プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Alessandra D.に依頼

Italy

Professor | Clinical Biochemistry | Translational Research | Cancer | Diagnostics & Biomarker Consultant

プロフィール概要

I am a Professor of Clinical Biochemistry at Roma Tre University (Italy) with over 20 years of experience in biomedical research, molecular and cellular biochemistry, and translational medicine. I have authored more than 120 peer-reviewed publications and have been recognized among Elsevier's Top 2% Most Influential Scientists. My research spans academia, international collaborations, and industry-funded projects, with a strong focus on translating fundamental discoveries into biomedical and diagnostic applications. I provide scientific consulting to biotechnology, pharmaceutical, diagnostics, and healthcare companies in areas including biomarker discovery and validation, cancer biology, molecular mechanisms of disease, laboratory medicine, experimental design, data interpretation, and scientific strategy. My expertise includes cancer research, particularly DNA damage response, genome stability, acute promyelocytic leukemia, cancer metabolism, and molecular mechanisms underlying tumor development and therapeutic response. I also have extensive experience in human serum albumin biology, innate immunity, host-pathogen interactions, redox biology, oxidative stress, and the development of innovative diagnostic and biotechnological applications, including biosensors and drug delivery systems. I regularly collaborate with multidisciplinary teams and support clients with research planning, critical literature reviews, scientific and medical writing, manuscript editing, grant proposals, peer review, and the interpretation of complex experimental data. My experience as Principal Investigator of competitive research projects and as Associate Editor and reviewer for leading international journals allows me to provide rigorous, evidence-based scientific advice. Whether you need support in early-stage research, biomarker development, translational oncology, laboratory diagnostics, scientific publications, or research funding applications, I can provide reliable, high-quality expertise tailored to your project's objectives. I welcome collaborations with biotechnology companies, pharmaceutical and diagnostics industries, research organizations, start-ups, and academic institutions worldwide.

専門分野

• ☆ Biochemistry
• ☆ Biochemical Assays
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Antioxidants
• ☆ Enzyme Activity Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ Omics
• ☆ Transcriptomics
• ☆ Proteomics
• ☆ Metabolomics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ Microinjection
• ☆ Mutagenesis
• ☆ Recombinant DNA
• ☆ Plasmid DNA
• ☆ DNA Damage & Repair
• ☆ Kinases
• ☆ Monoclonal Antibody Production
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Nutrition Science
• ☆ Biomarker Discovery
• ☆ Biosensors
• ☆ Chemical Biology
• ☆ Biomolecular Engineering
• ☆ Protein/Enzyme Engineering
• ☆ Antibody Engineering
• ☆ Gene Delivery
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Human Biology
• ☆ Hematology
• ☆ Hematology-Oncology
• ☆ Leukemia & Lymphoma
• ☆ Clinical Laboratory Science
• ☆ Clinical Biochemistry
• ☆ Medical Sciences
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Carcinogenesis

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing, Technical Writing, Business & Legal Writing, Copywriting, Newswriting, Audio Transcription, General Proofreading & Editing, Translation

Research Feasibility Study, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Image Processing, Image Analysis, Data Visualization, Text Mining & Analytics, Data Mining, Data Cleaning

職務経験

Associate Professor

Roma Tre University

- 現在

Docenti di ruolo di IIa fascia

Universita' degli Studi Roma Tre

11月 2021 - 現在

Ricercatori

Universita' degli Studi Roma Tre

1月 2013 - 10月 2021

Assegnisti

Universita' degli Studi Roma Tre

7月 2008 - 12月 2008

Assegnisti

Universita' degli Studi Roma Tre

7月 2006 - 6月 2008

Personale esterno ed autonomi

Universita' degli Studi Roma Tre

11月 2005 - 6月 2006

Personale esterno ed autonomi

Universita' degli Studi Roma Tre

11月 2003 - 10月 2005

学歴

PhD in Biology

Roma Tre University

1月 2000 - 1月 2003

認定資格

• Theoretical and Practical Certification in the Use of the Zebrafish Animal Model for Studies Applied to Human Health

  University of Naples "Federico II" and the Experimental Zooprophylactic Institute (Italy)

  8月 2021 - 現在

出版物

JOURNAL ARTICLE

Scarinci, F. and De Simone, G. and Coco, G. and Caggiano, C. and Pocobelli, G. and Boselli, F. and Di Masi, A(2026). CROSS-LINKED CARBOXYMETHYL CELLULOSE AND SILK PROTEINS FOR DRY EYE DISEASE MANAGEMENT AND CORNEAL WOUND HEALING: IN VIVO AND IN VITRO RESULTS . EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. (2).

Franza, M., Melfi, A., Acconcia, F., di Masi, A.(2026). CHK1 as a Metabolic and Immunological Regulator: Implications for Cancer Therapy . Oncology Research. 34. (6).

Scarinci, F., de Simone, G., Coco, G., Caggiano, C., Pocobelli, G., Boselli, F., Di Masi, A.(2026). CROSS-LINKED CARBOXYMETHYL CELLULOSE AND SILK PROTEINS FOR DRY EYE DISEASE MANAGEMENT AND CORNEAL WOUND HEALING: IN VIVO AND IN VITRO RESULTS . European Review for Medical and Pharmacological Sciences. 30. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 62-70.

Alessandra Di Masi, Elena Hardt, Romualdo Varricchio, Carlos Alvarado Chavarin, Giovanna De Simone, Oliver Skibitzki, Paolo Ascenzi, Giovanni Capellini (2025). Sensing of Hemin Binding to Albumin Using Ge-Based Plasmonic Antennas Operating in the THz Range . IEEE Sensors Journal.

Alessandra Di Masi, Fabio Scarinci, Giovanna De Simone, Chiara Ciancimino, Claudio Caggiano, Giulio Pocobelli (2025). Enhancing Corneal Sensitivity in Diabetic Patients Through an Innovative Ophthalmic Solution: In Vivo and Vitro Results . Journal of Clinical Medicine.

Hardt, Elena and Varricchio, Romualdo and Chavarin, Carlos A. and Simone, Giovanna De and Skibitzki, Oliver and Ascenzi, Paolo and Di Masi, Alessandra and Capellini, Giovanni(2025). Sensing of hemin binding to albumin using Gebased plasmonic antennas operating in the THz range . IEEE SENSORS JOURNAL. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--1.

Scarinci, Fabio and De Simone, Giovanna and Ciancimino, Chiara and Caggiano, Claudio and Pocobelli, Giulio and Di Masi, Alessandra(2025). Enhancing Corneal Sensitivity in Diabetic Patients Through an Innovative Ophthalmic Solution: In Vivo and Vitro Results . JOURNAL OF CLINICAL MEDICINE. 14. (1).

Di Gioacchino, Michael and Verri, Martina and Naciu, Anda Mihaela and Paolucci, Alessio and di Masi, Alessandra and Taffon, Chiara and Palermo, Andrea and Crescenzi, Anna and Ricci, Maria Antonietta and Sodo, Armida(2025). Could Raman spectroscopy investigate the changes of cell oxidative stress status in thyroid diseases? A pilot study on cytological samples . SPECTROCHIMICA ACTA. PART A, MOLECULAR AND BIOMOLECULAR SPECTROSCOPY. 326.

De Simone, Giovanna and Di Masi, Alessandra and Tundo, Grazia R. and Messias, Andresa and Estrin, Dario A. and Coletta, Massimo and Ascenzi, Paolo(2025). Proteins and Carbon Dioxide Struggle Against Peroxynitrite . BIOFACTORS. 51. (4).

Fardelli, Elisa and De Simone, Giovanna and Georgieva, Radostina and Xiong, Yu and Di Gioacchino, Michael and Sotgiu, Simone and Nucara, Alessandro and Tavella, Angelo and Baldassarre, Leonetta and Sodo, Armida and Ricci, Agnese and Gasperi, Tecla and Ascenzi, Paolo and Bäumler, Hans and Di Masi, Alessandra and Capellini, Giovanni(2025). Structural Instability of Human Serum Albumin during Microparticles Synthesis . ACS APPLIED BIO MATERIALS.

Alessandra Di Masi, Fabio Scarinci, Giovanna De Simone, Chiara Ciancimino, Claudio Caggiano, Giulio Pocobelli (2025). Enhancing Corneal Sensitivity in Diabetic Patients Through an Innovative Ophthalmic Solution: In Vivo and Vitro Results . Journal of Clinical Medicine.

Scarinci, F., De Simone, G., Ciancimino, C., Caggiano, C., Pocobelli, G., Di Masi, A.(2025). Enhancing Corneal Sensitivity in Diabetic Patients Through an Innovative Ophthalmic Solution: In Vivo and Vitro Results . Journal of Clinical Medicine. 14. (1).

Hardt, E., Varricchio, R., Chavarin, C.A., De Simone, G., Skibitzki, O., Ascenzi, P., Di Masi, A., Capellini, G.(2025). Sensing of Hemin Binding to Albumin Using Ge-Based Plasmonic Antennas Operating in the THz Range . IEEE Sensors Journal. 25. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12881-12890.

Fardelli, E., De Simone, G., Georgieva, R., Xiong, Y., Di Gioacchino, M., Sotgiu, S., Nucara, A., Tavella, A., Baldassarre, L., Sodo, A., et al.(2025). Structural Instability of Human Serum Albumin during Microparticles Synthesis . ACS Applied Bio Materials. 8. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9907-9915.

De Simone, G., di Masi, A., Tundo, G.R., Messias, A., Estrin, D.A., Coletta, M., Ascenzi, P.(2025). Proteins and Carbon Dioxide Struggle Against Peroxynitrite . Biofactors. 51. (4).

Di Gioacchino, M., Verri, M., Naciu, A.M., Paolucci, A., di Masi, A., Taffon, C., Palermo, A., Crescenzi, A., Ricci, M.A., Sodo, A.(2025). Could Raman spectroscopy investigate the changes of cell oxidative stress status in thyroid diseases? A pilot study on cytological samples . Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy. 326.

Di Bella, S., Marini, B., Stroffolini, G., Geremia, N., Giacobbe, D.R., Campanile, F., Bartoletti, M., Alloisio, G., Di Risio, L., Viglietti, G., et al.(2025). The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications . European Journal of Clinical Microbiology and Infectious Diseases. 44. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1797-1816.

Alessandra di Masi, Maria Franza, Romualdo Varricchio, Giulia Alloisio, Giovanna De Simone, Stefano Di Bella, Paolo Ascenzi (2024). Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases . International Journal of Molecular Sciences.

Alessandra di Masi, Maria Franza, Romualdo Varricchio, Giulia Alloisio, Giovanna De Simone, Stefano Di Bella, Paolo Ascenzi (2024). Zebrafish (<i>Danio rerio</i>) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases . International Journal of Molecular Sciences.

Alessandra di Masi, Giovanna De Simone, Diego Sbardella, Paolo Ascenzi, Massimiliano Coletta (2024). Nitric Oxide Binding Geometry in Heme-Proteins: Relevance for Signal Transduction . Antioxidants.

Alessandra di Masi, Giovanna De Simone, Diego Sbardella, Paolo Ascenzi, Massimiliano Coletta (2024). Nitric Oxide Binding Geometry in Heme-Proteins: Relevance for Signal Transduction . Antioxidants.

De Simone, Giovanna and di Masi, Alessandra and Pasquadibisceglie, Andrea and Coletta, Andrea and Sebastiani, Federico and Smulevich, Giulietta and Coletta, Massimo and Ascenzi, Paolo(2024). Nitrobindin versus myoglobin: A comparative structural and functional study . JOURNAL OF INORGANIC BIOCHEMISTRY. 250.

Franza, Maria and Varricchio, Romualdo and Alloisio, Giulia and De Simone, Giovanna and Di Bella, Stefano and Ascenzi, Paolo and di Masi, Alessandra(2024). Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25. (22).

Varricchio, R. and De Simone, G. and Vita, G. M. and Nocera Cariola, W and Viscardi, M. and Brandi, S. and Picazio, G. and Zerbato, V. and Koncan, R. and Segat, L. and Di Bella, S. and Fusco, G. and Ascenzi, P. and Di Masi, A.(2024). Human serum albumin binds spike protein and protects cells from SARS-CoV-2 infection by modulating the RAS pathway . ASPECTS OF MOLECULAR MEDICINE.

De Simone, Giovanna and di Masi, Alessandra and Sbardella, Diego and Ascenzi, Paolo and Coletta, Massimiliano(2024). Nitric Oxide Binding Geometry in Heme-Proteins: Relevance for Signal Transduction . ANTIOXIDANTS. 13. (6).

Quantifying pH-induced changes in plasma strong ion difference during experimental acidosis: clinical implications for base excess interpretation @article{ 11590_469087, author = {Giosa, Lorenzo and Zadek, Francesco and Busana, Mattia and De Simone, Giovanna and Brusatori, Serena and Krbec, Martin and Duška, František and Brambilla, Paolo and Zanella, Alberto and Di Masi, Alessandra and Caironi, Pietro and Perez, Emanuele and Gattinoni, Luciano and Langer, Thomas}, title = {Quantifying pH-induced changes in plasma strong ion difference during experimental acidosis: clinical implications for base excess interpretation}, year = {2024}, journal = {JOURNAL OF APPLIED PHYSIOLOGY}, abstract = {It is commonly assumed that changes in plasma strong ion difference (SID) result in equal changes in whole-blood base excess (BE). However, at varying pH, albumin ionic-binding and transerythrocyte shifts alter the SID of plasma without affecting that of whole-blood (SIDwb), i.e., the BE. We hypothesize that, during acidosis, 1) an expected plasma SID (SIDexp) reflecting electrolytes redistribution can be predicted from albumin and hemoglobin's charges, and 2) only deviations in SID from SIDexp reflect changes in SIDwb, and therefore, BE. We equilibrated whole-blood of 18 healthy subjects (albumin=4.8±0.2 g/dL, hemoglobin=14.2±0.9 g/dL), 18 hypoalbuminemic and anemic septic patients (albumin=3.1±0.5 g/dL, hemoglobin=10.4±0.8 g/dL), and 10 healthy subjects after in-vitro induced isolated anemia (albumin=5.0±0.2 g/dL, hemoglobin=7.0±0.9 g/dL) with varying CO2 concentrations (2-20%). Plasma SID increased by 12.7±2.1, 9.3±1.7, and 7.8±1.6 mEq/L, respectively (p&lt;0.01) and its agreement (bias[limits of agreement]) with SIDexp was strong: 0.5[-1.9;2.8], 0.9[-0.9;2.6], and 0.3[-1.4;2.1] mEq/L, respectively. Separately, we added 7.5 or 15 mEq/L of lactic or hydrochloric acid to whole-blood of 10 healthy subjects obtaining BE of -6.6±1.7, -13.4±2.2, -6.8±1.8, and -13.6±2.1 mEq/L, respectively. The agreement between ∆BE and ∆SID was weak (2.6[-1.1;6.3] mEq/L), worsening with varying CO2 (2-20%): 6.3[-2.7;15.2] mEq/L. Conversely, ∆SIDwb (the deviation of SID from SIDexp) agreed strongly with ∆BE at both constant and varying CO2: -0.1[-2.0;1.7], and -0.5[-2.4;1.5] mEq/L, respectively. We conclude that BE reflects only changes in plasma SID that are not expected from electrolytes redistribution, the latter being predictable from albumin and hemoglobin's charges.}, keywords = {Albumin; Hemoglobin; Non-carbonic whole-blood buffer value; Plasma strong ion difference; Whole-blood base-excess}, doi = {10.1152/japplphysiol.00917.2023}, number = {4} } .

