プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Céline R.に依頼

Switzerland

Biomedical scientist with 15+ years of experience in Gene and Cell Therapy

プロフィール概要

Senior scientist with over 15 years of experience in gene and cell therapy in academic and industrial environments. Recognized for leading preclinical and translational research programs involving viral vectors, gene editing, CAR-T, and hematopoietic stem and progenitor cells (HSPCs). Proven ability to drive projects from concept to in vivo validation, generate intellectual property, and communicate complex scientific data to multidisciplinary stakeholders. Multilingual (French, Italian, English), adaptable, and results-driven, with strong experience in team supervision, cross-functional collaboration, and innovation-focused research delivery.

専門分野

• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ DNA Sequencing
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ Mutagenesis
• ☆ Recombinant DNA
• ☆ RNA Synthesis
• ☆ RNA Sequencing
• ☆ DNA/Gene Synthesis
• ☆ Oligonucleotide Synthesis
• ☆ Plasmid DNA
• ☆ DNA Damage & Repair
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cytochemistry
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Stem Cell Research
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Light Microscopy
• ☆ Electron Microscopy
• ☆ Fluorescence Microscopy
• ☆ Scanning Probe Microscopy
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Line Engineering
• ☆ Cell Surface Receptors
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Tissue Engineering
• ☆ Cytometry
• ☆ Drug Development
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Investigational New Drug (IND) Application Consulting
• ☆ Immunotherapy
• ☆ Gene Therapy
• ☆ Medical Sciences

サービス

• Writing

Writing Technical Writing, General Proofreading & Editing, Translation

職務経験

Senior Scientist

HemostOD

9月 2022 - 11月 2025

Chargée de Recherche

Généthon

3月 2020 - 8月 2022

Postdoctoral Scholar/ Assistant Project Scientist

University of California San DIego (UCSD)

9月 2011 - 2月 2020

PostdoctoralResearcher

Royal Holloway University of London

7月 2009 - 7月 2011

学歴

PhD Physiology

Université Pierre et Marie Curie (Paris VI) - France

9月 2005 - 2月 2009

認定資格

• Good Clinical Practice

  NIDA Clinical Trials Network

  8月 2025 - 8月 2026

出版物

JOURNAL ARTICLE

Maxime Ferrand, Céline J. Rocca, Guillaume Corre, Valentina Buffa, Sophie Frin, Francine Garnache-Ottou, Elodie Bôle-Richard, Sonia Albini, Isabelle Richard, Anne Galy (2025). FAP-CAR-T cells reduce dystrophic muscle fibrosis, improving adeno-associated virus gene transfer efficacy . Molecular Therapy Methods & Clinical Development.

Valentina Buffa, José Roberto Alvarez Vargas, Anne Galy, Simone Spinozzi, Céline J. Rocca (2023). Hematopoietic stem and progenitors cells gene editing: Beyond blood disorders . Frontiers in Genome Editing.

Corre, G., Seye, A., Frin, S., Ferrand, M., Winkler, K., Luc, C., Dorange, F., Rocca, C.J., Galy, A.(2022). Lentiviral standards to determine the sensitivity of assays that quantify lentiviral vector copy numbers and genomic insertion sites in cells . Gene Therapy.

(2020). CRISPR-Cas9 Gene Editing of Hematopoietic Stem Cells from Patients with Friedreich's Ataxia . Molecular therapy. Methods & clinical development.

Rocca, C.J., Rainaldi, J.N., Sharma, J., Shi, Y., Haquang, J.H., Luebeck, J., Mali, P., Cherqui, S.(2020). CRISPR-Cas9 Gene Editing of Hematopoietic Stem Cells from Patients with Friedreich's Ataxia . Molecular Therapy - Methods and Clinical Development. 17. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1026-1036.

(2019). Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis . Kidney international.

(2019). Gene Transfer to Mouse Kidney In Vivo . Methods in molecular biology (Clifton, N.J.).

Lobry, T., Miller, R., Nevo, N., Rocca, C.J., Zhang, J., Catz, S.D., Moore, F., Thomas, L., Pouly, D., Bailleux, A., et al.(2019). Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis . Kidney International. 96. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 350-362.

Rocca, C.J., Cherqui, S.(2019). Potential use of stem cells as a therapy for cystinosis . Pediatric Nephrology. 34. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 965-973.

(2018). Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency . Scientific reports.

(2018). Potential use of stem cells as a therapy for cystinosis . Pediatric nephrology (Berlin, Germany).

Abdul-Razak, H.H., Rocca, C.J., Howe, S.J., Alonso-Ferrero, M.E., Wang, J., Gabriel, R., Bartholomae, C.C., Gan, C.H.V., Garín, M.I., Roberts, A., et al.(2018). Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency . Scientific Reports. 8. (1).

Celine J. Rocca, Spencer M. Goodman, Jennifer N. Dulin, Joseph H. Haquang, Ilya Gertsman, Jordan Blondelle, Janell L. M. Smith, Charles J. Heyser, Stephanie Cherqui (2017). Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich’s ataxia . Science Translational Medicine.

