プロフィール詳細

プロジェクトを作成

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Dr. Amal R.に依頼

Spain

Biochemist and Molecular Biologist | Translational Research & Therapeutics Expert

プロフィール概要

Accomplished scientist with 15+ years of experience leading translational research and drug discovery programs in academia and industry. Proven expertise in viral therapeutics, gene editing, and RNA-based platforms, with a track record of securing funding, managing cross-functional teams, and translating academic discoveries into biotech ventures. Skilled in strategic scientific consulting, portfolio development, and high-throughput platform design, bridging the gap between research, clinical applications, and business strategy. Experienced educator and mentor with a strong foundation in molecular and cell biology. Key Highlights: • Led multi-institutional research programs targeting coronaviruses and other viral diseases. • Contributed to a patent founding a biotech start-up in gene therapy. • Designed synthetic RNA platforms for targeted oncology therapies in biotech. • Managed multidisciplinary teams and large-scale translational research initiatives. • Provided scientific guidance to senior management, investors, and collaborators.

専門分野

• ★ Biotechnology & Bioengineering
• ★ Synthetic Biology
• ★ High Throughput Screening (HTS)
• ☆ Microbiology
• ☆ Virology
• ☆ Coronaviruses
• ☆ Zika Virus
• ☆ Molecular Virology
• ☆ Microbiological Assays
• ☆ Biochemistry
• ☆ Biochemical Assays
• ☆ Enzyme Activity Assays
• ☆ Recombinant Protein Expression
• ☆ Biomolecular Engineering
• ☆ Protein/Enzyme Engineering
• ☆ Drug Discovery
• ☆ Phenotypic Assays

サービス

• Writing
• Research
• Consulting

Writing Technical Writing

Research Market Research, Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Senior Research Scientist

Universitat Pompeu Fabra

3月 2020 - 現在

Senior Principal Scientist

University Pompeu Fabra (Barcelona, Spain)

2月 2020 - 8月 2025

Principal scientist

Oncorus Inc

11月 2018 - 1月 2020

Senior Principal Scientist

Oncorus Inc

10月 2018 - 1月 2020

Assistant Professor

American University of Beirut

8月 2017 - 8月 2018

Assistant director for Center for Translational Research

Harvard Medical School

11月 2014 - 8月 2017

Assistant Director ( Center for Translational Research)

Harvard Medical School

11月 2014 - 8月 2017

Postdoctoral fellow

Harvard Medical School

6月 2006 - 11月 2014

学歴

PhD

New York Medical College

9月 1999 - 1月 2006

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Pallarès-Masmitjà M, Ivančić D, Mir-Pedrol J, Jaraba-Wallace J, Tagliani T, Oliva B, Rahmeh A, Sánchez-Mejías A, Güell M(2021). Find and cut-and-transfer (FiCAT) mammalian genome engineering . Nature communications.

Lian W, Jang J, Potisopon S, Li PC, Rahmeh A, Wang J, Kwiatkowski NP, Gray NS, Yang PL(2018). Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein . ACS infectious diseases.

Wang X, Zhang S, Zheng R, Yue F, Lin SH, Rahmeh AA, Lee EY, Zhang Z, Lee MY(2016). PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ . Oncotarget.

Liang B, Li Z, Jenni S, Rahmeh AA, Morin BM, Grant T, Grigorieff N, Harrison SC, Whelan SPJ(2015). Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy . Cell.

Morin B, Kranzusch PJ, Rahmeh AA, Whelan SP(2013). The polymerase of negative-stranded RNA viruses . Current opinion in virology.

Rahmeh AA, Morin B, Schenk AD, Liang B, Heinrich BS, Brusic V, Walz T, Whelan SP(2012). Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus . Proceedings of the National Academy of Sciences of the United States of America.

Heinrich BS, Morin B, Rahmeh AA, Whelan SP(2012). Structural properties of the C terminus of vesicular stomatitis virus N protein dictate N-RNA complex assembly, encapsidation, and RNA synthesis . Journal of virology.

Morin B, Rahmeh AA, Whelan SP(2012). Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase . The EMBO journal.