De Simone, G., di Masi, A., Sbardella, D., Ascenzi, P., Coletta, M.(2024). Nitric Oxide Binding Geometry in Heme-Proteins: Relevance for Signal Transduction . Antioxidants. 13. (6).

Varricchio, R., De Simone, G., Vita, G.M., Nocera Cariola, W., Viscardi, M., Brandi, S., Picazio, G., Zerbato, V., Koncan, R., Segat, L., et al.(2024). Human serum albumin binds spike protein and protects cells from SARS-CoV-2 infection by modulating the RAS pathway . Aspects of Molecular Medicine. 3.

Franza, M., Varricchio, R., Alloisio, G., De Simone, G., Di Bella, S., Ascenzi, P., di Masi, A.(2024). Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases . International Journal of Molecular Sciences. 25. (22).

Giosa, L., Zadek, F., Busana, M., De Simone, G., Brusatori, S., Krbec, M., Duska, F., Brambilla, P., Zanella, A., Masi, A.D., et al.(2024). Quantifying pH-induced changes in plasma strong ion difference during experimental acidosis: clinical implications for base excess interpretation . Journal of Applied Physiology. 136. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 966-976.

De Simone, G., di Masi, A., Pasquadibisceglie, A., Coletta, A., Sebastiani, F., Smulevich, G., Coletta, M., Ascenzi, P.(2024). Nitrobindin versus myoglobin: A comparative structural and functional study . Journal of Inorganic Biochemistry. 250.

Alessandra di Masi, Giovanna De Simone, Romualdo Varricchio, Tommaso Francesco Ruberto, Paolo Ascenzi (2023). Heme Scavenging and Delivery: The Role of Human Serum Albumin . Biomolecules.

Alessandra di Masi, Giovanna De Simone, Grazia R. Tundo, Massimo Coletta, Paolo Ascenzi (2023). Nitrite Reductase Activity of Ferrous Nitrobindins: A Comparative Study . International Journal of Molecular Sciences.

Alessandra di Masi, Giovanna De Simone, Romualdo Varricchio, Tommaso Francesco Ruberto, Paolo Ascenzi (2023). Heme Scavenging and Delivery: The Role of Human Serum Albumin . Biomolecules.

Alessandra di Masi (2023). Human Serum Albumin: From Molecular Aspects to Biotechnological Applications . International Journal of Molecular Sciences.

Alessandra di Masi (2023). Human Serum Albumin: From Molecular Aspects to Biotechnological Applications . International Journal of Molecular Sciences.

Alessandra di Masi, Gianfranco Sanson, Amedeo De Nicol&#242;, Verena Zerbato, Ludovica Segat, Raffaella Koncan, Stefano Di Bella, Jessica Cusato, Andrea Palermo, Pietro Caironi, et al. (2023). A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in COVID-19 patients . Irish Journal of Medical Science (1971 -).

di masi, A(2023). Human Serum Albumin: From Molecular Aspects to Biotechnological Applications . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. (4).

De Simone, G and di Masi, A and Ascenzi, P(2023). Nitrite Reductase Activity of Ferrous Nitrobindins: A Comparative Study . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. (7).

Franza, Maria and Albanesi, Jacopo and Mancini, Benedetta and Pennisi, Rosa and Leone, Stefano and Acconcia, Filippo and Bianchi, Fabrizio and di Masi, Alessandra(2023). The clinically relevant CHK1 inhibitor MK-8776 induces the degradation of the oncogenic protein PML-RARα and overcomes ATRA resistance in acute promyelocytic leukemia cells . BIOCHEMICAL PHARMACOLOGY. 214.

De Simone, G and Varricchio, R and Ruberto, Tf and di Masi, A and Ascenzi, P(2023). Heme Scavenging and Delivery: The Role of Human Serum Albumin . BIOMOLECULES. (3).

Sanson, Gianfranco and De Nicolò, Amedeo and Zerbato, Verena and Segat, Ludovica and Koncan, Raffaella and Di Bella, Stefano and Cusato, Jessica and di Masi, Alessandra and Palermo, Andrea and Caironi, Pietro and D'Agaro, Pierlanfranco and Luzzati, Roberto and D'Avolio, Antonio(2023). A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in COVID-19 patients . IRISH JOURNAL OF MEDICAL SCIENCE. (1).

De Santis, Serena and Varricchio, Romualdo and Ceccucci, Anita and Sotgiu, Giovanni and Di Masi, Alessandra and Magna, Gabriele and Sennato, Simona and Orsini, Monica(2023). Cerium Coatings on Pristine and Nanostructured Ti and Ti6Al4V Surfaces: Bioactivity, Resistance in Simulated Inflammatory Conditions, and Antibacterial Performance . ACS BIOMATERIALS SCIENCE & ENGINEERING. 9. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3262--3272.

Sanson, G., De Nicol&#242;, A., Zerbato, V., Segat, L., Koncan, R., Di Bella, S., Cusato, J., di Masi, A., Palermo, A., Caironi, P., et al.(2023). A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in COVID-19 patients . Irish Journal of Medical Science. 192. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 423-430.

De Santis, S., Varricchio, R., Ceccucci, A., Sotgiu, G., Di Masi, A., Magna, G., Sennato, S., Orsini, M.(2023). Cerium Coatings on Pristine and Nanostructured Ti and Ti6Al4V Surfaces: Bioactivity, Resistance in Simulated Inflammatory Conditions, and Antibacterial Performance . ACS Biomaterials Science and Engineering. 9. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3262-3272.

De Simone, G., Varricchio, R., Ruberto, T.F., di Masi, A., Ascenzi, P.(2023). Heme Scavenging and Delivery: The Role of Human Serum Albumin . Biomolecules. 13. (3).

di Masi, A.(2023). Human Serum Albumin: From Molecular Aspects to Biotechnological Applications . International Journal of Molecular Sciences. 24. (4).

Franza, M., Albanesi, J., Mancini, B., Pennisi, R., Leone, S., Acconcia, F., Bianchi, F., di Masi, A.(2023). The clinically relevant CHK1 inhibitor MK-8776 induces the degradation of the oncogenic protein PML-RARα and overcomes ATRA resistance in acute promyelocytic leukemia cells . Biochemical Pharmacology. 214.

De Simone, G., di Masi, A., Tundo, G.R., Coletta, M., Ascenzi, P.(2023). Nitrite Reductase Activity of Ferrous Nitrobindins: A Comparative Study . International Journal of Molecular Sciences. 24. (7).

Strategies of Pathogens to Escape from NO-Based Host Defense <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Antioxidants.

Alessandra di Masi, Giovanna De Simone, Paolo Ascenzi (2022). Strategies of Pathogens to Escape from NO-Based Host Defense . Antioxidants.

The Balancing of Peroxynitrite Detoxification between Ferric Heme-Proteins and CO2: The Case of Zebrafish Nitrobindin <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Antioxidants.

Alessandra di Masi, Gian Marco Vita, Giovanna De Simone, Elisabetta De Marinis, Clara Nervi, Paolo Ascenzi (2022). Serum albumin and nucleic acids biodistribution: From molecular aspects to biotechnological applications . IUBMB Life.

Alessandra di Masi, Giovanna De Simone, Andrea Coletta, Massimo Coletta, Paolo Ascenzi (2022). The Balancing of Peroxynitrite Detoxification between Ferric Heme-Proteins and CO₂: The Case of Zebrafish Nitrobindin . Antioxidants.

Alessandra di Masi, Rosario Luigi Sessa, Ylenia Cerrato, Gianni Pastore, Barbara Guantario, Roberto Ambra, Michael Di Gioacchino, Armida Sodo, Martina Verri, Pierfilippo Crucitti, et al. (2022). Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma . Antioxidants.

Alessandra di Masi, Rosario Luigi Sessa, Ylenia Cerrato, Gianni Pastore, Barbara Guantario, Roberto Ambra, Michael Di Gioacchino, Armida Sodo, Martina Verri, Pierfilippo Crucitti, et al. (2022). Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma . Antioxidants.

Alessandra di Masi, Verena Zerbato, Gianfranco Sanson, Marina De Luca, Stefano Di Bella, Pietro Caironi, Bruna Marini, Rudy Ippodrino, Roberto Luzzati(2022). The Impact of Serum Albumin Levels on COVID-19 Mortality . Infectious Disease Reports. 14. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 278--286. {MDPI} {AG}

Alessandra di Masi, Verena Zerbato, Gianfranco Sanson, Marina De Luca, Stefano Di Bella, Pietro Caironi, Bruna Marini, Rudy Ippodrino, Roberto Luzzati (2022). The Impact of Serum Albumin Levels on COVID-19 Mortality . Infectious Disease Reports.

Alessandra di Masi, Giovanna De Simone, Andrea Pasquadibisceglie, Fabio Polticelli, Paolo Ascenzi(2022). Haptoglobin and the related haptoglobin protein: the N-terminus makes the difference . Journal of Biomolecular Structure and Dynamics. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--10. Informa {UK} Limited

Colangelo, Tommaso and Carbone, Annalucia and Mazzarelli, Francesco and Cuttano, Roberto and Dama, Elisa and Nittoli, Teresa and Albanesi, Jacopo and Barisciano, Giovannina and Forte, Nicola and Palumbo, Orazio and Graziano, Paolo and Di Masi, Alessandra and Colantuoni, Vittorio and Sabatino, Lina and Bianchi, Fabrizio and Mazzoccoli, Gianluigi(2022). Loss of circadian gene Timeless induces EMT and tumor progression in colorectal cancer via Zeb1-dependent mechanism . CELL DEATH AND DIFFERENTIATION. (8).

Palermo, A and Sodo, A and Naciu, Am and Di Gioacchino, M and Paolucci, A and di Masi, A and Maggi, D and Crucitti, P and Longo, F and Perrella, E and Taffon, C and Verri, M and Ricci, Ma and Crescenzi, A(2022). Clinical Use of Raman Spectroscopy Improves Diagnostic Accuracy for Indeterminate Thyroid Nodules . THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. 107. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3309--3319.

Schiavi, Sara and Carbone, Emilia and Melancia, Francesca and di Masi, Alessandra and Jarjat, Marielle and Brau, Fréderic and Cardarelli, Silvia and Giorgi, Mauro and Bardoni, Barbara and Trezza, Viviana(2022). Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder . TRANSLATIONAL PSYCHIATRY. 12. (1).

Hardt, Elena and Chavarin, Carlos Alvarado and Gruessing, Soenke and Flesch, Julia and Skibitzki, Oliver and Spirito, Davide and Vita, Gian Marco and Simone, Giovanna De and Masi, Alessandra di and You, Changjiang and Witzigmann, Bernd and Piehler, Jacob and Capellini, Giovanni(2022). Quantitative protein sensing with germanium THz-antennas manufactured using CMOS processes . OPTICS EXPRESS. 30. (22). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 40265--40276.

Rashid, Saqib and Marco Vita, Gian and Persichetti, Luca and Iucci, Giovanna and Battocchio, Chiara and Daniel, Rostislav and Visaggio, Daniela and Marsotto, Martina and Visca, Paolo and Bemporad, Edoardo and Ascenzi, Paolo and Capellini, Giovanni and Sebastiani, Marco and di Masi, Alessandra(2022). Biocompatibility and antibacterial properties of TiCu(Ag) thin films produced by physical vapor deposition magnetron sputtering . APPLIED SURFACE SCIENCE. 573.

Zerbato, Verena and Sanson, Gianfranco and De Luca, Marina and Di Bella, Stefano and di Masi, Alessandra and Caironi, Pietro and Marini, Bruna and Ippodrino, Rudy and Luzzati, Roberto(2022). The Impact of Serum Albumin Levels on COVID-19 Mortality . INFECTIOUS DISEASE REPORTS. 14. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 278--286.

di Masi, Alessandra and Sessa, Rosario Luigi and Cerrato, Ylenia and Pastore, Gianni and Guantario, Barbara and Ambra, Roberto and Di Gioacchino, Michael and Sodo, Armida and Verri, Martina and Crucitti, Pierfilippo and Longo, Filippo and Naciu, Anda Mihaela and Palermo, Andrea and Taffon, Chiara and Acconcia, Filippo and Bianchi, Fabrizio and Ascenzi, Paolo and Ricci, Maria Antonietta and Crescenzi, Anna(2022). Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma . ANTIOXIDANTS. 11. (8).

Vita, Gm and De Simone, G and De Marinis, E and Nervi, C and Ascenzi, P and di Masi, A(2022). Serum albumin and nucleic acids biodistribution: From molecular aspects to biotechnological applications . IUBMB LIFE. 74. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 866--879.

De Simone, Giovanna and di Masi, Alessandra and Ascenzi, Paolo(2022). Strategies of Pathogens to Escape from NO-Based Host Defense . ANTIOXIDANTS. 11. (11).

De Simone, Giovanna and Coletta, Andrea and di Masi, Alessandra and Coletta, Massimo and Ascenzi, Paolo(2022). The Balancing of Peroxynitrite Detoxification between Ferric Heme-Proteins and CO2: The Case of Zebrafish Nitrobindin . ANTIOXIDANTS. 11. (10).

De Simone, G. and Quattrocchi, A. and Mancini, B. and Di Masi, A. and Nervi, C. and Ascenzi, P.(2022). Thalassemias: from gene to therapy . MOLECULAR ASPECTS OF MEDICINE. 84.

Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells @article{ 11590_403059, author = {Pescatori, Sara and Leone, Stefano and Cipolletti, Manuela and Bartoloni, Stefania and DI MASI, Alessandra and Acconcia, Filippo}, title = {Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells}, year = {2022}, journal = {JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH}, abstract = {Background Challenges exist in the clinical treatment of luminal estrogen receptor α (ERα)-positive breast cancers (BCs) both to prevent resistance to endocrine therapy (ET) and to treat ET-resistant metastatic BCs (MBC). Therefore, we evaluated if kinases could be new targets for the treatment of luminal primary and MBCs. Methods  ~ 170 kinase inhibitors were applied to MCF-7 cells either with adaptative or genetic resistance to ET drugs and both ERα levels and cell proliferation were measured. Robust-Z-score calculation identified AZD7762 (CHK1/CHK2 inhibitor) as a positive hit. Subsequently, Kaplan–Meier analyses of CHK1 and CHK2 impact on ERα-positive BC patients relapse-free-survival (RFS), bioinformatic evaluations of CHK1 and CHK2 expression and activation status as a function of ERα activation status as well as drug sensitivity studies in ERα-positive BC cell lines, validation of the impact of the ATR:CHK1 and ATM:CHK2 pathways on the control of ERα stability and BC cell proliferation via inhibitor- and siRNA-based approaches, identification of the molecular mechanism required for inhibitor-dependent ERα degradation in BC and the impact of CHK1 and CHK2 inhibition on the 17β-estradiol (E2):ERα signaling, synergy proliferation studies between ET-drugs and clinically relevant CHK1 inhibitors in different luminal BC cell lines, were performed. Results A reduced CHK1 expression correlates with a longer RFS in women with ERα-positive BCs. Interestingly, women carrying luminal A BC display an extended RFS when expressing low CHK1 levels. Accordingly, CHK1 and ERα activations are correlated in ERα-positive BC cell lines, and the ATR:CHK1 pathway controls ERα stability and cell proliferation in luminal A BC cells. Mechanistically, the generation of DNA replication stress rather than DNA damage induced by ATR:CHK1 pathway inhibition is a prerequisite for ERα degradation. Furthermore, CHK1 inhibition interferes with E2:ERα signaling to cell proliferation, and drugs approved for clinical treatment of primary and MBC (4OH-tamoxifen and the CDK4/CDK6 inhibitors abemaciclib and palbociclib) exert synergic effects with the CHK1 inhibitors in clinical trials for the treatment of solid tumors (AZD7762, MK8776, prexasertib) in preventing the proliferation of cells modeling primary and MBC. Conclusions CHK1 could be considered as an appealing novel pharmacological target for the treatment of luminal primary and MBCs.}, doi = {10.1186/s13046-022-02360-y}, number = {1} } .

De Simone, G., Quattrocchi, A., Mancini, B., di Masi, A., Nervi, C., Ascenzi, P.(2022). Thalassemias: from gene to therapy . Molecular Aspects of Medicine. 84.

De Simone, G., di Masi, A., Ascenzi, P.(2022). Strategies of Pathogens to Escape from NO-Based Host Defense . Antioxidants. 11. (11).

di Masi, A., Sessa, R.L., Cerrato, Y., Pastore, G., Guantario, B., Ambra, R., Di Gioacchino, M., Sodo, A., Verri, M., Crucitti, P., et al.(2022). Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma . Antioxidants. 11. (8).

Zerbato, V., Sanson, G., De Luca, M., Bella, S.D., Di Masi, A., Caironi, P., Marini, B., Ippodrino, R., Luzzati, R.(2022). The Impact of Serum Albumin Levels on COVID-19 Mortality . Infectious Disease Reports. 14. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 278-286.

Palermo, A., Sodo, A., Naciu, A.M., Di Gioacchino, M., Paolucci, A., Di Masi, A., Maggi, D., Crucitti, P., Longo, F., Perrella, E., et al.(2022). Clinical Use of Raman Spectroscopy Improves Diagnostic Accuracy for Indeterminate Thyroid Nodules . Journal of Clinical Endocrinology and Metabolism. 107. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3309-3319.

Rashid, S., Vita, G.M., Persichetti, L., Iucci, G., Battocchio, C., Daniel, R., Visaggio, D., Marsotto, M., Visca, P., Bemporad, E., et al.(2022). Biocompatibility and antibacterial properties of TiCu(Ag) thin films produced by physical vapor deposition magnetron sputtering . Applied Surface Science. 573.

Vita, G.M., De Simone, G., De Marinis, E., Nervi, C., Ascenzi, P., di Masi, A.(2022). Serum albumin and nucleic acids biodistribution: From molecular aspects to biotechnological applications . IUBMB Life. 74. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 866-879.

De Simone, G., Pasquadibisceglie, A., Polticelli, F., di Masi, A., Ascenzi, P.(2022). Haptoglobin and the related haptoglobin protein: the N-terminus makes the difference . Journal of Biomolecular Structure and Dynamics. 40. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2244-2253.

Hardt, E., Chavarin, C.A., Gruessing, S., Flesch, J., Skibitzki, O., Spirito, D., Vita, G.M., Simone, G.D.E., Masi, A.D.I., You, C., et al.(2022). Quantitative protein sensing with germanium THz-antennas manufactured using CMOS processes . Optics Express. 30. (22). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 40265-40276.

Schiavi, S., Carbone, E., Melancia, F., di Masi, A., Jarjat, M., Brau, F., Cardarelli, S., Giorgi, M., Bardoni, B., Trezza, V.(2022). Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder . Translational Psychiatry. 12. (1).

Pescatori, S., Leone, S., Cipolletti, M., Bartoloni, S., di Masi, A., Acconcia, F.(2022). Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells . Journal of Experimental and Clinical Cancer Research. 41. (1).

Colangelo, T., Carbone, A., Mazzarelli, F., Cuttano, R., Dama, E., Nittoli, T., Albanesi, J., Barisciano, G., Forte, N., Palumbo, O., et al.(2022). Loss of circadian gene Timeless induces EMT and tumor progression in colorectal cancer via Zeb1-dependent mechanism . Cell Death and Differentiation. 29. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1552-1568.

De Simone, G., Coletta, A., di Masi, A., Coletta, M., Ascenzi, P.(2022). The Balancing of Peroxynitrite Detoxification between Ferric Heme-Proteins and CO2: The Case of Zebrafish Nitrobindin . Antioxidants. 11. (10).

Alessandra di Masi, Giovanna De Simone, Paolo Ascenzi(2021). Serum Albumin: A Multifaced Enzyme . International Journal of Molecular Sciences. 22. (18). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 10086. {MDPI} {AG}

Alessandra di Masi, Guido Granata, Davide Mariotti, Paolo Ascenzi, Nicola Petrosillo (2021). High Serum Levels of Toxin A Correlate with Disease Severity in Patients with Clostridioides difficile Infection . Antibiotics.

Alessandra di Masi, Guido Granata, Davide Mariotti, Paolo Ascenzi, Nicola Petrosillo (2021). High Serum Levels of Toxin A Correlate with Disease Severity in Patients with <i>Clostridioides difficile</i> Infection . Antibiotics.

Alessandra di Masi, Giovanna De Simone, Paolo Ascenzi (2021). Serum Albumin: A Multifaced Enzyme . International Journal of Molecular Sciences.

Alessandra di Masi, Sara Pescatori, Francesco Berardinelli, Jacopo Albanesi, Paolo Ascenzi, Maria Marino, Antonio Antoccia, Filippo Acconcia(2021). A Tale of Ice and Fire: The Dual Role for 17β-Estradiol in Balancing DNA Damage and Genome Integrity . Cancers. 13. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1583. {MDPI} {AG}

Alessandra di Masi, Sara Pescatori, Francesco Berardinelli, Jacopo Albanesi, Paolo Ascenzi, Maria Marino, Antonio Antoccia, Filippo Acconcia (2021). A Tale of Ice and Fire: The Dual Role for 17β-Estradiol in Balancing DNA Damage and Genome Integrity . Cancers.

Alessandra di Masi, Giovanna De Simone, Andrea Pasquadibisceglie, Valeria Buzzelli, Viviana Trezza, Gabriele Macari, Fabio Polticelli, Paolo Ascenzi (2021). Binding of direct oral anticoagulants to the FA1 site of human serum albumin . Journal of Molecular Recognition.

Alessandra di Masi, Giovanna De Simone, Alessandra Pesce, Martino Bolognesi, Chiara Ciaccio, Lorenzo Tognaccini, Giulietta Smulevich, Stefania Abbruzzetti, Cristiano Viappiani, Stefano Bruno, et al. (2021). Mycobacterial and Human Ferrous Nitrobindins: Spectroscopic and Reactivity Properties . International Journal of Molecular Sciences.

Alessandra di Masi, Giovanna De Simone, Alessandra Pesce, Martino Bolognesi, Chiara Ciaccio, Lorenzo Tognaccini, Giulietta Smulevich, Stefania Abbruzzetti, Cristiano Viappiani, Stefano Bruno, et al. (2021). Mycobacterial and Human Ferrous Nitrobindins: Spectroscopic and Reactivity Properties . International Journal of Molecular Sciences.

Binding of direct oral anticoagulants to the FA1 site of human serum albumin @article{ 11590_373110, author = {De Simone, Giovanna and Pasquadibisceglie, Andrea and di Masi, Alessandra and Buzzelli, Valeria and Trezza, Viviana and Macari, Gabriele and Polticelli, Fabio and Ascenzi, Paolo and De Simone, Giovanna and Pasquadibisceglie, Andrea and di Masi, Alessandra and Buzzelli, Valeria and Trezza, Viviana and Macari, Gabriele and Polticelli, Fabio and Ascenzi, Paolo}, title = {Binding of direct oral anticoagulants to the FA1 site of human serum albumin}, year = {2021}, journal = {JOURNAL OF MOLECULAR RECOGNITION}, abstract = {The anticoagulant therapy is widely used to prevent and treat thromboembolic events. Until the last decade, vitamin K antagonists were the only available oral anticoagulants; recently, direct oral anticoagulants (DOACs) have been developed. Since 55% to 95% of DOACs are bound to plasma proteins, the in silico docking and ligand-binding properties of drugs apixaban, betrixaban, dabigatran, edoxaban, and rivaroxaban and of the prodrug dabigatran etexilate to human serum albumin (HSA), the most abundant plasma protein, have been investigated. DOACs bind to the fatty acid (FA) site 1 (FA1) of ligand-free HSA, whereas they bind to the FA8 and FA9 sites of heme-Fe(III)- and myristic acid-bound HSA. DOACs binding to the FA1 site of ligand-free HSA has been validated by competitive inhibition of heme-Fe(III) recognition. Values of the dissociation equilibrium constant for DOACs binding to the FA1 site (ie, calc KDOAC ) derived from in silico docking simulations (ranging between 1.2 × 10-8 M and 1.4 × 10-6 M) agree with those determined experimentally from competitive inhibition of heme-Fe(III) binding (ie, exp KDOAC ; ranging between 2.5 × 10-7 M and 2.2 × 10-6 M). In addition, this study highlights the inequivalence of rivaroxaban binding to mammalian serum albumin. Given the HSA concentration in vivo (~7.5 × 10-4 M), values of KDOAC here determined indicate that the formation of the HSA:DOACs complexes in the absence and presence of FAs and heme-Fe(III) may occur in vivo. Therefore, HSA appears to be an important determinant for DOACs transport.}, keywords = {competitive inhibition of heme binding; direct oral anticoagulants; human serum albumin; human serum albumin:direct oral anticoagulant recognition; molecular docking; competitive inhibition of heme binding; direct oral anticoagulants; human serum albumin; human serum albumin:direct oral anticoagulant recognition; molecular docking}, doi = {10.1002/jmr.2877}, number = {3} } .

De Simone, G. and Di Masi, A. and Pesce, A. and Bolognesi, M. and Ciaccio, C. and Tognaccini, L. and Smulevich, G. and Abbruzzetti, S. and Viappiani, C. and Bruno, S. and Della Monaca, S. and Pietraforte, D. and Fattibene, P. and Coletta, M. and Ascenzi, P.(2021). Mycobacterial and human ferrous nitrobindins: Spectroscopic and reactivity properties . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--27.

A Tale of Ice and Fire: The Dual Role for 17beta-Estradiol in Balancing DNA Damage and Genome Integrity @article{ 11590_385825, author = {Pescatori, S and Berardinelli, F and Albanesi, J and Ascenzi, P and Marino, M and Antoccia, A and di Masi, A and Acconcia, F}, title = {A Tale of Ice and Fire: The Dual Role for 17beta-Estradiol in Balancing DNA Damage and Genome Integrity}, year = {2021}, journal = {CANCERS}, abstract = {17beta-estradiol (E2) regulates human physiology both in females and in males. At the same time, E2 acts as a genotoxic substance as it could induce DNA damages, causing the initiation of cellular transformation. Indeed, increased E2 plasma levels are a risk factor for the development of several types of cancers including breast cancer. This paradoxical identity of E2 undermines the foundations of the physiological definition of “hormone” as E2 works both as a homeostatic regulator of body functions and as a genotoxic compound. Here, (i) the molecular circuitries underlying this double face of E2 are reviewed, and (ii) a possible framework to reconcile the intrinsic discrepancies of the E2 function is reported. Indeed, E2 is a regulator of the DNA damage response, which this hormone exploits to calibrate its genotoxicity with its physiological effects. Accordingly, the genes required to maintain genome integrity belong to the E2-controlled cellular signaling network and are essential for the appearance of the E2-induced cellular effects. This concept requires an “upgrade” to the vision of E2 as a “genotoxic hormone”, which balances physiological and detrimental pathways to guarantee human body homeostasis. Deregulation of this equilibrium between cellular pathways would determine the E2 pathological effects.}, keywords = {17-estradiol; estrogen receptor alpha; breast cancer; DNA damage; DNA repair}, doi = {10.3390/cancers13071583}, number = {7} } .

Granata, G. and Mariotti, D. and Ascenzi, P. and Petrosillo, N. and Di Masi, A.(2021). High serum levels of toxin a correlate with disease severity in patients with clostridioides difficile infection . ANTIBIOTICS. 10. (9).

De Simone, G. and di Masi, A. and Fattibene, P. and Ciaccio, C. and Platas-Iglesias, C. and Coletta, M. and Pesce, A. and Ascenzi, P.(2021). Oxygen-mediated oxidation of ferrous nitrosylated nitrobindins . JOURNAL OF INORGANIC BIOCHEMISTRY. 224.

De Simone, G. and Di Masi, A. and Ascenzi, P.(2021). Serum albumin: A multifaced enzyme . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22. (18).

Sodo, A., Verri, M., Palermo, A., Naciu, A.M., Sponziello, M., Durante, C., Di Gioacchino, M., Paolucci, A., Di Masi, A., Longo, F., et al.(2021). Raman spectroscopy discloses altered molecular profile in thyroid adenomas . Diagnostics. 11. (1).

De Simone, G., Di Masi, A., Ascenzi, P.(2021). Serum albumin: A multifaced enzyme . International Journal of Molecular Sciences. 22. (18).

Granata, G., Mariotti, D., Ascenzi, P., Petrosillo, N., Di Masi, A.(2021). High serum levels of toxin a correlate with disease severity in patients with clostridioides difficile infection . Antibiotics. 10. (9).

