プロフィール詳細

プロジェクトを作成

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Dr. Flávia M.に依頼

Portugal

Experienced Molecular Biologist Specializing in Cancer Research, 3D Cell Models, and Advanced Genomic Techniques

プロフィール概要

Experienced molecular biologist and Ph.D. candidate specializing in cancer research with expertise in molecular techniques, 3D cell culture, and in vivo experimentation. Recognized for publications, presentations, and international collaborations, skilled in data analysis and software applications. Passionate about advancing cancer biology and therapeutic development.

専門分野

• ☆ Biostatistics
• ☆ Molecular Biology
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ Next Generation Sequencing (NGS)
• ☆ Gene Expression Analysis
• ☆ RNA Sequencing
• ☆ Cell Biology
• ☆ Cell Signaling Pathways
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Electron Microscopy
• ☆ Fluorescence Microscopy
• ☆ Data Collection
• ☆ Cell Culture
• ☆ 3D Cell Culture
• ☆ Blotting
• ☆ Cytometry
• ☆ Python
• ☆ SPSS
• ☆ Excel
• ☆ R

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Translation

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Data Processing

職務経験

PhD student

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto

1月 2020 - 現在

Research Fellowship (MSc)

Universidade do Porto Instituto de Investigação e Inovação em Saúde

2月 2018 - 1月 2020

学歴

PhD in Biomedicine

Universidade do Porto Faculdade de Medicina

9月 2019 - 現在

Master's in Cellular and Molecular Biology (Biology)

Universidade do Porto Faculdade de Ciências

9月 2015 - 12月 2017

Licenciado/ Bachelor's (Biology)

Universidade do Porto Faculdade de Ciências

9月 2012 - 7月 2015

認定資格

• 認定資格の詳細は未入力です。

出版物

PREPRINT

Susana Mendonça Oliveira, Patrícia Dias Carvalho, André Roma, Patrícia Oliveira, Andreia Ribeiro, Joana Carvalho, Flávia Martins, Ana Luísa Machado, Maria José Oliveira, Sérgia Velho (2024). Unveiling the Mechanisms to Bypass KRAS Inhibition:In VitroInsights into the Influence of Fibroblast-Secretome .

Patrícia Dias Carvalho, Susana Mendonça, Flávia Martins, Maria José Oliveira, Sérgia Velho (2022). Modulation of fibroblasts phenotype by colorectal cancer cells-secreted factors is mostly independent of oncogenic KRAS .

Modulation of fibroblasts phenotype by colorectal cancer cells-secreted factors is mostly independent of oncogenic KRAS @null { doi = {10.1101/2022.07.05.498793} } .

Patrícia Dias Carvalho, Flávia Martins, Joana Carvalho, Maria José Oliveira, Sérgia Velho(2022). Mutant KRAS-associated proteome is mainly controlled by exogenous factors . Cold Spring Harbor Laboratory

Mutant KRAS-associated proteome is mainly controlled by exogenous factors @null { doi = {10.1101/2022.01.05.475056} } .

JOURNAL ARTICLE

Patrícia Dias Carvalho, Susana Mendonça, Flávia Martins, Maria José Oliveira, Sérgia Velho (2022). Modulation of Fibroblast Phenotype by Colorectal Cancer Cell-Secreted Factors Is Mostly Independent of Oncogenic KRAS . Cells.

Patrícia Dias Carvalho, Susana Mendonça Oliveira, Flávia Martins, MJ Oliveira, Maria J Oliveira, M J Oliveira, Sérgia Velho (2022). Modulation of Fibroblast Phenotype by Colorectal Cancer Cell-Secreted Factors Is Mostly Independent of Oncogenic KRAS . Cells.

Mutant KRAS-Associated Proteome Is Mainly Controlled by Exogenous Factors @article { author = {Dias Carvalho, Patrícia and Martins, Flávia and Carvalho, Joana and Oliveira, Maria José and Velho, Sérgia}, title = {Mutant KRAS-Associated Proteome Is Mainly Controlled by Exogenous Factors}, journal = {Cells}, volume = {11}, number = {13}, pages = {1988}, year = {2022}, month = {jun}, url = {http://dx.doi.org/10.3390/cells11131988}, doi = {10.3390/cells11131988} } . Cells.

Patrícia Dias Carvalho, Flávia Martins, Joana Carvalho, Maria José Oliveira, Sérgia Velho(2022). Mutant KRAS-Associated Proteome Is Mainly Controlled by Exogenous Factors . Cells. 11. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1988. {MDPI} {AG}

Patrícia Dias Carvalho, Flávia Martins, Carvalho J, MJ Oliveira, Maria J Oliveira, M J Oliveira, Sérgia Velho (2022). Mutant KRAS-Associated Proteome Is Mainly Controlled by Exogenous Factors . Cells.

