プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

ERIK D.に依頼

United States

Tenured Neuroscience Professor | NIH Funded PI | Genetics, Neuroscience, and Data Analysis

プロフィール概要

I am a tenured professor of neuroscience and genetics with over 15 years of experience leading federally funded research programs. My work spans systems neuroscience, molecular biology, and evolutionary genetics, with a strong focus on translational applications. I run an active NIH-funded lab where we use genetic, neurophysiological, and behavioral tools to understand brain function and stress-related traits. I have extensive experience in experimental design, scientific writing, and data analysis, and regularly teach university-level courses in genetics and related life sciences. In addition to my academic work, I am skilled in MATLAB, Python, and R, and bring broad expertise in medically relevant science, manuscript editing, and protocol development.

専門分野

• ☆ Developmental Biology
• ☆ Embryology
• ☆ Evolutionary Biology
• ☆ Biostatistics
• ☆ Zoology
• ☆ Aquatic Mammals
• ☆ Mammalian Biology
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Molecular Evolution
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Mutagenesis
• ☆ Recombinant DNA
• ☆ Neuroscience
• ☆ Visual Neuroscience
• ☆ Behavioral Neuroscience
• ☆ Neuroanatomy
• ☆ Neuropsychology
• ☆ Developmental Neuroscience
• ☆ Molecular Neuroscience
• ☆ Systems Neuroscience
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Data Analysis
• ☆ Image Processing
• ☆ Cluster Analysis
• ☆ Data Visualization
• ☆ Data Cleaning

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Clinical Trial Documentation, Medical Writing

Research User Research, Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Processing, Image Analysis, Data Cleaning

職務経験

Associate Professor

Florida Atlantic University

9月 2021 - 現在

Associate Professor

Florida Atlantic University

8月 2017 - 現在

Postdoctoral Fellow

Carnegie Institution for Science

2月 2012 - 7月 2017

学歴

Ph.D. (Biology)

New York University

9月 2007 - 1月 2012

M.S. (School of Science and Engineering)

Tulane University

9月 2006 - 5月 2007

B.S. (Paul Tulane College)

Tulane University

9月 2000 - 5月 2006

B.A. (Paul Tulane College)

Tulane University

9月 2000 - 5月 2006

認定資格

• 認定資格の詳細は未入力です。

出版物

OTHER

Padmanaban, N., Ambosie, R., Choy, S., Marcus, S., Nilsson, S.R.O., Keene, A.C., Kowalko, J.E., Duboué, E.R.(2025). Automated behavioral profiling using neural networks reveals differences in stress-like behavior between cave and surface-dwelling Astyanax mexicanus . Biorxiv.

Lloyd, E., Xia, F., Moore, K., Zertuche, C., Rastogi, A., Kozol, R., Kenzior, O., Warren, W., Appelbaum, L., Moran, R.L., et al.(2024). Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish . Biorxiv.

Kozol, R.A., Canavan, A., Tolentino, B., Keene, A.C., Kowalko, J.E., Duboué, E.R.(2024). Evolution of a central dopamine circuit underlies adaptation of light-evoked sensorimotor response in the blind cavefish, Astyanax mexicanus . Biorxiv.

Gallman, K., Rastogi, A., North, O., O’Gorman, M., Hutton, P., Lloyd, E., Warren, W., Kowalko, J.E., Duboue, E.R., Rohner, N., et al.(2024). Postprandial sleep in short-sleeping Mexican cavefish . Biorxiv.

Shennard, D., Sifuentes-Romero, I., Ambosie, R., Abdelaziz, J., Duboue, E.R., Kowalko, J.E.(2024). The rx3 gene contributes to the evolution of eye loss in the cavefish Astyanax mexicanus . Biorxiv.

Paz, A., Holt, K.J., Clarke, A., Aviles, A., Abraham, B., Keene, A.C., Duboué, E.R., Fily, Y., Kowalko, J.E.(2023). Changes in local interaction rules during ontogeny underlie the evolution of collective behavior . Biorxiv.

Starkey, J., Hageter, J., Kozol, R., Emmerich, K., Mumm, J.S., Duboué, E.R., Horstick, E.J.(2023). Thalamic neurons drive distinct forms of motor asymmetry that are conserved in teleost and dependent on visual evolution . Biorxiv.

Kozol, R.A., Conith, A.J., Yuiska, A., Cree-Newman, A., Tolentino, B., Banesh, K., Paz, A., Lloyd, E., Kowalko, J.E., Keene, A.C., et al.(2022). A brain-wide analysis maps structural evolution to distinct anatomical modules . Biorxiv.

