プロフィール詳細

プロジェクトを作成

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Dr. Ekta A.に依頼

India

Exepert in cell and molecular biology, cell metabolism, understanding signaling pathways in cancer metastasis.

プロフィール概要

I am a Ph.D. in Biochemsitry and Molecular Biology from University of Nebraska Medical Center, USA. I am very well trained in understanding and delineating molecular mechanisms responsible for cancer cell survival and metastasis. I received a very competeitive fellowship for two years during Ph.D. program for my excellent research proposal. I did postdoctoral fellowship from The Wistar Institute, USA. I have extensively studied cell metabolism and role of mitochondrial genes in cancer cell metastasis in multiple cancer models as prostate cancer, gliobalstoma, ovarian cancer, lung cancer and leukemia. I have published 20 first and coauthor research articles in reupted international journals. My work has been selected as " Editors' Pick" (refers to top 2% of the work done in that particular year) by Journal of Biological Chemistry (JBC). I have reviewed about 50 research manuscripts for publication in international journals. I am extensively trained in designing invitro and invivo experiments, trouble shooting, data analysis, data interpretation, data presentation, I have also worked in drug discovery program for assay development and validation.

専門分野

• ☆ Biostatistics
• ☆ Molecular Biology
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Gene Expression Analysis
• ☆ RNA Synthesis
• ☆ DNA/Gene Synthesis
• ☆ Plasmid DNA
• ☆ ChIP-Seq
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Cell Culture
• ☆ Cell Banking
• ☆ Cell Line Engineering
• ☆ Blotting
• ☆ Immunohistochemistry

サービス

• Writing
• Research
• Consulting

Writing Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Post doctoral fellow

The Wistar Institute

2月 2017 - 現在

Principal Investigator

Syngene International (India)

7月 2021 - 9月 2022

Principal Investigator (PI)

Syngene International Limited

7月 2021 - 9月 2022

Post Doctoral Fellow

The Wistar Institute

2月 2017 - 6月 2021

学歴

Ph.D.

University of Nebraska Medical Center Omaha - United States

8月 2011 - 5月 2016

認定資格

• Regulatory Affairs Certificate Program in Medical Devices and Pharmaceutical from Regulatory Affairs Professional Society (RAPS)

  Regulatory Affairs Professional

  5月 2020 - 現在

出版物

JOURNAL ARTICLE

Ekta Agarwal (2022). Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability . Proceedings of the National Academy of Sciences of the United States of America.

Ekta Agarwal (2021). A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression . Science advances.

Ekta Agarwal (2020). The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells . Science signaling.

Ekta Agarwal (2020). Correction: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy . Oncotarget.

Ekta Agarwal (2020). The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis . Journal of extracellular vesicles.

Ekta Agarwal (2019). MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer . Cancer research.

Ekta Agarwal (2019). Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer . EBioMedicine.

Ekta Agarwal (2019). IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α<i>-</i>regulated pseudohypoxic state . FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Ekta Agarwal (2019). Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits . Oncogene.

Ekta Agarwal (2019). Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits . Oncogene.

Ekta Agarwal (2019). Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis . Molecular and cellular biology.

Ekta Agarwal (2019). Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth . The Journal of biological chemistry.

Ekta Agarwal (2018). Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements . Cancer research.

Ekta Agarwal (2017). Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy . Oncotarget.

Ekta Agarwal (2017). TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells . PloS one.

Ekta Agarwal (2017). Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis . Oncogene.

Ekta Agarwal (2014). Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer . BMC cancer.

Ekta Agarwal (2014). Ezrin expression and cell survival regulation in colorectal cancer . Cellular signalling.

Ekta Agarwal (2013). In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer . Oncology reports.

Ekta Agarwal (2013). Differential PKA activation and AKAP association determines cell fate in cancer cells . Journal of molecular signaling.

Ekta Agarwal (2013). Establishment and Validation of an Orthotopic Metastatic Mouse Model of Colorectal Cancer . ISRN hepatology.

Ekta Agarwal (2013). Cell survival and metastasis regulation by Akt signaling in colorectal cancer . Cellular signalling.