Flávia Martins, Rosa Oliveira, Bruno Cavadas, Filipe Pinto, Ana Patrícia Cardoso, Flávia Castro, Bárbara Sousa, Marta Laranjeiro Pinto, Ana João Silva, Diogo Adão, et al. (2020). Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer . Cancers.

Flávia Martins, Rosa Oliveira, Bruno Cavadas, Filipe Pinto, Ana Patrícia Cardoso, Flávia Castro, Bárbara Sousa, Marta Pinto, Ana João Silva, Diogo Adão, et al. (2020). Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer . Cancers.

Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors @article { author = {Dias Carvalho, Patrícia and Machado, Ana Luísa and Martins, Flávia and Seruca, Raquel and Velho, Sérgia}, title = {Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors}, journal = {Cancers}, volume = {11}, number = {12}, pages = {2010}, year = {2019}, month = {dec}, url = {http://dx.doi.org/10.3390/cancers11122010}, doi = {10.3390/cancers11122010} } . Cancers.

Barbosa-Vasconcelos, A., Mendes, A., Martins, F., Lopes, E., Machado, A., Bordalo, A.A., Vaz-Pires, P., Vieira, N., Da Costa, P.M., Bessa, L.J.(2018). River water analysis using a multiparametric approach: Portuguese river as a case study . Journal of Water and Health. 16. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 991-1006.

River water analysis using a multiparametric approach: Portuguese river as a case study @article { author = {Barbosa-Vasconcelos, A. and Mendes, A. and Martins, F. and Lopes, E. and Machado, A. and Bordalo, A.A. and Vaz-Pires, P. and Vieira, N. and Da Costa, P.M. and Bessa, L.J.}, title = {River water analysis using a multiparametric approach: Portuguese river as a case study}, journal = {Journal of Water and Health}, volume = {16}, number = {6}, pages = {991--1006}, year = {2018}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-85058610345&partnerID=MN8TOARS}, doi = {10.2166/wh.2018.047} } . Journal of Water and Health.

CONFERENCE POSTER

Chromatin remodeling and gene expression alterations as mechanisms of resistance to KRAS inhibition @misc { author = {F.Martins}, title = {Chromatin remodeling and gene expression alterations as mechanisms of resistance to KRAS inhibition}, year = {2022}, month = {jun} }. 5th ASPIC International Congress.

Chromatin remodeling and gene expression alterations as mechanisms of resistance to KRAS inhibition @misc { title = {Chromatin remodeling and gene expression alterations as mechanisms of resistance to KRAS inhibition}, year = {2022}, month = {mar} }. 8th MCBiology Symposium.

Chromatin remodeling and gene expression alterations as mechanisms of resistance to KRAS loss @misc { author = {Martins, Flávia}, title = {Chromatin remodeling and gene expression alterations as mechanisms of resistance to KRAS loss}, year = {2021}, month = {nov} }. 4th PhDay: Break Borders, Build Opportunities.

KRAS-C-MET-HGF axis: an important modulator of fibroblast-induced colorectal cancer cell invasion @misc { title = {KRAS-C-MET-HGF axis: an important modulator of fibroblast-induced colorectal cancer cell invasion}, year = {2021}, month = {oct} }. II ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer.

Eixo KRAS-C-MET-HGF: um importante modulador da invasão de células de cancro colorretal induzida por fibroblastos @misc { title = {Eixo KRAS-C-MET-HGF: um importante modulador da invasão de células de cancro colorretal induzida por fibroblastos}, year = {2021}, month = {sep} }. 3º Encontro Nacional de Jovens Investigadores em Oncologia.

Looking to the impact of 3D cultures in the proteomic profile of oncogenic KRAS signaling @misc { author = {Martins, Flávia}, title = {Looking to the impact of 3D cultures in the proteomic profile of oncogenic KRAS signaling}, year = {2021}, month = {jun} }. 27th Congress of the European Association for Cancer Research.

Friend or foe: the different roles of oncogenic KRAS in fibroblast-induced colorectal cancer cell invasion @misc { title = {Friend or foe: the different roles of oncogenic KRAS in fibroblast-induced colorectal cancer cell invasion}, year = {2021}, month = {jun} }. 27th Congress of the European Association for Cancer Research.

2D versus 3D proteomic profile of oncogenic KRAS signaling @misc { author = {Martins, Flávia and Dias Carvalho, Patrícia and Carvalho, J and Matthiesen, R and VELHO, SERGIA}, title = {2D versus 3D proteomic profile of oncogenic KRAS signaling}, year = {2020}, month = {oct} }. 3rd PhDay - Back to the Future.

Looking to the cell surface proteome of mutant KRAS cancer cells: a 3D approach @misc { author = {Martins, Flávia and Carvalho, Patrícia Dias and Carvalho, Joana and VELHO, SERGIA}, title = {Looking to the cell surface proteome of mutant KRAS cancer cells: a 3D approach}, year = {2020}, month = {mar} }. EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment.

