プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Dakshinamurthy S.に依頼

United Arab Emirates

Computational chemist with strong experience (Industry/Academia) in drug design, serving 17+years in Bioinformatics

プロフィール概要

- Practicing structural bioinformatics for more than 17 years with 7+ years post Ph.D. exp. - Worked on identifying the crucial determinants of drug binding selectivity for highly similar proteins with profound experience in Molecular dynamics, QSAR, and Pharmacophore. - Hands-on working experience in different AI/ML methods (like RL(reinforcement learning), generative models, RNN-LSTM) in drug design and cheminformatics projects. - Excellent communication and networking skills, leadership, scientific writing and teamwork skills proved in multifaceted projects and various computational chemistry publications. - Reach me for 1 to 1 consultation and professional training on the broad areas of structural bioinformatics.

専門分野

• ☆ Catalysis
• ☆ Chemoinformatics
• ☆ Computational Chemistry
• ☆ Molecular Biology
• ☆ Next Generation Sequencing (NGS)
• ☆ Data Analysis
• ☆ Machine Learning
• ☆ Bioinformatics
• ☆ Structural Bioinformatics
• ☆ Personal Training
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Drug Design
• ☆ Combinatorial Chemistry
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical ADME/PK/PD

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Technical Writing, Copywriting, General Proofreading & Editing

Research User Research, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Data Visualization, Text Mining & Analytics, Data Mining, Data Cleaning, Data Processing, Data Insights

Product Development Concept Development

職務経験

Discovery Scientist

Cresset Discovery, UK

3月 2023 - 10月 2023

Senior Principal Scientist

PharmCADD

7月 2020 - 2月 2023

学歴

PhD

SASTRA Deemed University - India

4月 2010 - 3月 2016

M.Tech Bioinformatics

SASTRA Deemed University - India

4月 2004 - 5月 2006

認定資格

• Career Essentials in Generative AI by Microsoft and LinkedIn

  Microsoft

  https://www.linkedin.com/learning/certificates/3f3a2f60eab352d70226fed1faad120186aaedc6f30b030b4a6e2f46e53646a8?accountId=54550724&u=54550724&success=true&authUUID=wFzHDSzxT0+g/O4eyo5ISA==

  8月 2023 - 現在

• Complete Python Developer in 2023: Zero to Mastery

  udemy

  https://www.udemy.com/certificate/UC-0b9b7a03-7442-4b81-94db-ba4465970c0f/

  9月 2022 - 現在

出版物

JOURNAL ARTICLE

Dakshinamurthy Sivakumar, Seong Hun Jang, Sathish Kumar Mudedla, Jaehan Choi, Sungmin Lee, Minjun Jeon, Suneel Kumar Bvs, Jinha Hwang, Minsung Kang, Eun Gyeong Shin, et al.(2022). PCW-A1001, AI-assisted de novo design approach to design a selective inhibitor for FLT-3(D835Y) in acute myeloid leukemia . Frontiers in Molecular Biosciences. 9. Frontiers Media {SA}

Dakshinamurthy Sivakumar, Sangwook Wu (2022). Classical and Machine Learning Methods for Protein - Ligand Binding Free Energy Estimation . Current Drug Metabolism.

Dakshinamurthy Sivakumar, Sathishkumar Mudedla, Seonghun Jang, Hyunjun Kim, Hyunjin Park, Yonwon Choi, Joongyo Oh, Sangwook Wu(2021). Computational Study on Selective PDE9 Inhibitors on PDE9-Mg/Mg, PDE9-Zn/Mg, and PDE9-Zn/Zn Systems . Biomolecules. 11. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 709. {MDPI} {AG}

Dakshinamurthy Sivakumar, Sathishkumar Mudedla, Seonghun Jang, Hyunjun Kim, Hyunjin Park, Yonwon Choi, Joongyo Oh, Sangwook Wu (2021). Computational Study on Selective PDE9 Inhibitors on PDE9-Mg/Mg, PDE9-Zn/Mg, and PDE9-Zn/Zn Systems . Biomolecules.

Dakshinamurthy Sivakumar, Matthias Stein (2021). Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases . Biomolecules.

Dakshinamurthy Sivakumar, Vikash Kumar, Michael Naumann, Matthias Stein(2020). Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases . Journal of Biological Chemistry. 295. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6972--6982. Elsevier {BV}

(2020). Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases . Journal of Biological Chemistry.

(2019). NADH oxidase from Lactobacillus reuteri: A versatile enzyme for oxidized cofactor regeneration . International Journal of Biological Macromolecules.

(2018). Insights into Cell-Free Conversion of CO2 to Chemicals by a Multienzyme Cascade Reaction . ACS Catalysis.

