プロフィール詳細

プロジェクトを作成

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Dr. Drashti D.に依頼

India

Computational & Medicinal Chemist | Molecular Docking, QSAR & Drug Discovery

プロフィール概要

I am a PhD-trained Medicinal and Computational Chemist with 4+ years of combined postdoctoral and industry experience in drug discovery and chemical biology. I completed my PhD in Organic/Medicinal Chemistry (2021), focusing on the design, synthesis, and in-silico evaluation of nitrogen-based heterocyclic compounds, integrating molecular docking and structure-based drug design with wet-lab synthesis. I have worked as a Postdoctoral Research Fellow in the USA on an NIH-funded project involving the design and optimization of novel antifungal agents targeting fungal Acetyl-CoA synthetase. My expertise includes computational modeling, SAR analysis, ligand optimization, and biological data interpretation, along with mentoring students in computational and experimental techniques. Previously, I served as a Senior Research Associate in the pharmaceutical industry, gaining hands-on experience in route synthesis, compound purification, and analytical characterization (¹H/¹³C NMR, HPLC, LC-MS, HRMS). My core skills include molecular docking, QSAR, virtual screening, medicinal chemistry, drug-like molecule design, scientific writing, and data analysis. I am a peer reviewer for international journals and am interested in remote consulting and project-based work in computational drug discovery and medicinal chemistry.

専門分野

• ☆ Computational Chemistry

サービス

• Writing
• Research

Writing Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research

職務経験

Post Doctoral Fellow

Northern Illinois University

4月 2022 - 現在

Post-doctoral Fellow

Northern Illinois University

4月 2022 - 7月 2025

学歴

Ph.D., Chemistry

Gujarat University Ahmedabad - India

9月 2017 - 2月 2021

Master of Philosophy (Department of Chemistry )

Gujarat University

9月 2015 - 1月 2017

Master of Science (Department of Chemistry )

Gujarat University

6月 2013 - 4月 2015

Bachelor of Science (M. G. Science College)

Gujarat University

7月 2010 - 5月 2013

認定資格

• n/a

  n/a

  1月 2025 - 1月 2025

出版物

JOURNAL ARTICLE

Andrew J. Jezewski, Taiwo E. Esan, Jonah Propp, Andrew J. Fuller, Drashti G. Daraji, Charles Lail, III, Bart L. Staker, Elijah L. Woodward, Linjun Liu, Kevin P. Battaile, et al. (2024). A single Leishmania adenylate–forming enzyme of the ANL superfamily generates both acetyl- and acetoacetyl-CoA . Journal of Biological Chemistry.

Sharma, I., Chen, C., Daraji, D., Horn, J.R., Hagen, T.J.(2023). Novel inhibitors of Rickettsia prowazekii methionine aminopeptidase from the Malaria Box . Bioorganic and Medicinal Chemistry Letters. 87.

Daraji, D.G., Rajani, D.P., Jayanthi, S., Patel, H.D.(2022). Design, synthesis, and biological evaluations of (E)-2-(1-[2-mercapto-4-methyl-1-phenyl-1H-imidazol-5-yl]ethylidene)hydrazinecarbothioamide derivatives as antimicrobial agents . Journal of Heterocyclic Chemistry. 59. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 178-193.

Patel, K.R., Brahmbhatt, J.G., Pandya, P.A., Bhadresha, K., Daraji, D.G., Patel, H.D., Rawal, R.M., Baran, S.K., Jayanthi, S.(2021). Design, Synthesis and Biological Evaluation of Novel 5-Phenyl-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiols as an Anticancer Agent . ChemistrySelect. 6. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3240-3255.

Patel, K.R., Brahmbhatt, J.G., Pandya, P.A., Daraji, D.G., Patel, H.D., Rawal, R.M., Baran, S.K.(2021). Design, synthesis and biological evaluation of novel 5-(4-chlorophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as an anticancer agent . Journal of Molecular Structure. 1231.

Daraji, D.G., Rajani, D.P., Rajani, S.D., Pithawala, E.A., Jayanthi, S., Patel, H.D.(2021). Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme . Bioorganic and Medicinal Chemistry Letters. 36.

Dhaval B. Patel, Drashti G. Darji, Krupa R. Patel, Dhanji P. Rajani, Smita D. Rajani, Hitesh D. Patel(2020). Synthesis of novel quinoline‐thiosemicarbazide hybrids and evaluation of their biological activities, molecular docking, molecular dynamics, pharmacophore model studies, and ADME‐Tox properties . Journal of Heterocyclic Chemistry. 57. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1183--1200. Wiley

Drashti G. Daraji, Neelam P. Prajapati, Hitesh D. Patel(2019). Synthesis and Applications of 2‐Substituted Imidazole and Its Derivatives: A Review . Journal of Heterocyclic Chemistry. 56. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2299--2317. Wiley

Drashti G. Daraji, Neelam P. Prajapati, Hitesh D. Patel(2019). Synthesis and Applications of 2‐Substituted Imidazole and Its Derivatives: A Review . Journal of Heterocyclic Chemistry. Wiley

Drashti G. Daraji, Kinjal D. Patel, Hitesh D. Patel, Dhanji P. Rajani (2019). Synthesis, In Vitro Biological Screening, and In Silico Computational Studies of Some Novel Imidazole‐2‐thiol Derivatives . Journal of Heterocyclic Chemistry.

Daraji, D.G., Patel, K.D., Patel, H.D., Rajani, D.P.(2019). Synthesis, In Vitro Biological Screening, and In Silico Computational Studies of Some Novel Imidazole-2-thiol Derivatives . Journal of Heterocyclic Chemistry. 56. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 539-551.

Daraji, D.G., Prajapati, N.P., Patel, H.D.(2019). Synthesis and Applications of 2-Substituted Imidazole and Its Derivatives: A Review . Journal of Heterocyclic Chemistry. 56. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2299-2317.