients with grade IV glioma. CONCLUSIONS. TSI and TII were found to be reliable in discriminating the patients with high-grade versus low-grade glioma and allowed for the semiquantitative evaluation of change in viable glioma tissue after surgery and after radiation treatment in patients with grade IV glioma.}, URL= {http://europepmc.org/abstract/MED/22481370}} . Medicina (Kaunas, Lithuania).

Tamasauskas, A., Sinkunas, K., Bunevicius, A., Radziunas, A., Skiriute, D., Deltuva, V.P.(2012). Transsphenoidal surgery for microprolactinomas in women: Results and prognosis . Acta Neurochirurgica. 154. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1889-1893.

Adomas Bunevicius, Jane Leserman, Susan S. Girdler(2012). Hypothalamic-Pituitary-Thyroid Axis Function in Women With a Menstrually Related Mood Disorder . Psychosomatic Medicine. 74. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 810--816. Ovid Technologies (Wolters Kluwer Health)

Adomas Bunevicius and Margarita Staniute and Julija Brozaitiene and Antoinette M. Pommer and Victor J. M. Pop and Stuart A. Montgomery and Robertas Bunevicius(2012). Evaluation of depressive symptoms in patients with coronary artery disease using the Montgomery Åsberg Depression Rating Scale . International clinical psychopharmacology. 27. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 249--255.

Deltuva, V.P., Jurkiene, N., Kulakiene, I., Bunevičius, A., Matukevičius, A., Tamašauskas, A.(2012). Introduction of novel semiquantitative evaluation of 99mTc-MIBI SPECT before and after treatment of glioma . Medicina (Lithuania). 48. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 15-21.

Adomas Bunevicius, Margarita Staniute, Julija Brozaitiene, Antoinette M. Pommer, Victor J.M. Pop, Stuart A. Montgomery, Robertas Bunevicius(2012). Evaluation of depressive symptoms in patients with coronary artery disease using the Montgomery Åsberg Depression Rating Scale . International Clinical Psychopharmacology. 27. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 249--255. Ovid Technologies (Wolters Kluwer Health)

Deltuva VP, Jurkienė N, Kulakienė I, Bunevičius A, Matukevičius A, Tamašauskas A, Medicina (Kaunas, Lithuania), 2012, vol. 48, no. 1, pp. 15-21 .

Vytenis Pranas Deltuva and Nemira Jurkienė and Ilona Kulakienė and Adomas Bunevicius and Algimantas Matukevičius and Arimantas Tamasauskas(2012). Introduction of novel semiquantitative evaluation of (99m)Tc-MIBI SPECT before and after treatment of glioma . Medicina (Kaunas, Lithuania). 48. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 15--21.

Deltuva, V.P., Jurkiene, N., Kulakiene, I., Bunevičius, A., Matukevičius, A., Tamašauskas, A.(2012). Introduction of novel semiquantitative evaluation of <sup>99m</sup>Tc-MIBI SPECT before and after treatment of glioma . Medicina (Lithuania). 48. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 15-21.

Adomas Bunevicius and Vytenis Pranas Deltuva and Sarunas Tamasauskas and Arimantas Tamasauskas and Robertas Bunevicius(2012). Screening for psychological distress in neurosurgical brain tumor patients using the Patient Health Questionnaire-2 . Psycho-oncology. 22. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1895--1900.

Adomas Bunevicius and Margarita Staniute and Julija Brozaitiene and Dalia Stropute and Robertas Bunevicius and Johan Denollet(2012). Type D (distressed) personality and its assessment with the DS14 in Lithuanian patients with coronary artery disease . Journal of health psychology. 18. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1242--1251.

A. Bunevicius, V. Gintauskiene, J. Brozaitiene, R. Bunevicius(2011). P.2.g.016 Depressive symptoms in coronary artery disease patients: association with neuro-endocrine factors . European Neuropsychopharmacology. 21. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S449. Elsevier {BV}

A. Bunevicius, V.P. Deltuva, S. Tamasauskas, A. Tamasauskas, R. Bunevicius(2011). P.1.i.003 Depression, anxiety and delirium are associated with thyroid axis function in brain tumor patients . European Neuropsychopharmacology. 21. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S353--S354. Elsevier {BV}

Bunevicius, A., Stankus, A., Brozaitiene, J., Girdler, S.S., Bunevicius, R.(2011). Relationship of fatigue and exercise capacity with emotional and physical state in patients with coronary artery disease admitted for rehabilitation program . American Heart Journal. 162. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 310-316.

Adomas Bunevicius and Vytenis Pranas Deltuva and Šarūnas Tamašauskas and A. Tamasauskas and Robertas Bunevicius(2011). P.1.i.003 Depression, anxiety and delirium are associated with thyroid axis function in brain tumor patients . European Neuropsychopharmacology. 21. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S353--S354.