Rodriguez-Morales, R., Gonzalez-Lerma, P., Yuiska, A., Han, J.H., Guerra, Y., Crisostomo, L., Keene, A.C., Duboue, E.R., Kowalko, J.(2022). Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus . Biorxiv.

Kozol, R.A., Yuiska, A., Han, J.H., Tolentino, B., Lopatto, A., Lewis, P., Paz, A., Keene, A.C., Kowalko, J.E., Duboué, E.R.(2022). Novel husbandry practices result in rapid rates of growth and sexual maturation without impacting adult behavior in the blind Mexican cavefish . Biorxiv.

Oliva, C., Hinz, N.K., Robinson, W., Barrett Thompson, A.M., Booth, J., Crisostomo, L.M., Zanineli, S., Tanner, M., Lloyd, E., O’Gorman, M., et al.(2021). Characterizing the genetic basis of trait evolution in the Mexican cavefish . Biorxiv.

Chin, J.S.R., Phan, T.-A.N., Albert, L.T., Keene, A.C., Duboué, E.R.(2021). Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish . Biorxiv.

Lloyd, E., McDole, B., Privat, M., Jaggard, J.B., Duboué, E., Sumbre, G., Keene, A.(2021). Blind cavefish retain functional connectivity in the tectum despite loss of retinal input . Biorxiv.

Choi, J.-H., Duboué, E., Macurak, M., Chanchu, J.-M., Halpern, M.E.(2021). Specialized neurons in the right habenula mediate response to aversive olfactory cues . Biorxiv.

Chin, J.S.R., Loomis, C.L., Albert, L.T., Medina-Trenche, S., Kowalko, J., Keene, A.C., Duboué, E.R.(2020). Analysis of stress responses in astyanax larvae reveals heterogeneity among different populations . Biorxiv.

O'Gorman, M., Thakur, S., Imrie, G., Moran, R.L., Duboue, E., Rohner, N., McGaugh, S.E., Keene, A.C., Kowalko, J.E.(2020). Pleiotropic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish . Biorxiv.

Patch, A., Paz, A., Holt, K., Duboue, E., Kowalko, J., Keene, A., Fily, Y.(2020). Analysis of social swimming dynamics in the Mexican cavefish . Biorxiv.

Loomis, C., Peuß, R., Jaggard, J., Wang, Y., McKinney, S., Raftopoulos, S., Raftopoulos, A., Whu, D., Green, M., McGaugh, S.E., et al.(2019). An adult brain atlas reveals broad neuroanatomical changes in independently evolved populations of Mexican cavefish . Biorxiv.

Jaggard, J., Lloyd, E., Yuiska, A., Patch, A., Fily, Y., Kowalko, J.E., Appelbaum, L., Duboue, E.R., Keene, A.C.(2019). Cavefish brain atlases reveal functional and anatomical convergence across independently evolved populations . Biorxiv.

Paz, A., McDole, B., Kowalko, J.E., Duboue, E.R., Keene, A.C.(2019). Evolution of the acoustic startle response of Mexican cavefish . Biorxiv.

Stahl, B.A., Peuß, R., McDole, B., Kenzior, A., Jaggard, J.B., Gaudenz, K., Krishnan, J., McGaugh, S.E., Duboue, E.R., Keene, A.C., et al.(2019). Stable transgenesis in Astyanax mexicanus using the Tol2 transposase system . Biorxiv.

Jaggard, J.B., Stahl, B.A., Lloyd, E., Prober, D.A., Duboue, E.R., Keene, A.C.(2017). Hypocretin underlies the evolution of sleep loss in the Mexican cavefish . Biorxiv.

JOURNAL ARTICLE

Gallman, K., Rastogi, A., North, O., O'Gorman, M., Hutton, P., Lloyd, E., Warren, W.C., Kowalko, J.E., Duboue, E.R., Rohner, N., et al.(2024). Postprandial Sleep in Short-Sleeping Mexican Cavefish . Journal of Experimental Zoology Part A Ecological and Integrative Physiology. 341. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1084-1096.

Lloyd, E., Privat, M., Sumbre, G., Duboué, E.R., Keene, A.C.(2023). A protocol for whole-brain Ca2+ imaging in Astyanax mexicanus, a model of comparative evolution . STAR Protocols. 4. (4).

Kozol, R.A., Conith, A.J., Yuiska, A., Cree-Newman, A., Tolentino, B., Benesh, K., Paz, A., Lloyd, E., Kowalko, J.E., Keene, A.C., et al.(2023). A brain-wide analysis maps structural evolution to distinct anatomical module . Elife. 12.

