プロフィール詳細

プロジェクトを作成

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Dr. Floriano S.に依頼

Brazil

Researcher in Computational Biochemistry and Drug Discovery with 15+ years of experience on international collaboration

プロフィール概要

Dr. Floriano Paes Silva-Jr graduated in Pharmacy (Industry) from Fluminense Federal University in Niteroi, Brazil (2002) and got a Ph.D. in Organic Chemistry from the Federal University of Rio de Janeiro (UFRJ), Brazil (2005). Dr. Silva-Jr was a Postdoctoral fellow in the Department of Biochemistry and Molecular Biology at Instituto Oswaldo Cruz (IOC), FIOCRUZ, Brazil (2006) and at the Department of Molecular Biosciences, University of Kansas, USA (2008). Currently, he is Full Researcher and Head of the Laboratory of Experimental and Computational Biochemistry of Drugs at IOC, FIOCRUZ. He is also leader of the Research Group of CNPq on "Structure of Biomolecular Systems" - GPESB (http://www.ioc.fiocruz.br/gpesb) and coordinates the platform for Bioassays and Drug Screening at FIOCRUZ. Dr. Silva-Jr has experience in the area of biochemistry, with an emphasis on Structure and Chemistry of Proteins, acting on the following research themes: Molecular Modeling, Drug Design, High Throughput/Content Screening (HTS/HCS) and Structural and Molecular Biology. He was the director of the graduate program in Computational and Systems Biology, Instituto Oswaldo Cruz / FIOCRUZ (2010-2013). Dr. Silva-Jr is faculty of the graduate programs on Cellular and Molecular Biology and on Computational and Systems Biology at IOC, FIOCRUZ and of the graduate program on Pharmacology and Medicinal Chemistry at UFRJ. He is a Board Member of the Brazilian Association for Bioinformatics and Computational Biology - AB3C (2012-2014). He is an Ordinary Member of the Brazilian Society of Biochemistry and Molecular Biology and an effective member of the Brazilian Chemical Society. Dr. Silva-Jr is a fellow of the "Young Scientist of Our State Fellowship Program" (FAPERJ) and a receives a Research Productivity Scholarship from the Brazilian National Council for Scientific Development (CNPq) since 2009 . Dr. Silva-Jr belongs to the editorial board of the journal "Computational Chemistry" (http://www.scirp.org/journal/cc/).

専門分野

• ★ Medicinal Chemistry
• ☆ Computational Chemistry
• ☆ Computational Biology
• ☆ Biochemistry

サービス

• Writing
• Research
• Product Development

Writing Technical Writing

Research Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Product Development Formulation, Stability/Shelf Life Testing

職務経験

Researcher

FIOCRUZ

11月 2006 - 現在

学歴

PhD

Universidade Federal do Rio de Janeiro

2002 - 12月 2005

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Marcos V. S. Santana, Floriano P. Silva-Jr(2021). De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning . BMC Chemistry. 15. (1). Springer Science and Business Media {LLC}

(2021). De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning . BMC chemistry.

Bruno Junior Neves, Jonathan Paulo Agnes, Marcelo do Nascimento Gomes, Marcio Roberto Henriques Donza, Rosângela Mayer Gonçalves, Marina Delgobo, Lauro Ribeiro de Souza Neto, Mario Roberto Senger, Floriano Paes Silva-Junior, Sabrina Baptista Ferreira, et al.(2020). Efficient identification of novel anti-glioma lead compounds by machine learning models . European Journal of Medicinal Chemistry. 189. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 111981. Elsevier {BV}

(2020). Efficient identification of novel anti-glioma lead compounds by machine learning models . European journal of medicinal chemistry.

(2020). Schistosoma mansoni cathepsin D1: Biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells . Protein expression and purification.

(2020). COVID-19: molecular targets, drug repurposing and new avenues for drug discovery . Memorias do Instituto Oswaldo Cruz.