De Simone, G., Di Masi, A., Pesce, A., Bolognesi, M., Ciaccio, C., Tognaccini, L., Smulevich, G., Abbruzzetti, S., Viappiani, C., Bruno, S., et al.(2021). Mycobacterial and human ferrous nitrobindins: Spectroscopic and reactivity properties . International Journal of Molecular Sciences. 22. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-27.

De Simone, G., Pasquadibisceglie, A., di Masi, A., Buzzelli, V., Trezza, V., Macari, G., Polticelli, F., Ascenzi, P.(2021). Binding of direct oral anticoagulants to the FA1 site of human serum albumin . Journal of Molecular Recognition. 34. (3).

Pescatori, S., Berardinelli, F., Albanesi, J., Ascenzi, P., Marino, M., Antoccia, A., Di Masi, A., Acconcia, F.(2021). A tale of ice and fire: The dual role for 17β-estradiol in balancing DNA damage and genome integrity . Cancers. 13. (7).

De Simone, G., di Masi, A., Fattibene, P., Ciaccio, C., Platas-Iglesias, C., Coletta, M., Pesce, A., Ascenzi, P.(2021). Oxygen-mediated oxidation of ferrous nitrosylated nitrobindins . Journal of Inorganic Biochemistry. 224.

Alessandra di Masi, Armida Sodo, Martina Verri, Andrea Palermo, Anda Mihaela Naciu, Marialuisa Sponziello, Cosimo Durante, Michael Di Gioacchino, Alessio Paolucci, Filippo Longo, et al. (2020). Raman Spectroscopy Discloses Altered Molecular Profile in Thyroid Adenomas . Diagnostics.

Alessandra di Masi, Giovanna De Simone, Chiara Ciaccio, Massimo Coletta, Paolo Ascenzi (2020). NO Scavenging through Reductive Nitrosylation of Ferric Mycobacterium tuberculosis and Homo sapiens Nitrobindins . International Journal of Molecular Sciences.

Alessandra di Masi, Federica Tonon, Stefano Di Bella, Gabriele Grassi, Roberto Luzzati, Paolo Ascenzi, Cristina Zennaro(2020). Extra-Intestinal Effects of C. difficile Toxin A and B: An In Vivo Study Using the Zebrafish Embryo Model . Cells. 9. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2575. {MDPI} {AG}

Alessandra di Masi, Federica Tonon, Stefano Di Bella, Gabriele Grassi, Roberto Luzzati, Paolo Ascenzi, Cristina Zennaro (2020). Extra-Intestinal Effects of <i>C.</i> <i>difficile</i> Toxin A and B: An In Vivo Study Using the Zebrafish Embryo Model . Cells.

Alessandra di Masi, Armida Sodo, Martina Verri, Andrea Palermo, Anda Mihaela Naciu, Marialuisa Sponziello, Cosimo Durante, Michael Di Gioacchino, Alessio Paolucci, Filippo Longo, et al. (2020). Raman Spectroscopy Discloses Altered Molecular Profile in Thyroid Adenomas . Diagnostics.

Alessandra di Masi, Giovanna De Simone, Chiara Ciaccio, Massimo Coletta, Paolo Ascenzi (2020). NO Scavenging through Reductive Nitrosylation of Ferric <i>Mycobacterium tuberculosis</i> and <i>Homo sapiens</i> Nitrobindins . International Journal of Molecular Sciences.

Alessandra di Masi, Jacopo Albanesi, Nelida Ines Noguera, Cristina Banella, Tommaso Colangelo, Elisabetta De Marinis, Stefano Leone, Orazio Palumbo, Maria Teresa Voso, Paolo Ascenzi, et al. (2020). Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells . Cells.

Leboffe, L. and Di Masi, A. and Polticelli, F. and Trezza, V. and Ascenzi, P.(2020). Structural basis of drug recognition by human serum albumin . CURRENT MEDICINAL CHEMISTRY. 27. (30). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4907--4931.

Principe, Luigi and Vecchio, Graziella and Sheehan, Gerard and Kavanagh, Kevin and Morroni, Gianluca and Viaggi, Valentina and di Masi, Alessandra and Giacobbe, Daniele Roberto and Luzzaro, Francesco and Luzzati, Roberto and Di Bella, Stefano(2020). Zinc Chelators as Carbapenem Adjuvants for Metallo-β-Lactamase-Producing Bacteria: In Vitro and In Vivo Evaluation . MICROBIAL DRUG RESISTANCE. 26. (10).

De Simone, G. and Di Masi, A. and Ciaccio, C. and Coletta, M. and Ascenzi, P.(2020). NO scavenging through reductive nitrosylation of ferric Mycobacterium tuberculosis and Homo sapiens nitrobindins . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--10.

Vita, Gian Marco and De Simone, Giovanna and Leboffe, Loris and Montagnani, Francesca and Mariotti, Davide and Di Bella, Stefano and Luzzati, Roberto and Gori, Andrea and Ascenzi, Paolo and di Masi, Alessandra(2020). Human Serum Albumin Binds Streptolysin O (SLO) Toxin Produced by Group A Streptococcus and Inhibits Its Cytotoxic and Hemolytic Effects . FRONTIERS IN IMMUNOLOGY. 11.

Albanesi, J. and Noguera, N. I. and Banella, C. and Colangelo, T. and De Marinis, E. and Leone, S. and Palumbo, O. and Voso, M. T. and Ascenzi, P. and Nervi, C. and Bianchi, F. and di Masi, A.(2020). Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells . CELLS. 9. (11).

Sbroscia, Marco and Di Gioacchino, Michael and Ascenzi, Paolo and Crucitti, Pierfilippo and di Masi, Alessandra and Giovannoni, Isabella and Longo, Filippo and Mariotti, Davide and Naciu, Anda Mihaela and Palermo, Andrea and Taffon, Chiara and Verri, Martina and Sodo, Armida and Crescenzi, Anna and Ricci, Maria Antonietta(2020). Thyroid cancer diagnosis by Raman spectroscopy . SCIENTIFIC REPORTS. 10. (1).

Tonon, F. and Di Bella, S. and Grassi, G. and Luzzati, R. and Ascenzi, P. and di Masi, A. and Zennaro, C.(2020). Extra-Intestinal Effects of C.difficile Toxin A and B: An In Vivo Study Using the Zebrafish Embryo Model . CELLS. 9. (12).

Gioia, Magda and Ciaccio, Chiara and Calligari, Paolo and De Simone, Giovanna and Sbardella, Diego and Tundo, Grazia and Fasciglione, Giovanni Francesco and Di Masi, Alessandra and Di Pierro, Donato and Bocedi, Alessio and Ascenzi, Paolo and Coletta, Massimo(2020). Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches . BIOCHEMICAL PHARMACOLOGY. 182.

Leboffe, L. and di Masi, A. and Trezza, V. and Pasquadibisceglie, A. and Macari, G. and Polticelli, F. and Ascenzi, P.(2020). Neonicotinoid trapping by the FA1 site of human serum albumin . IUBMB LIFE. 72. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 716--723.

di Masi, Alessandra and De Simone, Giovanna and Ciaccio, Chiara and D'Orso, Silvia and Coletta, Massimo and Ascenzi, Paolo(2020). Haptoglobin: From hemoglobin scavenging to human health . MOLECULAR ASPECTS OF MEDICINE. 73.

De Simone, G. and Di Masi, A. and Vita, G. M. and Polticelli, F. and Pesce, A. and Nardini, M. and Bolognesi, M. and Ciaccio, C. and Coletta, M. and Turilli, E. S. and Fasano, M. and Tognaccini, L. and Smulevich, G. and Abbruzzetti, S. and Viappiani, C. and Bruno, S. and Ascenzi, P.(2020). Mycobacterial and Human Nitrobindins: Structure and Function . ANTIOXIDANTS & REDOX SIGNALING. 33. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 229--246.

Sodo, A. and Verri, M. and Palermo, A. and Naciu, A. M. and Sponziello, M. and Durante, C. and Di Gioacchino, M. and Paolucci, A. and Di Masi, A. and Longo, F. and Crucitti, P. and Taffon, C. and Ricci, M. A. and Crescenzi, A.(2020). Raman spectroscopy discloses altered molecular profile in thyroid adenomas . DIAGNOSTICS. 11. (1).

De Simone, Giovanna and Pasquadibisceglie, Andrea and Polticelli, Fabio and di Masi, Alessandra and Ascenzi, Paolo(2020). Haptoglobin and the related haptoglobin protein: the N-terminus makes the difference . JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. (5).

Vita, G.M., De Simone, G., Leboffe, L., Montagnani, F., Mariotti, D., Di Bella, S., Luzzati, R., Gori, A., Ascenzi, P., di Masi, A.(2020). Human Serum Albumin Binds Streptolysin O (SLO) Toxin Produced by Group A Streptococcus and Inhibits Its Cytotoxic and Hemolytic Effects . Frontiers in Immunology. 11.

di Masi, A., Leboffe, L., Sodo, A., Tabacco, G., Cesareo, R., Sbroscia, M., Giovannoni, I., Taffon, C., Crucitti, P., Longo, F., et al.(2020). Metabolic profile of human parathyroid adenoma . Endocrine. 67. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 699-707.

Tonon, F., Di Bella, S., Grassi, G., Luzzati, R., Ascenzi, P., Di Masi, A., Zennaro, C.(2020). Extra-intestinal effects of c. Difficile toxin a and b: An in vivo study using the zebrafish embryo model . Cells. 9. (12).

De Simone, G., Di Masi, A., Vita, G.M., Polticelli, F., Pesce, A., Nardini, M., Bolognesi, M., Ciaccio, C., Coletta, M., Turilli, E.S., et al.(2020). Mycobacterial and Human Nitrobindins: Structure and Function . Antioxidants and Redox Signaling. 33. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 229-246.

De Simone, G., Di Masi, A., Ciaccio, C., Coletta, M., Ascenzi, P.(2020). NO scavenging through reductive nitrosylation of ferric Mycobacterium tuberculosis and Homo sapiens nitrobindins . International Journal of Molecular Sciences. 21. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-10.

Leboffe, L., di Masi, A., Trezza, V., Pasquadibisceglie, A., Macari, G., Polticelli, F., Ascenzi, P.(2020). Neonicotinoid trapping by the FA1 site of human serum albumin . IUBMB Life. 72. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 716-723.

di Masi, A., De Simone, G., Ciaccio, C., D&#39;Orso, S., Coletta, M., Ascenzi, P.(2020). Haptoglobin: From hemoglobin scavenging to human health . Molecular Aspects of Medicine. 73.

Leboffe, L., Di Masi, A., Polticelli, F., Trezza, V., Ascenzi, P.(2020). Structural basis of drug recognition by human serum albumin . Current Medicinal Chemistry. 27. (30). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4907-4931.

Principe, L., Vecchio, G., Sheehan, G., Kavanagh, K., Morroni, G., Viaggi, V., Di Masi, A., Giacobbe, D.R., Luzzaro, F., Luzzati, R., et al.(2020). Zinc Chelators as Carbapenem Adjuvants for Metallo-β-Lactamase-Producing Bacteria: In Vitro and in Vivo Evaluation . Microbial Drug Resistance. 26. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1133-1143.

Gioia, M., Ciaccio, C., Calligari, P., De Simone, G., Sbardella, D., Tundo, G., Fasciglione, G.F., Di Masi, A., Di Pierro, D., Bocedi, A., et al.(2020). Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches . Biochemical Pharmacology. 182.

Albanesi, J., Noguera, N.I., Banella, C., Colangelo, T., De Marinis, E., Leone, S., Palumbo, O., Voso, M.T., Ascenzi, P., Nervi, C., et al.(2020). Transcriptional and metabolic dissection of atra-induced granulocytic differentiation in NB4 acute promyelocytic leukemia cells . Cells. 9. (11).

Sbroscia, M., Di Gioacchino, M., Ascenzi, P., Crucitti, P., di Masi, A., Giovannoni, I., Longo, F., Mariotti, D., Naciu, A.M., Palermo, A., et al.(2020). Thyroid cancer diagnosis by Raman spectroscopy . Scientific Reports. 10. (1).

Berardinelli, F. and Tanori, M. and Muoio, D. and Buccarelli, M. and Di Masi, A. and Leone, S. and Ricci-Vitiani, L. and Pallini, R. and Mancuso, M. and Antoccia, A.(2019). G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells . JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 38. (1).

Bosso, G and Cipressa, F and Moroni, Ml and Pennisi, R and Albanesi, J and Brandi, V and Cugusi, S and Renda, F and Ciapponi, L and Polticelli, F and Antoccia, A and di Masi, A and Cenci, G(2019). NBS1 interacts with HP1 to ensure genome integrity . CELL DEATH & DISEASE. 10. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 951--952.

di Masi, A. and Leboffe, L. and Sodo, A. and Tabacco, G. and Cesareo, R. and Sbroscia, M. and Giovannoni, I. and Taffon, C. and Crucitti, P. and Longo, F. and Manfrini, S. and Ricci, M. A. and Ascenzi, P. and Crescenzi, A. and Palermo, A.(2019). Metabolic profile of human parathyroid adenoma . ENDOCRINE. (3).

Ascenzi, P and di Masi, A and De Simone, G and Gioia, M and Coletta, M(2019). Fluoride and azide binding to ferric human hemoglobin:haptoglobin complexes highlights the ligand-dependent inequivalence of the α and β hemoglobin chains . INTERNATIONAL JOURNAL OF INORGANIC CHEMISTRY. (2).

Bosso, G., Cipressa, F., Moroni, M.L., Pennisi, R., Albanesi, J., Brandi, V., Cugusi, S., Renda, F., Ciapponi, L., Polticelli, F., et al.(2019). NBS1 interacts with HP1 to ensure genome integrity . Cell Death and Disease. 10. (12).

Berardinelli, F., Tanori, M., Muoio, D., Buccarelli, M., Di Masi, A., Leone, S., Ricci-Vitiani, L., Pallini, R., Mancuso, M., Antoccia, A.(2019). G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells . Journal of Experimental and Clinical Cancer Research. 38. (1).

Ascenzi, P., di Masi, A., De Simone, G., Gioia, M., Coletta, M.(2019). Fluoride and azide binding to ferric human hemoglobin:haptoglobin complexes highlights the ligand-dependent inequivalence of the α and β hemoglobin chains . Journal of Biological Inorganic Chemistry. 24. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 247-255.

Alessandra di Masi, Rosa Pennisi, Jacopo Albanesi, Paolo Ascenzi, Clara Nervi (2018). Are DNA damage response kinases a target for the differentiation treatment of acute myeloid leukemia? . IUBMB Life.