Bunevicius, A., Brozaitiene, J., Stankus, A., Bunevicius, R.(2011). Specific fatigue-related items in self-rating depression scales do not bias an association between depression and fatigue in patients with coronary artery disease . General Hospital Psychiatry. 33. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 527-529.

Adomas Bunevicius and Albinas Stankus and Julija Brozaitiene and Susan S. Girdler and Robertas Bunevicius(2011). Relationship of fatigue and exercise capacity with emotional and physical state in patients with coronary artery disease admitted for rehabilitation program . American heart journal. 162. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 310--316.

Relationship of fatigue and exercise capacity with emotional and physical state in patients with coronary artery disease admitted for rehabilitation program @article{PMID:21835292, Title= {Relationship of fatigue and exercise capacity with emotional and physical state in patients with coronary artery disease admitted for rehabilitation program}, Author= {Bunevicius, Adomas and Stankus, Albinas and Brozaitiene, Julija and Girdler, Susan S and Bunevicius, Robertas}, DOI= {10.1016/j.ahj.2011.05.003}, Number= {2}, Volume= {162}, Month= {August}, Year= {2011}, Journal= {American heart journal}, ISSN= {0002-8703}, Pages= {310—316}, Abstract= {BACKGROUND: The relationship between subjective fatigue, exercise capacity, and symptoms of depression and anxiety in patients with coronary artery disease (CAD) needs to be specified. METHODS: In this cross-sectional study, a total of 1,470 (64% men; mean age 57 ± 11 years) consecutive CAD patients admitted for cardiac rehabilitation after treatment of acute cardiac events were evaluated for demographic characteristics, for past and current diagnosis and treatment, for New York Heart Association (NYHA) class, for symptoms of depression and for symptoms of anxiety using the Hospital Anxiety and Depression Scale, and for subjective fatigue using the Multidimensional Fatigue Inventory. On the next day, all patients underwent exercise capacity evaluation using a standard bicycle ergometer testing procedure. RESULTS: In univariate regression analyses, there was the strongest positive association between scores on all Multidimensional Fatigue Inventory subscales and scores on the Hospital Anxiety and Depression Scale depression and anxiety subscales and between exercise capacity and NYHA class. Multivariate regression analyses revealed that symptoms of depression were the strongest positive determinants of all dimensions of subjective fatigue and, together with other significant variables, accounted for 17% to 29% of the variance. However, neither depressive nor anxious symptoms were significant determinants of exercise capacity. The association between subjective fatigue and exercise capacity and vice versa was minimal. CONCLUSION: Subjective fatigue in CAD patients is strongly related to symptoms of depression and symptoms of anxiety. In contrast, exercise capacity in CAD patients is strongly related to NYHA functional class, with no relationship to symptoms of depression and anxiety.}, URL= {https://doi.org/10.1016/j.ahj.2011.05.003}} . American heart journal.

Specific fatigue-related items in self-rating depression scales do not bias an association between depression and fatigue in patients with coronary artery disease @article{PMID:21851985, Title= {Specific fatigue-related items in self-rating depression scales do not bias an association between depression and fatigue in patients with coronary artery disease}, Author= {Bunevicius, Adomas and Brozaitiene, Julija and Stankus, Albinas and Bunevicius, Robertas}, DOI= {10.1016/j.genhosppsych.2011.06.009}, Number= {5}, Volume= {33}, Year= {2011}, Journal= {General hospital psychiatry}, ISSN= {0163-8343}, Pages= {527—529}, Abstract= {OBJECTIVE: Self-rating instruments for depression include questions targeting fatigue, which is a common symptom of coronary artery disease (CAD) patients. We evaluated if specific fatigue-related questions in self-reported instruments of depression bias an association between fatigue and depression in CAD patients. METHODS: A total of 1470 CAD patients attending cardiac rehabilitation program were evaluated for fatigue using the Multidimensional Fatigue Inventory (MFI-20) and for symptoms of depression using the depression subscale of the Hospital Anxiety and Depression scale (HADS-D) and the Beck Depression Inventory-II (BDI-II). RESULTS: There was moderate correlation in MFI-20 scores vs. HADS-D scores and in MFI-20 scores vs. BDI-II scores, with stronger association in patients with less severe heart failure when compared to patients with more severe heart failure. Removal of questions targeting fatigue from the HADS-D and the BDI-II did not significantly change the association. CONCLUSIONS: Fatigue-related items should not be removed from the HADS-D and the BDI-II when evaluating CAD patients for depressive symptoms.}, URL= {https://doi.org/10.1016/j.genhosppsych.2011.06.009}} . General hospital psychiatry.

