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プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Guido L.に依頼

Italy

プロフィール概要

My research interests cover several areas related to the understanding of functional role of genome expression products. I'm trained in microarray rnaseq chipseq exomeseq data analysis and in development of predictors of disease outcome with machine learning methods. I have strong experience in analyzing exomeseq data to discover somatic mutations in cancer patients

専門分野

• ☆ Genetics
• ☆ Microarrays
• ☆ Mutagenesis
• ☆ Bioinformatics

サービス

• Data & AI

職務経験

bioinformatician

Nouscom

9月 2015 - 現在

Bioinformatician

Nouscom

1月 2015 - 現在

post doc

Universita degli Studi di Roma La Sapienza

2月 2012 - 9月 2015

学歴

Phd in biochemistry

Università degli Studi di Roma La Sapienza Dipartimento di Fisica

1月 2010 - 6月 2012

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Guido Leoni, Anna Morena D'Alise, Gabriella Cotugno, Francesca Langone, Irene Garzia, Maria De Lucia, Imma Fichera, Rosa Vitale, Veronica Bignone, Fabio Giovanni Tucci, et al.(2020). A genetic vaccine encoding shared cancer neoantigens to treat tumors with Microsatellite Instability . Cancer Research. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString canres.1072.2020. American Association for Cancer Research ({AACR})

Guido Leoni, Anna Morena D’Alise, Gabriella Cotugno, Fulvia Troise, Francesca Langone, Imma Fichera, Maria De Lucia, Lidia Avalle, Rosa Vitale, Adriano Leuzzi, et al.(2019). Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade . Nature Communications. 10. (1). Springer Science and Business Media {LLC}

D’Alise, A.M., Leoni, G., Cotugno, G., Troise, F., Langone, F., Fichera, I., De Lucia, M., Avalle, L., Vitale, R., Leuzzi, A., et al.(2019). Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade . Nature Communications. 10. (1).

Giannuzzi, D., Marconato, L., Elgendy, R., Ferraresso, S., Scarselli, E., Fariselli, P., Nicosia, A., Pegolo, S., Leoni, G., Laganga, P., et al.(2019). Longitudinal transcriptomic and genetic landscape of radiotherapy response in canine melanoma . Veterinary and Comparative Oncology. 17. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 308-316.

Chang K, Taggart MW, Reyes-Uribe L, Borras E, Riquelme E, Barnett RM, Leoni G, San Lucas FA, Catanese MT, Mori F, et al.(2018). Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome . JAMA oncology.

Chang, K., Taggart, M.W., Reyes-Uribe, L., Borras, E., Riquelme, E., Barnett, R.M., Leoni, G., Anthony San Lucas, F., Catanese, M.T., Mori, F., et al.(2018). Immune profiling of premalignant lesions in patients with Lynch syndrome . JAMA Oncology. 4. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1085-1092.

Guantario, B., Capolupo, A., Monti, M.C., Leoni, G., Ranaldi, G., Tosco, A., Marzullo, L., Murgia, C., Perozzi, G.(2018). Proteomic analysis of Zn depletion/repletion in the hormone-secreting thyroid follicular cell line FRTL-5 . Nutrients. 10. (12).

Lucchetti, S., Pastore, G., Leoni, G., Arima, S., Merendino, N., Baima, S., Ambra, R.(2018). A simple microsatellite-based method for hazelnut oil DNA analysis . Food Chemistry. 245. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 812-819.

Farina, B., Di Sorbo, G., Chambery, A., Caporale, A., Leoni, G., Russo, R., Mascanzoni, F., Raimondo, D., Fattorusso, R., Ruvo, M., et al.(2017). Structural and biochemical insights of CypA and AIF interaction . Scientific Reports. 7. (1).

Volpicella, M., Leoni, C., Fanizza, I., Distaso, M., Leoni, G., Farioli, L., Naumann, T., Pastorello, E., Ceci, L.R.(2017). Characterization of maize chitinase-A, a tough allergenic molecule . Allergy: European Journal of Allergy and Clinical Immunology. 72. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1423-1429.