Servadio, Michela and Manduca, Antonia and Melancia, Francesca and Leboffe, Loris and Schiavi, Sara and Campolongo, Patrizia and Palmery, Maura and Ascenzi, Paolo and di Masi, Alessandra and Trezza, Viviana(2018). Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid . EUROPEAN NEUROPSYCHOPHARMACOLOGY. 28. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 85--96.

Monticelli, J and Di Bella, S and Di Masi, A and Zennaro, C and Tonon, F and Luzzati, R.(2018). Septic Cardiomyopathy and Bacterial Exotoxins . CRITICAL CARE MEDICINE. 46. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e965--e966.

Muoio, Daniela and Berardinelli, F and Leone, S and Coluzzi, E and di Masi, A and Doria, F and Freccero, M and Sgura, A and Folini, M and Antoccia, A.(2018). Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells . THE FEBS JOURNAL. (20).

Giacobbe, Dr and di Masi, A and Leboffe, L and Del Bono, V and Rossi, M and Cappiello, D and Coppo, E and Marchese, A and Casulli, A and Signori, A and Novelli, A and Perrone, K and Principe, L and Bandera, A and Vender, Le and Misin, A and Occhilupo, P and Melone, M and Ascenzi, P and Gori, A and Luzzati, R and Viscoli, C and Di Bella, S(2018). Hypoalbuminemia as a predictor of acute kidney injury during colistin treatment . SCIENTIFIC REPORTS. 8. (1).

di Masi, A and Leboffe, L and Polticelli, F and Tonon, F and Zennaro, C and Caterino, M and Stano, P and Fischer, S and Hägele, M and Müller, M and Kleger, A and Papatheodorou, P and Nocca, G and Arcovito, A and Gori, A and Ruoppolo, M and Barth, H and Petrosillo, N and Ascenzi, P and Di Bella, S(2018). Human Serum Albumin is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication . THE JOURNAL OF INFECTIOUS DISEASES. (9).

De Simone, Giovanna and di Masi, Alessandra and Polticelli, Fabio and Ascenzi, Paolo(2018). Human nitrobindin: the first example of an all-β-barrel ferric heme-protein that catalyzes peroxynitrite detoxification . FEBS OPENBIO. 8. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2002--2010.

Pennisi, R and Albanesi, J and Ascenzi, P and Nervi, C and di Masi, A.(2018). Are DNA damage response kinases a target for the differentiation treatment of acute myeloid leukemia? . IUBMB LIFE. 70. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1057--1066.

De Simone, G., di Masi, A., Polticelli, F., Ascenzi, P.(2018). Human nitrobindin: the first example of an all-β-barrel ferric heme-protein that catalyzes peroxynitrite detoxification . FEBS Open Bio. 8. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2002-2010.

Pennisi, R., Albanesi, J., Ascenzi, P., Nervi, C., di Masi, A.(2018). Are DNA damage response kinases a target for the differentiation treatment of acute myeloid leukemia? . IUBMB Life. 70. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1057-1066.

Muoio, D., Berardinelli, F., Leone, S., Coluzzi, E., di Masi, A., Doria, F., Freccero, M., Sgura, A., Folini, M., Antoccia, A.(2018). Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells . FEBS Journal. 285. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3769-3785.

Giacobbe, D.R., di Masi, A., Leboffe, L., Del Bono, V., Rossi, M., Cappiello, D., Coppo, E., Marchese, A., Casulli, A., Signori, A., et al.(2018). Hypoalbuminemia as a predictor of acute kidney injury during colistin treatment . Scientific Reports. 8. (1).

Monticelli, J., Di Bella, S., Di Masi, A., Zennaro, C., Tonon, F., Luzzati, R.(2018). Septic Cardiomyopathy and Bacterial Exotoxins . Critical Care Medicine. 46. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString E965-E966.

Servadio, M., Manduca, A., Melancia, F., Leboffe, L., Schiavi, S., Campolongo, P., Palmery, M., Ascenzi, P., di Masi, A., Trezza, V.(2018). Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid . European Neuropsychopharmacology. 28. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 85-96.

Di Masi, A., Leboffe, L., Polticelli, F., Tonon, F., Zennaro, C., Caterino, M., Stano, P., Fischer, S., H&#228;gele, M., M&#252;ller, M., et al.(2018). Human serum albumin is an essential component of the host defense mechanism against clostridium difficile intoxication . Journal of Infectious Diseases. 218. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1424-1435.

Leboffe, Loris and di Masi, Alessandra and Trezza, Viviana and Polticelli, Fabio and Ascenzi, Paolo(2017). Human serum albumin: A modulator of cannabinoid drugs . IUBMB LIFE. 69. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 834--840.

Gioia, M and Tomao, Luigi and Sbardella, D and Ciaccio, C and Tundo, Gr and DI MASI, Alessandra and Fasciglione, Gf and Marini, S and Cozza, P and Ascenzi, Paolo and Coletta, M.(2017). Enzyme catalysis: the case of the prostate-specific antigen . RENDICONTI LINCEI. SCIENZE FISICHE E NATURALI. 28. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 229--237.

Ascenzi, Paolo and DI MASI, Alessandra and Leboffe, Loris and Fanali, G and Fasano, M.(2017). The drug-dependent five- to six-coordination transition of the heme-Fe atom modulates allosterically human serum heme-albumin reactivity . RENDICONTI LINCEI. SCIENZE FISICHE E NATURALI. 28. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 207--215.

Pennisi, Rosa and Antoccia, Antonio and Leone, Stefano and Ascenzi, Paolo and DI MASI, Alessandra(2017). Hsp90 alpha regulates ATM and NBN functions in sensing and repair of DNA double-strand breaks . THE FEBS JOURNAL. 284. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2378--2395.

DE SIMONE, Giovanna and Ascenzi, Paolo and DI MASI, Alessandra and Polticelli, Fabio(2017). Nitrophorins and nitrobindins: structure and function . BIOMOLECULAR CONCEPTS. 8. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105--118.

Gioia, M., Tomao, L., Sbardella, D., Ciaccio, C., Tundo, G.R., Di Masi, A., Fasciglione, G.F., Marini, S., Cozza, P., Ascenzi, P., et al.(2017). Enzyme catalysis: the case of the prostate-specific antigen . Rendiconti Lincei. 28. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 229-237.

Ascenzi, P., di Masi, A., Leboffe, L., Fanali, G., Fasano, M.(2017). The drug-dependent five- to six-coordination transition of the heme-Fe atom modulates allosterically human serum heme-albumin reactivity . Rendiconti Lincei. 28. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 207-215.

Pennisi, R., Antoccia, A., Leone, S., Ascenzi, P., di Masi, A.(2017). Hsp90α regulates ATM and NBN functions in sensing and repair of DNA double-strand breaks . FEBS Journal. 284. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2378-2395.

De Simone, G., Ascenzi, P., Di Masi, A., Polticelli, F.(2017). Nitrophorins and nitrobindins: Structure and function . Biomolecular Concepts. 8. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105-118.

Leboffe, L., di Masi, A., Trezza, V., Polticelli, F., Ascenzi, P.(2017). Human serum albumin: A modulator of cannabinoid drugs . IUBMB Life. 69. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 834-840.

Alessandra Di Masi, Rosa Pennisi, Paolo Ascenzi (2016). Correction: Pennisi, R., et al. Hsp90: A New Player in DNA Repair? Biomolecules 2015, 5, 2589–2618 . Biomolecules.

(2016). Correction: Pennisi, R., et al. Hsp90: A New Player in DNA Repair? <em>Biomolecules</em> 2015, <em>5</em>, 2589–2618 . Biomolecules.

Alessandra Di Masi, Stefano Di Bella, Paolo Ascenzi, Steven Siarakas, Nicola Petrosillo (2016). Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects . Toxins.

(2016). <em>Clostridium difficile</em> Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects . Toxins.

Alessandra di Masi, Viviana Trezza, Loris Leboffe, Paolo Ascenzi(2016). Human plasma lipocalins and serum albumin: Plasma alternative carriers? . Journal of Controlled Release. 228. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 191--205. Elsevier {BV}

Ascenzi, Paolo and DI MASI, Alessandra and Leboffe, L and Fiocchetti, Marco and Nuzzo, MARIA TERESA and Brunori, M and Marino, Maria(2016). Neuroglobin: From structure to function in health and disease . MOLECULAR ASPECTS OF MEDICINE. 52. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--48.

DI MASI, Alessandra and Cilli, Domenica and Berardinelli, Francesco and Talarico, A and Pallavicini, I and Pennisi, Rosa and Leone, Stefano and Antoccia, Antonio and Noguera, Ni and Lo Coco, F and Ascenzi, Paolo and Minucci, S and Nervi, C.(2016). PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL . CELL DEATH & DISEASE. 7. (7).

Servadio, Michela and Melancia, Francesca and Manduca, Antonia and DI MASI, Alessandra and Schiavi, Sara and Cartocci, Veronica and Pallottini, Valentina and Campolongo, P and Ascenzi, Paolo and Trezza, Viviana(2016). Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid . TRANSLATIONAL PSYCHIATRY. 6. (9).

DI MASI, Alessandra and Trezza, Viviana and Leboffe, Loris and Ascenzi, Paolo(2016). Human plasma lipocalins and serum albumin: Plasma alternative carriers? . JOURNAL OF CONTROLLED RELEASE. 228. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 191--205.

Di Bella, S and Ascenzi, Paolo and Siarakas, S and Petrosillo, N and DI MASI, Alessandra(2016). Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects . TOXINS. 8. (5).

DI MUZIO, Elena and Polticelli, Fabio and DI MASI, Alessandra and Fanali, G and Fasano, M and Ascenzi, Paolo(2016). All-trans-retinoic acid and retinol binding to the FA1 site of human serum albumin competitively inhibits heme-Fe(III) association . ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 590. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 56--63.

Di Bella, S., Ascenzi, P., Siarakas, S., Petrosillo, N., di Masi, A.(2016). Clostridium difficile toxins A and B: Insights into pathogenic properties and extraintestinal effects . Toxins. 8. (5).

Di Muzio, E., Polticelli, F., Di Masi, A., Fanali, G., Fasano, M., Ascenzi, P.(2016). All-trans-retinoic acid and retinol binding to the FA1 site of human serum albumin competitively inhibits heme-Fe(III) association . Archives of Biochemistry and Biophysics. 590. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 56-63.

Servadio, M., Melancia, F., Manduca, A., Di Masi, A., Schiavi, S., Cartocci, V., Pallottini, V., Campolongo, P., Ascenzi, P., Trezza, V.(2016). Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid . Translational Psychiatry. 6. (9).

Di Masi, A., Cilli, D., Berardinelli, F., Talarico, A., Pallavicini, I., Pennisi, R., Leone, S., Antoccia, A., Noguera, N.I., Lo-Coco, F., et al.(2016). PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL . Cell Death and Disease. 7. (7).

Ascenzi, P., di Masi, A., Leboffe, L., Fiocchetti, M., Nuzzo, M.T., Brunori, M., Marino, M.(2016). Neuroglobin: From structure to function in health and disease . Molecular Aspects of Medicine. 52. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-48.

Di Masi, A., Trezza, V., Leboffe, L., Ascenzi, P.(2016). Human plasma lipocalins and serum albumin: Plasma alternative carriers? . Journal of Controlled Release. 228. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 191-205.

Alessandra Di Masi, Rosa Pennisi, Paolo Ascenzi (2015). Hsp90: A New Player in DNA Repair? . Biomolecules.

DI MASI, Alessandra and Leboffe, Loris and DE MARINIS, Elisabetta and Pagano, F and Cicconi, L and Rochette Egly, C and Lo Coco, F and Ascenzi, Paolo and Nervi, C.(2015). Retinoic acid receptors: from molecular mechanisms to cancer therapy . MOLECULAR ASPECTS OF MEDICINE. 41. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--115.

Ascenzi, Paolo and DI MASI, Alessandra and Leboffe, Loris and Frangipani, Emanuela and Nardini, Marco and Verde, Cinzia and Visca, Paolo(2015). Structural Biology of Bacterial Haemophores . ADVANCES IN MICROBIAL PHYSIOLOGY. 67. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 127--176.

Di Bella, S and DI MASI, Alessandra and Turla, S and Ascenzi, Paolo and Gouliouris, T and Petrosillo, N.(2015). Protective Role of Albumin in Clostridium difficile Infection: A Step Toward Solving the Puzzle . INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY. 36. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1478--1480.

Ligand binding to the FA3-FA4 cleft inhibits the esterase-like activity of human serum albumin @article{ 11590_283246, author = {Ascenzi, Paolo and Leboffe, Loris and DI MASI, Alessandra and Trezza, Viviana and Fanali, Gabriella and Gioia, Magda and Coletta, Massimo and Fasano, Mauro}, title = {Ligand binding to the FA3-FA4 cleft inhibits the esterase-like activity of human serum albumin}, year = {2015}, journal = {PLOS ONE}, volume = {10}, abstract = {The hydrolysis of 4-nitrophenyl esters of hexanoate (NphOHe) and decanoate (NphODe) by human serum albumin (HSA) at Tyr411, located at the FA3-FA4 site, has been investigated between pH 5.8 and 9.5, at 22.0°C. Values of Ks, k+2, and k+2/Ks obtained at [HSA] ≥ 5×[NphOXx] and [NphOXx] ≥ 5×[HSA] (Xx is NphOHe or NphODe) match very well each other; moreover, the deacylation step turns out to be the rate limiting step in catalysis (i.e., k+3 < k+2). The pH dependence of the kinetic parameters for the hydrolysis of NphOHe and NphODe can be described by the acidic pKa-shift of a single amino acid residue, which varies from 8.9 in the free HSA to 7.6 and 7.0 in the HSA:NphOHe and HSA:NphODe complex, respectively; the pK>a-shift appears to be correlated to the length of the fatty acid tail of the substrate. The inhibition of the HSA-Tyr411-catalyzed hydrolysis of NphOHe, NphODe, and 4-nitrophenyl myristate (NphOMy) by five inhibitors (i.e., diazepam, diflunisal, ibuprofen, 3-indoxyl-sulfate, and propofol) has been investigated at pH 7.5 and 22.0°C, resulting competitive. The affinity of diazepam, diflunisal, ibuprofen, 3-indoxyl-sulfate, and propofol for HSA reflects the selectivity of the FA3-FA4 cleft. Under conditions where Tyr411 is not acylated, the molar fraction of diazepam, diflunisal, ibuprofen, and 3-indoxyl-sulfate bound to HSA is higher than 0.9 whereas the molar fraction of propofol bound to HSA is ca. 0.5.}, doi = {10.1371/journal.pone.0120603}, number = {3} } .