Adomas Bunevicius and Julija Brozaitiene and Albinas Stankus and Robertas Bunevicius(2011). Specific fatigue-related items in self-rating depression scales do not bias an association between depression and fatigue in patients with coronary artery disease . General hospital psychiatry. 33. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 527--529.

Adomas Bunevicius and Vilte Marija Gintauskiene and Julija Brozaitiene and Robertas Bunevicius(2011). P.2.g.016 Depressive symptoms in coronary artery disease patients: association with neuro-endocrine factors . European Neuropsychopharmacology. 21. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S449--.

A. Bunevicius, L. Kusminskas, V.J. Pop, C. Pedersen, R. Bunevicius(2009). P.2.a.007 Screening for depression during pregnancy . European Neuropsychopharmacology. 19. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S364--S365. Elsevier {BV}

Adomas Bunevičius, Laima Kusminskas, Robertas Bunevičius(2009). Validation of the Lithuanian version of the Edinburgh Postnatal Depression Scale . Medicina. 45. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 544. {MDPI} {AG}

A. Bunevicius, L. Kusminskas, R. Bunevicius(2009). P02-206 Validity of the Edinburgh postnatal depression scale . European Psychiatry. 24. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S896. Elsevier {BV}

Bunevicius, A., Kusminskas, L., Pop, V.J., Pedersen, C.A., Bunevicius, R.(2009). Screening for antenatal depression with the Edinburgh Depression Scale . Journal of Psychosomatic Obstetrics and Gynecology. 30. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 238-243.

Bunevicius, R., Kusminskas, L., Bunevicius, A., Nadisauskiene, R.J., Jureniene, K., Pop, V.J.M.(2009). Psychosocial risk factors for depression during pregnancy . Acta Obstetricia et Gynecologica Scandinavica. 88. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 599-605.

Bunevicius A, Kusminskas L, Bunevicius R, Medicina (Kaunas, Lithuania), 2009, vol. 45, no. 7, pp. 544-548 .

Robertas Bunevicius and Laima Kusminskas and Narseta Mickuviene and Adomas Bunevicius and Cort Pedersen and Victor Pop(2009). Depressive disorder and thyroid axis functioning during pregnancy . World Journal of Biological Psychiatry. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--6.

Bunevicius, R., Kusminskas, L., Mickuviene, N., Bunevicius, A., Pedersen, C.A., Pop, V.J.M.(2009). Depressive disorder and thyroid axis functioning during pregnancy . World Journal of Biological Psychiatry. 10. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 324-329.

Robertas Bunevicius and Laima Kusminskas and Narseta Mickuviene and Adomas Bunevicius and Cort A. Pedersen and Victor J. M. Pop(2009). Depressive disorder and thyroid axis functioning during pregnancy . The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 10. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 324--329.

Robertas Bunevicius and Laima Kusminskas and Adomas Bunevicius and Ruta J. Nadisauskiene and Kristina Jureniene and Victor J. M. Pop(2009). Psychosocial risk factors for depression during pregnancy . Acta obstetricia et gynecologica Scandinavica. 88. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 599--605.

Bunevičius, A., Kusminskas, L., Bunevičius, R.(2009). Validation of the Lithuanian version of the Edinburgh postnatal depression scale,Edinburgo pogimdyminės depresijos skalės lietuviškos versijos validizacija . Medicina. 45. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 544-548.

Validation of the Lithuanian version of the Edinburgh Postnatal Depression Scale @article{PMID:19667749, Title= {Validation of the Lithuanian version of the Edinburgh Postnatal Depression Scale}, Author= {Bunevicius, Adomas and Kusminskas, Laima and Bunevicius, Robertas}, Number= {7}, Volume= {45}, Year= {2009}, Journal= {Medicina (Kaunas, Lithuania)}, ISSN= {1010-660X}, Pages= {544—548}, Abstract= {Depression is prevalent postpartum and is a major health problem. OBJECTIVE. In this study, we aimed to evaluate how precise the Edinburgh Postnatal Depression Scale (EPDS) is in screening for depressive disorders postpartum. MATERIALS AND METHODS. A random sample of 94 women was interviewed two weeks postpartum using the Composite International Diagnostics Interview Short-Form (CIDI-SF). In addition, they filled in the EPDS. We evaluated (a) internal consistency of the EPDS by the means of Cronbach's alpha coefficient; (b) area under the ROC curve, sensitivity, specificity of the EPDS against the CIDI-SF diagnoses of depressive disorders. RESULTS. The internal consistency of the EPDS was 0.83. The optimal cutoff score of the EPDS for screening CIDI-SF diagnoses of depressive disorders was found to be 7 and more with an area under the ROC curve of 0.83, sensitivity of 92%, and specificity of 73%. CONCLUSIONS. The EPDS has a good reliability as a screening instrument, and a cutoff score of 7 and more has to be used in screening for postpartum depressive disorders.}, URL= {http://europepmc.org/abstract/MED/19667749}} . Medicina (Kaunas, Lithuania).