Rahmeh AA, Zhou Y, Xie B, Li H, Lee EY, Lee MY(2011). Phosphorylation of the p68 subunit of Pol δ acts as a molecular switch to regulate its interaction with PCNA . Biochemistry.

Tekes G, Rahmeh AA, Whelan SP(2011). A freeze frame view of vesicular stomatitis virus transcription defines a minimal length of RNA for 5' processing . PLoS pathogens.

Rahmeh AA, Schenk AD, Danek EI, Kranzusch PJ, Liang B, Walz T, Whelan SP(2010). Molecular architecture of the vesicular stomatitis virus RNA polymerase . Proceedings of the National Academy of Sciences of the United States of America.

Kranzusch PJ, Schenk AD, Rahmeh AA, Radoshitzky SR, Bavari S, Walz T, Whelan SP(2010). Assembly of a functional Machupo virus polymerase complex . Proceedings of the National Academy of Sciences of the United States of America.

Heinrich BS, Cureton DK, Rahmeh AA, Whelan SP(2010). Protein expression redirects vesicular stomatitis virus RNA synthesis to cytoplasmic inclusions . PLoS pathogens.

Rahmeh AA, Li J, Kranzusch PJ, Whelan SP(2009). Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein . Journal of virology.

Li J, Rahmeh A, Brusic V, Whelan SP(2008). Opposing effects of inhibiting cap addition and cap methylation on polyadenylation during vesicular stomatitis virus mRNA synthesis . Journal of virology.

Gao Y, Zhou Y, Xie B, Zhang S, Rahmeh A, Huang HS, Lee MY, Lee EY(2008). Protein phosphatase-1 is targeted to DNA polymerase delta via an interaction with the p68 subunit . Biochemistry.

Mikati MA, Zeinieh M, Habib RA, El Hokayem J, Rahmeh A, El Sabban M, Usta J, Dbaibo G(2008). Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus . Epilepsy research.

Mikati MA, Rizk E, El Dada S, Zeinieh M, Kurdi R, El Hokayem J, Rahmeh A, Koubeissi M, Azzam D, Usta J, et al.(2008). Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms . Brain & development.

Li J, Rahmeh A, Morelli M, Whelan SP(2007). A conserved motif in region v of the large polymerase proteins of nonsegmented negative-sense RNA viruses that is essential for mRNA capping . Journal of virology.

Rytkönen AK, Vaara M, Nethanel T, Kaufmann G, Sormunen R, Läärä E, Nasheuer HP, Rahmeh A, Lee MY, Syväoja JE, et al.(2006). Distinctive activities of DNA polymerases during human DNA replication . The FEBS journal.

Li H, Xie B, Rahmeh A, Zhou Y, Lee MY(2006). Direct interaction of p21 with p50, the small subunit of human DNA polymerase delta . Cell cycle (Georgetown, Tex.).

Li H, Xie B, Zhou Y, Rahmeh A, Trusa S, Zhang S, Gao Y, Lee EY, Lee MY(2006). Functional roles of p12, the fourth subunit of human DNA polymerase delta . The Journal of biological chemistry.

Xie B, Li H, Wang Q, Xie S, Rahmeh A, Dai W, Lee MY(2005). Further characterization of human DNA polymerase delta interacting protein 38 . The Journal of biological chemistry.

Mikati MA, Kurdit RM, Rahmeh AA, Farhat F, Abu Rialy S, Lteif L, Francis E, Geha G, Maraashli W(2004). Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats . Brain injury.

Xie B, Mazloum N, Liu L, Rahmeh A, Li H, Lee MY(2002). Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme . Biochemistry.

Mikati MA, Werner S, Gatt A, Liu Z, Rahmeh AA, Rachid RA, Stafstrom CE, Holmes GL(1999). Consequences of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain . Brain research. Developmental brain research.

PREPRINT

Kennedy E, Denslow A, Hewett J, Kong L, De Almeida A, Bryant J, Lee J, Jacques J, Feau S, Hayes M, et al.(2021). Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer .