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プロフィール詳細

プロジェクトを作成

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Dr. Carrie F.に依頼

United States

プロフィール概要

RESEARCH EXPERIENCE: 1999-2006 - Graduate Student My research focused on the role that the extracellular matrix protein CCN1 (Cyr61) played in the regulation of pro-apoptotic TRAIL activity in prostate cancer cells. Androgen-dependent prostate carcinoma cells with low expression of CCN1 were resistant to TRAIL-induced apoptosis, but became sensitized when CCN1 was induced. Androgen independent prostate carcinoma cells, which express a high level of CCN1, were sensitive to TRAIL-induced apoptosis. When CCN1 was knocked down, the cells became resistant to TRAIL-induced apoptosis. 2006-2011 – Post-doctoral research fellow, Dr. Jill Pelling’s laboratory, Northwestern University, Department of Pathology My research focuses on the chemoprevention studies of apigenin in metastatic prostate cancer. Metastatic prostate cancer cell (PC3-M) motility and invasion are inhibited by apigenin. In addition, cell attachment to the extracellular matrix is inhibited correlating with a decrease in p-FAK Tyr397 in apigenin-treated PC3-M cells. Apigenin treatment also disrupts filopodia formation, suggesting that apigenin may also disrupt the directionality of cell movement. 2011-2012 – Post-doctoral research fellow, Dr. Raymond Bergan’s laboratory, Northwestern University, Department of Medicine, Division of Hematology and Oncology My research is a continuation of my work with apigenin’s inhibition of prostate cancer motility and invasion. Based on my previous findings, I have continued to develop my research focus to the effect of apigenin on integrin signaling, cell-extracellular matrix interactions, and the microtubule cytoskeleton. 2012-Present – Post-doctoral Research Fellow, Dr. Gopal Gupta’s laboratory, Loyola University Chicago, Department of Urology My research focuses on the role of bladder cancer exosomes on cell adhesion, motility, and invasion of primary urothelial cells. Additionally, we are investigating the RNA content of exosomes from bladder cancer cell lines as compared to primary urothelial cells, as well as the RNA content of exosomes isolated from patient specimens. TEACHING/MENTORING EXPERIENCE: 2007-2008 Organized Northwestern Calandra Forum, a monthly student/postdoctoral research seminar class 2007 Invited to judge the UIC College of Medicine student research forum 2006-Present - Mentored three graduate students, one high school student, one medical student, and two urology residents in experimental design and execution; writing papers and grants; and preparing for conference presentations 1996 – Present - Tutored elementary school, high school, and college students in basic math, pre-algebra, algebra, geometry, algebra 2, trigonometry, biology, genetics, and ACT prep (English, Math, Reading, Science, Writing, and test taking strategies)

専門分野

• ☆ Biology/Life Sciences
• ☆ Biochemistry
• ☆ Apoptosis
• ☆ Molecular Biology
• ☆ RNA Sequencing
• ☆ Microscopy
• ☆ Technical & Scientific Writing

サービス

• Writing
• Consulting
• Data & AI
• Product Development

職務経験

Research Professional

University of Chicago

6月 2019 - 現在

Research Professional

University of Chicago

1月 2017 - 6月 2019

Postdoctoral Research Fellow

Loyola University Medical Center

7月 2012 - 7月 2015

Postdoctoral Research Fellow

Northwestern University - Chicago

4月 2011 - 6月 2012

Postdoctoral Research Fellow

Northwestern University - Chicago

9月 2006 - 4月 2011

学歴

PhD (Molecular Genetics)

University of Illinois at Chicago

7月 1999 - 8月 2006

Bachelor of Arts

Augustana College

9月 1996 - 5月 1999

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

(2015). Alcohol Inhibits Osteopontin-dependent Transforming Growth Factor-β1 Expression in Human Mesenchymal Stem Cells. Journal of Biological Chemistry.

(2014). Osteopontin mediates an MZF1-TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer. Oncogene.

(2014). The untapped potential of urine shed bladder cancer exosomes: biomarkers, signaling, and therapeutics. Bladder.

(2014). Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism. Molecular Carcinogenesis.

(2014). Characterization of uptake and internalization of exosomes by bladder cancer cells. Biomed Research International.

(2013). The Constituents and Potential Targets of the Extracellular Matrix: Implications for Carcinogenesis and Cancer Treatment. Carcinogenesis and Mutagenesis.

(2012). The desmosomal armadillo protein plakoglobin regulates prostate cancer cell adhesion and motility through vitronectin-dependent Src signaling. PLoS One.

(2009). The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism. Cancer Prevention Research.

(2009). Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Molecular Cancer Research.

(2008). Inhibition of HIF-1 alpha and VEGF Expression by the Chemopreventive Bioflavonoid Apigenin is Accompanied by Akt Inhibition in Human Prostate Carcinoma PC3-M Cells. Molecular Carcinogenesis.

Urothelial Cells Undergo Epithelial to Mesenchymal Transition After Exposure to Muscle Invasive Bladder Cancer Exosomes. Oncogenesis.

Urinary Exosomes: The Potential for Biomarker Utility, Intercellular Signaling, and Therapeutics in Urologic Malignancy. Journal of Urology.

CONFERENCE ABSTRACT

The extracellular matrix protein CCN1 (CYR61) sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.

Exosome-Mediated Regulation of PTEN Expression in Bladder Cancer.

UROTHELIAL CELLS UNDERGO EPITHELIAL TO MESENCHYMAL TRANSITION AFTER EXPOSURE TO MUSCLE INVASIVE BLADDER CANCER EXOSOMES.

Apigenin regulates prostate cancer matrix composition, cell attachment, and cell motility through an integrin alpha 1 dependent pathway.

Apigenin regulates prostate cancer matrix composition, cell attachment, and cell motility through an integrin alpha 1 dependent pathway.

Apigenin inhibits PC3-M cell motility through the FAK/Src signaling pathway.

Novel Method Of Exosome Quantification And Cellular Uptake Using The Amnis ImageStreamX.

PLK1 Silencing in Bladder Cancer by siRNA Delivered with Exosomes.