(2020). Strategies to Support Fragment-to-Lead Optimization in Drug Discovery . Frontiers in chemistry.

Mario Roberto Senger, Tereza Cristina Santos Evangelista, Rafael Ferreira Dantas, Marcos Vinicius da Silva Santana, Luiz Carlos Saramago Gonçalves, Lauro Ribeiro de Souza Neto, Sabrina Baptista Ferreira, Floriano Paes Silva-Junior(2020). COVID-19: molecular targets, drug repurposing and new avenues for drug discovery . Memórias do Instituto Oswaldo Cruz. 115. {FapUNIFESP} ({SciELO})

Carolina Escardó Pereyra, Rafael Ferreira Dantas, Sabrina Baptista Ferreira, Luciano Pinho Gomes, Floriano Paes Silva-Jr(2019). The diverse mechanisms and anticancer potential of naphthoquinones . Cancer Cell International. 19. (1). Springer Science and Business Media {LLC}

Rafael F. Dantas, Mario R. Senger, Mariana F. C. Cardoso, Vitor F. Ferreira, Maria Cecília B. V. de Souza, Fernando de C. da Silva, Floriano P. Silva, Jr.(2019). Screening of 1,2-furanonaphthoquinones 1,2,3-1H-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity . Medicinal Chemistry Research. 28. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1579--1588. Springer Science and Business Media {LLC}

Pedro H. M. Torres, Ana C. R. Sodero, Paula Jofily, Floriano P. Silva-Jr(2019). Key Topics in Molecular Docking for Drug Design . International Journal of Molecular Sciences. 20. (18). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4574. {MDPI} {AG}

Pedro Torres, Ana C. R. Sodero, Paula Jofily, Floriano Silva-Jr (2019). Key Topics in Molecular Docking for Drug Design . International Journal of Molecular Sciences.

(2019). Key Topics in Molecular Docking for Drug Design . International journal of molecular sciences.

(2019). Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation . Pharmaceutical biology.

(2019). Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling . MedChemComm.

(2019). Screening of 1,2-furanonaphthoquinones 1,2,3-1H-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity . Medicinal Chemistry Research.

(2019). Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings . Expert opinion on drug discovery.

(2019). FindTargetsWEB: A User-Friendly Tool for Identification of Potential Therapeutic Targets in Metabolic Networks of Bacteria . Frontiers in genetics.

(2019). The diverse mechanisms and anticancer potential of naphthoquinones . Cancer cell international.

Alberto Oliveira, Lucas Bleicher, Carlos G. Schrago, Floriano Paes Silva Junior(2018). Conservation analysis and decomposition of residue correlation networks in the phospholipase A2 superfamily (PLA2s): Insights into the structure-function relationships of snake venom toxins . Toxicon. 146. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 50--60. Elsevier {BV}

Teixeira MAC, Belloze KT, Cavalcanti MC, Silva-Junior FP(2018). Data mart construction based on semantic annotation of scientific articles: A case study for the prioritization of drug targets . Computer methods and programs in biomedicine.

(2018). Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives . Bioorganic & medicinal chemistry.

Sodero AC, Abrahim-Vieira B, Torres PH, Pascutti PG, Garcia CR, Ferreira VF, Rocha DR, Ferreira SB, Silva FP, Memorias do Instituto Oswaldo Cruz, 2017, vol. 112, no. 4, pp. 299-308, 2017 .

Gasparotto J, Kunzler A, Senger MR, Souza CD, Simone SG, Bortolin RC, Somensi N, Dal-Pizzol F, Moreira JC, Abreu-Silva AL, Calabrese KD, Silva FP, Gelain DP, Memorias do Instituto Oswaldo Cruz, 2017, vol. 112, no. 2, pp. 146-154, 2017 .