Screening for antenatal depression with the Edinburgh Depression Scale @article{PMID:19845492, Title= {Screening for antenatal depression with the Edinburgh Depression Scale}, Author= {Bunevicius, Adomas and Kusminskas, Laima and Pop, Victor J and Pedersen, Cort A and Bunevicius, Robertas}, DOI= {10.3109/01674820903230708}, Number= {4}, Volume= {30}, Month= {December}, Year= {2009}, Journal= {Journal of psychosomatic obstetrics and gynaecology}, ISSN= {0167-482X}, Pages= {238—243}, Abstract= {This study aimed to evaluate how precise the Edinburgh Depression Scale (EDS) is in screening for major depressive disorder (MDD) during different periods of pregnancy. A random sample of 230 pregnant women was interviewed in the first, second, and third trimesters of pregnancy using the EDS and not-patient version of the Structured Clinical Interview for DSM-III-R (SCID-NP). We evaluated test-retest reliability of the EDS; area under the ROC curve (AUC), sensitivity, specificity, and positive predictive value (PPV) of the EDS against the SCID-NP diagnoses in the first, second, and third trimesters of pregnancy. Test-retest reliability of the EDS was 0.81 (p < 0.001). An optimal cutoff score of the EDS for screening current SCID-NP diagnosis of MDD was 12 and higher in the first trimester of pregnancy (AUC 0.94, sensitivity 92%, specificity 95%, and PPV 52%) and 11 and higher in the second and third trimesters of pregnancy (AUC 0.96 and 0.90, respectively; sensitivity 100% and 88%, respectively; specificity 92% and 92%, respectively; PPV 25% and 29%, respectively). The EPDS is a reliable instrument for repeated evaluations of depressive symptoms during pregnancy. It has a good sensitivity and specificity for detecting antenatal MDD with optimal cutoff of 11/12 or higher.}, URL= {https://doi.org/10.3109/01674820903230708}} . Journal of psychosomatic obstetrics and gynaecology.

Psychosocial risk factors for depression during pregnancy @article{PMID:19308810, Title= {Psychosocial risk factors for depression during pregnancy}, Author= {Bunevicius, Robertas and Kusminskas, Laima and Bunevicius, Adomas and Nadisauskiene, Ruta J and Jureniene, Kristina and Pop, Victor J M}, DOI= {10.1080/00016340902846049}, Number= {5}, Volume= {88}, Year= {2009}, Journal= {Acta obstetricia et gynecologica Scandinavica}, ISSN= {0001-6349}, Pages= {599—605}, Abstract= {OBJECTIVE: To assess the prevalence of antenatal depressive disorder in different trimesters and to evaluate the relation of psychosocial risk factors to antenatal depressive disorder. DESIGN: Cohort follow-up. SETTING: University Hospital, Kaunas, Lithuania. SAMPLE: Two hundred and thirty pregnant women consecutively admitted. METHODS: At 12-16 weeks, 22-26 weeks, and 32-36 weeks of pregnancy, participants were screened for depression using the World Health Organization's Composite International Diagnostic Interview Short Form (CIDI-SF). Women who gave at least one positive answer to the CIDI-SF depression-screening question were evaluated for depressive disorder using the non-patient version of the Structured Clinical Interview for DSM-III-R (SCID-NP). Psychosocial stressors and two Big Five Personality dimensions, neuroticism and extraversion, were also evaluated. MAIN OUTCOME MEASURES: Prevalence of depressive disorder. RESULTS: The prevalence of the antenatal depressive disorder at 12-16 weeks' gestation was 6.1%, at 22-26 weeks 3.5%, and at 32-36 weeks 4.4%. In the first trimester, a greater prevalence of current depressive disorder was independently associated with unplanned and unwanted pregnancy, high neuroticism, low education, and a previous history of depression; in the second trimester with unplanned and unwanted pregnancy and high neuroticism; in the third trimester with unplanned and unwanted pregnancy, high neuroticism, and the occurrence of psychosocial stressors during the last year. CONCLUSIONS: The highest prevalence of depressive disorders was found in the first trimester, the lowest in mid-pregnancy. Several determinants (unwanted and unplanned pregnancy, high neuroticism) were independent predictors of antenatal depressive disorders throughout whole pregnancy, while other determinants (low education, previous history of depression, the occurrence of psychosocial stressors at the end of pregnancy) were trimester specific.}, URL= {https://doi.org/10.1080/00016340902846049}} . Acta obstetricia et gynecologica Scandinavica.

