プロフィール詳細

プロジェクトを作成

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Amiq G.に依頼

Switzerland

MD–PhD with 20+ years of experience at the intersection of lung regeneration and translational medicine

プロフィール概要

MD–PhD and senior scientific advisor with 20+ years of experience at the intersection of lung biology, regenerative medicine, and translational research, spanning basic science, preclinical development, and clinical interface. Recognized leader and trusted advisor to academic and industry stakeholders on R&D strategy and translational risk assessment. Deep expertise in complex biological systems, high-dimensional evidence, and judgment-based decision-making under uncertainty.

専門分野

• ☆ Cell Biology
• ☆ Stem Cell Research
• ☆ Cell Culture
• ☆ 3D Cell Culture
• ☆ Biomolecular Engineering
• ☆ Gene Delivery
• ☆ Drug Development
• ☆ Pulmonology/Respiratory Disease
• ☆ Lung Cancer
• ☆ Gene Therapy

サービス

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing, Creative Writing

Research Market Research, User Research, Meta-Research, Feasibility Study, Technology Scouting, Fact Checking

Consulting Healthcare Consulting

Product Development Material Sourcing

職務経験

Group leader, Senior Scientist

Inselspital Universitätsspital Bern

2月 2009 - 現在

Post doctoral fellow

Inselspital Universitätsspital Bern

10月 2007 - 3月 2008

Research Fellow (Post doctoral fellow)

Keele University Faculty of Health

3月 2007 - 1月 2008

Research Associate

University of Heidelberg Bioquant

10月 2001 - 11月 2002

Research Associate

Inselspital Universitätsspital Bern

4月 2001 - 9月 2001

Junior Medical Officer

Bombay Hospital and Medical Research Centre

3月 1999 - 4月 2001

学歴

Master of Advance studies (University of Bern )

Swiss Institute for Translational and Entrepreneurial Medicine

4月 2017 - 10月 2020

MD-PhD (Thoracic Surgery )

University of Bern

3月 2003 - 1月 2007

MBBS (ACPM Medical Collage )

North Maharastra University

8月 1992 - 1月 1998

認定資格

• AI in Health Care

  John hopkins

  1月 2026 - 現在

出版物

JOURNAL ARTICLE

Mutlu S, Fytianos K, Ferrié C, Scalise M, Mykoniati S, Gazdhar A, Blank F (2025). Adoptive Transfer of T Cells as a Potential Therapeutic Approach in the Bleomycin-Injured Mouse Lung . The journal of gene medicine.

Amiq Gazdhar, Vedat Burak Ozan, Huijuan Wang, Akshay Akshay, Deepika Anand, Youssef Hibaoui, Anis Feki, Janine Gote-Schniering, Ali Hashemi Gheinani, Manfred Heller, et al. (2025). Influence of Microenvironmental Orchestration on Multicellular Lung Alveolar Organoid Development from Human Induced Pluripotent Stem Cells . Stem Cell Reviews and Reports.

Amiq Gazdhar, Emma Richert, Andrea Nienhaus, Silje Ekroll Jahren, Maximilian Grab, Jürgen Hörer, Thierry Carrel, Dominik Obrist, Paul Philipp Heinisch (2023). Biogenic polymer-based patches for congenital cardiac surgery: a feasibility study . Frontiers in Cardiovascular Medicine.

Amiq Gazdhar, Salome M. Brütsch, Elizabeta Madzharova, Sophia Pantasis, Till Wüstemann, Selina Gurri, Heiko Steenbock, Gisela Kuhn, Peter Angel, Saverio Bellusci, et al. (2023). Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome . Cellular and Molecular Life Sciences.

Seyran M, Melanie S, Philip S, Amiq G, Fabian B (2022). Allies or enemies? The effect of regulatory T cells and related T lymphocytes on the profibrotic environment in bleomycin-injured lung mouse models . Clinical and experimental medicine.

Amiq Gazdhar, Kleanthis Fytianos, Ronja Schliep, Sofia Mykoniati, Petra Khan, Katrin E. Hostettler, Michael Tamm, Lars Knudsen, Thomas Geiser (2022). Anti-Fibrotic Effect of SDF-1β Overexpression in Bleomycin-Injured Rat Lung . Pharmaceutics.

Amiq Gazdhar, Kleanthis Fytianos, Ronja Schliep, Sofia Mykoniati, Petra Khan, Katrin E. Hostettler, Michael Tamm, Lars Knudsen, Thomas Geiser (2022). Anti-Fibrotic Effect of SDF-1β Overexpression in Bleomycin-Injured Rat Lung . Pharmaceutics.

(2022). Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects <i>In Vitro</i> and <i>In Vivo</i> . Frontiers in bioengineering and biotechnology.

