プロフィール詳細

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Dr. Arslan A.に依頼

Pakistan

Mass spectrometry Application Specialist

プロフィール概要

Vast experience (14+ years) in mass spectrometry applications: metabolism, drug quantification, natural product analysis, proteomics, etc. Deep knowledge of the metabolomics and proteomics work flow: sample preparation from biological, clinical, and plant samples; data acquisition and analysis using proprietary and open software. Experience in research project writing and management. Experience in teaching and training mass spectrometry to students, technicians, and researchers. Work experience: University of Hamburg, Lund University, TUBITAK, University of Karachi Mass Spectrometry: LC-MS and GC-Ms systems based on Orbitraps, QTOF, QqQ, IT, analyzers and MALDI-TOF/TOF-MS instruments from Bruker Daltonics, ThermoFischer Scientific, Agilent Technologies, and ABSciex Proteomics: ProteomeDiscoverer, Skyline, Maxquant, Byonic, Proteinscape, Biotools, etc. Metabolomics: MS-DIAL, MPP, Metaboscape Natural Products dereplication: GNPS, DNP etc. Chromatography, ChemStation Analytical Methods Development Good Laboratory Practices (GLP) High-Performance Liquid Chromatography (HPLC) Gas Chromatography

専門分野

• ☆ Analytical Chemistry
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Gas Chromatography
• ☆ Molecular Biology
• ☆ Omics
• ☆ Proteomics
• ☆ Metabolomics
• ☆ Herbal Products

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research User Research, Technology Scouting, Fact Checking

Consulting Operations Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Data Processing

職務経験

Assistant Professor

University of Karachi

11月 2018 - 現在

Alexander von Humboldt Mass spectrometry /Proteomics

Universität Hamburg

3月 2022 - 11月 2022

Research Officer

University of Karachi

2月 2018 - 10月 2018

Postdoctoral Fellow Proteomics

Universität Hamburg

2月 2017 - 1月 2018

学歴

PhD

University of Karachi

5月 2010 - 11月 2015

Exchange PhD Studies (Lund University Diabetes Centre (LUDC), Unit of Molecular Metabolism, CRC)

Lund University

9月 2013 - 5月 2014

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Arslan Ali, Tajwali Khan, Fizza Iftikhar, Rafia Akhlaq, Syed Ghulam Musharraf (2023). Acidotic and hypoxic tumor microenvironment induces changes to histone acetylation and methylation in oral squamous cell carcinoma . Biomedical Chromatography.

Arslan Ali, Rafia Akhlaq, Tajwali Khan, Tehmina Ahmed, Syed G. Musharraf (2023). PX‐12 synergistically enhances the therapeutic efficacy of vorinostat under hypoxic tumor microenvironment in oral squamous cell carcinoma in vitro . Drug Development Research.

Arslan Ali, Syed Shah, Muhammad Khan, Adeeba Khadim, Mufarreh Asmari, Jalal Uddin, Syed Musharraf (2022). Sensitive Detection of Pharmaceutical Drugs and Metabolites in Serum Using Data-Independent Acquisition Mass Spectrometry and Open-Access Data Acquisition Tools . Pharmaceuticals.

Arslan Ali, Syed Muhammad Zaki Shah, Muhammad Noman Khan, Adeeba Khadim, Mufarreh Asmari , Jalal Uddin, Syed Ghulam Musharraf (2022). Sensitive Detection of Pharmaceutical Drugs and Metabolites in Serum Using Data-Independent Acquisition Mass Spectrometry and Open-Access Data Acquisition Tools . Pharmaceuticals.

