プロフィール詳細

プロジェクトを作成

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Dr. Dominic C.に依頼

Germany

Freelance Chemistry & Legal Consultant | Expert in Medicinal Chemistry & Material Science.

プロフィール概要

I am a PhD-trained synthetic organic chemist with over a decade of international experience in academia, industry, and intellectual property consulting. My background combines hands-on laboratory research, interdisciplinary collaboration, and scientific communication, with expertise in organic synthesis, crystallization, analytical techniques, and functional materials development. Currently, I work as a scientific and legal consultant, supporting R&D and IP teams with experimental design, troubleshooting, and analytical interpretation, while also contributing to patent drafting and litigation support. As an expert witness, I provide technical assessments through reproduction of prior art, data analysis, and clear, structured technical reporting. During my postdoctoral research at the University of Limerick, I led the LightSorb project on light-responsive smart materials and supported multiple successful grant proposals. At H3D (University of Cape Town), I contributed to antimalarial drug discovery projects in partnership with Merck and MMV, helping to advance candidates through Hit-to-Lead and Lead Optimization stages while supporting laboratory operations and mentoring junior scientists. My doctoral and postdoctoral research at Stellenbosch University focused on inherently chiral calixarenes and light-responsive materials, where I secured funding and trained students. Alongside research, I have developed a strong interest in scientific editing and communication. I have authored more than a dozen peer-reviewed publications in leading journals (Angew. Chem., Nat. Chem., J. Am. Chem. Soc., Chem. Commun., J. Mater. Chem. A), and I enjoy refining complex scientific ideas into clear, concise, and accessible writing. This experience, combined with my consulting work, has strengthened both my technical precision and my editorial skills. My technical expertise includes advanced separation and characterization methods (HPLC, GC, NMR, MS, PXRD, SCXRD, DSC), as well as DMPK assays and pharmacokinetic studies. I am proficient with a wide range of laboratory and analysis software (ChemOffice, Dotmatics, Stardrop, ACD/Labs). Fluent in English, German, and Afrikaans, I bring strong communication skills, a collaborative mindset, and a proven ability to bridge chemistry, materials science, pharmaceuticals, and intellectual property.

専門分野

• ☆ Catalysis
• ☆ Natural Product Chemistry
• ☆ Analytical Chemistry
• ☆ Separation & Purification
• ☆ Crystallography
• ☆ X-Ray Crystallography
• ☆ Spectroscopy
• ☆ UV Spectroscopy
• ☆ IR Spectroscopy
• ☆ NMR Spectroscopy
• ☆ Circular Dichroism Spectroscopy
• ☆ Spectrophotometry
• ☆ Mass Spectrometry
• ☆ Organic Chemistry
• ☆ Retrosynthesis
• ☆ Drug Discovery
• ☆ Medicinal Chemistry

サービス

• Writing

Writing Medical Writing, Technical Writing, Copywriting, General Proofreading & Editing

職務経験

Scientific and legal consultant

Glenntex

2月 2024 - 現在

Expert witness and legal consultant

Aitken Klee LLP

6月 2022 - 現在

Postdoctoral Research fellow

Bernal Institute, University of Limerick

1月 2021 - 12月 2022

Chief Scientific Officer

H3D

6月 2018 - 12月 2020

Postdoctoral Research fellow

Stellenbosch University

12月 2016 - 6月 2018

学歴

PhD in synthetic organic chemistry

Stellenbosch University

1月 2014 - 12月 2016

BSc Honours Chemistry

Stellenbosch University

1月 2009 - 12月 2013

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Kyriaki Koupepidou, Shi-Qiang Wang, Varvara I. Nikolayenko, Dominic C. Castell, Catiúcia R. M. O. Matos, Matthias Vandichel, Michael J. Zaworotko (2024). Gate-opening Induced by C8 Aromatics in a Double Diamondoid Coordination Network . ACS Materials Letters.

