プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

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Dr. David C.に依頼

Canada

Epigenetics & Bioinformatics Consultant | NGS, DNA Methylation, Clinical Validation Expert

プロフィール概要

PhD-trained molecular biologist and epigenetics specialist with 15+ years in academia and industry. Expert in bioinformatics analysis of NGS data (ChIPseq, RNAseq, bisulfite sequencing), DNA methylation profiling, and biomarker discovery. Led clinical trials for non-invasive cancer detection, with experience in CAP/CLIA accreditation and FDA registration. Published 30+ papers on cancer epigenetics and developed patented diagnostic markers. Offering high-quality data analysis, assay design, and regulatory consulting for biotech and clinical projects.

専門分野

• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Omics
• ☆ Genomics
• ☆ Epigenetics
• ☆ Next Generation Sequencing (NGS)
• ☆ DNA Sequencing
• ☆ Genome Sequencing
• ☆ Exome Sequencing
• ☆ RNA Sequencing
• ☆ Cell Biology
• ☆ Gene Regulation
• ☆ Data Analysis
• ☆ Data Processing
• ☆ Data Visualization
• ☆ Big Data Analytics
• ☆ Data Management
• ☆ Machine Learning
• ☆ Data Mining
• ☆ Neural Networks
• ☆ Statistics
• ☆ Health Data Analysis
• ☆ Bioinformatics
• ☆ Biomarker Discovery
• ☆ R
• ☆ Clinical Trials
• ☆ Clinical Trials Data Analysis
• ☆ Oncology
• ☆ Cancer Research

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Technical Writing, Business & Legal Writing

Research Meta-Research, Feasibility Study, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Healthcare Consulting, Scientific and Technical Consulting, Regulatory Consulting

Data & AI Predictive Modeling, Statistical Analysis, Image Processing, Image Analysis, Data Visualization, Big Data Analytics, Data Mining, Data Cleaning, Data Processing

Product Development Product Validation, Quality Assurance & Control (QA/QC), Product Launch Support

職務経験

Chief Innovation Officer

EpiMedTechGlobal (EMTG)

- 現在

Founder / CEO

Biotech Insight Solutions, Montreal, Canada

1月 2024 - 現在

Vise-President

MTL Epitherapeutics

3月 2019 - 現在

Chief Innovation Officer

EpiMedTech Global

10月 2016 - 現在

Postdoctoral Fellow

McGiill University, Canada

11月 2011 - 11月 2016

学歴

PhD

Hebrew University of Jerusalem

1月 2006 - 1月 2011

MSc

Hebrew University of Jerusalem

1月 2003 - 1月 2005

BSc, MSc in Biomedical Ecology

Kutaisi State University

9月 1990 - 9月 1995

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

David Cheishvili, Chifat Wong, Mohammad Mahbubul Karim, Mohammad Golam Kibria, Nusrat Jahan, Pappu Chandra Das, Abul Khair Yousuf, Atikul Islam, Dulal Chandra Das, Sheikh Mohammad Noor-E-Alam, et al. (2024). Clinical validation of peripheral blood mononuclear cell DNA methylation markers for accurate early detection of hepatocellular carcinoma in Asian patients . Communications Medicine.

David Cheishvili, Mariam El‐Zein, Moshe Szyf, Eduardo L. Franco (2024). Validation of novel DNA methylation markers in cervical precancer and cancer . International Journal of Cancer.

I. Yovchev, Ch. Maayan, N. Simanovsky, A. J. Foldes, R. Brooks, L. Kaplan, Z. Meiner, D. Cheishvili (2023). The Relationship Between Scoliosis, Spinal Bone Density, and Truncal Muscle Strength in Familial Dysautonomia Patients . Calcified Tissue International.

David Cheishvili, Chifat Wong, Mohammad Mahbubul Karim, Mohammad Golam Kibria, Nusrat Jahan, Pappu Chandra Das, Md. Abul Khair Yousuf, Md. Atikul Islam, Dulal Chandra Das, Sheikh Mohammad Noor-E-Alam, et al. (2023). A high-throughput test enables specific detection of hepatocellular carcinoma . Nature Communications.