Binish Khaliq and Sven Falke and Qamar Saeed and Muhammad Bilal and Aisha Munawar and Arslan Ali and Gunnar Baermann and Habib-ur-Rehman Athar and Seema Mahmood and Christian Betzel and Qurban Ali and Ahmed Akrem(2021). Eruca sativa seed napin structural insights and thorough functional characterization . Scientific Reports. 11. (1). Springer Science and Business Media {LLC}

Adeeba Khadim and Bibi Zareena and Saddam Hussain and Syed Usama Yaseen Jeelani and Arslan Ali and Syed Ghulam Musharraf(2021). Pooling strategy to construct in-house high-resolution electrospray ionization tandem mass spectrometry database of drugs . Journal of Industrial and Engineering Chemistry. Elsevier {BV}

Sophie C. Brandt and H{\'{e}}vila Brognaro and Arslan Ali and Bernhard Ellinger and Katharina Maibach and Martin Rühl and Carsten Wrenger and Hartmut Schlüter and Wilhelm Schäfer and Christian Betzel and Stefan Janssen and Martin Gand(2021). Insights into the genome and secretome of Fusarium metavorans DSM105788 by cultivation on agro-residual biomass and synthetic nutrient sources . Biotechnology for Biofuels. 14. (1). Springer Science and Business Media {LLC}

Kiran Ali and Arslan Ali and Muhammad Noman Khan and Saeedur Rahman and Shaheen Faizi and Muhammad Shaiq Ali and Shaden A. M. Khalifa and Hesham R. El-Seedi and Syed Ghulam Musharraf(2021). Rapid Identification of Common Secondary Metabolites of Medicinal Herbs Using High-Performance Liquid Chromatography with Evaporative Light Scattering Detector in Extracts . Metabolites. 11. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 489. {MDPI} {AG}

Arslan Ali, Kiran Ali, Muhammad Noman Khan, Saeedur Rahman, Shaheen Faizi, Muhammad Shaiq Ali, Shaden A. M. Khalifa, Hesham R. El-Seedi, Syed Ghulam Musharraf (2021). Rapid Identification of Common Secondary Metabolites of Medicinal Herbs Using High-Performance Liquid Chromatography with Evaporative Light Scattering Detector in Extracts . Metabolites.

Bibi Zareena and Adeeba Khadim and Syed Usama Y. Jeelani and Saddam Hussain and Arslan Ali and Syed Ghulam Musharraf(2021). High-Throughput Detection of an Alkaloidal Plant Metabolome in Plant Extracts Using LC-ESI-QTOF-MS . Journal of Proteome Research. American Chemical Society ({ACS})

Arslan Ali, Bernhard Ellinger, Sophie C. Brandt, Christian Betzel, Martin Rühl, Carsten Wrenger, Hartmut Schlüter, Wilhelm Schäfer, Hévila Brognaro, Martin Gand(2021). Genome and Secretome Analysis of Staphylotrichum longicolleum DSM105789 Cultured on Agro-Residual and Chitinous Biomass . Microorganisms. 9. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1581. {MDPI} {AG}

Arslan Ali, Bernhard Ellinger, Sophie C. Brandt, Christian Betzel, Martin R&#252;hl, Carsten Wrenger, Hartmut Schluter, Wilhelm Sch&#228;fer, H&#233;vila Brognaro, Martin Gand (2021). Genome and Secretome Analysis of <i>Staphylotrichum longicolleum</i> DSM105789 Cultured on Agro-Residual and Chitinous Biomass . Microorganisms.

Arslan Ali, Kiran Ali, Muhammad Noman Khan, Saeedur Rahman, Shaheen Faizi, Muhammad Shaiq Ali, Shaden A. M. Khalifa, Hesham R. El-Seedi, Syed Ghulam Musharraf (2021). Rapid Identification of Common Secondary Metabolites of Medicinal Herbs Using High-Performance Liquid Chromatography with Evaporative Light Scattering Detector in Extracts . Metabolites.

