プロフィール詳細

プロジェクトを作成

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Alireza S.に依頼

United Arab Emirates

Scientist & Founder | Tissue Engineering, Cell Therapy, FDA Regulatory & Product Development | PhD

プロフィール概要

I am a PhD-trained biomedical engineer and startup founder with 15+ years of experience in regenerative medicine, biofabrication, and cell therapy. I have led a life sciences startup from inception through preclinical validation, IP development (8+ patents), and $2.5M+ in fundraising, bridging deep bench science with commercial execution. My technical expertise spans tissue engineering, cell-based therapeutic construct development, and ML-driven data analysis. I have hands-on experience navigating FDA regulatory frameworks relevant to cell and tissue-based products (HCT/Ps), including documentation and preclinical data packages. Beyond the lab, I work extensively in CAD (SolidWorks), Python-based data pipelines, and 3D printing, and regularly take on scientific writing across manuscripts, patents, and regulatory documents. I have published 18+ peer-reviewed papers (h-index 12, 400+ citations), including two journal cover articles. I am available for consulting in biofabrication and cell therapy strategy, regulatory preparation, scientific writing, data analysis, CAD/product conceptualization, and R&D project management across pharma, medtech, and life sciences.

専門分野

• ☆ Biotechnology & Bioengineering
• ☆ Biomedical Engineering
• ☆ Biomechanics
• ☆ Tissue Engineering
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Pharmaceutical Regulatory Affairs
• ☆ Clinical Trials
• ☆ Clinical Trial Design
• ☆ Clinical Trials Data Analysis
• ☆ Regulatory Affairs
• ☆ Entrepreneurship

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Creative Writing

Research Market Research, Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Scientific and Technical Research, Systematic Literature Review

Consulting Business Strategy Consulting, Go-to-Market Strategy Consulting, Scientific and Technical Consulting, Regulatory Consulting, Manufacturing Consulting

Data & AI Predictive Modeling, Image Processing, Image Analysis, Algorithm Design-ML, Data Visualization, Big Data Analytics

Product Development Formulation, Recipe Development, Stability/Shelf Life Testing, Product Evaluation, Manufacturing, Product Compliance , Concept Development, Prototyping, Reverse Engineering, Device Fabrication

職務経験

CEO

Evolved Bio

9月 2021 - 現在

Postdoctoral Fellow

McMaster University

9月 2020 - 8月 2021

学歴

PhD (school of biomedical engineering)

McMaster University

5月 2017 - 現在

MSc of Tissue Engineering (Department of Biomedical Engineering)

Amirkabir University of Technology

10月 2014 - 9月 2016

BSc of Biomaterials (Department of Biomedical Engineering)

Amirkabir University of Technology

1月 2011 - 9月 2014

BSc of Biomechanics (Department of Biomedical Engineering)

Amirkabir University of Technology

9月 2009 - 9月 2014

認定資格

• Machine Learning

  Vector Institute

  10月 2023 - 現在

出版物

PREPRINT

Alireza Shahin-Shamsabadi, John Cappuccitti (2025). The Tissue Engineering Grail: Seamless Biofabrication of Scaffold-free Hollow Constructs .

Alireza Shahin-Shamsabadi, John Cappuccitti (2024). Muscle-Specific ECM Fibers Made with Anchored Cell Sheet Engineering Support Tissue Regeneration in Rat Models of Volumetric Muscle Loss .

Alireza Shahin-Shamsabadi, John Cappuccitti (2024). in vivo-like Scaffold-free 3Din vitroModels of Muscular Dystrophies: The Case for Anchored Cell Sheet Engineering in Personalized Medicine .

JOURNAL ARTICLE

Alireza Shahin-Shamsabadi, John Cappuccitti (2025). Muscle-specific acellular ECM fibers made with anchored cell sheet engineering support regeneration in rat models of volumetric muscle loss . Acta Biomaterialia.

Alireza Shahin‐Shamsabadi, John Cappuccitti (2025). In Vivo‐Like Scaffold‐Free 3D In Vitro Models of Muscular Dystrophies: The Case for Anchored Cell Sheet Engineering in Personalized Medicine . Advanced Healthcare Materials.