Novelli, MR D'Apice A. and DI MASI, Alessandra and Biancolella, M. and Antoccia, Antonio and Gullotta, F. and Licata, N. and Minella, D. and Testa, B. and Nardone, Am and Palmieri, G. and Calabrese, E. and Biancone, L. and Tanzarella, Caterina and Frontali, M. and Sangiuolo, F. and Novelli, G. and Pallone, F.(2015). Deletion of REXO1L1 locus in a patient with malabsorption syndrome growth retardation and dysmorphic features: a novel recognizable microdeletion syndrome? . BMC MEDICAL GENETICS. 16. (1).

Pennisi, Rosa and Ascenzi, Paolo and DI MASI, Alessandra(2015). A New Player in DNA Repair? . BIOMOLECULES. 5. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2589--2618.

DI MASI, Alessandra and Leboffe, Loris and Trezza, Viviana and Fanali, Gabriella and Coletta, Massimo and Fasano, Mauro and Ascenzi, Paolo(2015). Drugs modulate allosterically heme-Fe-recognition by human serum albumin and heme-fe-mediated reactivity . CURRENT PHARMACEUTICAL DESIGN. 21. (14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1837--1847.

Ascenzi, Paolo and DI MASI, Alessandra and Fanali, G and Fasano, M.(2015). Heme-based catalytic properties of human serum albumin . CELL DEATH DISCOVERY. 1. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 15025--15026.

Pennisi, Rosa and Ascenzi, Paolo and DI MASI, Alessandra(2015). Hsp90: A New Player in DNA Repair? . BIOMOLECULES. 5. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2589--2618.

Ascenzi, Paolo and DI MASI, Alessandra and Fanali, G and Fasano, M.(2015). Heme-albumin: an honorary enzyme . CELL DEATH DISCOVERY. 8. (6).

D&#39;Apice, M.R., Novelli, A., di Masi, A., Biancolella, M., Antoccia, A., Gullotta, F., Licata, N., Minella, D., Testa, B., Nardone, A.M., et al.(2015). Deletion of REXO1L1 locus in a patient with malabsorption syndrome, growth retardation, and dysmorphic features: A novel recognizable microdeletion syndrome? . BMC Medical Genetics. 16. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1.

Ascenzi, P., di Masi, A., Fanali, G., Fasano, M.(2015). Heme-based catalytic properties of human serum albumin . Cell Death Discovery. 1. (1).

Di Masi, A., Leboffe, L., Trezza, V., Fanali, G., Coletta, M., Fasano, M., Ascenzi, P.L.(2015). Drugs modulate allosterically heme-fe-recognition by human serum albumin and heme-fe-mediated reactivity . Current Pharmaceutical Design. 21. (14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1837-1847.

Di Bella, S., Di Masi, A., Turla, S., Ascenzi, P., Gouliouris, T., Petrosillo, N.(2015). The protective role of albumin in clostridium difficile infection: A step toward solving the puzzle . Infection Control and Hospital Epidemiology. 36. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1478-1479.

Di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., Nervi, C.(2015). Retinoic acid receptors: From molecular mechanisms to cancer therapy . Molecular Aspects of Medicine. 41. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-115.

Ascenzi, P., Leboffe, L., Masi, A.D., Trezza, V., Fanali, G., Gioia, M., Coletta, M., Fasano, M.(2015). Ligand binding to the FA3-FA4 cleft inhibits the esterase-like activity of human serum albumin . Plos One. 10. (3).

Pennisi, R., Ascenzi, P., di Masi, A.(2015). Hsp90: A new player in DNA Repair? . Biomolecules. 5. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2589-2618.

Cilli, D and Mirasole, C and Pennisi, R and Pallotta, V and D'Alessandro, A and Antoccia, A and Zolla, L and Ascenzi, Paolo and DI MASI, Alessandra(2014). Identification of the Interactors of Human Nibrin (NBN) and of Its 26 kDa and 70 kDa Fragments Arising from the NBN 657del5 Founder Mutation . PLOS ONE. 9. (12).

Tomao, L and Sbardella, D and Gioia, M and DI MASI, Alessandra and Marini, S and Ascenzi, Paolo and Coletta, M.(2014). Characterization of the prostate-specific antigen (PSA) catalytic mechanism: a pre-steady-state and steady-state study . PLOS ONE. 9. (7).

Berardinelli, F and Sgura, Antonella and DI MASI, Alessandra and Leone, S and Cirrone, Gap and Romano, F and Tanzarella, C and Antoccia, Antonio(2014). Radiation-induced telomere length variations in normal and in Nijmegen Breakage Syndrome cells . INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 90. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 45--52.

Ascenzi, Paolo and DI MASI, Alessandra and Tundo, Gr and Pesce, A and Visca, Paolo and Coletta, M.(2014). Nitrosylation mechanisms of Mycobacterium tuberculosis and Campylobacter jejuni truncated hemoglobins N, O, and P . PLOS ONE. 9. (7).

Berardinelli, F., Sgura, A., Di Masi, A., Leone, S., Cirrone, G.A.P., Romano, F., Tanzarella, C., Antoccia, A.(2014). Radiation-induced telomere length variations in normal and in Nijmegen Breakage Syndrome cells . International Journal of Radiation Biology. 90. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 45-52.

Tomao, L., Sbardella, D., Gioia, M., Di Masi, A., Marini, S., Ascenzi, P., Coletta, M.(2014). Characterization of the Prostate-Specific Antigen (PSA) catalytic mechanism: A pre-steady-state and steady-state study . Plos One. 9. (7).

Cilli, D., Mirasole, C., Pennisi, R., Pallotta, V., D&#39;Alessandro, A., Antoccia, A., Zolla, L., Ascenzi, P., Di Masi, A.(2014). Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation . Plos One. 9. (12).

Ascenzi, P., Di Masi, A., Tundo, G.R., Pesce, A., Visca, P., Coletta, M.(2014). Nitrosylation mechanisms of Mycobacterium tuberculosis and Campylobacter jejuni truncated hemoglobins N, O, and P . Plos One. 9. (7).

Berardinelli, Francesco and DI MASI, Alessandra and Antoccia, Antonio(2013). NBN Gene Polymorphisms and Cancer Susceptibility: A Systemic Review. * di Masi A. and Antoccia A. are co-corresponding authors of this work . CURRENT GENOMICS. 14. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 425--440.

DI MASI, Alessandra and Ascenzi, Paolo(2013). H2S: a "double face" molecule in health and disease . BIOFACTORS ONLINE. 39. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 186--196.

Ascenzi, Paolo and DI MASI, Alessandra and Leboffe, L and Alberio, T and Fanali, G and Fasano, M.(2013). Molecular phylogenetic analyses of albuminoids reveal the molecular evolution of allosteric properties . IUBMB LIFE. 65. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 544--549.

Bocedi, A and De Sanctis, G and Ciaccio, C and Tundo, Gr and DI MASI, Alessandra and Fanali, G and Nicoletti, Fp and Fasano, M and Smulevich, G and Ascenzi, Paolo and Coletta, M.(2013). Reciprocal allosteric modulation of carbon monoxide and warfarin binding to ferrous human serum heme-albumin . PLOS ONE. 8. (3).

Ascenzi, P., Di Masi, A., Leboffe, L., Alberio, T., Fanali, G., Fasano, M.(2013). Molecular phylogenetic analyses of albuminoids reveal the molecular evolution of allosteric properties . IUBMB Life. 65. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 544-549.

Berardinelli, F., di Masi, A., Antoccia, A.(2013). NBN gene polymorphisms and cancer susceptibility: A systemic review . Current Genomics. 14. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 425-440.

Bocedi, A., De Sanctis, G., Ciaccio, C., Tundo, G.R., Di Masi, A., Fanali, G., Nicoletti, F.P., Fasano, M., Smulevich, G., Ascenzi, P., et al.(2013). Reciprocal Allosteric Modulation of Carbon Monoxide and Warfarin Binding to Ferrous Human Serum Heme-Albumin . Plos One. 8. (3).

Masi, A.D., Ascenzi, P.(2013). H2S: A "Double face" molecule in health and disease . Biofactors. 39. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 186-196.

Gullotta, F and DI MASI, Alessandra and Ascenzi, Paolo(2012). Carbon monoxide: an unusual drug . IUBMB LIFE. 64. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 378--386.

Gullotta, F and DI MASI, Alessandra and Coletta, M and Ascenzi, Paolo(2012). CO metabolism, sensing, and signaling. * di Masi A. and Gullotta F. contributed equally to this work . BIOFACTORS. 38. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--13.

Mendez, G and Cilli, Domenica and Berardinelli, Francesco and Viganotti, M and Ascenzi, Paolo and Tanzarella, C and Antoccia, Antonio and DI MASI, Alessandra(2012). Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation . IUBMB LIFE. 64. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 853--861.

Cao, Y and Nicoletti, Fp and DE SANCTIS, G and Bocedi, A and Ciaccio, C and Gullotta, F and Fanali, G and Tundo, Gr and DI MASI, Alessandra and Fasano, M and Smulevich, G and Ascenzi, Paolo and Coletta, M.(2012). Evidence for pH-dependent multiple conformers in iron(II) heme-human serum albumin: spectroscopic and kinetic investigation of carbon monoxide binding . JBIC. 17. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 133--147.

Fanali, G and DI MASI, Alessandra and Trezza, Viviana and Marino, Maria and Fasano, M and Ascenzi, Paolo(2012). Human serum albumin: from bench to bedside. * di Masi A. and Fanali G. contributed equally to this work . MOLECULAR ASPECTS OF MEDICINE. 33. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 209--290.

Fanali, G., Di Masi, A., Trezza, V., Marino, M., Fasano, M., Ascenzi, P.(2012). Human serum albumin: From bench to bedside . Molecular Aspects of Medicine. 33. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 209-290.

Mendez, G., Cilli, D., Berardinelli, F., Viganotti, M., Ascenzi, P., Tanzarella, C., Antoccia, A., Di Masi, A.(2012). Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation . IUBMB Life. 64. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 853-861.

Cao, Y., Nicoletti, F.P., Sanctis, G.D., Bocedi, A., Ciaccio, C., Gullotta, F., Fanali, G., Tundo, G.R., Masi, A.D., Fasano, M., et al.(2012). Evidence for pH-dependent multiple conformers in iron(II) heme-human serum albumin: Spectroscopic and kinetic investigation of carbon monoxide binding . Journal of Biological Inorganic Chemistry. 17. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 133-147.

Gullotta, F., Di Masi, A., Ascenzi, P.(2012). Carbon monoxide: An unusual drug . IUBMB Life. 64. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 378-386.

Gullotta, F., di Masi, A., Coletta, M., Ascenzi, P.(2012). CO metabolism, sensing, and signaling . Biofactors. 38. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-13.

DI MASI, Alessandra and Gullotta, F and Bolli, A and Fanali, G and Fasano, M and Ascenzi, Paolo(2011). Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme-albumin . THE FEBS JOURNAL. 278.

Ascenzi, Paolo and Bolli, A and DI MASI, Alessandra and Tundo, Gr and Fanali, G and Coletta, M and Fasano, M.(2011). Isoniazid and rifampicin inhibit allosterically heme binding to albumin and peroxynitrite isomerization by heme-albumin . JBIC. 16. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 97--108.

Marino, Maria and Di Masi, Alessandra and Trezza, Viviana and Pallottini, Valentina and Polticelli, Fabio and Ascenzi, Paolo(2011). Xenosensors CAR and PXR at work: impact on statin metabolism . CURRENT DRUG METABOLISM. 12. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 300--311.

DI MASI, Alessandra and Gullotta, F and Cappadonna, V and Leboffe, L and Ascenzi, Paolo(2011). Cancer predisposing mutations in BRCT domains . IUBMB LIFE. 63.

Marino, Maria and DI MASI, Alessandra and Trezza, Viviana and Pallottini, Valentina and Polticelli, Fabio and Ascenzi, Paolo(2011). Xenosensors CAR and PXR at work: impact on statin metabolism. CURRENT DRUG METABOLISM. 12. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 300--311.

Di Masi, A., Gullotta, F., Bolli, A., Fanali, G., Fasano, M., Ascenzi, P.(2011). Erratum: Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme-albumin (FEBS Journal (2011) 278 (654-662)) . FEBS Journal. 278. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4166.

Di Masi, A., Gullotta, F., Bolli, A., Fanali, G., Fasano, M., Ascenzi, P.(2011). Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme-albumin . FEBS Journal. 278. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 654-662.

Ascenzi, P., Di Masi, A., Coletta, M., Ciaccio, C., Fanali, G., Nicoletti, F.P., Smulevich, G., Fasano, M.(2011). Ibuprofen impairs allosterically peroxynitrite isomerization by ferric human serum heme-albumin (Journal of Biological Chemistry (2009) 284, (31006-31017)) . Journal of Biological Chemistry. 286. (33). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 29441.

Di Masi, A., Gullotta, F., Cappadonna, V., Leboffe, L., Ascenzi, P.(2011). Cancer predisposing mutations in BRCT domains . IUBMB Life. 63. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 503-512.

Ascenzi, P., Bolli, A., Di Masi, A., Tundo, G.R., Fanali, G., Coletta, M., Fasano, M.(2011). Isoniazid and rifampicin inhibit allosterically heme binding to albumin and peroxynitrite isomerization by heme-albumin . Journal of Biological Inorganic Chemistry. 16. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 97-108.

Fanali, G and Rampoldi, V and DI MASI, Alessandra and Bolli, A and Lopiano, L and Ascenzi, Paolo and Fasano, M.(2010). Binding of anti-Parkinson's disease drugs to human serum albumin is allosterically modulated . IUBMB LIFE. 62. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 371--376.

Fanali, G and Rampoldi, V and DI MASI, Alessandra and Bolli, A and Lopiano, L and Ascenzi, Paolo and Fasano, M.(2010). Binding of anti-Parkinson's disease drugs to human serum albumin is allosterically modulated . IUBMB LIFE. 62. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 371--376.

Alessandra, DI MASI and M., Viganotti and A., Antoccia and A., Magrelli and M., Salvatore and G., Azzalin and F., Tosto and S., Lorenzetti and F., Maranghi and A., Mantovani and G., Macino and C., Tanzarella and Taruscio, D.(2010). CHARACTERIZATION OF HUH6, HEP3B, HEPG2 AND HLE LIVER CANCER CELL LINES BY WNT/beta-CATENIN PATHWAY, MICRORNA EXPRESSION AND PROTEIN EXPRESSION PROFILE . CELLULAR AND MOLECULAR BIOLOGY. 56. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1299--1317.

Maranghi, F and Lorenzetti, S and Tassinari, R and Moracci, G and Tassinari, V and Marcoccia, D and Di, and Virgilio, A and Eusepi, A and Romeo, A and Magrelli, A and Salvatore, M and Tosto, F and Viganotti, M and Antoccia, A and DI MASI, Alessandra and Azzalin, G and Tanzarella, C and Macino, G and Taruscio, D and Mantovani, A.(2010). In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice . REPRODUCTIVE TOXICOLOGY.