Nurmeen Adil and Hamad Ali and Amna Jabbar Siddiqui and Arslan Ali and Ayaz Ahmed and Hesham R. El-Seedi and Syed Ghulam Musharraf(2021). Evaluation of cytotoxicity of areca nut and its commercial products on normal human gingival fibroblast and oral squamous cell carcinoma cell lines . Journal of Hazardous Materials. 403. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 123872. Elsevier {BV}

Nudrat Aziz and Muhammad Noman Khan and Faraz Ul Haq and Fayaz Ahmed and Arslan Ali and Hesham R. El-Seedi and Syed Ghulam Musharraf(2021). Erythroid induction activity of Aquilegia fragrans and Aquilegia pubiflora and identification of compounds using liquid chromatography-tandem mass spectrometry . Journal of King Saud University - Science. 33. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 101227. Elsevier {BV}

Sindhia Kumari and Arslan Ali and Talat Roome and Anam Razzak and Ayesha Iqbal and Amna Jabbar Siddiqui and Syed Muhammad Zahid Azam and Hafeezullah Shaikh and Hesham R. El-Seedi and Syed Ghulam Musharraf(2021). Metabolomics approach to understand the hepatitis C virus induced hepatocellular carcinoma using LC-ESI-MS/MS . Arabian Journal of Chemistry. 14. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 102907. Elsevier {BV}

Arslan Ali, Junaid Ullah, Zainab Khanum, Ishtiaq Ahmad Khan, Abdul Nasir Khalid, Syed Ghulam Musharraf(2021). Metaproteomics reveals the structural and functional diversity of Dermatocarpon miniatum (L.) W. Mann. Microbiota . Fungal Biology. Elsevier {BV}

Arslan Ali, Junaid Ullah, Satwat Hashmi, Faisal Khan, Shahid Ahmed Sami, Nageeb Basir, Syeda Saira Bokhari, Hasanat Sharif, Hesham R. El-Seedi, Syed Ghulam Musharraf (2021). Pericardial fluid proteomic label-free quantification of differentially expressed proteins in ischemic heart disease patients with systolic dysfunction by nano-LC-ESI-MS/MS analysis . RSC Advances.

Nasir Abbas and Arslan Ali and Sindhia Kumari and Ayesha Iqbal and Adnan Husain and Talat Saeed and Zainab AbdulAmer Al-Ballam and Nisar Ahmed and Hesham R. El-Seedi and Syed Ghulam Musharraf(2020). Untargeted-metabolomics differentiation between poultry samples slaughtered with and without detaching spinal cord . Arabian Journal of Chemistry. 13. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9081--9089. Elsevier {BV}

(2020). CYTOTOXIC EVALUATION OF ANTIOXIDANT AND GAMMA-AMINO BUTYRIC ACID (GABA) ENRICHED MANGO (MANGIFERA INDICA CV. CHAUNSA) MESOCARP EXTRACT ON HER2-POSITIVE BREAST CANCER CELLS . Journal of the Chemical Society of Pakistan.

(2020). Model prediction of a Kunitz-type trypsin inhibitor protein from seeds of Acacia nilotica L. with strong antimicrobial and insecticidal activity . Turkish Journal of Biology.

(2020). A high-throughput method for dereplication and assessment of metabolite distribution in Salvia species using LC-MS/MS . Journal of Advanced Research.

(2020). Profiling of hydroxyurea‐treated β ‐thalassemia/ serum proteome through nano‐LC–ESI–MS/ MS in combination with microsol‐isoelectric focusing . Biomedical Chromatography.

(2020). Metabolite distribution and correlation studies of Ziziphus jujuba and Ziziphus nummularia using LC-ESI-MS/MS . Journal of Pharmaceutical and Biomedical Analysis.

(2020). Phosphoproteomic Strategies in Cancer Research: A Minireview . The Analyst.

Arslan Ali, Zainab Khanum, Mart&#237;n E. Tiznado-Hern&#225;ndez, Syed Ghulam Musharraf, Muhammad Shakeel, Ishtiaq Ahmad Khan (2020). Adaptation mechanism of mango fruit (Mangifera indica L. cv. Chaunsa White) to heat suggest modulation in several metabolic pathways . RSC Advances.

Arslan Ali, Mustafa Gani S&#252;rmen, Saime S&#252;rmen, Syed Ghulam Musharraf, Nesrin Emekli (2020). Phosphoproteomic strategies in cancer research: a minireview . The Analyst.