Crystal O. Mahadeo, Alireza Shahin-Shamsabadi, Maedeh Khodamoradi, Margaret Fahnestock, Ponnambalam Ravi Selvaganapathy (2025). The Effects of Electrical Stimulation on a 3D Osteoblast Cell Model . Cells.

Crystal O. Mahadeo, Alireza Shahin-Shamsabadi, Maedeh Khodamoradi, Margaret Fahnestock, Ponnambalam Ravi Selvaganapathy (2025). The Effects of Electrical Stimulation on a 3D Osteoblast Cell Model . Cells.

Mahadeo, C.O., Shahin-Shamsabadi, A., Khodamoradi, M., Fahnestock, M., Selvaganapathy, P.R.(2025). The Effects of Electrical Stimulation on a 3D Osteoblast Cell Model . Cells. 14. (6).

Shahin-Shamsabadi, A., Cappuccitti, J.(2025). In Vivo-Like Scaffold-Free 3D In Vitro Models of Muscular Dystrophies: The Case for Anchored Cell Sheet Engineering in Personalized Medicine . Advanced Healthcare Materials. 14. (12).

Shahin-Shamsabadi, A., Cappuccitti, J.(2025). Muscle-specific acellular ECM fibers made with anchored cell sheet engineering support regeneration in rat models of volumetric muscle loss . Acta Biomaterialia. 200. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 416-431.

Alireza Shahin-Shamsabadi, John Cappuccitti (2024). Proteomics and machine learning: Leveraging domain knowledge for feature selection in a skeletal muscle tissue meta-analysis . Heliyon.

Alireza Shahin‐Shamsabadi, John Cappuccitti (2024). Anchored Cell Sheet Engineering: A Novel Scaffold‐Free Platform for in vitro Modeling (Adv. Funct. Mater. 13/2024) . Advanced Functional Materials.

Alireza Shahin‐Shamsabadi, John Cappuccitti (2024). Anchored Cell Sheet Engineering: A Novel Scaffold‐Free Platform for in vitro Modeling . Advanced Functional Materials.

Shahin-Shamsabadi, A., Cappuccitti, J.(2024). Anchored Cell Sheet Engineering: A Novel Scaffold-Free Platform for in vitro Modeling . Advanced Functional Materials. 34. (13).

Shahin-Shamsabadi, A., Cappuccitti, J.(2024). Proteomics and machine learning: Leveraging domain knowledge for feature selection in a skeletal muscle tissue meta-analysis . Heliyon. 10. (24).

Shahin-Shamsabadi, A., Selvaganapathy, P.R.(2022). Engineering Murine Adipocytes and Skeletal Muscle Cells in Meat-like Constructs Using Self-Assembled Layer-by-Layer Biofabrication: A Platform for Development of Cultivated Meat . Cells Tissues Organs. 211. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 304-312.

Li, F.-C., Shahin-Shamsabadi, A., Selvaganapathy, P.R., Kishen, A.(2022). Engineering a Novel Stem Cells from Apical Papilla-Macrophages Organoid for Regenerative Endodontics . Journal of Endodontics. 48. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 741-748.

Alireza Shahin-Shamsabadi, P. Ravi Selvaganapathy (2020). π-SACS: pH Induced Self-Assembled Cell Sheets Without the Need for Modified Surfaces . ACS Biomaterials Science & Engineering.

Shahin-Shamsabadi, A., Selvaganapathy, P.R.(2020). A 3D Self-Assembled In Vitro Model to Simulate Direct and Indirect Interactions between Adipocytes and Skeletal Muscle Cells . Advanced Biosystems. 4. (6).

Dabaghi, M., Rochow, N., Saraei, N., Fusch, G., Monkman, S., Da, K., Shahin-Shamsabadi, A., Brash, J.L., Predescu, D., Delaney, K., et al.(2020). A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress . Advanced Science. 7. (21).

Shahin-Shamsabadi, A., Selvaganapathy, P.R.(2020). Tissue-in-a-Tube: three-dimensional in vitro tissue constructs with integrated multimodal environmental stimulation . Materials Today Bio. 7.

Shahin-Shamsabadi, A., Selvaganapathy, P.R.(2020). π-SACS: PH Induced Self-Assembled Cell Sheets without the Need for Modified Surfaces . ACS Biomaterials Science and Engineering. 6. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5346-5356.