(2022). LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity . Life science alliance.

Paulius Ruzgys and Stephan Böhringer and Ayse Sila Dokumaci and Yvonne Hari and Christian M. Schürch and Frido Brühl and Stefan Schürch and Sönke Szidat and Carsten Riether and Saulius {\v{S}}atkauskas and Thomas Geiser and David Hradetzky and Amiq Gazdhar(2021). Electrospray Mediated Localized and Targeted Chemotherapy in a Mouse Model of Lung Cancer . Frontiers in Pharmacology. 12. Frontiers Media {SA}

(2021). Efficacy of Combined <i>in-vivo</i> Electroporation-Mediated Gene Transfer of VEGF, HGF, and IL-10 on Skin Flap Survival, Monitored by Label-Free Optical Imaging: A Feasibility Study . Frontiers in surgery.

(2021). Enhancing CRISPR deletion via pharmacological delay of DNA-PKcs . Genome research.

(2021). Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro . International journal of molecular sciences.

Amiq Gazdhar, Luca Tam&#242;, Kleanthis Fytianos, Fabienne Caldana, Cedric Simillion, Anis Feki, Izabela Nita, Manfred Heller, Thomas Geiser(2021). Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro . International Journal of Molecular Sciences. 22. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 958. {MDPI} {AG}

Amiq Gazdhar, Luca Tam&#242;, Kleanthis Fytianos, Fabienne Caldana, Cedric Simillion, Anis Feki, Izabela Nita, Manfred Heller, Thomas Geiser (2021). Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro . International Journal of Molecular Sciences.

(2020). Non-viral Gene Delivery Methods for Bone and Joints . Frontiers in bioengineering and biotechnology.

(2020). Inhalational delivery of induced pluripotent stem cell secretome improves postpneumonectomy lung structure and function . Journal of applied physiology (Bethesda, Md. : 1985).

Amiq Gazdhar, Marco Sutter, Tiziana Cremona, Izabela Nita, Eleonora Cavarra, Giuseppe Lungarella, Eli Lewis, Johannes Schittny, Thomas Geiser(2020). In Vivo Electroporation-Mediated, Intrahepatic Alpha1 Antitrypsin Gene Transfer Reduces Pulmonary Emphysema in Pallid Mice . Pharmaceutics. 12. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 793. {MDPI} {AG}

Amiq Gazdhar, Marco A. Sutter, Tiziana P. Cremona, Izabela Nita, Eleonora Cavarra, Giuseppe Lungarella, Eli C. Lewis, Johannes C. Schittny, Thomas Geiser (2020). In Vivo Electroporation-Mediated, Intrahepatic Alpha1 Antitrypsin Gene Transfer Reduces Pulmonary Emphysema in Pallid Mice . Pharmaceutics.

(2020). Transcriptomic profiling reveals disease-specific characteristics of epithelial cells in idiopathic pulmonary fibrosis . Respiratory research.

(2019). Mitochondrial DNA mutations and respiratory chain dysfunction in idiopathic and connective tissue disease-related lung fibrosis . Scientific reports.

Amiq Gazdhar, Aline Sch&#246;gler, Oliver Caliaro, Melanie Br&#252;gger, Blandina I. Oliveira Esteves, Izabela Nita, Thomas Geiser, Marco P. Alves(2019). Modulation of the unfolded protein response pathway as an antiviral approach in airway epithelial cells . Antiviral Research. 162. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 44--50. Elsevier {BV}

Sch&#246;gler A, Caliaro O, Br&#252;gger M, Oliveira Esteves BI, Nita I, Gazdhar A, Geiser T, Alves MP(2018). Modulation of the unfolded protein response pathway as an antiviral approach in airway epithelial cells . Antiviral research.

Pier&#243;g J, Fytianos K, Tam&#242; L, Simillion C, Taddeo A, Kocher G, Gugger M, Grodzki T, Heller M, Blank F, et al.(2018). Stem cell secretome attenuates acute rejection in rat lung allotransplant . Interactive cardiovascular and thoracic surgery.

Khan P, Fytianos K, Tam&#242; L, Roth M, Tamm M, Geiser T, Gazdhar A, Hostettler KE(2018). Culture of human alveolar epithelial type II cells by sprouting . Respiratory research.

Tamo L, Hibaoui Y, Kallol S, Alves MP, Albrecht C, Hostettler KE, Feki A, Rougier JS, Abriel H, Knudsen L, et al.(2018). Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells . American journal of physiology. Lung cellular and molecular physiology.

Hradetzky D, Boehringer S, Ruzgys P, Satkauskas S, Geiser T, Gazdhar A(2018). Method for analysis of electrospray for gene transfer and the impact on cell viability of A549 alveolar epithelial like cells . Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.

