プロフィール詳細

プロジェクトを作成

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Dr. Hilary S.に依頼

United States

PhD Neuroscientist | Systems Translator Bridging Research, Data & AI

プロフィール概要

I am a PhD trained neuroscientist and systems translator who specializes in turning complex biological, data rich, and AI enabled problems into clear, actionable insight. My work sits at the interface of experimental science, large-scale analytics, and emerging computational methods. Across academic research, clinical and translational programs, and industry settings, I have repeatedly operated in the same role: bridging the gap between biological meaning, quantitative analysis, and the people responsible for making decisions. I focus on the translation layer where many projects stall. When sophisticated experiments and powerful models exist, but shared causal understanding, appropriate question framing, and decision-relevant interpretation are not yet aligned. Through my consultancy, Seifert C2O (“Chaos to Order”), I help research teams, data scientists, and leadership: • Bridge communication across disciplinary boundaries • Reframe complex biological and clinical questions so data and AI are applied in ways that actually answer the right questions • Align analytical approaches with underlying mechanisms and real-world decision constraints • Integrate machine learning and AI responsibly into research and strategy workflows, with attention to both capability and limitation The unifying theme of my work is transforming complexity into clarity, ensuring that biological mechanisms, statistical results, and model outputs are not only technically correct, but causally understood and usable by the people who must act on them. This same mission now extends into developing and sharing frameworks that help scientists, clinicians, and organizations reason clearly about emerging technologies such as AI.

専門分野

• ★ Clinical Immunology
• ★ Medical Affairs
• ★ Gap Analysis
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Neuroscience
• ☆ Neuropharmacology
• ☆ Neurobiology
• ☆ Basic Immunology
• ☆ Statistics
• ☆ Comparative Analysis
• ☆ Statistical Review
• ☆ Logic
• ☆ Leadership
• ☆ Communication Theory
• ☆ Drug Development
• ☆ Neurology
• ☆ Stroke & Cerebrovascular Disease
• ☆ Oncology
• ☆ Cardiovascular Disease
• ☆ Inflammation
• ☆ Cancer Research
• ☆ Technical & Scientific Writing
• ☆ Science Communication

サービス

• Research
• Consulting
• Data & AI

Research Meta-Research, Feasibility Study, Gap Analysis, Scientific and Technical Research, Systematic Literature Review

Consulting Business Strategy Consulting, Healthcare Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Insights

職務経験

Founder and Principal Scientific Systems Strategist

Seifert C2O, LLC

6月 2023 - 現在

Research Scientist, Clinical and Translational Research/Medical Affairs

Caris Life Sciences

4月 2022 - 2月 2023

Research Instructor

Oregon Health & Science University

10月 2020 - 1月 2022

Senior Research Associate

Oregon Health & Science University

8月 2019 - 10月 2020

Postdoctoral Fellow

Oregon Health & Science University

8月 2016 - 7月 2019

Postdoctoral Fellow

LSU Health Shreveport

1月 2014 - 7月 2016

Graduate Research Assisstant

University of South Florida

8月 2009 - 12月 2013

学歴

PhD

University of South Florida

8月 2009 - 8月 2013

M.S.

University of South Florida

8月 2008 - 5月 2009

B.S.

University of Florida

6月 2004 - 5月 2008

認定資格

• Certified ScrumMaster

  Scrum Alliance

  10月 2024 - 10月 2026

• Certified Scrum Product Owner

  Scrum Alliance

  8月 2024 - 10月 2026

出版物

JOURNAL ARTICLE

Hilary Seifert, Reilly Fankhauser, Matthew Chang, Zachary Garrison, Rachel Berryman, Olivia M. Lucero, Allison Fuiten, Nicholas DePatie, Rajan P. Kulkarni (2022). Single-Cell Identification of Melanoma Biomarkers in Circulating Tumor Cells . Cancers.

Vandenbark AA, Meza-Romero R, Wiedrick J, Gerstner G, Seifert H, Kent G, Piechycna M, Benedek G, Bucala R, Offner H (2022). "Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct . Cellular immunology.

Hilary Seifert, Arthur A Vandenbark, Roberto Meza-Romero, Jack Wiedrick, Grant Gerstner, Ashley Headrick, Gail Kent, Gil Benedek, Richard Bucala, Halina Offner (2021). Brief report: Enhanced DRα1-mMOG-35-55 treatment of severe EAE in MIF-1-deficient male mice . Cellular Immunology.

Wiedrick J, Meza-Romero R, Gerstner G, Seifert H, Chaudhary P, Headrick A, Kent G, Maestas A, Offner H, Vandenbark AA (2020). Sex differences in EAE reveal common and distinct cellular and molecular components . Cellular immunology.

(2019). Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE . Journal of neuroinflammation.

(2019). Sex differences in the therapeutic effects of anti-PDL2 neutralizing antibody on stroke . Metabolic brain disease.

(2018). Translational Evaluation of Acid/Base and Electrolyte Alterations in Rodent Model of Focal Ischemia . Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

(2018). The splenic response to stroke: from rodents to stroke subjects . Journal of neuroinflammation.

(2018). Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells . Metabolic brain disease.

(2018). Regulatory B cells in experimental stroke . Immunology.

(2017). Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen . Metabolic brain disease.

(2017). Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells . Journal of neuroimmunology.

(2017). Sex differences in regulatory cells in experimental stroke . Cellular immunology.

(2016). Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3 . Molecular neurobiology.

Davis SM, Collier LA, Leonardo CC, Seifert HA, Ajmo CT Jr, Pennypacker KR (2016). Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3 . Molecular neurobiology.

Decker D, Collier L, Lau T, Olivera R, Roma G, Leonardo C, Seifert H, Rowe D, Pennypacker KR (2016). The Effects of Clinically Relevant Hypertonic Saline and Conivaptan Administration on Ischemic Stroke . Acta neurochirurgica. Supplement.

(2015). Hypercoagulability and Platelet Abnormalities in Inflammatory Bowel Disease . Seminars in thrombosis and hemostasis.

(2015). Interleukin-6 mediates enhanced thrombus development in cerebral arterioles following a brief period of focal brain ischemia . Experimental neurology.

(2014). Pro-inflammatory interferon gamma signaling is directly associated with stroke induced neurodegeneration . Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.

(2014). Transient ischemia elicits a sustained enhancement of thrombus development in the cerebral microvasculature: effects of anti-thrombotic therapy . Experimental neurology.

(2014). Leukemia inhibitor factor promotes functional recovery and oligodendrocyte survival in rat models of focal ischemia . The European journal of neuroscience.

(2014). Molecular and cellular immune responses to ischemic brain injury . Translational stroke research.

(2012). A transient decrease in spleen size following stroke corresponds to splenocyte release into systemic circulation . Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.

(2012). The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling . Metabolic brain disease.

(2011). Clinical laboratory detection of AmpC β-lactamase: does it affect patient outcome? . American journal of clinical pathology.