プロフィール詳細

プロジェクトを作成

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Dr. Amish P.に依頼

United States

PhD Cancer Biologist | Oncology Drug Discovery & Translational Research Consultant | In Vitro/In Vivo Strategy

プロフィール概要

I am a PhD-trained cancer biologist with 10+ years of experience across academic research centers and biotech/pharma, including Memorial Sloan Kettering Cancer Center, PTC Therapeutics, and Inspirna. My expertise spans oncology drug discovery and translational research, with deep hands-on experience designing and executing in vitro and in vivo studies to identify & validate targets, understand mechanism of action, support SAR, and guide assay development. I have led biology efforts supporting hit-to-lead and early development programs, generated decision-ready data packages, and collaborated cross-functionally with chemistry, bioinformatics, and in vivo pharmacology teams. I now consult with biotech companies, investors, and research groups seeking rigorous scientific insight to de-risk oncology programs.

専門分野

• ☆ Computational Biology
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ Omics
• ☆ Transcriptomics
• ☆ Metabolomics
• ☆ Genomics
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ ATAC-Seq
• ☆ DNA Sequencing
• ☆ Gene Expression Analysis
• ☆ RNA Sequencing
• ☆ Plasmid DNA
• ☆ ChIP-Seq
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Data Analysis
• ☆ Algorithm Design
• ☆ Data Processing
• ☆ Data Exploration
• ☆ Cluster Analysis
• ☆ Data Visualization
• ☆ Bioinformatics
• ☆ Gene & Protein Expression Analysis
• ☆ Cell Culture
• ☆ Cell Line Engineering
• ☆ Biomolecular Engineering
• ☆ Gene Editing/CRISPR
• ☆ Blotting
• ☆ Python
• ☆ R
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Feasibility Studies

サービス

• Writing
• Research
• Consulting

Writing Technical Writing

Research Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Senior Scientist

Inspirna

12月 2023 - 3月 2025

Scientist II

PTC Therapeutics (United States)

3月 2023 - 12月 2023

Senior Research Scientist

Memorial Sloan-Kettering Cancer Center

4月 2022 - 3月 2023

Research Associate

Memorial Sloan-Kettering Cancer Center

4月 2020 - 3月 2022

Research Fellow

Memorial Sloan-Kettering Cancer Center

4月 2015 - 3月 2020

学歴

Cancer Biology (Dermatology)

University of Texas Southwestern Medical Center

2009 - 2014

Genetics

Rutgers University New Brunswick

2003 - 2007

認定資格

• Clinical Trials: Good Clinical Practice (GCP)

  Novartis

  https://coursera.org/share/045813964e86d8214c4fb97f36353d02

  11月 2025 - 現在

• Fundamentals of Immunology

  Rice University

  https://www.coursera.org/account/accomplishments/specialization/0YLZU02OENFJ

  9月 2025 - 現在

• Drug Hunting: The Science of Making New Medicines

  Novartis

  https://www.coursera.org/account/accomplishments/specialization/9W33QXHLY53I

  7月 2025 - 現在

出版物

JOURNAL ARTICLE

Miguel A. Miranda-Román, Cindy J. Lee, Eve Fishinevich, Leili Ran, Amish J. Patel, Juan Yan, Makhzuna N. Khudoynazarova, Sarah Warda, Mohini R. Pachai, Yu Chen, et al. (2024). MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor . Clinical Cancer Research.

Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Cindy J. Lee, Dan Li, Naitao Wang, Gabriella Bayshtok, et al.(2022). PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry . Cancer Discovery. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString OF1--OF20. American Association for Cancer Research ({AACR})

(2019). Overcoming BET Inhibitor Resistance in Malignant Peripheral Nerve Sheath Tumors . Clinical Cancer Research.

(2016). The role of nerve microenvironment for neurofibroma development . Oncotarget.

(2014). Cells of Origin in the Embryonic Nerve Roots for NF1-Associated Plexiform Neurofibroma . Cancer Cell.

(2014). Preclinical Therapeutic Efficacy of a Novel Pharmacologic Inducer of Apoptosis in Malignant Peripheral Nerve Sheath Tumors . Cancer Research.

(2013). BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction . Cell reports.

(2013). CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors . Cell.

PREPRINT

Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Cindy J. Lee, Dan Li, Naitao Wang, Gabriella Bayshtok, et al. (2023). Data from PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry .

Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Cindy J. Lee, Dan Li, Naitao Wang, Gabriella Bayshtok, et al. (2023). Supplementary Data from PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry .

Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Cindy J. Lee, Dan Li, Naitao Wang, Gabriella Bayshtok, et al. (2023). Supplementary Data from PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry .

Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Cindy J. Lee, Ning Yang, Yi Wang, et al.(2022). Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy . Cold Spring Harbor Laboratory