(2018). Application of electrochemotherapy in the management of primary and metastatic cutaneous malignant tumours: a systematic review and meta-analysis . European journal of dermatology : EJD.

Seyed Jafari SM, Jabbary Lak F, Gazdhar A, Shafighi M, Borradori L, Hunger RE(2018). Application of electrochemotherapy in the management of primary and metastatic cutaneous malignant tumours: a systematic review and meta-analysis . European journal of dermatology : EJD.

Boehringer S, Ruzgys P, Tam&#242; L, Šatkauskas S, Geiser T, Gazdhar A, Hradetzky D(2018). A new electrospray method for targeted gene delivery . Scientific reports.

Pier&#243;g J, Tamo L, Fakin R, Kocher G, Gugger M, Grodzki T, Geiser T, Gazdhar A, Schmid RA(2018). Bone marrow stem cells modified with human interleukin 10 attenuate acute rejection in rat lung allotransplantation . European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Tam&#242; L, Simillion C, Hibaoui Y, Feki A, Gugger M, Prasse A, J&#228;ger B, Goldmann T, Geiser T, Gazdhar A(2017). Gene Network Analysis of Interstitial Macrophages After Treatment with Induced Pluripotent Stem Cells Secretome (iPSC-cm) in the Bleomycin Injured Rat Lung . Stem cell reviews.

Gazdhar A, Ravikumar P, Pastor J, Heller M, Ye J, Zhang J, Moe OW, Geiser T, Hsia CCW(2017). Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury . Stem cells (Dayton, Ohio).

Seyed Jafari SM, Shafighi M, Beltraminelli H, Weber B, Schmid RA, Geiser T, Gazdhar A, Hunger RE(2017). Efficacy of In Vivo Electroporation-Mediated IL-10 Gene Delivery on Survival of Skin Flaps . The Journal of membrane biology.

Seyed Jafari SM, Shafighi M, Beltraminelli H, Geiser T, Hunger RE, Gazdhar A(2017). Improvement of Flap Necrosis in a Rat Random Skin Flap Model by In Vivo Electroporation-Mediated HGF Gene Transfer . Plastic and reconstructive surgery.

Nita I, Hostettler K, Tamo L, Medová M, Bombaci G, Zhong J, Allam R, Zimmer Y, Roth M, Geiser T, Gazdhar A, Scientific reports, 2017, vol. 7, pp. 41901, 2017 .

Gazdhar A, Blank F, Cesson V, Lovis A, Aubert JD, Lazor R, Spertini F, Wilson A, Hostettler K, Nicod LP, et al.(2017). Human Bronchial Epithelial Cells Induce CD141/CD123/DC-SIGN/FLT3 Monocytes That Promote Allogeneic Th17 Differentiation . Frontiers in immunology.

Hostettler KE, Gazdhar A, Khan P, Savic S, Tamo L, Lardinois D, Roth M, Tamm M, Geiser T(2017). Multipotent mesenchymal stem cells in lung fibrosis . PloS one.

Lutz D, Gazdhar A, Lopez-Rodriguez E, Ruppert C, Mahavadi P, Günther A, Klepetko W, Bates JH, Smith B, Geiser T, Ochs M, Knudsen L, American journal of respiratory cell and molecular biology, 2015, vol. 52, no. 2, pp. 232-243, 2015 .

Seiler C, Gazdhar A, Reyes M, Benneker LM, Geiser T, Siebenrock KA, Gantenbein-Ritter B, Journal of tissue engineering and regenerative medicine, 2014, vol. 8, no. 9, pp. 737-746, 2014 .

Tevaearai HT, Gazdhar A, Giraud MN, Flück M, Methods in molecular biology (Clifton, N.J.), 2014, vol. 1121, pp. 223-229, 2014 .

Seydoux E, Rothen-Rutishauser B, Nita IM, Balog S, Gazdhar A, Stumbles PA, Petri-Fink A, Blank F, von Garnier C, International journal of nanomedicine, 2014, vol. 9, pp. 3885-3902, 2014 .

Gazdhar A, Grad I, Tamò L, Gugger M, Feki A, Geiser T, Stem cell research & therapy, 2014, vol. 5, no. 6, pp. 123, 2014 .

Gazdhar A, Lebrecht D, Roth M, Tamm M, Venhoff N, Foocharoen C, Geiser T, Walker UA, Scientific reports, 2014, vol. 4, pp. 5336, 2014 .

Fiave PA, Boehringer S, Gazdhar A, Geiser T, Hradetzky D, Biomedizinische Technik. Biomedical engineering, 2013, 2013 .

Gazdhar A, Temuri A, Knudsen L, Gugger M, Schmid RA, Ochs M, Geiser T, Human gene therapy, 2013, vol. 24, no. 1, pp. 105-116, 2013 .

