プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Alan N.に依頼

Australia

PhD Neuroscientist | Neuroprotection & Neurodegeneration Expert | Scientific Content & Product Claim Review

プロフィール概要

I am a PhD researcher in neuroscience specializing in neuroprotection and neurodegeneration, with a focus on identifying and evaluating compounds that protect or restore neuronal function in diseases including Alzheimer's, Parkinson's, and glaucoma. I help health and supplement companies build scientific credibility through: - Evidence-based content writing (blog posts, white papers, product pages) - Scientific review of product claims and marketing materials - Formulation guidance based on the latest peer-reviewed research - Translation of complex neuroscience into clear, accessible language My expertise covers neuroprotective compounds including NAD+ precursors (nicotinamide, NMN), PQQ, B vitamins, and metabolic agents —molecules directly relevant to the cognitive health and longevity supplement space. I have 4+ years of scientific project leadership experience and have supervised 6 graduate and undergraduate students. Available for project-based work and ongoing consulting engagements.

専門分野

• ☆ Neuroscience
• ☆ Neurochemistry
• ☆ Visual Neuroscience
• ☆ Drug Discovery
• ☆ Drug Target Identification
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Biosafety Testing
• ☆ Bioanalytical Testing
• ☆ Drug Stability Testing
• ☆ Preclinical ADME/PK/PD
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology

サービス

• Writing
• Research
• Data & AI

Writing Medical Writing, Technical Writing, Copywriting

Research Scientific and Technical Research, Systematic Literature Review

Data & AI Statistical Analysis, Image Analysis

職務経験

PhD student

CERA

4月 2025 - 現在

学歴

PhD | Neuroscience

Karolinska Institute Stockholm - Sweden

4月 2025 - 4月 2026

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Alan Nicol, Petra Cuřínová, Melissa Jöe, Filip Cesar, Kristián Schwan, Michal Kohout, Carmine Varrichio, Aljona Saleh, Craig E. Wheelock, Gauti Jóhannesson, et al. (2026). Potent Neuronal Nicotinamide Adenine Dinucleotide-Boosting Tetrahydroquinoxalines: Structure–Activity Relationships and Early Drug Metabolism and Pharmacokinetics Evaluation . ACS Medicinal Chemistry Letters.

Alan Nicol, Emma Lardner, Gustav Stålhammar, Sebastian A. Lewandowski, James R. Tribble, Pete A. Williams (2026). SPP1 is Reduced in the Human Retina and Optic Nerve During Glaucoma Pathogenesis . The American Journal of Pathology.

Alan Nicol, Zaynab A. Mouhammad, James R. Tribble, Evgenia Andreopoulou, Mariana Y. García-Bermúdez, Blanca I. Aldana, Rupali Vohra, Miriam Kolko, Pete A. Williams (2026). Semaglutide Protects Retinal Ganglion Cells Against Rotenone-Induced Degeneration via Improved Glucose Metabolism . Investigative Ophthalmology & Visual Science.

Alan Nicol, Sai Kocherlakota, Filippo Locri, Karin J. Stebbins, Daniel S. Lorrain, James R. Tribble, Pete A. Williams (2026). Pharmacological Blockade of LPAR1 Does Not Provide Neuroprotection in a Rat Model of Ocular Hypertensive Glaucoma . Translational Vision Science & Technology.

Alan Nicol, Steffi M. Jonk, Vicki Chrysostomou, Emma Lardner, Shu-Che Yu, Gustav Stålhammar, Jonathan G. Crowston, James R. Tribble, Peter Swoboda, Pete A. Williams (2025). Metabolic analysis of sarcopenic muscle identifies positive modulators of longevity and healthspan in C. elegans . Redox Biology.

Alan Nicol, James R. Tribble, Vickie H.Y. Wong, Kelsey V. Stuart, Glyn Chidlow, Anne Rombaut, Alessandro Rabiolo, Anh Hoang, Pei Ying Lee, Carola Rutigliani, et al. (2025). Dysfunctional one-carbon metabolism identifies vitamins B6, B9, B12, and choline as neuroprotective in glaucoma . Cell Reports Medicine.

Alan Nicol, Aurélia Mouret, Constance Choquel, Aubin Thibault de Chanvalon, Florian Cesbron, Thierry Jauffrais, Didier Jézéquel, Patrick Launeau, Anthony Barbe, Romain Levrard, et al. (2024). Two-dimensional determination of dissolved manganese in sediment porewaters . Marine Chemistry.

Alan Nicol, Anne Rombaut, Danica Jovancevic, Raymond Ching-Bong Wong, Rune Brautaset, David I. Finkelstein, Christine T. O. Nguyen, James R. Tribble, Pete A. Williams (2024). Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection . Acta Neuropathologica Communications.

Alan Nicol, José M. León Ninin, E. Marie Muehe, Angelika Kölbl, Alejandra Higa Mori, Ben Gilfedder, Johanna Pausch, Livia Urbanski, Tillmann Lueders, Britta Planer-Friedrich (2024). Changes in arsenic mobility and speciation across a 2000-year-old paddy soil chronosequence . Science of The Total Environment.

Alan Nicol, Chun Qing, Ping Li, Britta Planer-Friedrich, Changguo Yuan, Zhu Kou (2023). Different sulfide to arsenic ratios driving arsenic speciation and microbial community interactions in two alkaline hot springs . Environmental Research.

PREPRINT

Alan Nicol, Maeve Long, James Tribble, Rahul Upadhyay, Alice Eddershaw, Nicholas D. D'Arcy-Evans, Sara Cano-Franco, Emma Scaletti Hutchinson, Alicia del Prado, Hannah Stigsdotter, et al. (2025). Mitochondria-Directed OGG1 Organocatalytic Switches Restore Organelle Function Under Oxidative Stress .

DATA SET

Hanna Grimm(2024). Arsenic immobilization and greenhouse gas emission depend on quantity and frequency of nitrogen fertilization in paddy soil . Zenodo