Bruno J. Neves, Rafael F. Dantas, Mario R. Senger, Cleber C. Melo-Filho, Walter C. G. Valente, Ana C. M. de Almeida, João M. Rezende-Neto, Elid F. C. Lima, Ross Paveley, Nicholas Furnham, et al.(2016). Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening . J. Med. Chem. 59. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7075--7088. American Chemical Society ({ACS})

Cleber C. Melo-Filho, Rafael F. Dantas, Rodolpho C. Braga, Bruno J. Neves, Mario R. Senger, Walter C. G. Valente, João M. Rezende-Neto, Willian T. Chaves, Eugene N. Muratov, Ross A. Paveley, et al.(2016). QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni . J. Chem. Inf. Model. 56. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1357--1372. American Chemical Society ({ACS})

Mario R. Senger, Carlos A.M. Fraga, Rafael F. Dantas, Floriano P. Silva(2016). Filtering promiscuous compounds in early drug discovery: is it a good idea? . Drug Discovery Today. 21. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 868--872. Elsevier {BV}

Bruno Junior Neves, Rafael Ferreira Dantas, Mario Roberto Senger, Walter César Góes Valente, João de Mello Rezende-Neto, Willian Távora Chaves, Lee Kamentsky, Anne Carpenter, Floriano Paes Silva-Junior, Carolina Horta Andrade(2016). The antidepressant drug paroxetine as a new lead candidate in schistosome drug discovery . Med. Chem. Commun. 7. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1176--1182. Royal Society of Chemistry ({RSC})

Costa, Livia Bandeira, de Oliveira Cardoso, Marcos Verssimo, de Oliveira Filho, Gevanio Bezerra, Teixeira de Moraes Gomes, Paulo Andre, Pontes Espindola, Jose Wanderlan, de Jesus Silva, Thays Gabrielle, Monteiro Torres, Pedro Henrique, Silva Junior, Floriano Paes, Martin, Julio, Bressan Queiroz de Figueiredo, Regina Celia, et al.(2016). Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi . Bioorganic & Medicinal Chemistry. 24. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1608-1618.

Gelain, D., Gasparotto, J., Bortolin, R., Girardi, C., Moreira, J. C., Senger, M. R., Schirato, G., Rezende-Neto, J., Dantas, R., Silva-, F., Jr.(2015). Mice experimentally infected with schistosoma mansoni exhibit molecular markers of idiopathic neurodegenerative diseases . Journal of Neurochemistry. 134. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 121.

Gasparotto, J., Senger, M.R., Kunzler, A., Degrossoli, A., de Simone, S.G., Bortolin, R.C., Somensi, N., Girardi, C.S., de Souza, C.D.S.F., Calabrese, K.D.S., et al.(2015). Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis . Brain, Behavior, and Immunity. 43. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 37-45.

Sadok Menna-Barreto, Rubem Figueiredo, Belloze, Kele Teixeira, Perales, Jonas, Silva-, Floriano Paes, Jr.(2014). Proteomic and Bioinformatic Analysis of Trypanosoma cruzi Chemotherapy and Potential Drug Targets: New Pieces for an Old Puzzle . Current Drug Targets. 15. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 255-271.

Gonzaga, Daniel, Senger, Mario Roberto, da Silva, Fernando de Carvalho, Ferreira, Vitor Francisco, Silva, Floriano Paes, Jr.(2014). 1-Phenyl-1H- and 2-phenyl-2H-1,2,3-triazol derivatives: Design, synthesis and inhibitory effect on alpha-glycosidases . European Journal of Medicinal Chemistry. 74. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 461-476.

Forezi, L.D.S.M., Tolentino, N.M.C., De Souza, A.M.T., Castro, H.C., Montenegro, R.C., Dantas, R.F., Oliveira, M.E.I.M., Silva Jr., F.P., Barreto, L.H., Burbano, R.M.R., et al.(2014). Synthesis, cytotoxicity and mechanistic evaluation of 4-oxoquinoline-3- carboxamide derivatives: Finding new potential anticancer drugs . Molecules. 19. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6651-6670.

