プロフィール詳細

プロジェクトを作成

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Dr. Chengming W.に依頼

Singapore

PhD | NUS Research Fellow | Expert in Molecular/Cell Biology, Extracellular Vesicles, Aging & Regenerative Medicine

プロフィール概要

I am a Research Fellow at the National University of Singapore (NUS), with a PhD in Pharmaceutical Sciences. My research expertise spans molecular and cell biology, extracellular vesicles (EVs), stem cell biology, regenerative medicine, aging/senescence, immunology, and osteoarthritis. I specialize in critically evaluating scientific literature, designing experiments, interpreting complex biological datasets (bulk RNA-seq, scRNA-seq, proteomics), and performing bioinformatics analysis using Python, R. I have authored multiple peer-reviewed publications in high-impact journals, including recent work on MSC-EVs for osteoarthritis, cGAS PROTAC degraders, ferroptosis in liver fibrosis, and FcRn signaling in ulcerative colitis. With hands-on experience in both wet-lab and computational biology, I help clients with: In-depth literature reviews and evidence evaluation Experimental design and troubleshooting Data analysis and interpretation of transcriptomics/proteomics datasets Scientific writing, manuscript preparation, and grant proposals AI-assisted research workflows and critical assessment of scientific claims My background combining rigorous experimental research with advanced data analysis and scientific communication makes me well-equipped to support academic, biotech, and pharmaceutical projects requiring high-quality, translational insights. I am available for short-term or ongoing consulting projects and look forward to collaborating with clients seeking expert input in cell biology, regenerative medicine, and related fields.

専門分野

• ★ Oxidative Stress & Mitochondrial Function
• ★ Molecular Biology
• ★ Cell Aging
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Enzyme Activity Assays
• ☆ Genetics
• ☆ Microarrays
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ Protein Sequencing
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ Plasmid DNA
• ☆ Cell Biology
• ☆ Cell Signaling Pathways
• ☆ Membrane Biology
• ☆ Stem Cell Research
• ☆ Histology
• ☆ Biotechnology & Bioengineering
• ☆ Nanobiotechnology
• ☆ Biomedical Engineering
• ☆ Biomarker Discovery
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Surface Receptors
• ☆ Synthetic Biology
• ☆ Blotting
• ☆ Immunohistochemistry

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Operations Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Processing, Data Visualization, Data Mining, Data Processing

Product Development Product Evaluation

職務経験

Research Fellow

National University of Singapore

8月 2025 - 現在

PostDoc

Tsinghua University

7月 2023 - 7月 2025

学歴

Doctor (Department of Clinical Pharmacy and Pharmacy Administration, West China School of Pharmacy)

Sichuan University

9月 2018 - 6月 2023

Bachelor (School of Pharmacy)

Fujian Medical University

9月 2013 - 6月 2018

認定資格

• Postdoctoral Fellowship Program of China Postdoctoral Science Foundation

  China Postdoctoral Science Foundation

  7月 2023 - 7月 2025

出版物

JOURNAL ARTICLE

Chengming Wen, Kristeen Ye Wen Teo, Raymond Chung Wen Wong, Wei Seong Toh (2026). MSC-EVs alleviate osteoarthritic joint pain and degeneration by suppressing IL-1β/NGF signaling . Genes & Diseases.

Chengming Wen, Haoyang Hu, Fuliang Lu, Xudong Guan, Xuehua Jiang, Ling Wang (2025). Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway . ACS Omega.

Chengming Wen, Peng He, Xinyu Zhang, Hang Yin (2025). Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis . Journal of Medicinal Chemistry.

Chengming Wen, Wenwen Zhang, Yice Zhang, Xuehua Jiang, Ling Wang (2023). In vitro Assessment of the Effects of Silybin on CYP2B6-mediated Metabolism . Planta Medica.

Chengming Wen, Weipei Yang, Zhongxu Liang, Xuehua Jiang, Ling Wang (2022). Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme . Molecules.

Chengming Wen, Weipei Yang, Zhongxu Liang, Xuehua Jiang, Ling Wang (2022). Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme . Molecules.

Chengming Wen, Haoyang Hu, Weipei Yang, Yingjie Zhao, Liang Zheng, Xuehua Jiang, Ling Wang(2022). Targeted inhibition of FcRn reduces NET formation to ameliorate experimental ulcerative colitis by accelerating ANCA clearance . International Immunopharmacology. 113. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 109474. Elsevier {BV}

Wen, Chengming, Hu, Haoyang, Yang, Weipei, Zhao, Yingjie, Zheng, Liang, Jiang, Xuehua, Wang, Ling (2022). Targeted inhibition of FcRn reduces NET formation to ameliorate experimental ulcerative colitis by accelerating ANCA clearance . International Immunopharmacology.

Chengming Wen, Haoyang Hu, Wenwen Zhang, Xin Liu, Xuehua Jiang, Ling Wang(2021). Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL−35 . Pharmaceutics. 13. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1492. {MDPI} {AG}

Wen, Chengming, Hu, Haoyang, Zhang, Wenwen, Liu, Xin, Jiang, Xuehua, Wang, Ling (2021). Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL-35 . Pharmaceutics.

Chengming Wen, Shiwei Tang, Ping Zhao, Liang Zheng, Ling Wang, Xuehua Jiang(2019). Impacts of Cytochrome P450 2D6*10 Allele and a High-Fat Meal on the Pharmacokinetics of Dapoxetine in Healthy Chinese Men: A Single-Dose, Two-Treatment Study . Advances in Therapy. 36. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2096--2105. Springer Science and Business Media {LLC}

Wen, Chengming, Tang, Shiwei, Zhao, Ping, Zheng, Liang, Wang, Ling, Jiang, Xuehua (2019). Impacts of Cytochrome P450 2D6*10 Allele and a High-Fat Meal on the Pharmacokinetics of Dapoxetine in Healthy Chinese Men: A Single-Dose, Two-Treatment Study . Advances in Therapy.

PREPRINT

Baicalein ameliorates experimental ulcerative colitis recurrency by downregulating neonatal Fc receptor via the NF-κB signaling pathway Haoyang Hu, Fuliang Lu, Xudong Guan, Xuehua Jiang, Chengming Wen, Ling Wang. Baicalein ameliorates experimental ulcerative colitis recurrency by downregulating neonatal Fc receptor via the NF-κB signaling pathway. bioRxiv 2024.10.22.619759; doi: https://doi.org/10.1101/2024.10.22.619759 . BioRxive.