Paz, A., Holt, K.J., Clarke, A., Aviles, A., Abraham, B., Keene, A.C., Duboué, E.R., Fily, Y., Kowalko, J.E.(2023). Changes in local interaction rules during ontogeny underlie the evolution of collective behavior . Iscience. 26. (9).

Kozol, R.A., Yuiska, A., Han, J.H., Tolentino, B., Lopatto, A., Lewis, P., Paz, A., Keene, A.C., Kowalko, J.E., Duboué, E.R.(2023). Novel Husbandry Practices Result in Rapid Rates of Growth and Sexual Maturation Without Impacting Adult Behavior in the Blind Mexican Cavefish . Zebrafish. 20. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 86-94.

Lloyd, E., McDole, B., Privat, M., Jaggard, J.B., Duboué, E.R., Sumbre, G., Keene, A.C.(2022). Blind cavefish retain functional connectivity in the tectum despite loss of retinal input . Current Biology. 32. (17). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3720-3730.e3.

Rodriguez-Morales, R., Gonzalez-Lerma, P., Yuiska, A., Han, J.H., Guerra, Y., Crisostomo, L., Keene, A.C., Duboue, E.R., Kowalko, J.E.(2022). Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus . BMC Ecology and Evolution. 22. (1).

Oliva, C., Hinz, N.K., Robinson, W., Barrett Thompson, A.M., Booth, J., Crisostomo, L.M., Zanineli, S., Tanner, M., Lloyd, E., O'Gorman, M., et al.(2022). Characterizing the genetic basis of trait evolution in the Mexican cavefish . Evolution and Development. 24. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 131-144.

Duboue, E.R., Kowalko, J.E., Keene, A.C.(2022). Course-based undergraduate research experiences (CURES) as a pathway to diversify science . Evolution and Development.

Coffman, J.A., Burman, M.A., Duboué, E.R.(2022). Editorial: Early Life Stress and Developmental Programming of Immune and Nervous System Responsivity . Frontiers in Cell and Developmental Biology. 10.

Patch, A., Paz, A., Holt, K.J., Duboué, E.R., Keene, A.C., Kowalko, J.E., Fily, Y.(2022). Kinematic analysis of social interactions deconstructs the evolved loss of schooling behavior in cavefish . Plos One. 17. (4 April 2022).

Chin, J.S.R., Phan, T.-A.N., Albert, L.T., Keene, A.C., Duboué, E.R.(2022). Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish . Scientific Reports. 12. (1).

O'Gorman, M., Thakur, S., Imrie, G., Moran, R.L., Choy, S., Sifuentes-Romero, I., Bilandžija, H., Renner, K.J., Duboué, E., Rohner, N., et al.(2021). Pleiotropic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish . Current Biology. 31. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3694-3701.e4.

Choi, J.-H., Duboue, E.R., Macurak, M., Chanchu, J.-M., Halpern, M.E.(2021). Specialized neurons in the right habenula mediate response to aversive olfactory cues . Elife. 10.

Zaupa, M., Naini, S.M.A., Younes, M.A., Bullier, E., Duboué, E.R., Le Corronc, H., Soula, H., Wolf, S., Candelier, R., Legendre, P., et al.(2021). Trans-inhibition of axon terminals underlies competition in the habenulo-interpeduncular pathway . Current Biology. 31. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4762-4772.e5.

Chin, J.S.R., Loomis, C.L., Albert, L.T., Medina-Trenche, S., Kowalko, J., Keene, A.C., Duboué, E.R.(2020). Analysis of stress responses in Astyanax larvae reveals heterogeneity among different populations . Journal of Experimental Zoology Part B Molecular and Developmental Evolution. 334. (7-8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 486-496.

Jaggard, J.B., Lloyd, E., Yuiska, A., Patch, A., Fily, Y., Kowalko, J.E., Appelbaum, L., Duboue, E.R., Keene, A.C.(2020). Cavefish brain atlases reveal functional and anatomical convergence across independently evolved populations . Science Advances. 6. (38).

Paz, A., McDole, B., Kowalko, J.E., Duboue, E.R., Keene, A.C.(2020). Evolution of the acoustic startle response of Mexican cavefish . Journal of Experimental Zoology Part B Molecular and Developmental Evolution. 334. (7-8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 474-485.

Loomis, C., Peuß, R., Jaggard, J.B., Wang, Y., McKinney, S.A., Raftopoulos, S.C., Raftopoulos, A., Whu, D., Green, M., McGaugh, S.E., et al.(2019). An Adult Brain Atlas Reveals Broad Neuroanatomical Changes in Independently Evolved Populations of Mexican Cavefish . Frontiers in Neuroanatomy. 13.