Dakshinamurthy Sivakumar, Vinoth Prasanna Gunasekaran, Kumari Nishi, Thirunavukkarasu Sivaraman, Ganeshan Mathan(2018). Identification of 2,4-dihydroxy-5-pyrimidinyl imidothiocarbomate as a novel inhibitor to Y box binding protein-1 (YB-1) and its therapeutic actions against breast cancer . European Journal of Pharmaceutical Sciences. 116. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2--14. Elsevier {BV}

Zhang, L., Singh, R., Sivakumar, D., Guo, Z., Li, J., Chen, F., He, Y., Guan, X., Kang, Y.C., Lee, J.-K.(2018). An artificial synthetic pathway for acetoin, 2,3-butanediol, and 2-butanol production from ethanol using cell free multi-enzyme catalysis . Green Chemistry. 20. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 230-242.

Dakshinamurthy Sivakumar, Thirunavukkarasu Sivaraman(2016). A Review on Structures and Functions of Bcl-2 Family Proteins from Homo sapiens . Protein & Peptide Letters. 23. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 932--941. Bentham Science Publishers Ltd.

Dakshinamurthy Sivakumar, SASTRA University, India, Thirunavukkarasu Sivaraman(2016). Crucial Residues Modulating Interface of hBcl-B - hBaxBH3 Heterodimer as Probed by Computational Methods . Brazilian Archives of Biology and Technology. 59. (0). {FapUNIFESP} ({SciELO})

Sivakumar, D., Surapaneni, K.M., Prabu, P.C., Hari, N., Thiruvasagam, P., Rajasekaran, M., Sivaraman, T.(2016). Evaluation of the anticancer properties of the predicted hBaxBH3-mimetic compound 2-hydroxy-3,5-dinitrobenzamide in a mammary carcinogenesis-induced rat model . RSC Advances. 6. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2854-2869.

Sivakumar, D., Hari, N., Sivaraman, T.(2014). Computational analyses on delineating specificity of 2-hydroxy-3,5-dinitrobenzamide, a BH3-mimetic, towards anti-apoptotic proteins . Bangladesh Journal of Pharmacology. 9. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 307-311.

Anthony, J., Rangamaran, V.R., Gopal, D., Shivasankarasubbiah, K.T., Thilagam, M.L.J., Peter Dhassiah, M., Padinjattayil, D.S.M., Valsalan, V.K.N., Manambrakat, V., Dakshinamurthy, S., et al.(2014). Ultraviolet and 5′Fluorodeoxyuridine Induced Random Mutagenesis in Chlorella vulgaris and Its Impact on Fatty Acid Profile: A New Insight on Lipid-Metabolizing Genes and Structural Characterization of Related Proteins . Marine Biotechnology. 17. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 66-80.

Sivakumar, D., Lahiri, C., Chakravortty, D.(2013). Computational studies on histidine kinase protein BaeS to target multidrug-resistant Salmonella . Medicinal Chemistry Research. 22. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1804-1811.

Sivakumar, D., Gorai, B., Sivaraman, T.(2013). Screening efficient BH3-mimetics to hBcl-B by means of peptidodynmimetic method . Molecular BioSystems. 9. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 700-712.

Sivakumar, D., Richa, T., Rajesh, S.S., Gorai, B., Sivaraman, T.(2012). In silico methods for designing antagonists to anti-apoptotic members of Bcl-2 family proteins . Mini-Reviews in Medicinal Chemistry. 12. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1144-1153.

Dakshinamurthy Sivakumar, Thirunavukkarasu Sivaraman(2011). In silico Designing and Screening of Lead Compounds to NS5-Methyltransferase of Dengue Viruses . Medicinal Chemistry. 7. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 655--662. Bentham Science Publishers Ltd.

Dakshinamurthy Sivakumar, Abhishek A. Singh, Pallavi Somvanshi(2011). Cataloguing functionally relevant polymorphisms in gene DNA ligase I: a computational approach . 3 Biotech. 1. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 47--56. Springer Nature

Sivakumar, D., Sivaraman, T.(2011). In silico designing and screening of lead compounds to NS5- methyltransferase of dengue viruses . Medicinal Chemistry. 7. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 655-662.

Sivakumar, D., Aashis, R., Sivaraman, T.(2011). In silico rationalization for the differential bioavailability of ABT-737 and ABT-263 that antagonise the anti-apoptotic proteins . Journal of Pharmaceutical Sciences and Research. 3. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1141-1145.

CONFERENCE PAPER

Sivakumar, D., Sivaraman, T.(2012). Designing of de novo dual inhibitors for Bcl-XL and Mcl-1 of Bcl2-family proteins by computational methods . IEEE-International Conference on Advances in Engineering, Science and Management, ICAESM-2012. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 174-178.