プロフィール詳細

プロジェクトを作成

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Dr. Atul J.に依頼

United States

Medicinal and Organic Chemist/Drug Discovery Scientist

プロフィール概要

• 8+ years of experience in Medicinal/Organic Chemistry and Drug Design involving various therapeutic targets. Efficient in multi-step organic synthesis and optimizing druggable properties of target compounds • Excellent knowledge of identifying, executing and trouble-shooting synthetic routes for target molecules • Highly skilled in comprehensive purification and characterization of target molecules using CombiFlash, Prep HPLC, FT-IR, NMR (1H & 13C), HPLC (Shimadzu) and LC-MS (Shimadzu), HRMS (IT-TOF) (Shimadzu) • Knowledge and understanding in performing, outlining or interpreting biological/biochemical characterization of target molecules, thus providing effective communication and participation between various teams in drug discovery • Adept in conducting scientific information retrieval using SciFinder, Pubmed, and Reaxys and preliminary computational studies using MOE, SYBYL 8.1, and GOLD 5.0 • Conducted structure-activity relationship projects in various therapeutic areas including; smoking cessation, Alzheimer's, cancer, drugs of abuse and diabetes

専門分野

• ☆ Separation & Purification
• ☆ NMR Spectroscopy
• ☆ Liquid Chromatography/HPLC
• ☆ Organic Chemistry
• ☆ Biochemistry
• ☆ Medicinal Chemistry
• ☆ Research Methodology
• ☆ Innovation Management

サービス

• Research

Research Secondary Data Collection

職務経験

Research Assoicate

Northwestern University

6月 2016 - 現在

Postdoctoral Research Associate

University of Illinois at Chicago

11月 2013 - 6月 2016

Commercialization Strategy Consultant

EnterpriseWorks Chicago

2月 2014 - 7月 2014

Commercialization Strategy Consultant

EnterpriseWorks Chicago

2月 2014 - 7月 2014

Research Fellow

Virginia Commonwealth University

2月 2013 - 10月 2013

学歴

PhD (Medicinal Chemistry)

Virginia Commonwealth University

8月 2008 - 2月 2013

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Yao, Y., Kong, C., Yin, L., Jain, A.D., Ratia, K., Thatcher, G.R.J., Moore, T.W., Driver, T.G., Miller, L.W.(2017). Time-Gated Detection of Cystathionine γ-Lyase Activity and Inhibition with a Selective, Luminogenic Hydrogen Sulfide Sensor . Chemistry - A European Journal. 23. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 752-756.

Wei, C., Bajpai, R., Sharma, H., Heitmeier, M., Jain, A.D., Matulis, S.M., Nooka, A.K., Mishra, R.K., Hruz, P.W., Schiltz, G.E., et al.(2017). Development of GLUT4-selective antagonists for multiple myeloma therapy . European Journal of Medicinal Chemistry. 139. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 573-586.

Hamouda, A.K., Wang, Z.-J., Stewart, D.S., Jain, A.D., Glennon, R.A., Cohen, J.B.(2015). Desformylflustrabromine (dFBr) and [³H]dFBr-labeled binding sites in a nicotinic acetylcholine receptor . Molecular Pharmacology. 88. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-11.

Jain, A.D., Potteti, H., Richardson, B.G., Kingsley, L., Luciano, J.P., Ryuzoji, A.F., Lee, H., Krunic, A., Mesecar, A.D., Reddy, S.P., et al.(2015). Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators . European Journal of Medicinal Chemistry. 103. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 252-268.

Richardson, B.G., Jain, A.D., Speltz, T.E., Moore, T.W.(2015). Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway . Bioorganic and Medicinal Chemistry Letters. 25. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2261-2268.

Kolanos, R., Sakloth, F., Jain, A.D., Partilla, J.S., Baumann, M.H., Glennon, R.A.(2015). Structural Modification of the Designer Stimulant α-Pyrrolidinovalerophenone (α-PVP) Influences Potency at Dopamine Transporters . ACS Chemical Neuroscience. 6. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1726-1731.

German, N., Kim, J.-S., Jain, A., Dukat, M., Pandya, A., Ma, Y., Weltzin, M., Schulte, M.K., Glennon, R.A.(2011). Deconstruction of the α4β2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine . Journal of Medicinal Chemistry. 54. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7259-7267.