Yassin H. Andaloussi, Debobroto Sensharma, Andrey A. Bezrukov, Dominic C. Castell, Tao He, Shaza Darwish, Michael J. Zaworotko (2024). Dinuclear Copper Sulfate-Based Square Lattice Topology Network with High Alkyne Selectivity . Crystal Growth & Design.

Kyriaki Koupepidou, Varvara I. Nikolayenko, Debobroto Sensharma, Andrey A. Bezrukov, Matthias Vandichel, Sousa Javan Nikkhah, Dominic C. Castell, Kolade A. Oyekan, Naveen Kumar, Aizhamal Subanbekova, et al. (2023). One Atom Can Make All the Difference: Gas-Induced Phase Transformations in Bisimidazole-Linked Diamondoid Coordination Networks . Journal of the American Chemical Society.

Kyriaki Koupepidou, Varvara I. Nikolayenko, Debobroto Sensharma, Andrey A. Bezrukov, Mohana Shivanna, Dominic C. Castell, Shi-Qiang Wang, Naveen Kumar, Ken-ichi Otake, Susumu Kitagawa, et al. (2023). Control over Phase Transformations in a Family of Flexible Double Diamondoid Coordination Networks through Linker Ligand Substitution . Chemistry of Materials.

Dominic C. Castell, Varvara I. Nikolayenko, Debobroto Sensharma, Kyriaki Koupepidou, Katherine A. Forrest, Carlos J. Solanilla‐Salinas, Brian Space, Leonard J. Barbour, Michael J. Zaworotko (2023). Crystal Engineering of Two Light and Pressure Responsive Physisorbents . Angewandte Chemie International Edition.

Varvara I. Nikolayenko, Dominic C. Castell, Debobroto Sensharma, Mohana Shivanna, Leigh Loots, Katherine A. Forrest, Carlos J. Solanilla-Salinas, Ken-ichi Otake, Susumu Kitagawa, Leonard J. Barbour, et al. (2023). Reversible transformations between the non-porous phases of a flexible coordination network enabled by transient porosity . Nature Chemistry.

Kyriaki Koupepidou, Andrey A. Bezrukov, Dominic C. Castell, Debobroto Sensharma, Soumya Mukherjee, Michael J. Zaworotko (2023). Water vapour induced structural flexibility in a square lattice coordination network . Chemical Communications.

Varvara I. Nikolayenko, Dominic C. Castell, Debobroto Sensharma, Mohana Shivanna, Leigh Loots, Ken-ichi Otake, Susumu Kitagawa, Leonard J. Barbour, Michael J. Zaworotko (2023). Metal cation substitution can tune CO2, H2O and CH4 switching pressure in transiently porous coordination networks . Journal of Materials Chemistry A.

Szymon Sobczak, Aleksandra Półrolniczak, Paulina Ratajczyk, Weizhao Cai, Andrzej Gładysiak, Varvara I. Nikolayenko, Dominic C. Castell, Leonard J. Barbour, Andrzej Katrusiak(2020). Large negative linear compressibility of a porous molecular co-crystal . Chemical Communications. 56. (31). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4324--4327. Royal Society of Chemistry ({RSC})

Varvara I. Nikolayenko, Dominic C. Castell, Dewald P. van Heerden, Leonard J. Barbour (2018). Guest‐Induced Structural Transformations in a Porous Halogen‐Bonded Framework . Angewandte Chemie.

Dominic C. Castell, Ntlama Lesotho, Varvara I. Nikolayenko, Gareth E. Arnott (2017). Inherently Chiral Calix[4]arenes: A Chiral Sulfoxide as an Ortholithiation Director . European Journal of Organic Chemistry.

Simon A Herbert, Laura J van Laeren, Dominic C Castell, Gareth E Arnott (2014). Inherently chiral calix[4]arenes via oxazoline directed ortholithiation: synthesis and probe of chiral space . Beilstein Journal of Organic Chemistry.

Simon A. Herbert, Dominic C. Castell, Jonathan Clayden, Gareth E. Arnott (2013). Manipulating the Diastereoselectivity of Ortholithiation in Planar Chiral Ferrocenes . Organic Letters.