Poloni, C., Szyf, M., Cheishvili, D., Tsoukas, C.M.(2022). Are the Healthy Vulnerable? Cytomegalovirus Seropositivity in Healthy Adults Is Associated With Accelerated Epigenetic Age and Immune Dysregulation . Journal of Infectious Diseases. 225. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 443-452.

Fitzgerald, K.N., Hodges, R., Hanes, D., Stack, E., Cheishvili, D., Szyf, M., Henkel, J., Twedt, M.W., Giannopoulou, D., Herdell, J., et al.(2022). Correction: “Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial7#x201D; (Albany NY, (2021), 13, (9419–9432), (10.18632/aging.202913)) . Aging. 14. (14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5959-5959.

Inserra, A., Campanale, A., Cheishvili, D., Dymov, S., Wong, A., Marcal, N., Syme, R.A., Taylor, L., De Gregorio, D., Kennedy, T.E., et al.(2022). Modulation of DNA methylation and protein expression in the prefrontal cortex by repeated administration of D-lysergic acid diethylamide (LSD): Impact on neurotropic, neurotrophic, and neuroplasticity signaling . Progress in Neuro-Psychopharmacology and Biological Psychiatry. 119.

Har-Zahav, A., Lixandru, D., Cheishvili, D., Matei, I.V., Florea, I.R., Aspritoiu, V.M., Blus-Kadosh, I., Meivar-Levy, I., Serban, A.M., Popescu, I., et al.(2022). The role of DNA demethylation in liver to pancreas transdifferentiation . Stem Cell Research and Therapy. 13. (1).

Perl, L., Hakimian, D., Maayan, C., Rekhtman, D., Fried, E., Salmon-Divon, M., Sapozhnikov, D.M., Cheishvili, D.(2022). Uncommon side effects of common drugs in patients with familial dysautonomia . Pharmacoepidemiology and Drug Safety. 31. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 128-140.

David Cheishvili, Stéphanie Grégoire, Mali Salmon-Divon, Sergiy Dymov, Lucas Topham, Virginie Calderon, Yoram Shir, Moshe Szyf, Laura S. Stone (2021). Epigenetic signature of chronic low back pain in human T cells . PAIN Reports.

Cheishvili, D., Parashar, S., Mahmood, N., Arakelian, A., Kremer, R., Goltzman, D., Szyf, M., Rabbani, S.A.(2021). Erratum to: Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women (Journal of Bone and Mineral Research, (2018), 33, 11, (1980-1989), 10.1002/jbmr.3527) . Journal of Bone and Mineral Research. 36. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2285-2286.

Fitzgerald, K.N., Hodges, R., Hanes, D., Stack, E., Cheishvili, D., Szyf, M., Henkel, J., Twedt, M.W., Giannopoulou, D., Herdell, J., et al.(2021). Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial . Aging. 13. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9419-9432.

Mehdi, A., Cheishvili, D., Arakelian, A., Bismar, T.A., Szyf, M., Rabbani, S.A.(2020). DNA methylation signatures of Prostate Cancer in peripheral T-cells . BMC Cancer. 20. (1).

Faulk, C., Mueller, K.R., Cheishvili, D., Colwell, M., Pepin, A.-S., Syzf, M., Hering, B.J., Burlak, C.(2020). Epigenetic biomarkers indicate islet cell death in xenotransplantation . Xenotransplantation. 27. (2).

El-Zein, M., Cheishvili, D., Gotlieb, W., Gilbert, L., Hemmings, R., Behr, M.A., Szyf, M., Franco, E.L.(2020). Genome-wide DNA methylation profiling identifies two novel genes in cervical neoplasia . International Journal of Cancer. 147. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1264-1274.

Hoye, J.R., Cheishvili, D., Yarger, H.A., Roth, T.L., Szyf, M., Dozier, M.(2020). Preliminary indications that the Attachment and Biobehavioral Catch-up Intervention alters DNA methylation in maltreated children . Development and Psychopathology. 32. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1486-1494.

Mahmood, N., Arakelian, A., Cheishvili, D., Szyf, M., Rabbani, S.A.(2020). S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis . Journal of Cellular and Molecular Medicine. 24. (18). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 10322-10337.

