プロフィール詳細

プロジェクトを作成

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Dr. Alice R.に依頼

United States

Scientific Consultant & PhD Researcher | Specialized in Biochemistry, Immunology, OMICs analysis & Grant Writing

プロフィール概要

During my PhD at the Établissement Français du Sang (Bordeaux, France), I investigated the impact of severe microenvironmental stress—specifically anoxia and aglycemia—on human hematopoietic and mesenchymal stem cells. This foundational work established my core expertise in how severe environmental cues dictate stem cell fate, survival, and bioenergetic adaptation under extreme metabolic strain. Building on this background in cellular stress responses, I joined Dr. Jordan S. Orange’s laboratory at Columbia University (New York, USA) as a Postdoctoral Researcher, later transitioning with the team to the Children’s Hospital of Philadelphia (CHOP, USA). During this international postdoctoral training, I leveraged my expertise in environmental/metabolic adaptation and applied it to immuno-oncology, investigating how immunometabolic and epigenetic rewiring regulates Natural Killer (NK) cell effector functions and cytotoxic responses against cancer. By establishing multi-omic platforms, high-dimensional spectral flow cytometry, and functional bioenergetic assays (e.g., Seahorse extracellular flux analysis), I identified targetable metabolic checkpoints capable of restoring NK cell fitness and reversing exhaustion within restrictive tumor microenvironments. Core Technical & Analytical Skills Laboratory Techniques: High-dimensional flow cytometry, Agilent Seahorse XF bioenergetic profiling (XFe96, XF Pro), primary human immune cell isolation and culture, cellular & molecular biology assays (Western Blot, RNA/DNA extraction, epigenetic profiling). Bioinformatics & Coding: Advanced data analysis and custom visualization in R / RStudio (packages including ggplot2, dplyr, pheatmap, factoextra), multi-omic data integration, ATAC-seq data analysis, and metabolomic workflows. Scientific Writing & Communications: First-author peer-reviewed publications in international high-impact journals, scientific review writing, technical reports, and comprehensive grant proposal writing (fellowship applications, research funding).

専門分野

• ☆ Computational Biology
• ☆ Evolutionary Biology
• ☆ Biostatistics
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Apoptosis
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Antioxidants
• ☆ Enzyme Activity Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ ATAC-Seq
• ☆ Protein Sequencing
• ☆ Gene Expression Analysis
• ☆ RNA Sequencing
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Membrane Biology
• ☆ Stem Cell Research
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Banking
• ☆ Cell Line Engineering
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Cytometry
• ☆ Information & Knowledge Management
• ☆ Excel
• ☆ R
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ Feasibility Studies
• ☆ Fact Checking
• ☆ Literature Search
• ☆ Skills Training
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Instructional Materials
• ☆ Experimental Protocols
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Language Translation
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research User Research, Feasibility Study, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Processing, Image Analysis, Data Visualization, Text Mining & Analytics, Data Mining, Data Cleaning, Data Processing, Data Insights

職務経験

PostdoctoralResearcher

Children Hospital of Philadelphia

1月 2026 - 現在

PostdoctoralResearcher

Columbia University

1月 2025 - 12月 2025

PhD Scientist

Etablissement Francais du Sang

1月 2021 - 1月 2024

学歴

PhD Physiology

Etablissement Francais du Sang

1月 2021 - 1月 2024

認定資格

• 認定資格の詳細は未入力です。