プロフィール詳細

プロジェクトを作成

★★★★★

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★★★★★

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Dr. Chun Lai T.に依頼

Japan

Protein Design, Protein Structure Analysis, Machine Learning and NGS Data Analysis

プロフィール概要

5+ years wet-lab plus 4+ years dry-lab experience in molecular biology and bioinformatics, Tam possesses the most in-demand experimental techniques (NGS library preparation, recombinant protein expression and purification, high-throughput assay design) and skills in bioinformatics data analysis (e.g. NGS data analysis, computational protein design). Tam is now a Ph.D. student at the University of Tokyo and concurrently an International Program Associate at the research institute RIKEN, Japan, working on his projects on structure-based computational protein design, an emerging field that delivers de novo designed proteins (e.g. enzymes and antibodies) with novel functions. Tam is now exploring different possibilities in his future career in molecular biology and bioinformatics, either in the context of biotech business or the academia. Tam is particularly interested in biotech companies related to applications of NGS and protein design (e.g. enzyme design and antibody design). If you have any questions, feel free to contact Tam for more discussions. Publications/ Conferences Tam, C.; Kumar, A.; Zhang, K.Y.J. NbX: Machine Learning-Guided Re-Ranking of Nanobody–Antigen Binding Poses. Pharmaceuticals 2021, 14, 968. Tam, C.; Yuen, M.H.; Nim, Y.S.; Xu, Y.F.; Au, S.W.N.; Ngo, J.C.K.; Huang, P.; Wong, K.B. Structure-based discovery of inhibitors of Helicobacter pylori urease: abridged secondary publication. Hong Kong Med. J. 2020, 26 Suppl 4, 29–31. Tam, C., Zhang, K.Y.J. FPredX: interpretable models for the prediction of spectral maxima, brightness and oligomeric states of fluorescent proteins. (manuscript under review) Wang, S.; Tam, C.; Naito, I.; Nishiyama, S.; Tao, R. Frequent reversion and continuous size variation in the small fruit mutant ‘Totsutanenashi’ persimmon. Acta Hortic. 2021, 117–122. Li, C.; Huang, P.; Wong, K.; Xu, Y.; Tan, L.; Chen, H.; Lu, Q.; Luo, C.; Tam, C.; Zhu, L.; et al. Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process. J. Enzyme Inhib. Med. Chem. 2018, 33, 1362–1375. 西山総一郎, Wang, S., Tam, C., 田尾龍太郎 カキ’平核無’に生じた小果変異の起源と多面発現. 園芸学会令和3年度春季大会 2021

専門分野

• ★ Bioinformatics
• ☆ Biochemical Assays
• ☆ Structural Biology
• ☆ Next Generation Sequencing (NGS)
• ☆ Recombinant Protein Expression
• ☆ Data Science
• ☆ Machine Learning
• ☆ Artificial Intelligence
• ☆ Deep Learning
• ☆ Protein/Enzyme Engineering
• ☆ Python
• ☆ Drug Design

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing

Research Market Research, User Research, Feasibility Study, Gap Analysis, Gray Literature Search, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Algorithm Design-Non ML, Data Visualization, Big Data Analytics, Data Processing, Data Insights

Product Development Formulation, Stability/Shelf Life Testing, Product Evaluation, Material Sourcing, Product Validation, Concept Development, Prototyping

職務経験

International Program Associate

RIKEN

9月 2018 - 現在

Junior research assistant

The Chinese University of Hong Kong

8月 2014 - 9月 2016

Lab Technician

Beijing Genomics Institute

12月 2013 - 7月 2014

学歴

Ph.D. Computational Biology and Medical Sciences

Tokyo University

10月 2018 - 12月 2021

MSc. Agronomy and Horticultural Sciences

Kyoto University

10月 2016 - 9月 2018

BSc. Food and Nutritional Sciences

The Chinese University of Hong Kong

9月 2010 - 8月 2018

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Chunlai Tam and Ashutosh Kumar and Kam Y. J. Zhang(2021). NbX: Machine Learning-Guided Re-Ranking of Nanobody–Antigen Binding Poses . Pharmaceuticals. 14. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 968. {MDPI} {AG}

S. Wang and C.L. Tam and I. Naito and S. Nishiyama and R. Tao(2021). Frequent reversion and continuous size variation in the small fruit mutant ‘Totsutanenashi’ persimmon . Acta Horticulturae. (1312). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 117--122. International Society for Horticultural Science ({ISHS})

(2020). Structure-based discovery of inhibitors of <i>Helicobacter pylori</i> urease: abridged secondary publication. Hong Kong medical journal = Xianggang yi xue za zhi.

(2018). Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process . Journal of enzyme inhibition and medicinal chemistry.