プロフィール詳細

プロジェクトを作成

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Dr. Esteban C.に依頼

United States

Expert in cancer and viral immunology, vaccine development and T cell based immunotherapy

プロフィール概要

I currently serve as the Director of the Cancer Vaccine Initiative and Leader of the Cancer Immunology, Inflammation and Tolerance Program of the Georgia Cancer Center of Augusta University. I currently work half time at Augusta University and spends the remainder of my time in San Diego, CA serving as a private consultant and as an Adjunct Professor, Scientific Associate in the La Jolla Institute of Immunology. Previously, I served as Professor of Immunology of the Moffitt Cancer Center . Prior to Moffitt, I was a Professor of Immunology at the Mayo Clinic where I initiated 3 clinical trials using peptide-based vaccines for various types of cancer and Epstein Barr Virus. I have several US patents issued and have authored more than 200 peer-reviewed scientific publications. I obtained my MD and PhD from the National University of Mexico. After my postdoctotal training at MIT, I worked in several Pharma /Biotech companies including: Centocor, T Cell Sciences Inc., Dupont and Cytel/Epimmune. At the Wistar Institute I worked in the Rabies Virus Unit developing subunit vaccines against this virus. I am a member of the American Association of Immunologists, and the American Association for Cancer Research. I served as a charter member of tof several NIH Study Sections, was a member of the Board of Scientific Counselors of the National Cancer Institute, and Section Editor of the Journal of Immunology and Associate Editor of Cancer Research.

専門分野

• ★ Vaccine Development
• ★ Immunotherapy
• ☆ Cancer Research

サービス

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing

Research Feasibility Study, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Product Development Formulation

職務経験

Professor

Augusta University

11月 2013 - 現在

Professor

H Lee Moffitt Cancer Center and Research Institute

2月 2006 - 11月 2013

Professor

Mayo Clinic

1月 1997 - 11月 2013

学歴

PhD

National University of Mexico (UNAM)

1月 1974 - 12月 1977

Medical Degree (MD)

National University of Mexico (UNAM)

1月 1971 - 12月 1976

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

(2020). Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma . Oncoimmunology.

(2020). Double-Stranded RNA Immunomodulators in Prostate Cancer . The Urologic clinics of North America.

(2020). Poly-IC enhances the effectiveness of cancer immunotherapy by promoting T cell tumor infiltration . Journal for immunotherapy of cancer.

(2020). Poly-ICLC, a multi-functional immune modulator for treating cancer . Seminars in immunology.

(2020). Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw . FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

(2019). PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma . Journal of translational medicine.

(2019). Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model . Nature communications.

(2019). The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice . Cancer immunology, immunotherapy : CII.

(2018). An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion . The Journal of clinical investigation.

(2018). Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma . Oncoimmunology.

(2018). H3K4me3 mediates the NF-κB p50 homodimer binding to the <i>pdcd1</i> promoter to activate PD-1 transcription in T cells . Oncoimmunology.

(2018). Identification of α-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy . Hepatology (Baltimore, Md.).

(2018). Role of MDA5 and interferon-I in dendritic cells for T cell expansion by anti-tumor peptide vaccines in mice . Cancer immunology, immunotherapy : CII.

(2018). Sustained Persistence of IL2 Signaling Enhances the Antitumor Effect of Peptide Vaccines through T-cell Expansion and Preventing PD-1 Inhibition . Cancer immunology research.

(2017). Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer . Nature communications.

(2017). Effective antitumor peptide vaccines can induce severe autoimmune pathology . Oncotarget.

(2017). Cancer immunotherapy: moving forward with peptide T cell vaccines . Current opinion in immunology.