プロフィール詳細

プロジェクトを作成

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Dr. Curt T.に依頼

United States

Scientist & Regulatory Writer | Nonclinical Development | Oncology, Pharmacology, Physiology

プロフィール概要

I'm a PhD-trained physiologist and biotechnology executive with over 20 years of experience in nonclinical drug development, with a focus on oncology, inflammation, and metabolic disease. I specialize in clear, concise scientific writing for regulatory submissions (e.g., IND-enabling studies, nonclinical pharmacology sections), academic publications, and technical documents for clinical-stage companies. My background spans small molecules, antibodies, ADCs, RNA therapeutics, and nanoparticle platforms. I’ve led cross-functional teams through preclinical development, candidate selection, and IND strategy, and I know how to present complex data to scientific, regulatory, and investor audiences. Services I offer include: - IND and regulatory document preparation (nonclinical sections) - Preclinical study summaries and pharmacology reports - Manuscripts, review articles, and white papers - Scientific editing, formatting, and ghostwriting I'm available for short- or long-term projects, consulting, or overflow writing support.

専門分野

• ★ Drug Development
• ★ Preclinical Pharmacology
• ★ Cancer Biology
• ☆ Small Molecule Drug Development
• ☆ Biologic & Biosimilar Development
• ☆ Preclinical ADME/PK/PD
• ☆ Preclinical Research
• ☆ Investigational New Drug (IND) Application Consulting
• ☆ Drug Efficacy Testing
• ☆ Clinical Trials
• ☆ Regulatory Affairs
• ☆ Cancer Research
• ☆ Carcinogenesis

サービス

• Writing
• Research
• Consulting

Writing Medical Writing, Technical Writing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting, Regulatory Consulting

職務経験

Nonclinical Drug Development Consultant

Consultant

1月 2020 - 現在

Vice President

Lisata Therapeutics, Inc.

10月 2022 - 5月 2023

Vice President

Cend Therapeutics, Inc.

11月 2021 - 9月 2022

Senior Director

Halozyme Therapeutics (United States)

3月 2007 - 1月 2020

Director, Pharmacology

Halozyme Therapeutics

1月 2010 - 12月 2012

Associate Director, Pharmacology

Halozyme Therapeutics

1月 2009 - 12月 2009

学歴

Master of Biotechnology Enterprise and Entrepreneurship (Advanced Academic Programs)

Johns Hopkins University

9月 2015 - 12月 2020

Doctor of Philosophy (Physiology and Biophysics)

Keck School of Medicine, University of Southern California

9月 1993 - 12月 1998

Bachelor of Science (BSc), Physiology

University of California, Davis

9月 1981 - 6月 1986

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Cowell, J. A., Printz, M. A., & Thompson, C. B. (2020). Recombinant human hyaluronidase PH20-mediated dermal spreading activity in mice is not altered by steroids, antihistamines, or salicylic acid. Drug metabolism and personalized therapy, 10.1515/dmpt-2020-0120. Advance online publication. https://doi.org/10.1515/dmpt-2020-0120 .

Li, X., & Thompson, C. B. (2018). Targeting hyaluronan accumulation in the tumor microenvironment. Oncotarget, 9(100), 37349–37351. https://doi.org/10.18632/oncotarget.26483 .

Li, X., Shepard, H. M., Cowell, J. A., Zhao, C., Osgood, R. J., Rosengren, S., Blouw, B., Garrovillo, S. A., Pagel, M. D., Whatcott, C. J., Han, H., Von Hoff, D. D., Taverna, D. M., LaBarre, M. J., Maneval, D. C., & Thompson, C. B. (2018). Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression. Clinical cancer research : an official journal of the American Association for Cancer Research, 24(19), 4798–4807. https://doi.org/10.1158/1078-0432.CCR-17-3284 .

DuFort, C. C., DelGiorno, K. E., Carlson, M. A., Osgood, R. J., Zhao, C., Huang, Z., Thompson, C. B., Connor, R. J., Thanos, C. D., Scott Brockenbrough, J., Provenzano, P. P., Frost, G. I., Michael Shepard, H., & Hingorani, S. R. (2016). Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase. Biophysical journal, 110(9), 2106–2119. https://doi.org/10.1016/j.bpj.2016.03.040 .

Manuel, E. R., Chen, J., D'Apuzzo, M., Lampa, M. G., Kaltcheva, T. I., Thompson, C. B., Ludwig, T., Chung, V., & Diamond, D. J. (2015). Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors. Cancer immunology research, 3(9), 1096–1107. https://doi.org/10.1158/2326-6066.CIR-14-0214 .

Kultti, A., Zhao, C., Singha, N. C., Zimmerman, S., Osgood, R. J., Symons, R., Jiang, P., Li, X., Thompson, C. B., Infante, J. R., Jacobetz, M. A., Tuveson, D. A., Frost, G. I., Shepard, H. M., & Huang, Z. (2014). Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment. BioMed research international, 2014, 817613. https://doi.org/10.1155/2014/817613 .