Oncogenic KRAS: Different roles in fibroblast-induced colorectal cancer cell invasion @misc { author = {Martins, Flávia and Carvalho, Patrícia Dias and Mendonça, S. and Oliveira, MJ and VELHO, SERGIA}, title = {Oncogenic KRAS: Different roles in fibroblast-induced colorectal cancer cell invasion}, year = {2020}, month = {mar} }. EACR-AACR-ASPIC Conference 2020 on Tumor Microenvironment.

The role of fibroblasts on colorectal cancer stem-like properties @misc { author = {Mendonça, S. and Dias Carvalho, P. and Cardoso, P. and Martins, Flávia and Ribeiro, A. and Oliveira, MJ and VELHO, SERGIA}, title = {The role of fibroblasts on colorectal cancer stem-like properties}, year = {2020}, month = {mar} }. EACR-AACR-ASPIC Conference 2020 on Tumor Microenvironment.

KRAS mutation as an alert for immunotherapy in colorectal cancer @misc { author = {Machado, AL and Mendonça. S and Carvalho, Patrícia Dias and Martins, Flávia and Ribeiro, A. and Carvalho, J. and Oliveira, MJ and VELHO, SERGIA}, title = {KRAS mutation as an alert for immunotherapy in colorectal cancer}, year = {2019}, month = {nov} }. 8th i3S ANNUAL MEETING.

Oncogenic KRAS: Different roles in fibroblasts-induced colorectal cancer cell invasion @misc { author = {Carvalho, Patrícia Dias and Martins, Flávia and Mendonça, S and Oliveira, MJ and VELHO, SERGIA}, title = {Oncogenic KRAS: Different roles in fibroblasts-induced colorectal cancer cell invasion}, year = {2019}, month = {nov} }. 8th i3S ANNUAL MEETING.

Modulation of macrophage-cancer cell interaction by the hypoxic colon cancer microenvironment @misc { author = {Costa, AM and Martins, Flávia and Oliveira, R. and Cavadas, B. and Pinto, F. and Cardoso, P. and Castro F. and et al.}, title = {Modulation of macrophage-cancer cell interaction by the hypoxic colon cancer microenvironment}, year = {2019}, month = {sep} }. I ASEICA-ASPIC International Meeting.

Oncogenic KRAS: Different roles in fibroblasts-induced colorectal cancer cell invasion @misc { author = {Carvalho, Patrícia Dias and Martins, Flávia and Mendonça, S. and Oliveira, MJ and VELHO, SERGIA}, title = {Oncogenic KRAS: Different roles in fibroblasts-induced colorectal cancer cell invasion}, year = {2019}, month = {sep} }. 2nd PhDay: PhD countdown: a time for Science.

Hypoxia alters colon cancer macrophage-cancer cell interactions @misc { author = {Martins, Flávia and Oliveira, Rosa and Cavadas, Bruno and Pinto, Filipe and Cardoso, Patrícia and Castro, Flávia T. and Loureiro, JP and et al.}, title = {Hypoxia alters colon cancer macrophage-cancer cell interactions}, year = {2019}, month = {jun} }. 3rd Symposium on Immunomodulation in Cancer and Regeneration,.

Colon cancer hypoxic ecosystem alters macrophage-cancer cell interactions @misc { author = {Oliveira, R. and Martins, Flávia and Cavadas, B. and Pinto, F. and Cardoso, AP. and Castro, F. and Loureiro, JP and et al.}, title = {Colon cancer hypoxic ecosystem alters macrophage-cancer cell interactions}, year = {2019}, month = {may} }. XLV Annual Meeting of Portuguese Immunology Society.

The impact of KRAS oncogenic signaling on the crosstalk between colorectal cancer cells and their microenvironment @misc { author = {Carvalho, Patrícia Dias and Machado, AL and Mendonça, S. and Martins, Flávia and Carvalho, J. and Oliveira, MJ and VELHO, SERGIA}, title = {The impact of KRAS oncogenic signaling on the crosstalk between colorectal cancer cells and their microenvironment }, year = {2019}, month = {may} }. - XXVI Porto Cancer Meeting.

Colon cancer hypoxic ecosystem alters macrophage-cancer cell interactions @misc { author = {Oliveira, R. and Martins, Flávia and Cavadas, B. and Pinto, F. and Cardoso, AP and Castro, F. and Loureiro, JP and et al.}, title = {Colon cancer hypoxic ecosystem alters macrophage-cancer cell interactions}, year = {2019}, month = {may} }. XXVI Porto Cancer Meeting.