Depressive disorder and thyroid axis functioning during pregnancy @article{PMID:19921974, Title= {Depressive disorder and thyroid axis functioning during pregnancy}, Author= {Bunevicius, Robertas and Kusminskas, Laima and Mickuviene, Narseta and Bunevicius, Adomas and Pedersen, Cort A and Pop, Victor J M}, DOI= {10.3109/15622970903144038}, Number= {4}, Volume= {10}, Year= {2009}, Journal= {The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry}, ISSN= {1562-2975}, Pages= {324—329}, Abstract= {BACKGROUND: Depression and thyroid dysfunction are prevalent in women, including pregnant women. The aim of this study was to assess the relationship between depression and thyroid function during pregnancy. METHODS: One hundred and ninety-nine pregnant women three times during pregnancy were assessed for depressive disorder and for thyroid stimulating hormone (TSH) and free thyroxine (FT(4)) concentrations. RESULTS: Prevalence of depressive disorder was 6.5% in early pregnancy, 3.0% in middle pregnancy and 3.5% in late pregnancy. There were no women with overt thyroid dysfunction. Subclinical hyperthyroidism was found in 23% of women in early pregnancy, in 5% of women in middle pregnancy and in 6% of women in late of pregnancy. In late pregnancy depressed women compared to non-depressed women had significantly higher FT(4) concentrations and a strong trend towards lower TSH concentrations as well as higher prevalence of subclinical hyperthyroidism. CONCLUSIONS: These findings show an association between thyroid dysfunction and depression in late pregnancy. Because gestational depression might interfere with pregnancy outcome, evaluation of thyroid function during gestation is warranted.}, URL= {https://doi.org/10.3109/15622970903144038}} . The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Bunevicius A, Deltuva VP, Deltuviene D, Tamasauskas A, Bunevicius R, CNS spectrums, 2008, vol. 13, no. 11, pp. 950-958 .

A. Bunevicius, L. Kusminskas, R. Bunevicius(2008). P.7.d.001 Anthropometric characteristics of neonates: impact of antenatal maternal stress, depression, anxiety and personality . European Neuropsychopharmacology. 18. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S564. Elsevier {BV}

Brain lesions manifesting as psychiatric disorders: eight cases @article{PMID:19037181, Title= {Brain lesions manifesting as psychiatric disorders: eight cases}, Author= {Bunevicius, Adomas and Deltuva, Vytenis Pranas and Deltuviene, Daiva and Tamasauskas, Arimantas and Bunevicius, Robertas}, DOI= {10.1017/s1092852900014000}, Number= {11}, Volume= {13}, Month= {November}, Year= {2008}, Journal= {CNS spectrums}, ISSN= {1092-8529}, Pages= {950—958}, Abstract= {Sometimes patients with organic brain lesions in neurologically silent brain areas might present only with psychiatric symptoms, such as depression, anxiety disorders, schizophrenia, anorexia nervosa, or cognitive dysfunction. This study presents eight cases of patients with brain lesions (four cases of meningiomas, one case of intracerebral cysts, one case of anaplastic oligodendroglioma, one case of multiform glioblastoma, and one case of occlusive hydrocephalus) who, for a significant period of time, were diagnosed and treated for psychiatric disorders (three cases of Alzheimer's disease, two cases of schizoaffective disorder, one case of schizophrenia, one case of depression, and one case of organic emotional lability disorder). When neurologic symptoms developed, they underwent neuroimaging studies and organic brain lesions were diagnosed. Further treatment required neurosurgical interventions. These cases show that brain tumors can be neurologically silent for a sufficient period of time and manifest as psychiatric disorders. Therefore, neuroimaging studies are needed when atypical changes in mental status or neurologic symptoms and signs develop.}, URL= {https://doi.org/10.1017/s1092852900014000}} . CNS spectrums.

Symptoms of anxiety and depression in medical students and in humanities students: relationship with big-five personality dimensions and vulnerability to stress @article{PMID:18974188, Title= {Symptoms of anxiety and depression in medical students and in humanities students: relationship with big-five personality dimensions and vulnerability to stress}, Author= {Bunevicius, Adomas and Katkute, Arune and Bunevicius, Robertas}, DOI= {10.1177/0020764008090843}, Number= {6}, Volume= {54}, Month= {November}, Year= {2008}, Journal= {The International journal of social psychiatry}, ISSN= {0020-7640}, Pages= {494—501}, Abstract= {AIMS: To evaluate the prevalence of anxiety and depression in medical students and in humanities students. To assess the relationship between symptoms of anxiety, symptoms of depression and Big-Five personality dimensions and vulnerability to stress in medical students. METHODS: Randomly selected 338 medical students and 73 humanities students were evaluated for symptoms of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS), for Big-Five personality dimensions using the Ten-Item Personality Inventory (TIPI), and for vulnerability to stress using the Stress Vulnerability Scale (SVS). RESULTS: Symptoms of anxiety and symptoms of depression were prevalent in medical students (43% and 14%, respectively) and in humanities students (52% and 12%, respectively). In medical students the score on the HADS anxiety subscale and the score on the HADS depression subscale correlated negatively with the score on the TIPI Emotional Stability scale (r = -0.39, p < 0.01 and r = -0.2, p < 0.01, respectively) and correlated positively with the score on the SVS (r = 0.38, p < 0.01 and r = 0.44, p < 0.01, respectively). CONCLUSIONS: Symptoms of anxiety and depression are prevalent in medical students and in humanities students. Severity of symptoms of anxiety and symptoms of depression in medical students is negatively related to emotional stability and positively related to stress vulnerability.}, URL= {https://doi.org/10.1177/0020764008090843}} . The International journal of social psychiatry.

