プロフィール詳細

プロジェクトを作成

★★★★★

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★★★★★

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Dr. Donald S.に依頼

United States

Director of Molecular Biology and Genomics at Homology Medicines, Inc.

プロフィール概要

With over 15 years of experience in leading and contributing to cutting-edge gene therapy initiatives, I was the Director of Molecular Biology and Genomics at Homology Medicines, Inc., a biotechnology company focused on developing novel treatments for life-threatening diseases. I have a Ph.D. in Molecular Biology and Biomedical Sciences, and a post-doctoral fellowship in Cardiology and Molecular Genetics. I am passionate and innovative in my field, and I have a proven track record of designing, identifying, and optimizing vectors and gene targets, ensuring the precision and efficacy of our therapeutic approach. I also leverage state-of-the-art long read sequencing analysis to refine and enhance vector designs. I have led and contributed to multiple exploratory and clinical programs at Homology, where I have developed and implemented novel sequencing methods, improved the percentage of fully loaded capsids, and supported the successful submission of an IND. I am driven by the mission of advancing gene therapy for the benefit of patients and society.

専門分野

• ★ DNA Sequencing
• ★ Gene Regulation
• ★ Bioprinting
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Microarrays
• ☆ Omics
• ☆ Transcriptomics
• ☆ Comparative Genomics
• ☆ Metabolomics
• ☆ Genomics
• ☆ Molecular Evolution
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ ATAC-Seq
• ☆ Synthetic Genomics
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ Microinjection
• ☆ Mutagenesis
• ☆ Exome Sequencing
• ☆ Recombinant DNA
• ☆ RNA Synthesis
• ☆ RNA Sequencing
• ☆ DNA/Gene Synthesis
• ☆ Oligonucleotide Synthesis
• ☆ Plasmid DNA
• ☆ DNA Damage & Repair
• ☆ ChIP-Seq
• ☆ Kinases
• ☆ Monoclonal Antibody Production
• ☆ Molecular Ecology
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cytochemistry
• ☆ Cytogenetics
• ☆ Cell Signaling Pathways
• ☆ Membrane Biology
• ☆ Stem Cell Research
• ☆ Biophysics
• ☆ Biotechnology & Bioengineering
• ☆ Biomedical Engineering
• ☆ Biological Systems Engineering
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Banking
• ☆ Cell Line Engineering
• ☆ Large Scale Cell Culture
• ☆ Cell Surface Receptors
• ☆ 3D Cell Culture
• ☆ Synthetic Biology
• ☆ Biomolecular Engineering
• ☆ Gene Synthesis
• ☆ Genetic Engineering
• ☆ Gene Editing/CRISPR
• ☆ Protein/Enzyme Engineering
• ☆ Gene Delivery
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Phylogenetics
• ☆ Population Genetics
• ☆ Tissue Engineering
• ☆ Artificial Organs
• ☆ Cytometry
• ☆ Cell Aging

サービス

• Research
• Consulting
• Product Development

Research Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review

Consulting Go-to-Market Strategy Consulting, Scientific and Technical Consulting

Product Development Product Launch Support, Prototyping, Reverse Engineering

職務経験

Director

Homology Medicines

10月 2020 - 8月 2023

Lead Assay Development

Thermo Fisher Scientific

2月 2013 - 9月 2020

Staff Scientist

Pacific Biosciences (United States)

4月 2011 - 2月 2013

学歴

Cardiology Fellow (Cardiology)

University of Vermont

8月 2006 - 4月 2011

Doctorate (Physiology)

University of North Texas Health Science Center

8月 1998 - 7月 2006

Bachelor (Biology)

The University of Texas at Arlington

8月 1991 - 5月 1995

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Soares LMM, Hanscom T, Selby DE, Adjei S, Wang W, Przybylski D, John F. Thompson (2022). DNA read count calibration for single-molecule, long-read sequencing . Scientific reports.

Runte KE, Bell SP, Selby DE, Häußler TN, Ashikaga T, LeWinter MM, Palmer BM, Markus Meyer (2017). Relaxation and the Role of Calcium in Isolated Contracting Myocardium From Patients With Hypertensive Heart Disease and Heart Failure With Preserved Ejection Fraction . Circulation. Heart failure.

Hefer D, Yi T, Selby DE, Fishbaugher DE, Tremble SM, Begin KJ, Gogo P, Lewinter MM, Markus Meyer, Palmer BM, et al. (2011). Erythropoietin induces positive inotropic and lusitropic effects in murine and human myocardium . Journal of molecular and cellular cardiology.

Selby DE, Palmer BM, LeWinter MM, Markus Meyer (2011). Tachycardia-induced diastolic dysfunction and resting tone in myocardium from patients with a normal ejection fraction . Journal of the American College of Cardiology.

Fatma S, Selby DE, Singla RD, Singla DK (2010). Factors Released from Embryonic Stem Cells Stimulate c-kit-FLK-1(+ve) Progenitor Cells and Enhance Neovascularization . Antioxidants & redox signaling.

Miller MS, Vanburen P, Lewinter MM, Lecker SH, Selby DE, Palmer BM, Maughan DW, Ades PA, Toth MJ (2009). Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function . Circulation. Heart failure.

Markus Meyer, LeWinter MM, Bell SP, Chen Z, Selby DE, Singla DK, Dauerman HL (2009). N-acetylcysteine-enhanced contrast provides cardiorenal protection . JACC. Cardiovascular interventions.