Cardoso, M.F.C., Rodrigues, P.C., Oliveira, M.E.I.M., Gama, I.L., Da Silva, I.M.C.B., Santos, I.O., Rocha, D.R., Pinho, R.T., Ferreira, V.F., De Souza, M.C.B.V., et al.(2014). Synthesis and evaluation of the cytotoxic activity of 1,2- furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines . European Journal of Medicinal Chemistry. 84. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 708-717.

Tschoeke, D.A., Nunes, G.L., Jardim, R., Lima, J., Dumaresq, A.S.R., Gomes, M.R., Pereira, L.M., Loureiro, D.R., Stoco, P.H., de Matos Guedes, H.L., et al.(2014). The comparative genomics and phylogenomics of Leishmania amazonensis parasite . Evolutionary Bioinformatics. 10. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 131-153.

Gonzaga, D., Senger, M.R., Da Silva, F.D.C., Ferreira, V.F., Silva Jr., F.P.(2014). 1-Phenyl-1H- and 2-phenyl-2H-1,2,3-triazol derivatives: Design, synthesis and inhibitory effect on alpha-glycosidases . European Journal of Medicinal Chemistry. 74. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 461-476.

Forezi, Luana da S. M., Tolentino, Nathalia M. C., de Souza, Alessandra M. T., Castro, Helena C., Montenegro, Raquel C., Dantas, Rafael F., Oliveira, Maria E. I. M., Silva, Floriano P., Jr., Barreto, Leilane H., Burbano, Rommel M. R., et al.(2014). Synthesis, Cytotoxicity and Mechanistic Evaluation of 4-Oxoquinoline-3-carboxamide Derivatives: Finding New Potential Anticancer Drugs . Molecules. 19. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6651-6670.

De Oliveira, R.B., Senger, M.R., Vasques, L.M., Gasparotto, J., Dos Santos, J.P.A., De Bittencourt Pasquali, M.A., Moreira, J.C.F., Silva, F.P., Gelain, D.P.(2013). Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice . International Journal for Parasitology. 43. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 371-379.

Farias, Leonardo P., Krautz-Peterson, Greice, Tararam, Cibele A., Araujo-Montoya, Bogar O., Fraga, Tatiana R., Rofatto, Henrique K., Silva-, Floriano P., Jr., Isaac, Lourdes, Da'dara, Akram A., Wilson, R. Alan, et al.(2013). On the Three-Finger Protein Domain Fold and CD59-Like Proteins in Schistosoma mansoni . Plos Neglected Tropical Diseases. 7. (10).

Silveira, L.B., Marchi-Salvador, D.P., Santos-Filho, N.A., Silva, F.P., Marcussi, S., Fuly, A.L., Nomizo, A., da Silva, S.L., Stábeli, R.G., Arantes, E.C., et al.(2013). Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A2 from Bothrops moojeni snake venom . Journal of Pharmaceutical and Biomedical Analysis. 73. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 35-43.

Silveira, Lucas B., Marchi-Salvador, Daniela P., Santos-Filho, Norival A., Silva, Floriano P., Jr., Marcussi, Silvana, Fuly, Andre L., Nomizo, Auro, da Silva, Saulo L., Stabeli, Rodrigo G., Arantes, Eliane C., et al.(2013). Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A(2) from Bothrops moojeni snake venom . Journal of Pharmaceutical and Biomedical Analysis. 73. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 35-43.

de Oliveira, Ramatis Birnfeld, Senger, Mario Roberto, Vasques, Laura Milan, Gasparotto, Juciano, Almeida dos Santos, Joao Paulo, de Bittencourt Pasquali, Matheus Augusto, Fonseca Moreira, Jose Claudio, Silva, Floriano Paes, Jr., Gelain, Daniel Pens(2013). Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice . International Journal For Parasitology. 43. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 371-379.