Schmidt, M., Lax, E., Zhou, R., Cheishvili, D., Ruder, A.M., Ludiro, A., Lapert, F., Macedo da Cruz, A., Sandrini, P., Calzoni, T., et al.(2019). Fetal glucocorticoid receptor (Nr3c1) deficiency alters the landscape of DNA methylation of murine placenta in a sex-dependent manner and is associated to anxiety-like behavior in adulthood . Translational Psychiatry. 9. (1).

Parashar, S., Cheishvili, D., Mahmood, N., Arakelian, A., Tanvir, I., Khan, H.A., Kremer, R., Mihalcioiu, C., Szyf, M., Rabbani, S.A.(2018). DNA methylation signatures of breast cancer in peripheral T-cells . BMC Cancer. 18. (1).

Cheishvili, D., Maayan, C., Sapozhnikov, D.M., Lax, E., Dresner-Pollak, R.(2018). Genetic Polymorphisms in the ESR1 and VDR Genes Do Not Correlate With Osteoporosis in Patients With Familial Dysautonomia . Journal of Clinical Densitometry. 21. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 205-212.

Cheishvili, D., Parashar, S., Mahmood, N., Arakelian, A., Kremer, R., Goltzman, D., Szyf, M., Rabbani, S.A.(2018). Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women . Journal of Bone and Mineral Research. 33. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1980-1989.

McMorrow, A.M., Connaughton, R.M., Magalhães, T.R., McGillicuddy, F.C., Hughes, M.F., Cheishvili, D., Morine, M.J., Ennis, S., Healy, M.-L., Roche, E.F., et al.(2018). Personalized Cardio-Metabolic Responses to an Anti-Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial . Molecular Nutrition and Food Research. 62. (10).

Zhang, Y., Petropoulos, S., Liu, J., Cheishvili, D., Zhou, R., Dymov, S., Li, K., Li, N., Szyf, M.(2018). The signature of liver cancer in immune cells DNA methylation . Clinical Epigenetics. 10. (1).

Mahmood, N., Cheishvili, D., Arakelian, A., Tanvir, I., Khan, H.A., Pépin, A.-S., Szyf, M., Rabbani, S.A.(2018). Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications . Oncotarget. 9. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5169-5183.

Cheishvili, D., Christiansen, S., Stochinsky, R., Pepin, A.-S., Sapozhnikov, D.M., Zhou, R., Schmeltzer, L., Dymov, S., Szyf, M.(2017). DNA methylation controls unmethylated transcription start sites in the genome in trans . Epigenomics. 9. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 611-633.

Enuka, Y., Feldman, M.E., Chowdhury, A., Srivastava, S., Lindzen, M., Sas-Chen, A., Massart, R., Cheishvili, D., Suderman, M.J., Zaltsman, Y., et al.(2017). Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone . Nucleic Acids Research. 45. (22). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12681-12699.

Lax, E., Friedman, A., Massart, R., Barnea, R., Abraham, L., Cheishvili, D., Zada, M., Ahdoot, H., Bareli, T., Warhaftig, G., et al.(2017). PARP-1 is required for retrieval of cocaine-associated memory by binding to the promoter of a novel gene encoding a putative transposase inhibitor . Molecular Psychiatry. 22. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 570-579.

Cheishvili, D., Maayan, C., Holzer, N., Tsenter, J., Lax, E., Petropoulos, S., Razin, A.(2016). Tocotrienol Treatment in Familial Dysautonomia: Open-Label Pilot Study . Journal of Molecular Neuroscience. 59. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 382-391.

Cheishvili, D., Stefanska, B., Yi, C., Li, C.C., Yu, P., Arakelian, A., Tanvir, I., Khan, H.A., Rabbani, S., Szyf, M.(2015). A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasiveness . Oncotarget. 6. (32). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 33253-33268.

Cheishvili, D., Boureau, L., Szyf, M.(2015). DNA demethylation and invasive cancer: Implications for therapeutics . British Journal of Pharmacology. 172. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2705-2715.

Lefler, S., Cohen, M.A., Kantor, G., Cheishvili, D., Even, A., Birger, A., Turetsky, T., Gil, Y., Even-Ram, S., Aizenman, E., et al.(2015). Familial dysautonomia (FD) human embryonic stem cell derived PNS neurons reveal that synaptic vesicular and neuronal transport genes are directly or indirectly affected by IKBKAP downregulation . PLoS ONE. 10. (10).