Ascenzi, Paolo and DI MASI, Alessandra and Gullotta, F and Mattu, M and Ciaccio, C and Coletta, M.(2010). Reductive nitrosylation of ferric cyanide horse heart myoglobin is limited by cyanide dissociation . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 393. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 196--200.

Ascenzi, Paolo and DI MASI, Alessandra and Gullotta, F and Mattu, M and Ciaccio, C and Coletta, M.(2010). Reductive nitrosylation of ferric cyanide horse heart myoglobin is limited by cyanide dissociation . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 393. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 196--200.

Ascenzi, Paolo and Cao, Y and DI MASI, Alessandra and Gullotta, F and DE SANCTIS, G and Fanali, G and Fasano, M and Coletta, M.(2010). Reductive nitrosylation of ferric human serum heme-albumin . THE FEBS JOURNAL. 277. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2474--2485.

Ascenzi, Paolo and Cao, Y and DI MASI, Alessandra and Gullotta, F and DE SANCTIS, G and Fanali, G and Fasano, M and Coletta, M.(2010). Reductive nitrosylation of ferric human serum heme-albumin . THE FEBS JOURNAL. 277. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2474--2485.

Gullotta, F and DE MARINIS, E and Ascenzi, Paolo and DI MASI, Alessandra(2010). Targeting the DNA Double Strand Breaks Repair for Cancer Therapy . CURRENT MEDICINAL CHEMISTRY. 17.

Ascenzi, Paolo and DI MASI, Alessandra and Sciorati, C and Clementi, E.(2010). Peroxynitrite-An ugly biofactor? . BIOFACTORS. 36. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 264--273.

DI MASI, Alessandra and Viganotti, M and Antoccia, Antonio and Magrelli, A and Salvatore, M and Azzalin, G and Tosto, F and Lorenzetti, S and Maranghi, F and Mantovani, A and Macino, G and Tanzarella, C. AND TARUSCIO D.(2010). Characterization of HUH6, HEP3B, HEPG2 and HLE liver cancer cells lines by WNT/b-catenin pathway, microRNA expression and protein expression profile . CELLULAR AND MOLECULAR BIOLOGY. 56. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1299--1317.

Ascenzi, Paolo and DI MASI, Alessandra and Sciorati, C and Clementi, E.(2010). Peroxynitrite-An ugly biofactor? . BIOFACTORS. 36. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 264--273.

Ascenzi, Paolo and DI MASI, Alessandra and Francesca, Gullotta and Marco, Mattu and Chiara, Ciaccio and Massimo, Coletta(2010). Reductive nitrosylation of ferric cyanide horse heart myoglobin is limited by cyanide dissociation . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 393. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 196--200.

Gullotta, F and DE MARINIS, E and Ascenzi, Paolo and DI MASI, Alessandra(2010). Targeting the DNA double strand breaks repair for cancer therapy . CURRENT MEDICINAL CHEMISTRY. 17. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2017--2048.

Maranghi, F. and Lorenzetti, S. and Tassinari, R. and Moracci, G. and Tassinari, V. and Marcoccia, D. and DI VIRGILIO, A. and Eusepi, A. and Romeo, A. and Magrelli, A. and Salvatore, M. and Tosto, F. and Viganotti, M. and Antoccia, Antonio and DI MASI, Alessandra and Azzalin, G. and Tanzarella, C. and Macino, G. and Taruscio, D. and Mantovani, A.(2010). In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice . REPRODUCTIVE TOXICOLOGY. 29. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 427--432.

Ascenzi, P., Cao, Y., Di Masi, A., Gullotta, F., De Sanctis, G., Fanali, G., Fasano, M., Coletta, M.(2010). Reductive nitrosylation of ferric human serum heme-albumin . FEBS Journal. 277. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2474-2485.

Gullotta, F., de Marinis, E., Ascenzi, P., di Masi, A.(2010). Targeting the DNA double strand breaks repair for cancer therapy . Current Medicinal Chemistry. 17. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2017-2048.

Maranghi, F., Lorenzetti, S., Tassinari, R., Moracci, G., Tassinari, V., Marcoccia, D., Di Virgilio, A., Eusepi, A., Romeo, A., Magrelli, A., et al.(2010). In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice . Reproductive Toxicology. 29. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 427-432.

Ascenzi, P., di Masi, A., Gullotta, F., Mattu, M., Ciaccio, C., Coletta, M.(2010). Reductive nitrosylation of ferric cyanide horse heart myoglobin is limited by cyanide dissociation . Biochemical and Biophysical Research Communications. 393. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 196-200.

Ascenzi, P., Di Masi, A., Sciorati, C., Clementi, E.(2010). Peroxynitrite-An ugly biofactor? . Biofactors. 36. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 264-273.

Fanali, G., Rampoldi, V., Di Masi, A., Bolli, A., Lopiano, L., Ascenzi, P., Fasano, M.(2010). Binding of anti-Parkinson's disease drugs to human serum albumin is allosterically modulated . IUBMB Life. 62. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 371-376.

Di Masi, A., Viganotti, M., Antoccia, A., Magrelli, A., Salvatore, M., Azzalin, G., Tosto, F., Lorenzetti, S., Maranghi, F., Mantovani, A., et al.(2010). Characterization of HUH6, HEP3B, HEPG2 and HLE liver cancer cell lines by WNT/Q- catenin pathway, microrna expression and protein expression profile . Cellular and Molecular Biology. 56. (SUPPL.1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString OL1299-OL1317.

Magrelli, A and Azzalin, G and Salvatore, M and Viganotti, M and Tosto, F and Colombo, T and Devito, R and DI MASI, Alessandra and Antoccia, A and Lorenzetti, S and Maranghi, F and Mantovani, A and Tanzarella, C and Macino, G and Taruscio, D.(2009). Altered microRNA Expression Patterns in Hepatoblastoma Patients . TRANSLATIONAL ONCOLOGY. 18. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 157--163.

Ascenzi, Paolo and DI MASI, Alessandra and Coletta, M and Ciaccio, C and Fanali, G and Nicoletti, Fp and Smulevich, G and Fasano, M.(2009). Ibuprofen impairs allosterically peroxynitrite isomerization by ferric human serum heme-albumin . THE JOURNAL OF BIOLOGICAL CHEMISTRY. 284. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 31006-17.--31017..

Ascenzi, Paolo and DI MASI, Alessandra and DE SANCTIS, G and Coletta, M and Fasano, M.(2009). Ibuprofen modulates allosterically NO dissociation from ferrous nitrosylated human serum heme-albumin by binding to three sites . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 387. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 83--86.

DI MASI, Alessandra and DE MARINIS, E and Ascenzi, Paolo and Marino, Maria(2009). Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects . MOLECULAR ASPECTS OF MEDICINE. 30. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 297--343.

Ascenzi, P and DI MASI, Alessandra and DE SANCTIS, G and Coletta, M and Fasano, M.(2009). Ibuprofen modulates allosterically NO dissociation from ferrous nitrosylated human serum heme-albumin by binding to three sites . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 38. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 83--86.

DI MASI, Alessandra and DE MARINIS, E and Ascenzi, Paolo and Marino, Maria(2009). Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects . MOLECULAR ASPECTS OF MEDICINE. 30. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 297--343.

Ascenzi, Paolo and DE MARINIS, E and DI MASI, Alessandra and Ciaccio, C and Coletta, M.(2009). Peroxynitrite scavenging by ferryl sperm whale myoglobin and human hemoglobin . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 390. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 27--31.

Ascenzi, Paolo and DE MARINIS, D and DI MASI, Alessandra and Ciaccio, C and Coletta, M.(2009). Peroxynitrite scavenging by ferryl sperm whale myoglobin and human hemoglobin . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 390. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 27--31.

Magrelli, A and Azzalin, G and Salvatore, M and Viganotti, M and Tosto, F and Colombo, T and Devito, R and DI MASI, Alessandra and Antoccia, Antonio and Lorenzetti, S and Maranghi, F and Mantovani, A and Tanzarella, C and Macino, G and Taruscio, D.(2009). Altered microRNA Expression Patterns in Hepatoblastoma Patients . TRANSLATIONAL ONCOLOGY. 2. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 157--163.

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects @article{ 11590_148521, author = {DI MASI, Alessandra and DE MARINIS, E and Ascenzi, Paolo and Marino, Maria}, title = {Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects}, year = {2009}, journal = {MOLECULAR ASPECTS OF MEDICINE}, volume = {30}, abstract = {Nuclear receptors (NRs) are ligand-activated transcription factors sharing a common evolutionary history and having similar sequence features at the protein level. Selective ligand(s) for some NRs is not known, therefore these NRs have been named “orphan receptors”. Whenever ligands have been recognized for any of the orphan receptor, it has been categorized and grouped as “adopted” orphan receptor. This group includes the constitutive androstane receptor (CAR) and the pregnane X receptor (PXR). They function as sensors of toxic byproducts derived from endogenous metabolites and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the steroid hormone receptors. The broad response profile has established that CAR and PXR are xenobiotic sensors that coordinately regulate xenobiotic clearance in the liver and intestine via induction of genes involved in drug and xenobiotic metabolism. In the past few years, research has revealed new and mostly unsuspected roles for CAR and PXR in modulating hormone, lipid, and energy homeostasis as well as cancer and liver steatosis. The purpose of this review is to highlight the structural and molecular bases of CAR and PXR impact on human health, providing information on mechanisms through which diet, chemical exposure, and environment ultimately impact health and disease.}, keywords = {Xenosensors; Constitutive androstane receptor; Pregnane X receptor; Structure; Function; Xenobiotics}, doi = {10.1016/j.mam.2009.04.002}, pages = {297--343}, number = {5} } .

di Masi, A., Marinis, E.D., Ascenzi, P., Marino, M.(2009). Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects . Molecular Aspects of Medicine. 30. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 297-343.

Ascenzi, P., di Masi, A., De Sanctis, G., Coletta, M., Fasano, M.(2009). Ibuprofen modulates allosterically NO dissociation from ferrous nitrosylated human serum heme-albumin by binding to three sites . Biochemical and Biophysical Research Communications. 387. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 83-86.

Ascenzi, P., Marinis, E.D., Masi, A.d., Ciaccio, C., Coletta, M.(2009). Peroxynitrite scavenging by ferryl sperm whale myoglobin and human hemoglobin . Biochemical and Biophysical Research Communications. 390. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 27-31.

Magrelli, A., Azzalin, G., Salvatore, M., Viganotti, M., Tosto, F., Colombo, T., Devito, R., Di Masi, A., Antoccia, A., Lorenzetti, S., et al.(2009). Altered microRNA expression patterns in hepatoblastoma patients . Translational Oncology. 2. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 157-163.

Ascenzi, P., di Masi, A., Coletta, M., Ciaccio, C., Fanali, G., Nicoletti, F.P., Smulevich, G., Fasano, M.(2009). Ibuprofen impairs allosterically peroxynitrite isomerization by ferric human serum heme-albumin . Journal of Biological Chemistry. 284. (45). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 31006-31017.

DI MASI, Alessandra(2008). May a missense mutation be more harmful than a truncating mutation? . IUBMB LIFE. 60. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 79--81.

DI MASI, Alessandra and Viganotti, M and Polticelli, Fabio and Ascenzi, Paolo and Tanzarella, C and Antoccia, A.(2008). The R215W mutation in NBS1 impairs &gamma;-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 369. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 835--840.

DI MASI, Alessandra and Antoccia, A.(2008). NBS1 heterozigosity and cancer risk . CURRENT GENOMICS. 9. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 275--281.

DI MASI, Alessandra and Viganotti, M and Polticelli, Fabio and Ascenzi, Paolo and Tanzarella, C and Antoccia, A.(2008). The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 369. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 835--840.

DI MASI, Alessandra and Dapice, Mr and Ricordy, R and Tanzarella, C and Novelli, G.(2008). The R527H mutation in LMNA protein causes an increased sensitivity to ionising radiation . CELL CYCLE. 7. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2030--2037.

DI MASI, Alessandra and Viganotti, M and Polticelli, Fabio and Ascenzi, Paolo and Tanzarella, C and Antoccia, Antonio(2008). The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: Molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 369. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 835--840.

DI MASI, Alessandra and Antoccia, Antonio(2008). NBS1 heterozygosity and cancer risk . CURRENT GENOMICS. 9. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 275--281.

Masi, A.d., Viganotti, M., Polticelli, F., Ascenzi, P., Tanzarella, C., Antoccia, A.(2008). The R215W mutation in NBS1 impairs γ-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients . Biochemical and Biophysical Research Communications. 369. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 835-840.

Di Masi, A., D&#39;Apice, M.R., Ricordy, R., Tanzarella, C., Novelli, G.(2008). The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation . Cell Cycle. 7. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2030-2037.

Di Masi, A.(2008). May a missense mutation be more deleterious than a truncating mutation? . IUBMB Life. 60. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 79-81.

di Masi, A., Antoccia, A.(2008). NBS1 heterozygosity and cancer risk . Current Genomics. 9. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 275-281.

A case report of a patient with microcephaly, facial dysmorphism, chromosomal radiosensitivity and telomere length alterations closely resembling “Nijmegen breakage syndrome” phenotype @article{ 11590_123528, author = {Berardinelli, F and DI MASI, Alessandra and Salvatore, M and Banerjee, S and Myung, K and DE VILLARTAY, Jp and Revy, P and Plebani, A and Soresina, A and Taruscio, D and Tanzarella, C and Antoccia, Antonio}, title = {A case report of a patient with microcephaly, facial dysmorphism, chromosomal radiosensitivity and telomere length alterations closely resembling “Nijmegen breakage syndrome” phenotype}, year = {2007}, journal = {EUROPEAN JOURNAL OF MEDICAL GENETICS}, volume = {501}, abstract = {Genetic heterogeneity in Nijmegen breakage syndrome (NBS) is highlighted by patients showing clinical and cellular features of NBS but with no mutations in NBS1 and normal levels of nibrin. NBS is an autosomal recessive disorder, whose clinical cellular signs include growth and developmental defects, dysmorphic facies, immunodeficiency, cancer predisposition, chromosomal instability and radiosensitivity. NBS is caused by mutations in the NBS1 gene, whose product is part of the MRE11/RAD50/ NBS1 complex involved in the DNA double-strand break (DSB) response pathway. Since the identification of the NBS1 gene, patients with NBS clinical signs, particularly severe congenital microcephaly, are screened for mutations in the NBS1 gene. Further analyses include X-ray-induced chromosome aberrations, telomere analysis, kinetics of DSBs repair, levels of a panel of proteins involved in the maintenance of genetic stability, radiation-induced phosphorylation of various substrates and cell cycle analysis.}, keywords = {Nijmegen breakage syndrome; Chromosome instability syndromes; radiosensitivity}, doi = {10.1016/j.ejmg.2007.01.01.006}, pages = {176--187}, number = {3} } .