The association of thyroid immunity with blood pressure and body mass index in primary care patients @article{PMID:19156567, Title= {The association of thyroid immunity with blood pressure and body mass index in primary care patients}, Author= {Bunevicius, Adomas and Peceliuniene, Jurate and Mickuviene, Narseta and Girdler, Susan S and Bunevicius, Robertas}, DOI= {10.1080/07435800802534126}, Number= {3}, Volume= {33}, Year= {2008}, Journal= {Endocrine research}, ISSN= {0743-5800}, Pages= {93—103}, Abstract= {OBJECTIVES: To evaluate the association of thyroid immunity with cardiovascular symptoms and body mass index (BMI). METHODS: Four hundred and sixty-five primary care patients underwent ultrasound evaluation of the thyroid gland, with hypo-echoic thyroid pattern indicating autoimmune involvement. BMI and blood pressure (BP) were the main outcomes. RESULTS: Men and women with hypo-echoic thyroid had higher BMI and higher BP in comparison to patients with normo-echoic thyroid. Among women with hypo-echoic thyroid, only those who were premenopausal had higher BMI and higher BP in comparison to women with normo-echoic thyroid. CONCLUSIONS: Thyroid immunity is related to higher BMI and higher BP in men and women, especially in premenopausal women.}, URL= {https://doi.org/10.1080/07435800802534126}} . Endocrine research.

Bunevicius, A., Peceliuniene, J., Mickuviene, N., Girdler, S.S., Bunevicius, R.(2008). The association of thyroid immunity with blood pressure and body mass index in primary care patients . Endocrine Research. 33. (3-4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93-103.

Bunevicius, A., Deltuva, V.P., Deltuviene, D., Tamasauskas, A., Bunevicius, R.(2008). Brain lesions manifesting as psychiatric disorders: eight cases . CNS spectrums. 13. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 950-958.

Adomas Bunevicius and Laima Kusminskas and Robertas Bunevicius(2008). P.7.d.001 Anthropometric characteristics of neonates: impact of antenatal maternal stress, depression, anxiety and personality . European Neuropsychopharmacology. 18. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S564--.

Adomas Bunevicius and Arune Katkute and Robertas Bunevicius(2008). Symptoms of Anxiety and Depression in Medical Students and in Humanities Students: Relationship With Big-Five Personality Dimensions and Vulnerability To Stress . The International journal of social psychiatry. 54. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 494--501.

Adomas Bunevicius and J. Peceliuniene and Narseta Mickuviene and Susan S. Girdler and Robertas Bunevicius(2008). The association of thyroid immunity with blood pressure and body mass index in primary care patients . Endocrine research. 33. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93--103.

Adomas Bunevicius and Jurate Peceliuniene and Narseta Mickuviene and Susan S. Girdler and Robertas Bunevicius(2008). The Association of Thyroid Immunity with Blood Pressure and Body Mass Index in Primary Care Patients . Endocrine Research. 33. (3-4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93--103.

Bunevicius, A., Katkute, A., Bunevicius, R.(2008). Symptoms of anxiety and depression in medical students and in humanities students: Relationship with big-five personality dimensions and vulnerability to stress . International Journal of Social Psychiatry. 54. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 494-501.