Bucher C, Gazdhar A, Benneker LM, Geiser T, Gantenbein-Ritter B, Stem cells international, 2013, vol. 2013, pp. 326828, 2013 .

Gazdhar A, Susuri N, Hostettler K, Gugger M, Knudsen L, Roth M, Ochs M, Geiser T, PloS one, 2013, vol. 8, no. 6, pp. e65453, 2013 .

Leuenberger A, Gazdhar A, Herrmann G, Ochs M, Geiser T, Knudsen L, Journal of applied physiology (Bethesda, Md. : 1985), 2012, vol. 113, no. 5, pp. 799-807, 2012 .

Felder M, Sallin P, Barbe L, Haenni B, Gazdhar A, Geiser T, Guenat O, Lab on a chip, 2012, vol. 12, no. 3, pp. 640-646, 2012 .

Hradetzky D, Boehringer S, Geiser T, Gazdhar A, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2012, vol. 2012, pp. 5753-5756, 2012 .

Fakin R, Hamacher J, Gugger M, Gazdhar A, Moser H, Schmid RA, Experimental lung research, 2011, vol. 37, no. 9, pp. 555-562, 2011 .

Goepfert C, Gazdhar A, Frey FJ, Frey BM, The Prostate, 2011, vol. 71, no. 8, pp. 872-880, 2011 .

Gaschen A, Lang D, Kalberer M, Savi M, Geiser T, Gazdhar A, Lehr CM, Bur M, Dommen J, Baltensperger U, Geiser M, Environmental science & technology, 2010, vol. 44, no. 4, pp. 1424-1430, 2010 .

Ayuni EL, Gazdhar A, Giraud MN, Kadner A, Gugger M, Cecchini M, Caus T, Carrel TP, Schmid RA, Tevaearai HT, PloS one, 2010, vol. 5, no. 12, pp. e14467, 2010 .

Hoksch B, Rufer B, Gazdhar A, Bilici M, Beshay M, Gugger M, Schmid RA, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2009, vol. 36, no. 6, pp. 1058-1063, 2009 .

Beshay M, Gazdhar A, Gugger M, Reymond M, Schmid RA, Development, growth & differentiation, 2009, vol. 51, no. 6, pp. 547-553, 2009 .

Carboni GL, Fahrner R, Gazdhar A, Printzen G, Schmid RA, Hoksch B, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, vol. 33, no. 5, pp. 777-780, 2008 .

Gazdhar A, Fachinger P, van Leer C, Pierog J, Gugger M, Friis R, Schmid RA, Geiser T, American journal of physiology. Lung cellular and molecular physiology, 2007, vol. 292, no. 2, pp. L529-36, 2007 .

Stammberger U, Bilici M, Gugger M, Gazdhar A, Hamacher J, Hyde SC, Schmid RA, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2006, vol. 25, no. 12, pp. 1474-1479, 2006 .

Su Y, Büchler P, Gazdhar A, Giese N, Reber HA, Hines OJ, Giese T, Büchler MW, Friess H, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006, vol. 10, no. 9, pp. 1230-41; discussion 1242, 2006 .

Gazdhar A, Bilici M, Pierog J, Ayuni EL, Gugger M, Wetterwald A, Cecchini M, Schmid RA, The journal of gene medicine, 2006, vol. 8, no. 7, pp. 910-918, 2006 .

Tavakoli R, Gazdhar A, Pierog J, Bogdanova A, Gugger M, Pringle IA, Gill DR, Hyde SC, Genoni M, Schmid RA, The journal of gene medicine, 2006, vol. 8, no. 2, pp. 242-248, 2006 .

Büchler P, Gazdhar A, Schubert M, Giese N, Reber HA, Hines OJ, Giese T, Ceyhan GO, Müller M, Büchler MW, Friess H, Annals of surgery, 2005, vol. 242, no. 6, pp. 791-800, discussion 800-1, 2005 .

Pierog J, Gazdhar A, Stammberger U, Gugger M, Hyde S, Mathiesen I, Grodzki T, Schmid RA, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2005, vol. 27, no. 6, pp. 1030-1035, 2005 .

Xiao Y, Kleeff J, Guo J, Gazdhar A, Liao Q, Di Cesare PE, Büchler MW, Friess H, Journal of gastroenterology and hepatology, 2004, vol. 19, no. 3, pp. 296-302, 2004 .

PREPRINT

Amiq Gazdhar, Kleanthis Fytianos, Burak Ozan, Eliane Pfister, Petra khan, Maximilian Boesch, Florent Baty, Sophia Pantasis, Sofia Mykoniati, Mattia Bordoli, et al. (2024). Matrix metalloproteinase 24 (MMP24) is a pro-fibrotic mediator in lung fibrosis .