Jaggard, J.B., Lloyd, E., Lopatto, A., Duboue, E.R., Keene, A.C.(2019). Automated Measurements of Sleep and Locomotor Activity in Mexican Cavefish . Journal of Visualized Experiments. 2019. (145).

Chin, J.S.R., Albert, L.T., Loomis, C.L., Keene, A.C., Duboué, E.R.(2019). Behavioral approaches to studying innate stress in Zebrafish . Journal of Visualized Experiments. 2019. (147).

Stahl, B.A., Jaggard, J.B., Chin, J.S.R., Kowalko, J.E., Keene, A.C., Duboué, E.R.(2019). Manipulation of gene function in Mexican cavefish . Journal of Visualized Experiments. 2019. (146).

Stahl, B.A., Peuß, R., McDole, B., Kenzior, A., Jaggard, J.B., Gaudenz, K., Krishnan, J., McGaugh, S.E., Duboue, E.R., Keene, A.C., et al.(2019). Stable transgenesis in Astyanax mexicanus using the Tol2 transposase system . Developmental Dynamics. 248. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 679-687.

Chin, J.S.R., Gassant, C.E., Amaral, P.M., Lloyd, E., Stahl, B.A., Jaggard, J.B., Keene, A.C., Duboue, E.R.(2018). Convergence on reduced stress behavior in the Mexican blind cavefish . Developmental Biology. 441. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 319-327.

Lloyd, E., Olive, C., Stahl, B.A., Jaggard, J.B., Amaral, P., Duboué, E.R., Keene, A.C.(2018). Evolutionary shift towards lateral line dependent prey capture behavior in the blind Mexican cavefish . Developmental Biology. 441. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 328-337.

Jaggard, J.B., Stahl, B.A., Lloyd, E., Prober, D.A., Duboue, E.R., Keene, A.C.(2018). Hypocretin underlies the evolution of sleep loss in the Mexican cavefish . Elife. 7.

Keene, A.C., Duboue, E.R.(2018). The origins and evolution of sleep . Journal of Experimental Biology. 221. (11).

Duboué, E.R., Hong, E., Eldred, K.C., Halpern, M.E.(2017). Left Habenular Activity Attenuates Fear Responses in Larval Zebrafish . Current Biology. 27. (14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2154-2162.e3.

Facchin, L., Duboué, E.R., Halpern, M.E.(2015). Disruption of epithalamic left-right asymmetry increases anxiety in Zebrafish . Journal of Neuroscience. 35. (48). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 15847-15859.

Yoshizawa, M., Robinson, B.G., Duboué, E.R., Masek, P., Jaggard, J.B., O'Quin, K.E., Borowsky, R.L., Jeffery, W.R., Keene, A.C.(2015). Distinct genetic architecture underlies the emergence of sleep loss and prey-seeking behavior in the Mexican cavefish . BMC Biology. 13. (1).

Duboué, E.R., Borowsky, R.L.(2012). Altered rest-activity patterns evolve via circadian independent mechanisms in cave adapted balitorid loaches . Plos One. 7. (2).

Duboué, E.R., Borowsky, R.L., Keene, A.C.(2012). β-adrenergic signaling regulates evolutionarily derived sleep loss in the mexican cavefish . Brain Behavior and Evolution. 80. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 233-243.

Duboué, E.R., Keene, A.C., Borowsky, R.L.(2011). Evolutionary convergence on sleep loss in cavefish populations . Current Biology. 21. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 671-676.

Keene, A.C., Duboué, E.R., McDonald, D.M., Dus, M., Suh, G.S.B., Waddell, S., Blau, J.(2010). Clock and cycle limit starvation-induced sleep loss in drosophila . Current Biology. 20. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1209-1215.

BOOK CHAPTER

Lloyd, E., Kozol, R.A., Duboue, E.R., Keene, A.C.(2023). Immunohistochemistry and In Vivo Neural Imaging in A. mexicanus . Neuromethods. 194. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 221-234.

Duboué, E.R., Halpern, M.E.(2017). Genetic and transgenic approaches to study zebrafish brain asymmetry and lateralized behavior . Neuromethods. 122. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 553-589.

Duboué, E.R., Keene, A.C.(2016). Investigating the Evolution of Sleep in the Mexican Cavefish . Biology and Evolution of the Mexican Cavefish. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 291-308.

CONFERENCE PAPER

McGaugh, S.E., Kowalko, J.E., Duboué, E., Lewis, P., Franz-Odendaal, T.A., Rohner, N., Gross, J.B., Keene, A.C.(2020). Dark world rises: The emergence of cavefish as a model for the study of evolution, development, behavior, and disease . Journal of Experimental Zoology Part B Molecular and Developmental Evolution. 334. (7-8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 397-404.