Screening for depression and anxiety disorders in primary care patients @article{PMID:17117433, Title= {Screening for depression and anxiety disorders in primary care patients}, Author= {Bunevicius, Adomas and Peceliuniene, Jurate and Mickuviene, Narseta and Valius, Leonas and Bunevicius, Robertas}, DOI= {10.1002/da.20274}, Number= {7}, Volume= {24}, Year= {2007}, Journal= {Depression and anxiety}, ISSN= {1091-4269}, Pages= {455—460}, Abstract= {Mood and anxiety disorders are highly prevalent in primary health care. In this study we assessed performance of the Hospital Anxiety and Depression Scale (HADS) for screening of depression and anxiety disorders in a population of primary care patients. A total of 503 primary care patients consecutively admitted to the primary care medical center in Kaunas, Lithuania, completed the study. We found that the HADS subscale of depression (HADS-D) at a cutoff score of 6 or more showed the best performance screening for a major depressive episode diagnosed by means of the Mini International Neuropsychiatric Interview (MINI), with a sensitivity of 80%, specificity of 69%, positive predictive value of 80%, negative predictive value of 92%, and area under the receiver operating characteristic (ROC) curve of 0.75. Performance of the HADS-D against MINI diagnosis of dysthymia was weak. The HADS subscale of anxiety (HADS-A) at a cutoff score of 9 or more showed the best performance screening for MINI diagnosis of overall anxiety disorders, with a sensitivity of 77%, specificity of 75%, positive predictive value of 53%, negative predictive value of 90%, and area under the ROC curve of 0.76. These results suggest that in primary care patients HADS is an adequate screening instrument for the MINI diagnoses of major depressive episode, but not for dysthymia at a cutoff score of 6, and for anxiety disorders at a cutoff score of 9.}, URL= {https://doi.org/10.1002/da.20274}} . Depression and anxiety.

Mood and thyroid immunity assessed by ultrasonographic imaging in a primary health care @article{PMID:16837056, Title= {Mood and thyroid immunity assessed by ultrasonographic imaging in a primary health care}, Author= {Bunevicius, Robertas and Peceliuniene, Jurate and Mickuviene, Narseta and Bunevicius, Adomas and Pop, Victor J and Girdler, Susan S}, DOI= {10.1016/j.jad.2006.05.029}, Number= {1-3}, Volume= {97}, Month= {January}, Year= {2007}, Journal= {Journal of affective disorders}, ISSN= {0165-0327}, Pages= {85—90}, Abstract= {BACKGROUND: Psychiatric morbidity is highly prevalent in the primary health care settings and it may be related to autoimmune thyroid disease (AITD). The aim of this study was to evaluate the impact of thyroid immunity, evident by hypo-echoic thyroid ultrasound pattern, on prevalence of depression and anxiety in a primary care setting. METHODS: In a cross-sectional design, 504 consecutive primary care patients were invited to the study and 474 patients completed the study. They were screened for depression and anxiety using the Hospital Anxiety and Depression Scale (HADS), were interviewed for affective disorders using the Mini International Neuropsychiatric Interview, and were evaluated by ultrasonographic imagining of the thyroid gland. RESULTS: Among patients with hypo-echoic thyroid (n=122) prevailed women and those patients were older than patients with normo-echoic thyroid (n=352). Women, but not men, with hypo-echoic thyroid compared to those with normo-echoic thyroid had higher scores on the anxiety subscale of the HADS (p=0.03). Among women with hypo-echoic thyroid, only those pre-menopause, but not those post-menopause, had greater prevalence of high scores on the depression subscale of the HADS (p=0.02) and a greater likelihood of using psychiatric medications (p=0.001). LIMITATIONS: Lack of cytological evaluation of the thyroid gland; lack of serum thyroid antibodies concentrations; and lack of thyroid hormone concentrations. CONCLUSIONS: Thyroid immunity is related to mood symptoms in primary care patients. These effects are gender specific and in women, they are most evident before menopause.}, URL= {https://doi.org/10.1016/j.jad.2006.05.029}} . Journal of affective disorders.

Bunevicius, A., Peceliuniene, J., Mickuviene, N., Valius, L., Bunevicius, R.(2007). Screening for depression and anxiety disorders in primary care patients . Depression and Anxiety. 24. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 455-460.

Bunevicius, R., Peceliuniene, J., Mickuviene, N., Bunevicius, A., Pop, V.J., Girdler, S.S.(2007). Mood and thyroid immunity assessed by ultrasonographic imaging in a primary health care . Journal of Affective Disorders. 97. (1-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 85-90.

Robertas Bunevicius and J. Peceliuniene and Narseta Mickuviene and Adomas Bunevicius and Victor J. M. Pop and Susan S. Girdler(2006). Mood and thyroid immunity assessed by ultrasonographic imaging in a primary health care . Journal of Affective Disorders. 97. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 85--90.

Adomas Bunevicius Comments: “Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome” . {Associa{\c c}{\~a}o M{\'e}dica Brasileira}

Adomas Bunevicius AND Arune Katkute AND Robertas Bunevicius Symptoms of Anxiety and Depression in Medical Students and in Humanities Students: Relationship With Big-Five Personality Dimensions and Vulnerability To Stress .