Comitato, R., Guantario, B., Leoni, G., Nesaretnam, K., Ronci, M.B., Canali, R., Virgili, F.(2016). Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells . Genes and Nutrition. 11. (1).

Leoni, G., Tramontano, A.(2016). A structural view of microRNA-target recognition . Nucleic Acids Research. 44. (9).

Grassi, L., Leoni, G., Tramontano, A.(2015). RNA editing differently affects protein-coding genes in D. melanogaster and H. sapiens . Scientific Reports. 5.

Natarelli, L., Ranaldi, G., Leoni, G., Roselli, M., Guantario, B., Comitato, R., Ambra, R., Cimino, F., Speciale, A., Virgili, F., et al.(2015). Nanomolar caffeic acid decreases glucose uptake and the effects of high glucose in endothelial cells . PLoS ONE. 10. (11).

(2014). Glucosinolates redox activities: Can they act as antioxidants? . Food Chemistry.

Canali, R., Natarelli, L., Leoni, G., Azzini, E., Comitato, R., Sancak, O., Barella, L., Virgili, F.(2014). Vitamin C supplementation modulates gene expression in peripheral blood mononuclear cells specifically upon an inflammatory stimulus: A pilot study in healthy subjects . Genes and Nutrition. 9. (3).

Leoni, G., Rosato, A., Perozzi, G., Murgia, C.(2014). Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies . Genes and Nutrition. 9. (6).

Natella, F., Leoni, G., Maldini, M., Natarelli, L., Comitato, R., Schonlau, F., Virgili, F., Canali, R.(2014). Absorption, metabolism, and effects at transcriptome level of a standardized french oak wood extract, Robuvit, in healthy volunteers: Pilot study . Journal of Agricultural and Food Chemistry. 62. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 443-453.

Baima, S., Forte, V., Possenti, M., Peñalosa, A., Leoni, G., Salvi, S., Felici, B., Ruberti, I., Morelli, G.(2014). Negative feedback regulation of auxin signaling by ATHB8/ACL5-BUD2 transcription module . Molecular Plant. 7. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1006-1025.

Ambra, R., Manca, S., Palumbo, M.C., Leoni, G., Natarelli, L., De Marco, A., Consoli, A., Pandolfi, A., Virgili, F.(2014). Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression . Genomics. 103. (5-6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 337-348.

Natella, F., Maldini, M., Leoni, G., Scaccini, C.(2014). Glucosinolates redox activities: Can they act as antioxidants? . Food Chemistry. 149. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 226-232.

Pecorelli, A., Leoni, G., Cervellati, F., Canali, R., Signorini, C., Leoncini, S., Cortelazzo, A., De Felice, C., Ciccoli, L., Hayek, J., et al.(2013). Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of rett syndrome patients . Mediators of Inflammation. 2013.

Ranaldi, G., Ferruzza, S., Canali, R., Leoni, G., Zalewski, P.D., Sambuy, Y., Perozzi, G., Murgia, C.(2013). Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα . Journal of Nutritional Biochemistry. 24. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 967-976.

Floris, M., Raimondo, D., Leoni, G., Orsini, M., Marcatili, P., Tramontano, A.(2011). MAISTAS: A tool for automatic structural evaluation of alternative splicing products . Bioinformatics. 27. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1625-1629.

Leoni, G., Le Pera, L., Ferrè, F., Raimondo, D., Tramontano, A.(2011). Coding potential of the products of alternative splicing in human . Genome Biology. 12. (1).

Comitato, R., Leoni, G., Canali, R., Ambra, R., Nesaretnam, K., Virgili, F.(2010). Tocotrienols activity in MCF-7 breast cancer cells: Involvement of ERβ signal transduction . Molecular Nutrition and Food Research. 54. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 669-678.

Comitato, R., Nesaretnam, K., Leoni, G., Ambra, R., Canali, R., Bolli, A., Marino, M., Virgili, F.(2009). A novel mechanism of natural vitamin E tocotrienol activity: Involvement of ERβ signal transduction . American Journal of Physiology - Endocrinology and Metabolism. 297. (2).