プロフィール詳細

プロジェクトを作成

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Dr. Amir T.に依頼

Sweden

CRISPR and Bioinformatics Expert | PhD | 10+ years of industry experience | 20+ publications | NGS Data Analysis

プロフィール概要

7 years of experience in large pharma setting (AstraZeneca) plus 2 years of leadership in a small biotech startup | CRISPR-Cas9 Discovery and Characterisation | DNA Repair Profiling | Deep-targeted DNA Sequencing and Analysis | in-silico sgRNA Design | Off-target DNA Cleavage Detection | GUIDE-Seq and CHANGE-Seq | NGS Data Analysis | Bioinformatics Pipeline Development

専門分野

• ★ Next Generation Sequencing (NGS)
• ★ DNA Damage & Repair
• ★ Gene Editing/CRISPR
• ☆ Molecular Biology
• ☆ Mutagenesis
• ☆ Biomolecular Engineering
• ☆ Genetic Engineering
• ☆ Gene Delivery

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research Market Research, Scientific and Technical Research, Systematic Literature Review

Consulting Business Strategy Consulting, Scientific and Technical Consulting

Data & AI Data Visualization, Big Data Analytics

職務経験

Director

Vector BioPharma

3月 2022 - 11月 2023

Senior Bioinformatician

AstraZeneca Mölndal

9月 2020 - 2月 2022

Senior Research Scientist

AstraZeneca

3月 2018 - 8月 2020

PostDoc

AstraZeneca Mölndal

3月 2015 - 3月 2018

Research Scientist

Birjand University of Medical Sciences

1月 2014 - 2月 2015

Research Assistant

Monash Institute of Medical Research

6月 2012 - 6月 2013

学歴

PhD (Animal Science Department)

Ferdowsi University of Mashhad Faculty of Agriculture

2009 - 6月 2014

MSc (Animal Science)

Ferdowsi University of Mashhad

2008 - 2010

BSc (Animal Science)

University of Kurdistan

2004 - 2006

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Bestas B, Wimberger S, Degtev D, Madsen A, Rottner AK, Karlsson F, Naumenko S, Callahan M, Touza JL, Francescatto M, et al.(2023). A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo . Nature communications.

Wimberger S, Akrap N, Firth M, Brengdahl J, Engberg S, Schwinn MK, Slater MR, Lundin A, Hsieh PP, Li S, et al.(2023). Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing . Nature communications.

Shamshirgaran Y, Liu J, Sumer H, Verma PJ, Taheri-Ghahfarokhi A(2022). Tools for Efficient Genome Editing; ZFN, TALEN, and CRISPR . Methods in molecular biology (Clifton, N.J.).

Lundin A, Porritt MJ, Jaiswal H, Seeliger F, Johansson C, Bidar AW, Badertscher L, Wimberger S, Davies EJ, Hardaker E, et al.(2020). Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery . Nature communications.

Carreras A, Pane LS, Nitsch R, Madeyski-Bengtson K, Porritt M, Akcakaya P, Taheri-Ghahfarokhi A, Ericson E, Bjursell M, Perez-Alcazar M, et al.(2019). In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model . BMC biology.

Amir Taheri-Ghahfarokhi, Benjamin J M Taylor, Roberto Nitsch, Anders Lundin, Anna-Lina Cavallo, Katja Madeyski-Bengtson, Fredrik Karlsson, Maryam Clausen, Ryan Hicks, Lorenz M Mayr, et al.(2018). Decoding non-random mutational signatures at Cas9 targeted sites . Nucleic Acids Research. Oxford University Press ({OUP})

Avivar-Valderas A, McEwen R, Taheri-Ghahfarokhi A, Carnevalli LS, Hardaker EL, Maresca M, Hudson K, Harrington EA, Cruzalegui F(2018). Functional significance of co-occurring mutations in <i>PIK3CA</i> and <i>MAP3K1</i> in breast cancer . Oncotarget.

Gupta SK, Wesolowska-Andersen A, Ringgaard AK, Jaiswal H, Song L, Hastoy B, Ingvorsen C, Taheri-Ghahfarokhi A, Magnusson B, Maresca M, et al.(2018). NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations . Stem cell research.

Bjursell M, Porritt MJ, Ericson E, Taheri-Ghahfarokhi A, Clausen M, Magnusson L, Admyre T, Nitsch R, Mayr L, Aasehaug L, et al.(2018). Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype . EBioMedicine.