Rocca, C.J., Goodman, S.M., Dulin, J.N., Haquang, J.H., Gertsman, I., Blondelle, J., Smith, J.L.M., Heyser, C.J., Cherqui, S.(2017). Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich’s ataxia . Science Translational Medicine. 9. (413).

Zhang, J., Johnson, J.L., He, J., Napolitano, G., Ramadass, M., Rocca, C., Kiosses, W.B., Bucci, C., Xin, Q., Gavathiotis, E., et al.(2017). Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A . Journal of Biological Chemistry. 292. (25). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 10328-10346.

Gaide Chevronnay, H.P., Janssens, V., Van Der Smissen, P., Rocca, C.J., Liao, X.H., Refetoff, S., Pierreux, C.E., Cherqui, S., Courtoy, P.J.(2016). Hematopoietic stem cells transplantation can normalize thyroid function in a cystinosis mouse model . Endocrinology. 157. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1363-1371.

Rocca, C.J., Soares, D.G., Bouzid, H., Henriques, J.A.P., Larsen, A.K., Escargueil, A.E.(2015). BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder . Cell Cycle. 14. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2080-2090.

Naphade, S., Sharma, J., Gaide Chevronnay, H.P., Shook, M.A., Yeagy, B.A., Rocca, C.J., Ur, S.N., Lau, A.J., Courtoy, P.J., Cherqui, S.(2015). Brief reports: Lysosomal cross-correction by hematopoietic stem cell-derived macrophages via tunneling nanotubes . Stem Cells. 33. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 301-309.

Napolitano, G., Johnson, J.L., He, J., Rocca, C.J., Monfregola, J., Pestonjamasp, K., Cherqui, S., Catz, S.D.(2015). Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis . EMBO Molecular Medicine. 7. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 158-174.

Rocca, C.J., Kreymerman, A., Ur, S.N., Frizzi, K.E., Naphade, S., Lau, A., Tran, T., Calcutt, N.A., Goldberg, J.L., Cherqui, S.(2015). Treatment of inherited eye defects by systemic hematopoietic stem cell transplantation . Investigative Ophthalmology and Visual Science. 56. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7214-7223.

Rocca, C.J., Ur, S.N., Harrison, F., Cherqui, S.(2014). RAAV9 combined with renal vein injection is optimal for kidney-targeted gene delivery: Conclusion of a comparative study . Gene Therapy. 21. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 618-628.

Harrison, F., Yeagy, B.A., Rocca, C.J., Kohn, D.B., Salomon, D.R., Cherqui, S.(2013). Hematopoietic stem cell gene therapy for the multisystemic lysosomal storage disorder cystinosis . Molecular Therapy. 21. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 433-444.

Johnson, J.L., Napolitano, G., Monfregola, J., Rocca, C.J., Cherqui, S., Catz, S.D.(2013). Upregulation of the Rab27a-Dependent Trafficking and Secretory Mechanisms Improves Lysosomal Transport, Alleviates Endoplasmic Reticulum Stress, and Reduces Lysosome Overload in Cystinosis . Molecular and Cellular Biology. 33. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2950-2962.

Soares, D.G., Machado, M.S., Rocca, C.J., Poindessous, V., Ouaret, D., Sarasin, A., Galmarini, C.M., Henriques, J.A.P., Escargueil, A.E., Larsen, A.K.(2011). Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells . Molecular Cancer Therapeutics. 10. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1481-1489.

Soares, D.G., Battistella, A., Rocca, C.J., Matuo, R., Henriques, J.A.P., Larsen, A.K., Escargueil, A.E.(2011). Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906 . Biochemical Journal. 437. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 63-73.

Rocca, C.J., Poindessous, V., Soares, D.G., Ouadrani, K.E., Sarasin, A., Guérin, E., de Gramont, A., Henriques, J.A.P., Escargueil, A.E., Larsen, A.K.(2010). The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: Implications for recognition and repair of antitumor alkylators . Biochemical Pharmacology. 80. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 335-343.

PREPRINT

Veenita Khare, Jean Claude Farre, Celine Rocca, Mouad Ait Kbaich, Cynthia Tang, Xuan Ma, Kavya Biederman, Ioli Mathur, Rafael A. Badell- Grau, Anusha Sivakumar, et al. (2025). Cystinosin is involved in Na+/H+ Exchanger 3 trafficking in the proximal tubular cells: new insights in the renal Fanconi syndrome in cystinosis .

BOOK CHAPTER

Rocca, C.J., Cherqui, S.(2019). Gene transfer to mouse kidney in vivo . Methods in Molecular Biology. 1937. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 227-234.

OTHER

Lobry, T., Miller, R., Nevo, N., Rocca, C.J., Zhang, J., Catz, S.D., Moore, F., Bailleux, A., Guerrera, I.C., Gubler, M.-C., et al.(2018). Cystinosin regulates kidney inflammation through its interaction with galectin-3 . bioRxiv.

BOOK

Rocca, C.J., Abdul-Razak, H.H., Holmes, M.C., Gregory, P.D., Yáñez-Muñoz, R.J.(2014). A southern blot protocol to detect chimeric nuclease-mediated gene repair . Methods in Molecular Biology. 1114. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 325-338.