Parashar, S., Cheishvili, D., Arakelian, A., Hussain, Z., Tanvir, I., Khan, H.A., Szyf, M., Rabbani, S.A.(2015). S-adenosylmethionine blocks osteosarcoma cells proliferation and invasion in vitro and tumor metastasis in vivo: Therapeutic and diagnostic clinical applications . Cancer Medicine. 4. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 732-744.

Cheishvili, D., Laiba, E., Rekhtman, D., Claman, A., Razin, A., Maayan, C.(2014). Dynamic changes in IKBKAP mRNA levels during crisis of familial dysautonomia patients . Autonomic Neuroscience: Basic and Clinical. 180. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 59-65.

Stefanska, B., Cheishvili, D., Suderman, M., Arakelian, A., Huang, J., Hallett, M., Han, Z.-G., Al-Mahtab, M., Akbar, S.M.F., Khan, W.A., et al.(2014). Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets . Clinical Cancer Research. 20. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3118-3132.

Cheishvili, D., Dietrich, P., Maayan, C., Even, A., Weil, M., Dragatsis, I., Razin, A.(2014). IKAP deficiency in an FD mouse model and in oligodendrocyte precursor cells results in downregulation of genes involved in oligodendrocyte differentiation and myelin formation . PLoS ONE. 9. (4).

Cheishvili, D., Chik, F., Li, C.C., Bhattacharya, B., Suderman, M., Arakelian, A., Hallett, M., Rabbani, S.A., Szyf, M.(2014). Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness . Carcinogenesis. 35. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2436-2446.

Kabro, A., Lachance, H., Marcoux-Archambault, I., Perrier, V., Doré, V., Gros, C., Masson, V., Gregoire, J.-M., Ausseil, F., Cheishvili, D., et al.(2013). Preparation of phenylethylbenzamide derivatives as modulators of DNMT3 activity . MedChemComm. 4. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1562-1570.

Cheishvili, D., Maayan, C., Cohen-Kupiec, R., Lefler, S., Weil, M., Ast, G., Razin, A.(2011). IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia . Human Molecular Genetics. 20. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1585-1594.

Cheishvili, D., Maayan, C., Smith, Y., Ast, G., Razin, A.(2007). IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in down regulation of genes involved in oligodendrocyte differentiation and in myelination . Human Molecular Genetics. 16. (17). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2097-2104.

OTHER

Cheishvili, D., Wong, C., Karim, M.M., Kibria, M.G., Jahan, N., Das, P.C., Yousuf, M.A.K., Islam, M.A., Das, D.C., Noor-E-Alam, S.M., et al.(2021). epiLiver a novel tumor specific, high throughput and cost-effective blood test for specific detection of liver cancer (HCC) . medRxiv.

Cheishvili, D., Wong, C., Karim, M., Kibria, M., Jahan, N., Das, P., Yousuf, Md.A., Islam, Md.A., Das, D., Nor-E-Alam, S., et al.(2021). epiLiver a novel tumor specific, high throughput and cost-effective blood test for specific detection of liver cancer (HCC) . ResearchSquare.

David Cheishvili, Kara N. Fitzgerald, Romilly Hodges, Douglas Hanes, Emily Stack, Moshe Szyf, Janine Henkel, Melissa W. Twedt, Despina Giannopoulou, Josette Herdell, et al.(2020). Reversal of Epigenetic Age with Diet and Lifestyle in a Pilot Randomized Clinical Trial . Cold Spring Harbor Laboratory

Fitzgerald, K.N., Hodges, R., Hanes, D., Stack, E., Cheishvili, D., Szyf, M., Henkel, J., Twedt, M.W., Giannopoulou, D., Herdell, J., et al.(2020). Reversal of epigenetic age with diet and lifestyle in a pilot randomized clinical trial . medRxiv.

BOOK CHAPTER

Petropoulos, S., Cheishvili, D., Szyf, M.(2017). High-throughput techniques for DNA methylation profiling . Methods in Pharmacology and Toxicology. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-15.

Cheishvili, D., Petropoulos, S., Christiansen, S., Szyf, M.(2017). Targeted DNA methylation analysis methods . Methods in Pharmacology and Toxicology. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 33-50.