BOOK CHAPTER

Julius Burkauskas and Aiste Pranckeviciene and Adomas Bunevicius(2020). Thyroid Hormones, Brain, and Heart . 339--360Springer International Publishing

BOOK

Sarah F. Frisken and Ma Luo and Inês Machado and Prashin Unadkat and Parikshit Juvekar and Adomas Bunevicius and Matthew Toews and William M. Wells and Michael I. Miga and Alexandra J. Golby(2019). Medical Imaging: Image-Guided Procedures - Preliminary Results Comparing Thin Plate Splines with Finite Element Methods for Modeling Brain Deformation during Neurosurgery using Intraoperative Ultrasound . 10951

CONFERENCE PAPER

Frisken, S., Luo, M., MacHado, I., Unadkat, P., Juvekar, P., Bunevicius, A., Toews, M., Wells, W.M., Miga, M.I., Golby, A.J.(2019). Preliminary results comparing thin-plate splines with finite element methods for modeling brain deformation during neurosurgery using intraoperative ultrasound . Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 10951.

OTHER

Adomas Bunevicius(2018). The Association of Digit Ratio (2D : 4D) with Cancer: A Systematic Review and Meta-Analysis . {Disease Markers}

Adomas Bunevicius, Julius Burkauskas(2018). Pilot study of neurocognitive functioning and health-related quality of life in coronary artery disease patients . Morressier

Miglė Kaminskaitė and Vida Žilinskaitė and Rimantas Vilcinis and Deividas Nekrosius and Aistė Pranckevičienė and Ramunas Jokubka and Adomas Bunevicius(2017). Brain dopaminergic system: genetic variations, personality traits and alcohol addiction risk .

Adomas Bunevicius(2016). Impact of depression and psychological distress on preoperative cognitive performance of brain tumor patients . Morressier

Adomas Bunevicius and Karolis Bareikis and Laimutis Kalasauskas and Arimantas Tamasauskas(2016). Penetrating Anterior Skull Base Fracture Inflicted by a Cow's Horn .

Adomas Bunevicius and Henrikas Kazlauskas and Nijole Raskauskiene and Vinsas Janusonis and Robertas Bunevicius(2015). Thyroid Hormone and C-Reactive Protein Serum Concentrations, Disease Severity and Discharge Outcomes of Ischemic Stroke Patients: A Dataset .

Dalia Stropute and Adomas Bunevicius and Margarita Staniute and Julija Brozaitiene and Robertas Bunevicius(2015). Type D (Distressed) Personality in Lithuanian Patients with Coronary Artery Disease: A Dataset .

Jurate Butnoriene and Adomas Bunevicius and Antanas Norkus and Robertas Bunevicius(2014). Depression but not anxiety is associated with metabolic syndrome in primary care based .

Bunevicius, A., Staniute, M., Brozaitiene, J., Pop, V.J., Neverauskas, J., Bunevicius, R.(2013). Screening for anxiety disorders in patients with coronary artery disease . Health and quality of life outcomes. 11.

Adomas Bunevicius AND Hong Yuan AND Weili Lin(2013). The Potential Roles of 18F-FDG-PET in Management of Acute Stroke Patients . {BioMed Research International}

Adomas Bunevi{\v c}ius AND Laima Kusminskas AND Robertas Bunevi{\v c}ius(2009). Validation of the Lithuanian version of the Edinburgh Postnatal Depression Scale . {Multidisciplinary Digital Publishing Institute}

Adomas Bunevičius(2005). Didžiojo penketo asmenybės dimensijos (DPAD) .

Neuro-oncologist at Columbia NYC

Columbia University Columbia College

NewYork–Presbyterian Hospital

Harvard University

Image Guided Neurosurgery Fellow

Brigham and Women's Hospital

Neurosurgeon, Assistant Professor

Hospital of Lithuanian University of Health Sciences Kaunas Clinics

Senior researcher, Lab head

Lithuanian University of Health Sciences

(Neuro-oncology fellowship)

Columbia University in the City of New York

Neurology residency (Neurology)

Columbia University Columbia College

Radiosurgery fellowship (Neurosurgery)

University of Virginia

(Neurosurgery)

Harvard Medical School

Image Guided Neurosurgery Fellow (Neurosurgery)

Brigham and Women's Hospital

Neurosurgery residency (Department of Neurosurgery)

Lithuanian University of Health Sciences

Postdoctoral research fellowship in neuroimaging (Department of Neurology and Biomedical Research Imaging Center)

University of North Carolina at Chapel Hill

Ph.D. (Department of Medical Psychology and Neuropsychology/ Center of Research on Psychology in Somatic diseases (CoRPS))

Tilburg University

Postdoctoral research fellowship (Department of Psychiatry)

University of North Carolina at Chapel Hill

M.D.

Lithuanian University of Health Sciences

The American Board of Psychiatry and Neurology

The American Board of Psychiatry and Neurology