プロフィール詳細

プロジェクトを作成

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Dr. Glynis J.に依頼

South Africa

Molecular biologist with particular experience in biomedical science

プロフィール概要

ACADEMIC INTEREST AREAS Structure, interactions and evolution of proteins Enzymology, including development of catalytic antibodies Protein modelling and functional prediction Developmental neuroscience Neurodegeneration, particularly Alzheimer's disease Host-pathogen interactions during infection Pesticides, particularly in relation to adverse effects on the nervous system

専門分野

• ★ Medical Sciences
• ★ Technical & Scientific Writing
• ☆ STEM
• ☆ Molecular Modeling
• ☆ Separation & Purification
• ☆ Developmental Biology
• ☆ Microbiology
• ☆ Microbiome Research
• ☆ Biochemistry
• ☆ Structural Biology
• ☆ Molecular Biology
• ☆ Molecular Evolution
• ☆ Neuroscience
• ☆ Basic Immunology
• ☆ Adjuvant & Antigen Research
• ☆ Protein/Enzyme Engineering
• ☆ Antibody Engineering
• ☆ Cancer Research
• ☆ Research Methodology

サービス

• Writing
• Research
• Consulting
• Product Development

Writing Medical Writing, Technical Writing, Copywriting

Research Gray Literature Search, Scientific and Technical Research, Systematic Literature Review

職務経験

Researcher

Stellenbosch University

7月 1992 - 12月 2018

Research officer

University of Cape Town

1月 1986 - 6月 1992

Postdoctoral fellow

University of Cape Town

1月 1984 - 12月 1985

学歴

PhD (Chemical Pathology)

University of Cape Town

1月 1979 - 12月 1983

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

(2019). Antioxidant effects of curcumin in models of neurodegeneration, ageing, oxidative and nitrosative stress: A Review. Neuroscience.

(2017). Exome sequencing identifies a novel TTC37 mutation in the first reported case of Trichohepatoenteric syndrome (THE-S) in South Africa. BMC Medical Genetics.

(2017). The α/β hydrolase fold proteins of Mycobacterium tuberculosis, with reference to their contribution to virulence. Current Protein and Peptide Science.

(2014). Neurodegenerative disorders: Dysregulation of a carefully maintained balance?. Experimental Gerontology.

(2013). The Leu-Arg-Glu (LRE) adhesion motif in proteins of the neuromuscular junction with special reference to proteins of the carboxylesterase/cholinesterase family. Comparative Biochemistry and Physiology Part D.

(2012). Why has butyrylcholinesterase been retained? Structural and functional diversification in a duplicated gene. Neurochemistry International.

(2011). The carboxylesterase/cholinesterase gene family in invertebrate deuterostomes. Comparative Biochemistry and Physiology Part D.

(2009). Investigations into the development of catalytic activity in anti-acetylcholinesterase idiotypic and anti-idiotypic antibodies. Journal of Molecular Recognition.

(2008). Non-enzymatic developmental functions of acetylcholinesterase – the question of redundancy. FEBS Journal.

(2008). Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1 chain. Biochemical Journal.

(2007). The acetylcholinesterase readthrough peptide shares sequence similarity with the 28-53 sequence of the adhesion-mediating site and competes with it for ligand binding in vitro. J. Mol. Neurosci. Journal of Molecular Neuroscience.

(2006). The peripheral anionic site of acetylcholinesterase: structure, function and potential role in rational drug design. Current Pharmaceutical Design.

(2005). Acetylcholinesterase in Hirschsprung’s disease. Pediatric Surgery International.

(2004). Functional molecular mimicry of an adhesion- and differentiation-promoting site on acetylcholinesterase. Journal of Cellular Biochemistry.

(2004). Identification of a structural site on acetylcholinesterase that promotes neurite outgrowth and binds laminin-1 and collagen IV. Biochemical and Biophysical Research Communications.

(2003). Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site. Journal of Neuroscience Letters.

(2002). Idiotypic mimicry of a catalytic antibody active site. Molecular Immunology.

(2002). Catalytic antibodies with acetylcholinesterase activity. Journal of Immunological Methods.

(2001). Association of the HNK-1 epitope with the detergent-soluble G4 isoform of acetylcholinesterase from human neuroblastoma cells. International Journal of Developmental Neuroscience.

(2000). Cholinesterases modulate cell adhesion in human neuroblastoma cells in vitro. International Journal of Developmental Neuroscience.

(2000). Elevated tissue immunoglobulins in Hirschsprung’s disease; indication of early immunologic response. European Journal of Pediatric Surgery.

(2000). Localization of a novel adhesion-promoting site on acetylcholinesterase using catalytic antiacetylcholinesterase antibodies displaying cholinesterase-like activity. Applied Biochemistry and Biotechnology.

(2000). )Cholinesterase-like catalytic antibodies: reaction with substrates and inhibitors. Molecular Immunology.

(1999). The adhesion function on acetylcholinesterase is located at the peripheral anionic site. Biochemical and Biophysical Research Communications.

(1998). Cholinesterase-like catalytic antibodies. Immunologist.

(1998). Hirschsprung’s disease: genetic and functional associations of Down’s and Waardenburg syndromes. Seminars in Pediatrics.

(1996). Role of magnesium in suppressing red blood cell acetylcholinesterase in the diagnosis of Hirschsprung’s disease on tissue section. Journal of Analytical Morphology.

(1995). Acetylcholinesterase of human intestinal tissue affected by Hirschsprung’s disease: effect of magnesium chloride on isoforms. Clinica Chimica Acta.

(1995). Anti-acetylcholinesterase antibodies display cholinesterase-like activity. European Journal of Immunology.

(1990). Bioavailabilty and the mechanisms of intestinal absorption of iron from ferrous ascorbate and ferric polymaltose in experimental animals. Experimental Hematology.

(1988). Properties of the transferrin associated with rat intestinal mucosa. Biochimica et Biophysica Acta.

(1985). The effects of cytoskeletal inhibitors on intestinal iron absorption in the rat. Bochimica et Biophysica Acta.

(1984). Oral iron therapy in human subjects, comparative absorption between ferrous salts and iron polymaltose.

(1983). Iron-binding proteins of iron-absorbing rat intestinal mucosa. Journal of Clinical Investigation.

BOOK CHAPTER

(1984). Intestinal transferrin. Protides of the Biological Fluids.