Farias, L.P., Krautz-Peterson, G., Tararam, C.A., Araujo-Montoya, B.O., Fraga, T.R., Rofatto, H.K., Silva-Jr, F.P., Isaac, L., Da'dara, A.A., Wilson, R.A., et al.(2013). On the Three-Finger Protein Domain Fold and CD59-Like Proteins in Schistosoma mansoni . PLoS Neglected Tropical Diseases. 7. (10).

Neves, A.P., Pereira, M.X.G., Peterson, E.J., Kipping, R., Vargas, M.D., Silva-Jr, F.P., Carneiro, J.W.M., Farrell, N.P.(2013). Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes . Journal of Inorganic Biochemistry. 119. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 54-64.

Neves, Amanda P., Pereira, Michelle X. G., Peterson, Erica J., Kipping, Ralph, Vargas, Maria D., Silva-, Floriano P., Jr., Carneiro, J. Walkimar M., Farrell, Nicholas P.(2013). Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes . Journal of Inorganic Biochemistry. 119. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 54-64.

Trevizano, Larissa Mattos, Ventorim, Rafaela Zandonade, de Rezende, Sebastiao Tavares, Silva Junior, Floriano Paes, Guimaraes, Valeria Monteze(2012). Thermostability improvement of Orpinomyces sp xylanase by directed evolution . Journal of Molecular Catalysis B-Enzymatic. 81. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12-18.

Trevizano, L.M., Ventorim, R.Z., De Rezende, S.T., Silva Jr., F.P., Guimarães, V.M.(2012). Thermostability improvement of Orpinomyces sp. xylanase by directed evolution . Journal of Molecular Catalysis B: Enzymatic. 81. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12-18.

Senger, Mario Roberto, Andrade Gomes, Lucas Da Costa, Ferreira, Sabrina Baptista, Kaiser, Carlos Roland, Ferreira, Vitor Francisco, Silva, Floriano Paes, Jr.(2012). Kinetics Studies on the Inhibition Mechanism of Pancreatic alpha-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity . Chembiochem. 13. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1584-1593.

Rubem Figueiredo Sadok Menna-Barreto, Daniela Gois Beghini, André Teixeira da Silva Ferreira, Vivian Corrêa de Almeida, Marcelle Almeida Caminha, Floriano Paes Silva-Jr, Jonas Perales(2012). New insights in Trypanosoma cruzi proteomic map: further post-translational modifications and potential drug targets in Y strain epimastigotes . JIOMICS. 2. (2). Proteomass

Senger, M.R., Gomes, L.D.C.A., Ferreira, S.B., Kaiser, C.R., Ferreira, V.F., Silva, F.P.(2012). Kinetics Studies on the Inhibition Mechanism of Pancreatic α-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity . ChemBioChem. 13. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1584-1593.

Teixeira, Sabrina S., Silveira, Lucas B., da Silva, Franco M. N., Marchi-Salvador, Daniela P., Silva, Floriano P., Jr., Izidoro, Luiz Fernando M., Fuly, Andre L., Juliano, Maria A., dos Santos, Camila R., Murakami, Mario T., et al.(2011). Molecular characterization of an acidic phospholipase A(2) from Bothrops pirajai snake venom: synthetic C-terminal peptide identifies its antiplatelet region . Archives of Toxicology. 85. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1219-1233.

Teixeira, S.S., Silveira, L.B., Da Silva, F.M.N., Marchi-Salvador, D.P., Silva Jr., F.P., Izidoro, L.F.M., Fuly, A.L., Juliano, M.A., Dos Santos, C.R., Murakami, M.T., et al.(2011). Molecular characterization of an acidic phospholipase A 2 from Bothrops pirajai snake venom: Synthetic C-terminal peptide identifies its antiplatelet region . Archives of Toxicology. 85. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1219-1233.