Arslan Ali, Saqib Hassan, Wardah Mazhar, Sabiha Farooq, Syed Ghulam Musharraf(2019). Assessment of heavy metals in calcium carbide treated mangoes by inductively coupled plasma-mass spectrometry (ICP-MS) . Food Additives & Contaminants: Part A. 36. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1769--1776. Informa {UK} Limited

(2019). Metabolite Profiling and Quantitation of Cucurbitacins in Cucurbitaceae Plants by Liquid Chromatography coupled to Tandem Mass Spectrometry . Scientific Reports.

(2019). Sensitive Determination of C-Alkylated Flavonoids by HPLC-ESI-MS/MS Using Multiple Reaction Monitoring Approach: Pseudarthria hookeri as a Case Study . Journal of Chromatographic Science.

(2019). Combining untargeted and targeted metabolomics approaches for the standardization of polyherbal formulations through UPLC–MS/MS . Metabolomics.

(2019). Determination of Important Phenolic Compounds in Pakistani Brown Rice Varieties in Controlled, Germinated and Fermented Conditions by High Performance Liquid Chromatography . Progress in Chemical and Biochemical Research.

Arslan Ali, Syed Ghulam Musharraf, Mariam Ameer(2017). MALDI-MS analysis and theoretical evaluation of olanzapine as a UV laser desorption ionization (LDI) matrix . Journal of Pharmaceutical and Biomedical Analysis. 132. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 190--194. Elsevier {BV}

Ali, A., Maher, S., Khan, S.A., Chaudhary, M.I., Musharraf, S.G.(2015). Sensitive quantification of six steroidal lactones in Withania coagulans extract by UHPLC electrospray tandem mass spectrometry . Steroids. 104. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 176-181.

Musharraf, S.G., Ali, A., Choudhary, M.I., Atta-Ur-Rahman(2014). Probing of metabolites in finely powdered plant material by direct laser desorption ionization mass spectrometry . Journal of the American Society for Mass Spectrometry. 25. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 530-537.

Musharraf, S.G., Ali, A., Khan, N.T., Yousuf, M., Choudhary, M.I., Atta-Ur-Rahman(2013). Tandem mass spectrometry approach for the investigation of the steroidal metabolism: Structure-fragmentation relationship (SFR) in anabolic steroids and their metabolites by ESI-MS/MS analysis . Steroids. 78. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 171-181.

Musharraf, S.G., Goher, M., Ali, A., Adhikari, A., Choudhary, M.I., Atta-Ur-Rahman(2012). Rapid characterization and identification of steroidal alkaloids in Sarcococca coriacea using liquid chromatography coupled with electrospray ionization quadropole time-of-flight mass spectrometry . Steroids. 77. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 138-148.

Ghulam Musharraf, S., Ali, A., Azher Ali, R., Yousuf, S., Rahman, A.-U., Iqbal Choudhary, M.(2011). Analysis and development of structure-fragmentation relationships in withanolides using an electrospray ionization quadropole time-of-flight tandem mass spectrometry hybrid instrument . Rapid Communications in Mass Spectrometry. 25. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 104-114.

Application of dyes as doping agents in MALDI-MS matrices for the signal enhancement of proteins .

Branched-chain amino acids are associated with odd-chain fatty acids in normoglycaemic individuals .

Electrospray Tandem Mass Spectrometric Study of a Furo-Furan Lactone in Heliotropium eichwaldi .

Fungi as a source of marker compounds for the control of illicit use of drugs: mesterolone as a case study . Metabolomics.

Isolation and Initial Structural Characterization of a 27 kDa Protein from Zingiber officinale . Journal of Molecular Structure.

Sensitive analysis of bioactive secondary metabolites in lichen species using liquid chromatography–mass spectrometry .

Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype.

Sensitive quantification of coixol, a potent insulin secretagogue, in Scoparia dulcis extract using high-performance liquid chromatography combined with tandem mass spectrometry and UV detection .