プロフィール詳細

プロジェクトを作成

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Dr. Annunziata C.に依頼

United States

Multitalented biomedical scientist with 14 years' multidisciplinary preclinical and clinical research experience.

プロフィール概要

Biomedical scientist with highly multidisciplinary expertise. BS/MS in microbiology, molecular genetics and assay development. PhD in drug discovery in the context of muscle biology and regenerative medicine, using pharmacological and genetic approaches to evaluate PKCθ inhibition as candidate immunomodulatory therapy for an orphan disease (Duchenne Muscular Dystrophy). II level Master’s degree in clinical drugs development. Experience in both basic (12+ years) and translational research (3+ years). 3+ years in an R&D-like academic lab designing, coordinating and analyzing clinical studies. 13+years autonomously designing, conducting and leading pre-clinical and basic research projects, coordinating teams of 3-10 people (technicians, PhD students, nutritionists, statisticians, data scientists), establishing, negotiating and coordinating collaborations with external partners and Companies/CROs. Extensive postdoctoral experience on aging/aging-related disorders, anti-aging therapies, immunology, inflammation, regenerative medicine, stem cells, muscle biology, cancer/chemotherapy, cognitive decline, mitochondria, biomaterials, stem cell differentiation, metabolic disorders, hypertension, obesity, cardiovascular disease, fasting, fasting-mimicking, clinical and preclinical nutritional interventions. Documented extensive experience in a high variety of cell/molecular biology and biochemical assays (flow cytometry, cell culture, RT-qPCR, ELISA, protein assays, RNA/DNA multiplex assays). Documented expertise generating IRB protocols, SOPs, IACUC and scientific protocols, technical documentation, and scientific reports. Multipotential, visionary, out-of-the-box-thinker. Particularly skilled at facilitating and promoting multidisciplinary collaborations. Solution oriented with strong critical-thinking abilities and entrepreneurial mindset. Extremely creative, logical, result-, efficiency- and quality-oriented. Full English and Italian proficiency. Basic Spanish. Multicultural and international teaming experience.

専門分野

• ★ Drug Development
• ★ Human Biology
• ☆ Evolutionary Biology
• ☆ Microbiology
• ☆ Immunoassay
• ☆ Molecular Biology
• ☆ Cell Biology
• ☆ Neurobiology
• ☆ Histology
• ☆ Nutrition Science
• ☆ Cell Aging
• ☆ Gerontology
• ☆ Clinical Trials
• ☆ Cardiovascular Disease
• ☆ Obesity
• ☆ Dietetics
• ☆ Inflammation
• ☆ Metabolism & Metabolic Disease

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Technical Writing, Copywriting, Newswriting

Research Market Research, User Research, Meta-Research, Feasibility Study, Fact Checking, Gap Analysis, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Digital Strategy Consulting, Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Data Visualization, Big Data Analytics, Data Insights

Product Development Formulation, Product Evaluation, Material Sourcing, Product Validation, Concept Development, Prototyping

職務経験

Postdoctoral Research Associate,

University of Southern California - Davis School of Gerontology

6月 2018 - 3月 2022

Postdoctoral Scientist

Cedars Sinai Medical Center - Regenerative Medicine Institute

3月 2016 - 6月 2018

Postdoc

Tecnologica Research Institute

9月 2015 - 2月 2016

Postdoc

ENEA Centro Ricerche Frascati

11月 2014 - 6月 2015

学歴

II level Master degree in Clinical and Preclinical Drug Development

Universita Cattolica del Sacro Cuore

3月 2014 - 11月 2014

PhD in Morphogenetic and Cytological Sciences (DAHFMO-Unit of Histology and Medical Embriology)

Università degli Studi di Roma La Sapienza

10月 2010 - 2月 2014

Master degree (Applied Cell Biology)

Università degli Studi di Roma La Sapienza

1月 2009 - 7月 2010

Bachelor's degree (Biological Sciences)

Università degli Studi di Roma La Sapienza

9月 2005 - 12月 2008

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Annunziata Nancy Crupi, Jonathan Haase, Sebastian Brandhorst, Valter D Longo(2020). Periodic and Intermittent Fasting in Diabetes and Cardiovascular Disease . Current Diabetes Reports. 20. (12). Springer Science and Business Media {LLC}

Marek-Iannucci S, Thomas A, Hou J, Crupi A, Sin J, Taylor DJ, Czer LS, Esmailian F, Mentzer RM, Andres AM, et al.(2019). Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury . Scientific reports.

Marrazzo P, Crupi AN, Alviano F, Teodori L, Bonsi L(2019). Exploring the roles of MSCs in infections: focus on bacterial diseases . Journal of molecular medicine (Berlin, Germany).

Crupi AN, Nunnelee JS, Taylor DJ, Thomas A, Vit JP, Riera CE, Gottlieb RA, Goodridge HS(2018). Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging . Aging.

Teodori, L., Crupi, A., Costa, A., Diaspro, A., Melzer, S., Tarnok, A.(2017). Three-dimensional imaging technologies: a priority for the advancement of tissue engineering and a challenge for the imaging community . Journal of Biophotonics. 10. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 24-45.

Crupi, A., Costa, A., Tarnok, A., Melzer, S., Teodori, L.(2015). Inflammation in tissue engineering: The Janus between engraftment and rejection . European Journal of Immunology. 45. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3222-3236.

Marrocco, V., Fiore, P., Madaro, L., Crupi, A., Lozanoska-Ochser, B., Bouché, M.(2014). Targeting PKCθ in skeletal muscle and muscle diseases: Good or bad? . Biochemical Society Transactions. 42. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1550-1555.

Madaro, L., Pelle, A., Nicoletti, C., Crupi, A., Marrocco, V., Bossi, G., Soddu, S., Bouché, M.(2012). PKC theta ablation improves healing in a mouse model of muscular dystrophy . PLoS ONE. 7. (2).