Bryan E. J. Lee, Alireza Shahin‐Shamsabadi, Michael K. Wong, Sandeep Raha, Ponnambalam Ravi Selvaganapathy, Kathryn Grandfield (2019). A Bioprinted In Vitro Model for Osteoblast to Osteocyte Transformation by Changing Mechanical Properties of the ECM . Advanced Biosystems.

Alireza Shahin-Shamsabadi, P. Ravi Selvaganapathy (2019). A rapid biofabrication technique for self-assembled collagen-based multicellular and heterogeneous 3D tissue constructs . Acta Biomaterialia.

Alireza Shahin-Shamsabadi, P Ravi Selvaganapathy (2019). ExCeL: combining extrusion printing on cellulose scaffolds with lamination to createin vitrobiological models . Biofabrication.

Shahin-Shamsabadi, A., Selvaganapathy, P.R.(2019). ExCeL: Combining extrusion printing on cellulose scaffolds with lamination to create in vitro biological models . Biofabrication. 11. (3).

Shahin-Shamsabadi, A., Selvaganapathy, P.R.(2019). A rapid biofabrication technique for self-assembled collagen-based multicellular and heterogeneous 3D tissue constructs . Acta Biomaterialia. 92. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 172-183.

Lee, B.E.J., Shahin-Shamsabadi, A., Wong, M.K., Raha, S., Selvaganapathy, P.R., Grandfield, K.(2019). A Bioprinted In Vitro Model for Osteoblast to Osteocyte Transformation by Changing Mechanical Properties of the ECM . Advanced Biosystems. 3. (10).

Alireza Shahin-Shamsabadi, Ata Hashemi, Mohammadreza Tahriri, Farshid Bastami, Majid Salehi, Fatemeh Mashhadi Abbas (2018). Mechanical, material, and biological study of a PCL/bioactive glass bone scaffold: Importance of viscoelasticity . Materials Science and Engineering: C.

Eslami, H., Azimi Lisar, H., Jafarzadeh Kashi, T.S., Tahriri, M., Ansari, M., Rafiei, T., Bastami, F., Shahin-Shamsabadi, A., Mashhadi Abbas, F., Tayebi, L.(2018). Poly(lactic-co-glycolic acid)(PLGA)/TiO2 nanotube bioactive composite as a novel scaffold for bone tissue engineering: In vitro and in vivo studies . Biologicals. 53. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 51-62.

Shahin-Shamsabadi, A., Hashemi, A., Tahriri, M.(2018). A Viscoelastic Study of Poly(ε-Caprolactone) Microsphere Sintered Bone Tissue Engineering Scaffold . Journal of Medical and Biological Engineering. 38. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 359-369.

Shahin-Shamsabadi, A., Hashemi, A., Tahriri, M., Bastami, F., Salehi, M., Mashhadi Abbas, F.(2018). Mechanical, material, and biological study of a PCL/bioactive glass bone scaffold: Importance of viscoelasticity . Materials Science and Engineering C. 90. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 280-288.

OTHER

Shahin-Shamsabadi, A., Cappuccitti, J.(2024). Muscle-Specific ECM Fibers Made with Anchored Cell Sheet Engineering Support Tissue Regeneration in Rat Models of Volumetric Muscle Loss . Biorxiv.

Shahin-Shamsabadi, A., Cappuccitti, J.(2024). in vivo-like Scaffold-free 3D in vitro Models of Muscular Dystrophies: The Case for Anchored Cell Sheet Engineering in Personalized Medicine . Biorxiv.

Dabaghi, M., Rochow, N., Saraei, N., Fusch, G., Monkman, S., Da, K., Shahin-Shamsabadi, A., Brash, J.L., Predescu, D., Delaney, K., et al.(2020). A pumpless microfluidic neonatal lung assist device for support of preterm neonates in respiratory distress . Biorxiv.

Shahin-Shamsabadi, A., Selvaganapathy, P.R.(2019). A Rapid Fabrication Technique for Self-Assembled Collagen Based Multicellular, Heterogeneous, 3D Tissue Constructs . Ssrn.