Taheri-Ghahfarokhi A, Malaver-Ortega LF, Sumer H(2015). Genome Modification of Pluripotent Cells by Using Transcription Activator-Like Effector Nucleases (TALENs) . Methods in molecular biology (Clifton, N.J.).

Malaver-Ortega LF, Taheri-Ghahfarokhi A, Sumer H(2015). Inducing Pluripotency in Cattle . Methods in molecular biology (Clifton, N.J.).

Hoshyar, Reyhane and Mostafavinia, Seyedeh Elham and Zarban, Asghar and Hassanpour, Mohammad and Partovfari, Mozhde and Taheri, Amir and Pouyan, Mohsen(2015). Correlation of Anticancer Effects of 12 Iranian Herbs on Human breast Adenocarcinoma cells with antioxidant Properties. Free Radicals and Antioxidants. 5. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 65--73.

Gholami, Maryam and Hemmati, Mina and Taheri-Ghahfarokhi, Amir and Hoshyar, Reyhane and Moossavi, Maryam(2015). Expression of glucokinase, glucose 6-phosphatase, and stress protein in streptozotocin-induced diabetic rats treated with natural honey. International Journal of Diabetes in Developing Countries. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--7. Springer

Taheri-Ghahfarokhi, A., Tahmoorespur, M., Dehghani, H., Shamshirgaran, Y., Sumer, H., Liu, J., Verma, P.J.(2014). Efficient TALEN-mediated mutagenesis on a highly conserved region of myostatin gene in mouse embryonic stem cells . Indian Journal of Animal Sciences. 84. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1185-1191.

Tahmoorespur, M., Taheri, A., Gholami, H., Ansary, M.(2011). PCR-SSCP variation of GH and STAT5A genes and their association with estimated breeding values of growth traits in baluchi sheep . Animal Biotechnology. 22. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 37-43.

Ansary, M., Tahmoorespur, M., Nassiry, M.R., Taheri, A., Valeh, M.V.(2011). Polymorphism in intron-I of myostatin gene and its association with estimated breeding values of growth traits in Baluchi sheep (Ovis aries) . Indian Journal of Animal Sciences. 81. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 75-78.

Tahmoorespur, M., Taheri, A., Valeh, M.V., Saghi, D.A., Ansary, M.(2010). Assessment relationship between leptin and Ghrelin genes polymorphisms and estimated breeding values (EBVs) of growth traits in Baluchi sheep . Journal of Animal and Veterinary Advances. 9. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2460-2465.

Valeh, M.V., Tahmoorespour, M., Ansari, M., Nassiry, M.R., Karimi, D., Taheri, A.(2009). Association of growth traits with SSCP polymorphisms at the growth hormone receptor (GHR) and growth hormone releasing hormone receptor (GHRHR) genes in the Baluchi sheep . Journal of Animal and Veterinary Advances. 8. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1063-1069.

CONFERENCE PAPER

Taheri-ghahfarokhi, Amir and Liu, Jun and Verma, Paul(2014). Fluorescence-tagged TALEN constructs enrich targeting outcomes. TRANSGENIC RESEARCH. 23. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 866--866.

Taheri Ghahfarokhi, Amir and Tahmoorespur, Mojtaba and Shamshirgaran, Yasaman(2012). Development of a New Quantitative Competitive PCR Assay for Rumen Butyrate-Producing Bacterium, Butyrivibrio fibrisolvens. 1st Asia Dairy Goat Conference.

Tahmoorespur, Mojtaba and Nassiri, Mohammad Reza and Naserian, Abbas Ali and TAHERI GHAHFAROKHI, AMIR and others(2012). Phylogenetic analysis of serotype Asia1 foot-and-mouth disease virus: Asia diversity and the Iran perspective. 1st Asia Dairy Goat Conference.

Tahmoorespur, Mojtaba and Nassiri, Mohammad Reza and Naserian, Abbas Ali and TAHERI GHAHFAROKHI, AMIR and others(2011). detection of mycobacterium avium subsp. paratuberclisis in feces samples from holestein dairy cattle by polymerase chain reaction. saadc2011.

SHAMSHIRGARAN, YASAMAN and Aslaminejad, Ali Asghar and Tahmoorespur, Mojtaba and TAHERI GHAHFAROKHI, AMIR and others(2010). Comparsion of fixed and random regression test-day models for genetic evaluation of milk yield trait of Iranian Holstein cows. 61st Annual Meeting of the European Association for Animal Production.