プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Anthony O.に依頼

United States

Expert in Synaptic Function, Data Analysis, and Microscopy with 15+ Years of Experience

プロフィール概要

As a neuroscientist with a focus on gene editing, I have worked on various research projects that have contributed to the understanding of neurodegenerative diseases and the role of specific proteins and enzymes in their pathogenesis. Here is a summary of my previous research and projects: Perturbations of the endolysosomal pathway in neurodegenerative diseases: I have extensively studied the role of VPS35 and the retromer complex in the endolysosomal system and their implications in Parkinson's disease (PD) and Alzheimer's disease (AD). My research has focused on the PD-linked D620N mutation in VPS35 and its impact on retromer dysfunction, as well as the connections between VPS35, the retromer, and other neurodegenerative diseases such as amyotrophic lateral sclerosis and primary tauopathies. Neuronal expression of Transglutaminase-2 (TG2) in rodent models of chronic-relapsing and non-relapsing EAE: My investigation has explored the expression of TG2 in subsets of macrophages, microglia, and astrocytes after experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). I have examined the neuronal pathology during disease progression and identified the induction of cytoplasmic TG2 in neurons surrounding perivascular lesion sites. Mitochondrial quality control and PTEN-induced kinase 1 (PINK1) in inflammatory lung injury and neurodegenerative diseases: My research has shown that the ubiquitin E3 ligase receptor component, FBXO7, targets PINK1 for cellular disposal, leading to mitochondrial injury and inflammation. I have identified a small molecule, BC1464, which disrupts the association between FBXO7 and PINK1, enhancing mitochondrial quality and limiting inflammatory injury. BC1464 has also demonstrated neuroprotective effects in various culture models of Parkinson's disease. My educational background and expertise in synaptic function, data analysis, and microscopy, as well as my experience in gene editing, have been instrumental in advancing the understanding of neurodegenerative diseases and their underlying mechanisms.

専門分野

• ★ Cell Biology
• ★ Neuroscience
• ★ Data Analysis
• ☆ Cell-Based Assays
• ☆ Cytochemistry
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Stem Cell Research
• ☆ Developmental Neuroscience
• ☆ Molecular Neuroscience
• ☆ Neurobiology
• ☆ Microscopy
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Surface Receptors
• ☆ R
• ☆ Neurology
• ☆ Parkinson's Disease
• ☆ Alzheimer's Disease

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Processing, Image Analysis, Data Visualization

職務経験

Postdoctoral Fellow

The Ohio State University

5月 2023 - 現在

Postdoctoral Research fellow

Van Andel Research Institute

9月 2020 - 5月 2023

Lab Manager

University of Pittsburgh

4月 2012 - 7月 2015

Lab Associate

University of Miami

6月 2011 - 3月 2012

Lab Manager

University of Pittsburgh

4月 2010 - 4月 2011

学歴

PhD (Pathology)

University of Pittsburgh

8月 2015 - 6月 2021

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Yuan Liu, Travis B. Lear, Manish Verma, Kent Z.Q. Wang, P. Anthony Otero, Alison C. McKelvey, Sarah R. Dunn, Erin Steer, Nicholas W. Bateman, Christine Wu, et al. (2020). Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1 . JCI Insight.

Patrick D. Wilkinson, Frances Alencastro, Evan R. Delgado, Madeleine P. Leek, Matthew P. Weirich, P. Anthony Otero, Nairita Roy, Whitney K. Brown, Michael Oertel, Andrew W. Duncan(2019). Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury . The American Journal of Pathology. 189. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1241--1255. Elsevier {BV}