A case report of a patient with microcephaly, facial dysmorphism, chromosomal radiosensitivity and telomere length alterations closely resembling “Nijmegen breakage syndrome” phenotype @article{ 11590_123527, author = {Berardinelli, F and DI MASI, Alessandra and Salvatore, M and Banerjee, S and Myung, K and P, DE VILLARTAY J. and Revy, P and Plebani, A and Soresina, A and Taruscio, D and Tanzarella, C and Antoccia, A.}, title = {A case report of a patient with microcephaly, facial dysmorphism, chromosomal radiosensitivity and telomere length alterations closely resembling “Nijmegen breakage syndrome” phenotype}, year = {2007}, journal = {EUROPEAN JOURNAL OF MEDICAL GENETICS}, volume = {50}, pages = {176--187} } .

Berardinelli, F., di Masi, A., Salvatore, M., Banerjee, S., Myung, K., De Villartay, J.P., Revy, P., Plebani, A., Soresina, A., Taruscio, D., et al.(2007). A case report of a patient with microcephaly, facial dysmorphism, chromosomal radiosensitivity and telomere length alterations closely resembling "Nijmegen breakage syndrome" phenotype . European Journal of Medical Genetics. 50. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 176-187.

DI MASI, Alessandra and Antoccia, A and Dimauro, I and ARGENTINO STORINO, A and Mosiello, A and Mango, R and Novelli, G and Tanzarella, C. and Antoccia, Antonio(2006). Gene expression and apoptosis induction in p53-heterozygous irradiated mice . MUTATION RESEARCH. 594. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 49--62.

Varon, R and Dutrannoy, V and Weikert, G and Tanzarella, C and Antoccia, A and Stockl, L and Spadoni, E and Kruger, La and DI MASI, Alessandra and Sperling, K and Digweed, M and Maraschio, P.(2006). Mild Nijmegen breakage syndrome phenotype due to alternative splicing . HUMAN MOLECULAR GENETICS. 15. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 679--689.

DI MASI, Alessandra and Antoccia, A and Spadoni, E and VARON MATEEVA, R and Maraschio, P and Tanzarella, C.(2006). Screening of NBS1 mutations in four NBS unrelated families by sequence-specific primer PCR . GENETIC TESTING. 10. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 24--30.

DI MASI, Alessandra and Antoccia, Antonio and Dimauro, I and ARGENTINO STORINO, A and Mosiello, A and Mango, R and Novelli, G and Tanzarella, C.(2006). Gene expression and apoptosis induction in p53-heterozygous irradiated mice . MUTATION RESEARCH. FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 594. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 49--62.

DI MASI, Alessandra and Antoccia, Antonio and Spadoni, E and VARON MATEEVA, R and Maraschio, P and Tanzarella(2006). Screening of nijmegen breakage syndrome 1 mutations in four unrelated families by polymerase chain reaction using sequence-specific primers . GENETIC TESTING. 10. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 24--30.

Di Masi, A., Antoccia, A., Spadoni, E., Varon-Mateeva, R., Maraschio, P., Tanzarella, C.(2006). Screening of Nijmegen breakage syndrome 1 mutations in four unrelated families by polymerase chain reaction using sequence-specific primers . Genetic Testing. 10. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 24-30.

Varon, R., Dutrannoy, V., Weikert, G., Tanzarella, C., Antoccia, A., St&#246;ckl, L., Spadoni, E., Kr&#252;ger, L.-A., di Masi, A., Sperling, K., et al.(2006). Mild Nijmegen breakage syndrome phenotype due to alternative splicing . Human Molecular Genetics. 15. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 679-689.

Di Masi, A., Antoccia, A., Dimauro, I., Argentino-Storino, A., Mosiello, A., Mango, R., Novelli, G., Tanzarella, C.(2006). Gene expression and apoptosis induction in p53-heterozygous irradiated mice . Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis. 594. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 49-62.

Maraschio, P and Spadoni, E and Tanzarella, C and Antoccia, A and DI MASI, Alessandra and Maghnie, M and Varon, R and Demuth, I and Tiepolo, L and Danesino, C.(2003). Genetic heterogeneity for a Nijmegen breakage-like syndrome . CLINICAL GENETICS. 63. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 283--290.

P., Maraschio and E., Spadoni and C., Tanzarella and Antonio, Antoccia and Alessandra, DI MASI and M., Maghnie and R., Varon and I., Demuth and L., Tiepolo and Danesino, C.(2003). Genetic heterogeneity for a Nijmegen breakage-like syndrome . CLINICAL GENETICS. 63. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 283--290.

Tanzarella, C. and Antoccia, Antonio and Spadoni, E and DI MASI, Alessandra and Pecile, V and Demori, E and Varon, R and Tiepolo, L and Maraschio, P.(2003). "Chromosome Instability and Nibrin Protein Variants in NBS Heterozygotes" .

Tanzarella, C and Antoccia, A and Spadoni, E and DI MASI, Alessandra and Pecile, V and Demori, E and Varon, R and Marseglia, Gl and Tiepolo, L and Maraschio, P.(2003). Chromosome instability and nibrin protein variants in NBS heterozygotes . EUROPEAN JOURNAL OF HUMAN GENETICS. 11. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 297--303.

Tanzarella, C., Antoccia, A., Spadoni, E., di Masi, A., Pecile, V., Demori, E., Varon, R., Marseglia, G.L., Tiepolo, L., Maraschio, P.(2003). Chromosome instability and nibrin protein variants in NBS heterozygotes . European Journal of Human Genetics. 11. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 297-303.

Maraschio, P., Spadoni, E., Tanzarella, C., Antoccia, A., di Masi, A., Maghnie, M., Varon, R., Demuth, I., Tiepolo, L., Danesino, C.(2003). Genetic heterogeneity for a Nijmegen breakage-like syndrome . Clinical Genetics. 63. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 283-290.

Antoccia, A and DI MASI, Alessandra and Maraschio, P and Stumm, M and Ricordy, R and Tanzarella, C.(2002). G2-phase radiation response in lymphoblastoid cell lines from Nijmegen breakage syndrome . CELL PROLIFERATION. 35. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93--104.

Antoccia, Antonio and DI MASI, Alessandra and Maraschio, P and Stumm, M and Ricordy, R and Tanzarella, C.(2002). G2-phase radiation response in lymphoblastoid cell lines from Nijmegen breakage syndrome . CELL PROLIFERATION. 35. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93--104.

Antoccia, A., Di Masi, A., Maraschio, P., Stumm, M., Ricordy, R., Tanzarella, C.(2002). G2-phase radiation response in lymphoblastoid cell lines from Nijmegen breakage syndrome . Cell Proliferation. 35. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 93-104.

BOOK CHAPTER

Palagiano, C and Pesaresi, C and Pavia, D and De Vito, C and Di Masi, A and Simonetti, O and Di Rosa, E(2025). Lessons from COVID-19 Pandemic for Future Preparedness. Examples of GIS and Geocoding Applications in Rome . 221--237

Palagiano, C., Pesaresi, C., Pavia, D., De Vito, C., di Masi, A., Simonetti, O., Di Rosa, E.(2025). Lessons from COVID-19 Pandemic for Future Preparedness. Examples of GIS and Geocoding Applications in Rome . Covid 19 Impacts on Health and Health Systems. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 221-237.

di Masi, A., Pesaresi, C., Di Bella, S., Palagiano, C.(2023). Possible Implications of Annual Temperature and Precipitation Changes in Tick-Borne Encephalitis and West Nile Virus Incidence in Italy, Between 2010 and 2020 . Global Perspectives on Health Geography. Part F7870. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 191-212.

Ascenzi, P., di Masi, A., Leboffe, L., Frangipani, E., Nardini, M., Verde, C., Visca, P.(2015). Structural Biology of Bacterial Haemophores . Advances in Microbial Physiology. 67. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 127-176.

Cancer Proneness in Nijmegen Breakage Syndrome Carriers @inbook{ 11590_267668, author = {DI MASI, Alessandra and Berardinelli, Francesco and Cilli, Domenica and Antoccia, Antonio}, title = {Cancer Proneness in Nijmegen Breakage Syndrome Carriers}, year = {2013}, publisher = {Bentham Science}, volume = {2}, booktitle = {Advances in Genome Science - Probing Intracellular Regulation}, abstract = {Biallelic mutations in the NBN gene are responsible for the Nijmegen breakage syndrome (NBS), a rare autosomal recessive disorder characterized by chromosome instability and hypersensitivity to ionising radiation (IR). Epidemiological data evidence that the NBN gene can be considered a susceptibility factor for cancer development, as demonstrated by the fact that almost 40% of NBS patients have developed a malignancy before the age of 21. Interestingly, also NBN heterozygotes, which are clinically asymptomatic, display an elevated risk to develop some types of malignant tumours, especially breast, prostate and colorectal cancers, lymphoblastic leukaemia, and non-Hodgkin’s lymphoma (NHL). So far, nine mutations in the NBN gene have been found, at the heterozygous state, in cancer patients. Among them, the 657del5, the I171V and the R215W mutations are the most frequently described. The pathogenicity of these mutations is presumably connected with their occurrence in the highly conserved BRCT tandem domains of the NBN protein, which are present in a large superfamily of proteins and are recognized as major mediators of processes related to cell-cycle checkpoints and DNA repair. This review will focus on the current state-of-knowledge regarding the correlation between carriers of NBN gene mutations and the proneness to the development of malignant tumours.}, isbn = {978-1-60805-757-3}, pages = {101--119} } .

DI MASI, Alessandra and Berardinelli, F and Antoccia, A.(2008). Nijmegen breakage syndrome: a DNA-double strand breaks repair defective disorder . NOVA Science Publishers Inc

Nijmegen breakage syndrome: a DNA-double strand breaks repair defective disorder @inbook{ 11590_165818, author = {DI MASI, Alessandra and Berardinelli, F and Antoccia, Antonio and IN GENETIC INHERITANCE, Patterns and NOVA SCIENCE, Publishers and Inc, }, title = {Nijmegen breakage syndrome: a DNA-double strand breaks repair defective disorder}, year = {2008}, booktitle = {IN: „GENETIC INHERITANCE PATTERNS} } .

CONFERENCE ABSTRACT

Cilli, D and Pallavicini, I and Antoccia, A and Berardinelli, F and Ascenzi, Paolo and Minucci, S and Nervi, C and DI MASI, Alessandra(2014). Oncogenic disruption of promyelocytic leukemia nuclear bodies results in defective DNA double strand breaks sensing and repair .

Cilli, D and Nervi, C and DI MASI, Alessandra(2013). Oncogenic disruption of promyelocytic leukemia nuclear bodies in APL cells results in defects in DNA double strand breaks sensing and repair .

The role of NBN protein in cell homeostasis: proteomic identification of the interactors of NBN and of its fragments arising from the pathological 657del5 founder mutation @conference{ 11590_187281, author = {Cilli, D and Mirasole, C and Pallotta, V and D’Alessandro, A and Zolla, L and Ascenzi, Paolo and DI MASI, Alessandra}, title = {The role of NBN protein in cell homeostasis: proteomic identification of the interactors of NBN and of its fragments arising from the pathological 657del5 founder mutation}, year = {2013}, booktitle = {Atti del: 57th National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB)} } .

Cilli, Domenica and Leboffe, L and Antonini, Giovanni and Antoccia, A and Ascenzi, Paolo and DI MASI, Alessandra(2012). The DNA damage sensor protein NBN: role of BRCT domains in the DNA damage response . IUBMB LIFE.

CONFERENCE PAPER

Berardinelli, Francesco and Langone, Francesca and Sgura, Antonella and DI MASI, Alessandra and Cirrone, Pablo and DI ROSA, Francesco and Cuttone, Gacomo and Tanzarella, Caterina and Antoccia, Antonio(2008). Cytogenetics and molecular markers of exposure to low- and high-LET radiation in lymphoblastoid cell lines .

Viganotti, Mara and DI MASI, Alessandra and Tanzarella, Caterina and Tosto, Fabrizio and Magrelli, Armando and Azzalin, Gianluca and Salvatore, Marco and Devito, Rita and Lorenzetti, Stefano and Maranghi, Francesca and Mantovani, Alberto and Macino, Giuseppe and Taruscio, Domenica(2008). Tackling rare diseases yet lacking diagnosis and/or prognosis: a pilot project integrating data collection and experimental studies .

Berardinelli, Francesco and Marullo, Fabrizia and Sgura, Antonella and DI MASI, Alessandra and Cirrone, Pablo and DI ROSA, Francesco and Cuttone, Giacomo and Antoccia, Antonio and Tanzarella, Caterina(2008). X-rays and carbon-ions differently affect the telomere length of lymphoblastoid cells . 190--191

DI MASI, Alessandra and Antoccia, Antonio and Viganotti, Mara and Polticelli, Fabio and Tanzarella, Caterina(2007). Role of the interaction between NBS1 and gamma-H2AX in the DNA double strand break response .

DI MASI, Alessandra and Antoccia, Antonio and Tanzarella, Caterina and Viganotti, Mara and Polticelli, Fabio(2007). Study of the role of specific mutations in NBS1 gene for the comprehension of the DNA-damage response .

Nbs1 and gamma-H2AX interaction in cell lines with two different mutations in Nbs1 gene @conference{ 11590_271926, author = {Viganotti, M. and DI MASI, Alessandra and Antoccia, Antonio and Polticelli, Fabio and Tanzarella, Caterina}, title = {Nbs1 and gamma-H2AX interaction in cell lines with two different mutations in Nbs1 gene}, year = {2006}, publisher = {x}, address = {x}, booktitle = {8°Congresso Federazione Italiana Scienze della Vita.(FISV)}, abstract = {a}, isbn = {x}, } .

Antoccia, Antonio and DI MASI, Alessandra and Salvatore, M and Berardinelli, Francesco and Silini, A and Plebani, A and Taruscio, D and Tanzarella, Caterina(2005). Genetic and cellular analysis of Italian patients with a Nijmegen breakage-like phenotype . a

OTHER

Antoccia, Antonio and DI MASI, Alessandra and Salvatore, M. and Fiorini, C. and Giliani, S. and Plebani, A. and Taruscio, D. and Tanzarella, Caterina(2004). Genetic heterogeneity among patients with nijmegen breakage syndrome .

WORKING PAPER

Biocompatibility and Antibacterial Properties of TiCu(Ag) Thin Films Produced by Physical Vapor Deposition Magnetron Sputtering .