Romero, L., Marcussi, S., Marchi-Salvador, D.P., Silva, F.P., Fuly, A.L., Stábeli, R.G., da Silva, S.L., González, J., Monte, A.D., Soares, A.M.(2010). Enzymatic and structural characterization of a basic phospholipase A 2 from the sea anemone Condylactis gigantea . Biochimie. 92. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1063-1071.

Romero, Lazara, Marcussi, Silvana, Marchi-Salvador, Daniela P., Silva, Floriano P., Jr., Fuly, Andre L., Stabeli, Rodrigo G., da Silva, Saulo L., Gonzalez, Jorge, del Monte, Alberto, Soares, Andreimar M.(2010). Enzymatic and structural characterization of a basic phospholipase A(2) from the sea anemone Condylactis gigantea . Biochimie. 92. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1063-1071.

Ferreira, Sabrina B., Sodero, Ana C. R., Cardoso, Mariana F. C., Lima, Emerson S., Kaiser, Carlos R., Silva, Floriano P., Jr., Ferreira, Vitor F.(2010). Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as alpha-Glucosidases Inhibitors . Journal of Medicinal Chemistry. 53. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2364-2375.

Ferreira, S., Sodero, A.C.R., Cardoso, M.F.C., Lima, E.S., Kaiser, C.R., Silva Jr., F.P., Ferreira, V.F.(2010). Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as a-Glucosidases Inhibitors . Journal of Medicinal Chemistry. 53. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2364-2375.

Teixeira, Raquel L. F., Silva Junior, Floriano P., Silveira, Aline R., Cabello, Pedro H., Mendonca-Lima, Leila, Rabahi, Marcelo F., Kritski, Afranio L., Mell, Fernanda C. Q., Suffys, Philip N., de Miranda, Antonio B., et al.(2010). Sequence analysis of NAT2 gene in Brazilians: Identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure . Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 683. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 43-49.

Teixeira, R.L.F., Silva Jr., F.P., Silveira, A.R., Cabello, P.H., Mendonça-Lima, L., Rabahi, M.F., Kritski, A.L., Mello, F.C.Q., Suffys, P.N., de Miranda, A.B., et al.(2010). Sequence analysis of NAT2 gene in Brazilians: Identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure . Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 683. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 43-49.

Ana C. R. Sodero, Salvatore G. De Simone, Floriano P. Silva-Jr(2009). Catalytic mechanism and protonation state of pepsin-like aspartyl protease active site . Revista Virtual de Química. 1. (2). Sociedade Brasileira de Quimica ({SBQ})

Davila, Alberto M. R., Mendes, Pablo N., Wagner, Glauber, Tschoeke, Diogo A., Cuadrat, Rafael R. C., Liberman, Felipe, Matos, Luciana, Satake, Thiago, Ocana, Kary A. C. S., Triana, Omar, et al.(2008). ProtozoaDB: dynamic visualization and exploration of protozoan genomes . Nucleic Acids Research. 36. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString D547-D552.

Guedes, H.L.M., Silva Jr., F.P., Netto, C.C., de Salles, C.M.C., Alexandre, G., Oliveira, C.L.P., Torriani, Í., De Simone, S.G.(2008). Structural characterization and low-resolution model of BJ-48, a thrombin-like enzyme from Bothrops jararacussu venom . Biophysical Chemistry. 132. (2-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 159-164.

Silva, F. P., Jr., Alexandre, G. M. C., Ramos, C. H. I., De-Simone, S. G.(2008). On the quaternary structure of a C-type lectin from Bothrops jararacussu venom - BJ-32 (BjcuL) . Toxicon. 52. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 944-953.

Dávila, A.M.R., Mendes, P.N., Wagner, G., Tschoeke, D.A., Cuadrat, R.R.C., Liberman, F., Matos, L., Satake, T., Ocaña, K.A.C.S., Triana, O., et al.(2008). ProtozoaDB: Dynamic visualization and exploration of protozoan genomes . Nucleic Acids Research. 36. (SUPPL. 1).