DelGiorno, K. E., Carlson, M. A., Osgood, R., Provenzano, P. P., Brockenbough, J. S., Thompson, C. B., Shepard, H. M., Frost, G. I., Potter, J. D., & Hingorani, S. R. (2014). Response to Chauhan et Al.: interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning. Cancer cell, 26(1), 16–17. https://doi.org/10.1016/j.ccr.2014.06.004 .

Huang, Z., Zhao, C., Chen, Y., Cowell, J. A., Wei, G., Kultti, A., Huang, L., Thompson, C. B., Rosengren, S., Frost, G. I., & Shepard, H. M. (2014). Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation. Journal of immunology (Baltimore, Md. : 1950), 192(11), 5285–5295. https://doi.org/10.4049/jimmunol.1303060 .

Kang, L., Lantier, L., Kennedy, A., Bonner, J. S., Mayes, W. H., Bracy, D. P., Bookbinder, L. H., Hasty, A. H., Thompson, C. B., & Wasserman, D. H. (2013). Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance. Diabetes, 62(6), 1888–1896. https://doi.org/10.2337/db12-1502 .

Kultti, A., Li, X., Jiang, P., Thompson, C. B., Frost, G. I., & Shepard, H. M. (2012). Therapeutic targeting of hyaluronan in the tumor stroma. Cancers, 4(3), 873–903. https://doi.org/10.3390/cancers4030873 .

Jiang, P., Li, X., Thompson, C. B., Huang, Z., Araiza, F., Osgood, R., Wei, G., Feldmann, M., Frost, G. I., & Shepard, H. M. (2012). Effective targeting of the tumor microenvironment for cancer therapy. Anticancer research, 32(4), 1203–1212.

Jacobetz, M. A., Chan, D. S., Neesse, A., Bapiro, T. E., Cook, N., Frese, K. K., Feig, C., Nakagawa, T., Caldwell, M. E., Zecchini, H. I., Lolkema, M. P., Jiang, P., Kultti, A., Thompson, C. B., Maneval, D. C., Jodrell, D. I., Frost, G. I., Shepard, H. M., Skepper, J. N., & Tuveson, D. A. (2013). Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut, 62(1), 112–120. https://doi.org/10.1136/gutjnl-2012-302529 .

Thompson, C. B., Shepard, H. M., O'Connor, P. M., Kadhim, S., Jiang, P., Osgood, R. J., Bookbinder, L. H., Li, X., Sugarman, B. J., Connor, R. J., Nadjsombati, S., & Frost, G. I. (2010). Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models. Molecular cancer therapeutics, 9(11), 3052–3064. https://doi.org/10.1158/1535-7163.MCT-10-0470 .

McDonough, A. A., Thompson, C. B., & Youn, J. H. (2002). Skeletal muscle regulates extracellular potassium. American journal of physiology. Renal physiology, 282(6), F967–F974. https://doi.org/10.1152/ajprenal.00360.2001 .

Müller-Ehmsen, J., Juvvadi, P., Thompson, C. B., Tumyan, L., Croyle, M., Lingrel, J. B., Schwinger, R. H., McDonough, A. A., & Farley, R. A. (2001). Ouabain and substrate affinities of human Na(+)-K(+)-ATPase alpha(1)beta(1), alpha(2)beta(1), and alpha(3)beta(1) when expressed separately in yeast cells. American journal of physiology. Cell physiology, 281(4), C1355–C1364. https://doi.org/10.1152/ajpcell.2001.281.4.C1355 .

Thompson, C. B., Dorup, I., Ahn, J., Leong, P. K., & McDonough, A. A. (2001). Glucocorticoids increase sodium pump alpha(2)- and beta(1)-subunit abundance and mRNA in rat skeletal muscle. American journal of physiology. Cell physiology, 280(3), C509–C516. https://doi.org/10.1152/ajpcell.2001.280.3.C509 .

Choi, C. S., Thompson, C. B., Leong, P. K., McDonough, A. A., & Youn, J. H. (2001). Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp. American journal of physiology. Renal physiology, 280(1), F95–F102. https://doi.org/10.1152/ajprenal.2001.280.1.F95 .

Nakhoul, F., Thompson, C. B., & McDonough, A. A. (2000). Developmental change in Na,K-ATPase alpha1 and beta1 expression in normal and hypothyroid rat renal cortex. American journal of nephrology, 20(3), 225–231. https://doi.org/10.1159/000013593 .

Thompson, C. B., Choi, C., Youn, J. H., & McDonough, A. A. (1999). Temporal responses of oxidative vs. glycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. The American journal of physiology, 276(6), C1411–C1419. https://doi.org/10.1152/ajpcell.1999.276.6.C1411 .

Thompson, C. B., & McDonough, A. A. (1996). Skeletal muscle Na,K-ATPase alpha and beta subunit protein levels respond to hypokalemic challenge with isoform and muscle type specificity. The Journal of biological chemistry, 271(51), 32653–32658. https://doi.org/10.1074/jbc.271.51.32653 .

McDonough, A. A., & Thompson, C. B. (1996). Role of skeletal muscle sodium pumps in the adaptation to potassium deprivation. Acta physiologica Scandinavica, 156(3), 295–304. https://doi.org/10.1046/j.1365-201X.1996.194000.x .