The importance of considering hypoxia on the macrophage-cancer cell interplay @misc { author = {Martins, F and Oliveira, R and Pinto, F and Castro, F and Cardoso, P and Cavadas, B and Pinto, M.L and et al.}, title = {The importance of considering hypoxia on the macrophage-cancer cell interplay}, year = {2018} }. 3rd ASPIC International Congress.

Unravel the role of hypoxia at the tumor microenvironment: a focus on macrophage-cancer cell interplay @misc { author = {Oliveira, Rosa and Martins, Flávia and Castro, Flávia T. and Cardoso, AP and Costa, Ângela M. }, title = {Unravel the role of hypoxia at the tumor microenvironment: a focus on macrophage-cancer cell interplay}, year = {2018} }. 7th i3S Annual Meeting.

Influence of KRAS activation in the colorectal cancer immunosurveillance escape @misc { author = {AL Machado and S Mendonça and P Dias Carvalho and F Martins and MJ Oliveira and S Velho}, title = {Influence of KRAS activation in the colorectal cancer immunosurveillance escape}, year = {2018}, doi = {10.1061/41183(418)10} } . 3rd ASPIC International Congres.

The importance of considering hypoxia on the macrophage-cancer cell cross-talk @misc { author = {Martins F and Oliveira R and Pinto F and Castro F and Cardoso P and Cavadas B and Pinto ML and et al.}, title = {The importance of considering hypoxia on the macrophage-cancer cell cross-talk}, year = {2018} }. XXV Porto Cancer Meeting.

Fibroblasts as stromal modulators of macrophage polarization @misc { author = {Carlos F. Guimarães and P.Carvalho and F.T. Castro and F.Martins and M.J.Oliveira and S.Velho}, title = {Fibroblasts as stromal modulators of macrophage polarization }, year = {2017}, month = {jun} }. 2nd Symposium on Immunomodulation in Cancer and Regeneration.

The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay @misc { author = {F. Martins and F. Castro and M.L. Pinto and A.J. Silva and B. Sousa and M.J. Oliveira and Â. M. Costa}, title = {The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay}, year = {2017} }. 12th Young European Scientist Meeting.

The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay @misc { author = {Martins, Flávia and Pinto, Marta L. and Silva, Ana João and Castro, Flávia T. and Oliveira, Maria José and Costa, Ângela M. }, title = {The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay}, year = {2017} }. 2nd Symposium on Immunomodulation in Cancer and Regeneration.

The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay @misc { author = {Martins, Flávia and Pinto, Marta L. and Silva, Ana João and Castro, Flávia T. and Oliveira, Maria José and Costa, Ângela M. }, title = {The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay}, year = {2017} }. 10th Encontro Investigação Jovem Universidade do Porto.

OTHER

Patrícia Dias Carvalho, Flávia Martins, Susana Mendonça, Andreia Ribeiro, Ana Luísa Machado, Joana Carvalho, Maria José Oliveira, Sérgia Velho(2021). Mutant KRAS modulates colorectal cancer cells invasive response to fibroblast-secreted factors through the HGF/C-MET axis . Cold Spring Harbor Laboratory

Mutant KRAS modulates colorectal cancer cells invasive response to fibroblast-secreted factors through the HGF/C-MET axis @other { url = {https://doi.org/10.1101/2021.11.16.468815}, doi = {10.1101/2021.11.16.468815} } .

BOOK CHAPTER

Animal Models to Study Cancer and Its Microenvironment @inbook { author = {Mendes, N. and Dias Carvalho, P. and Martins, F. and Mendonça, S. and Malheiro, A. R. and Ribeiro, A. and Carvalho, J. and Velho, S.}, title = {Animal Models to Study Cancer and Its Microenvironment}, pages = {389--401}, volume = {1219}, publisher = {Springer International Publishing}, year = {2020}, url = {http://dx.doi.org/10.1007/978-3-030-34025-4_20}, doi = {10.1007/978-3-030-34025-4_20} } . Advances in Experimental Medicine and Biology.

CONFERENCE ABSTRACT

The hypoxia impact in the macrophage-driven cancer cell invasive phenotype @inproceedings { author = {Costa AM and Martins F}, title = {The hypoxia impact in the macrophage-driven cancer cell invasive phenotype}, address = {Lisboa}, volume = {11}, pages = {47}, year = {2018} }. 8th International conference on Tumor Microenvironment.

(2017). The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay . Young European Scientist Meeting.

The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay @inproceedings { author = {Martins, Flávia}, title = {The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay}, year = {2017}, month = {oct}, doi = {10.1016/j.pbj.2017.07.098} } .

DISSERTATION THESIS

The role of the hypoxic microenvironment on the macrophage-tumor cell interplay @phdthesis { author = {Martins, Flávia}, title = {The role of the hypoxic microenvironment on the macrophage-tumor cell interplay}, year = {2017}, school = {Universidade do Porto Faculdade de Ciências} }. Universidade do Porto Faculdade de Ciências.