Guedes, Herbert L. M., Silva, Floriano P., Jr., Netto, Carlos Correa, de Salles, Cristiane M. C., Alexandre, Giani, Oliveria, Cristiano L. P., Torriani, Iris, De Simone, Salvatore Giovanni(2008). Structural characterization and low-resolution model of BJ-48, a thrombin-like enzyme from Bothrops jararacussu venom . Biophysical Chemistry. 132. (2-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 159-164.

Silva Jr., F.P., Alexandre, G.M.C., Ramos, C.H.I., De-Simone, S.G.(2008). On the quaternary structure of a C-type lectin from Bothrops jararacussu venom - BJ-32 (BjcuL) . Toxicon. 52. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 944-953.

Silva-Junior, F.P., Guedes, H.L.M., Garvey, L.C., Aguiar, A.S., Bourguignon, S.C., Di Cera, E., Giovanni-De-Simone, S.(2007). BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu venom with high selectivity for Arg over Lys in P1: Role of N-glycosylation in thermostability and active site accessibility . Toxicon. 50. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 18-31.

Silva-Junior, Floriano P., Guedes, Herbert L. M., Garvey, Laura C., Aguiar, Aniesse S., Bourguignon, Saulo C., Di Cera, Enrico, Giovanni-De-Simone, Salvatore(2007). BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu venom with high selectivity for Arg over Lys in P1: Role of N-glycosylation in thermostability and active site accessibility . Toxicon. 50. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 18-31.

Vermelho, A.B., De Simone, S.G., d'Avila-Levy, C.M., do Santos, A.L.S., de Melo, A.C.N., Silva Jr., F.P., da Silva Bon, E.P., Branquinha, M.H.(2007). Trypanosomatidae peptidases: A target for drugs development . Current Enzyme Inhibition. 3. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 19-48.

Silva, Floriano P., Jr., Ellena, Javier, de Lima Ferreira, Marcelle, Mascarenhas, Yvonne P., de Souza, Marcus V. N., Vasconcelos, Thatyana R. A., Wardell, James L., Wardell, Solange M. S. V.(2006). Experimental and theoretical structure characterization of two isoniazid derivatives: 2,4-difluoro-N '-isonicotinoylbenzohydrazide and 2,4-dichloro-N '-isonicotinoylbenzohydrazide hydrochloride . Journal of Molecular Structure. 788. (1-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 63-71.

De-Simone, S. G., Netto, C. C., Silva, F. P., Jr.(2006). Simple affinity chromatographic procedure to purify beta-galactoside binding lectins . Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 838. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 135-138.

Silva Jr., F.P., Antunes, O.A.C., De Alencastro, R.B., De Simone, S.G.(2006). The Na+ binding channel of human coagulation proteases: Novel insights on the structure and allosteric modulation revealed by molecular surface analysis . Biophysical Chemistry. 119. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 282-294.

de Salles, Cristiane M. C., Guedes, Herbert L. M., Salles, Joao B., Silva, Floriano P., Jr., De Simone, Salvatore G.(2006). Optimization of sample preparation from skin mucus of a neotropical fish for two-dimensional substrate gel electrophoresis . Analytical Biochemistry. 357. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 153-155.

Silva, FP, Antunes, OAC, de Alencastro, RB, De Simone, SG(2006). The Na+ binding channel of human coagulation proteases: Novel insights on the structure and allosteric modulation revealed by molecular surface analysis . Biophysical Chemistry. 119. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 282-294.

de Salles, C.M.C., Guedes, H.L.M., Salles, J.B., Silva Jr., F.P., De Simone, S.G.(2006). Optimization of sample preparation from skin mucus of a neotropical fish for two-dimensional substrate gel electrophoresis . Analytical Biochemistry. 357. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 153-155.

De-Simone, S.G., Netto, C.C., Silva Jr., F.P.(2006). Simple affinity chromatographic procedure to purify β-galactoside binding lectins . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 838. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 135-138.

Silva Jr., F.P., Ellena, J., Ferreira, M.d.L., Mascarenhas, Y.P., de Souza, M.V.N., Vasconcelos, T.R.A., Wardell, J.L., Wardell, S.M.S.V.(2006). Experimental and theoretical structure characterization of two isoniazid derivatives: 2,4-Difluoro-N′-isonicotinoylbenzohydrazide and 2,4-dichloro-N′-isonicotinoylbenzohydrazide hydrochloride . Journal of Molecular Structure. 788. (1-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 63-71.

De-Simone, SG, Correa-Netto, C, Antunes, OAC, De-Alencastro, RB, Silva, FP(2005). Biochemical and molecular modeling analysis of the ability of two p-aminobenzamidine-based sorbents to selectively purify serine proteases (fibrinogenases) from snake venoms . Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 822. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-9.

De-Simone, S.G., Correa-Netto, C., Antunes, O.A.C., De-Alencastro, R.B., Silva Jr., F.P.(2005). Biochemical and molecular modeling analysis of the ability of two p-aminobenzamidine-based sorbents to selectively purify serine proteases (fibrinogenases) from snake venoms . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 822. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-9.

Silva Jr., F.P., De-Simone, S.G.(2004). Erratum: S1 subsite in snake venom thrombin-like enzymes: Can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors? (Bioorganic Medicinal Chemistry (2004) 12 (2571) DOI: 10.1016/j.bmc.2004.03.024) . Bioorganic and Medicinal Chemistry. 12. (13).

Silva Jr., F.P., De-Simone, S.G.(2004). S1 subsite in snake venom thrombin-like enzymes: Can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors? . Bioorganic and Medicinal Chemistry. 12. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2571-2587.

Silva, FP, De-Simone, SG(2004). S1 subsite in snake venom thrombin-like enzymes: can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors? (vol 12, pg 2571, 2004) . Bioorganic & Medicinal Chemistry. 12. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3755.

Silva, FP, De-Simone, SG(2004). S1 subsite in snake venom thrombin-like enzymes: can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors? . Bioorganic & Medicinal Chemistry. 12. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2571-2587.

Silva Jr., F.P., Ribeiro, F., Katz, N., Giovanni-De-Simone, S.(2002). Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling . FEBS Letters. 514. (2-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 141-148.

Silva, FP, Ribeiro, F, Katz, N, Giovanni-De-Simone, S(2002). Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling . Febs Letters. 514. (2-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 141-148.

Silva, FP, Veyl, FZ, Clos, J, De Simone, SG(2002). Molecular modeling approaches for determining gene function: Application to a putative poly-A binding protein from Leishmania amazonensis (LaPABP) . Memorias Do Instituto Oswaldo Cruz. 97. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 335-341.

Bourguignon, S.C., Paes F.S., Jr., Calheiros, E.B., Juliano, M., Aguiar, A.S., Melgarejo, A.R., Giovanni-De-Simone, S.(2001). Bothrops moojeni venom peptides containing bradykinin potentiating peptides sequence . Protein and Peptide Letters. 8. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 21-26.

Bourguignon, SC, Paes, FS, Calheiros, EB, Juliano, M, Aguiar, AS, Melgarejo, AR, Giovanni-De-Simone, S(2001). Bothrops moojeni venom peptides containing bradykinin potentiating peptides sequence . Protein and Peptide Letters. 8. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 21-26.

OTHER

Marcos Santana, Floriano Paes Silva(2020). De Novo Design and Bioactivity Prediction of SARS-CoV-2 Main Protease Inhibitors Using ULMFit . Research Square

CONFERENCE PAPER

Belloze, K.T., Monteiro, D.I.S.B., Lima, T.F., Silva Jr., F.P., Cavalcanti, M.C.(2012). An evaluation of annotation tools for biomedical texts . CEUR Workshop Proceedings. 938. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 108-119.