プロフィール詳細

プロジェクトを作成

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Dr. Hadi H.に依頼

United Kingdom

Expert in Cell/Tissue Engineering, Cell Therapy, Stem Cell Technology, Advanced Biomaterials, and Regenerative Medicine

プロフィール概要

I am a senior scientist with extensive experience in cell engineering, tissue engineering, cell therapy, stem cell technology, advanced biomaterials, bionanotechnology, and regenerative medicine. My career spans over 15 years, during which I have developed and supervised numerous research projects, contributed to significant advancements in my field, and collaborated with leading universities and industrial partners globally. Experience and Skills Research and Project Management: Over a decade of experience managing and conducting high-impact research projects. Expertise in developing complex in vitro models for high throughput drug screening and designing strategies to modulate key signaling pathways in Cells. Proven track record in the functionalization of biomaterials, drug delivery systems, and 3D culture and differentiation of various stem cells. Proficient in stem cell culture and differentiation, cell isolation, proliferation, viability assays, and various characterization techniques (flow cytometry, immunostaining, PCR, genomics, metabolomics). Skilled in the fabrication and characterization of nanostructures, scaffolds, and other biomaterials using advanced techniques (electrospinning, 3D printing, plasma treatment). Experienced in rodent surgery, in vivo assays, and the development of spinal cord injury models. Previous and Ongoing Research Projects University of Birmingham (2021-Present): Leading research on cell engineering and nano/biomaterials for regenerative medicine applications. Developing complex in vitro models and aptamer-based strategies for drug screening and cell differentiation. Established productive collaborations with multiple universities and industrial partners. University of Nottingham (2017-2021): Focused on the functionalization of biomaterials, drug delivery systems, and the differentiation of iPSCs to functional cardiomyocytes. Contributed to significant advancements in tissue engineering and regenerative medicine. Italian Institute of Technology (2014-2017): Developed nanostructured scaffolds with anti-bacterial and anti-inflammatory properties. Published research findings in renowned peer-reviewed journals and established collaborations with industry. Brigham and Women's Hospital, Harvard Medical School (2016): Worked on hydrogel systems, spinal cord injury models, and stem cell differentiation. Collaborated with leading scientists in the US to develop new technologies in regenerative medicine. Educational Background Ph.D. in Bioengineering (Bionanotechnology), University of Genoa and Italian Institute of Technology (IIT), Italy (2014-2017) Thesis: “Design and Fabrication of Nanofibrous Scaffolds for Regenerative Medicine.” Visiting Ph.D. Training Program, Harvard Medical School, MA, USA (2016) Focus: “Studying the interactions between stem cells and scaffolds in controlled microenvironments.” M.Sc. in Biomedical Engineering (Biomaterials), Iran University of Science and Technology, Tehran, Iran (2007-2010) Thesis: “Synthesize Nanocomposite Scaffolds and Examine their Properties for Bone Tissue Engineering.” B.Sc. in Medical Engineering (Prosthetics), Isfahan University of Medical Sciences, Isfahan, Iran (2003-2007) Publications and Honors Authored numerous high-impact papers in top-tier journals with over 1000 citations, underscoring the significance of my work in advancing bionanotechnology and regenerative medicine. Invited speaker at several international conferences and recipient of multiple honors and awards, including a Ph.D. scholarship and membership in elite scientific organizations. My commitment to pushing the boundaries of science and technology in regenerative medicine has been demonstrated through my consistent contributions to research, education, and collaborative projects. I am eager to bring my expertise and innovative approach to new challenges and opportunities.

専門分野

• ☆ Materials Science & Engineering
• ☆ Nanotechnology
• ☆ Biomaterials
• ☆ Collagen
• ☆ Bioplastics
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Stem Cell Research
• ☆ Biotechnology & Bioengineering
• ☆ Nanobiotechnology
• ☆ Biomedical Engineering
• ☆ Biomechanics
• ☆ Bioprinting
• ☆ Biological Systems Engineering
• ☆ Cell Culture
• ☆ Industrial Biotechnology
• ☆ Tissue Engineering
• ☆ Artificial Organs
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Medical Devices
• ☆ Medical Device Development
• ☆ Biocompatibility Testing
• ☆ Medical Device Manufacturing
• ☆ Medical Device Safety Testing
• ☆ Medical Device Validation
• ☆ Medical Device Design
• ☆ Medical Implants
• ☆ In vitro Diagnostics
• ☆ Biomarker Analysis
• ☆ Drug Delivery Technologies
• ☆ Liposomes
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Technical Writing, General Proofreading & Editing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Healthcare Consulting, Operations Consulting, Scientific and Technical Consulting, Manufacturing Consulting

Data & AI Predictive Modeling, Statistical Analysis, Image Processing

Product Development Concept Development

職務経験

The University of Birmingham

- 現在

Research Fellow in Regenerative Medicine

University of Birmingham

6月 2021 - 現在

Post Doctoral Research Associate in Regenerative Medicine and Cellular Therapies Division

University of Nottingham

6月 2017 - 5月 2021

学歴

PhD in Bioengineering (Bionanotechnology)

University of Genoa

1月 2014 - 4月 2017

認定資格

• Concepts in Development, Self-Renewal, and Repair, CELLBIO 226

  Harvard medical school

  11月 2016 - 現在

出版物

JOURNAL ARTICLE

Hadi Hajiali, Jane McLaren, Cristina Gonzalez-García, Salah Abdelrazig, Dong-Hyun Kim, Matthew J. Dalby, Manuel Salmerón-Sánchez, Felicity R.A.J. Rose (2024). Sustained adenosine release: Revealing its impact on osteogenic signalling pathways of human mesenchymal stromal cells . Engineered Regeneration.

Hadi Hajiali, Michael Rotherham, Alicia J. El Haj (2023). Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis . Pharmaceutics.

Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis @article{32dcaf3860524e71b709e50ed80952fc, title = "Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis", abstract = "Bone regeneration and repair are complex processes in the adult skeleton, and current research has focused on understanding and controlling these processes. Magnetic nanoparticle (MNP)-based platforms have shown potential in tissue engineering and regenerative medicine through the use of magnetic nanomaterials combined with remotely applied dynamic fields. Previous studies have demonstrated the ability of MNP-induced mechanoactivation to trigger downstream signaling and promote new bone formation. In this study, we aimed to compare the osteogenic induction achieved using the mechanoreceptor targets, Piezo1, Fzd1, Fzd2, and integrin alpha-5. We compared the binding efficacy of different types of agonists (antibodies vs. aptamers) to these receptors. Moreover, we optimized the aptamer concentration (2.5, 5, and 10 μg/mg) for the selected receptor to determine the optimum concentration for promoting bone formation. Our data demonstrated that the mechanoactivation of integrins (CD49e) significantly upregulated the RUNX2 and LEF1 genes compared to other selected receptors. Furthermore, comparing the mechanoactivation of cells using MNPs conjugated with CD49e antibodies and aptamers revealed that MNP–aptamers significantly enhanced the upregulation of LEF1 genes. This suggests that aptamer-mediated mechanoactivation is a promising alternative to antibody-mediated activation. Finally, our results showed that the concentration of the aptamer loaded onto the MNPs strongly influenced the mechanoactivation of the cells. These findings provide valuable insights into the use of MNP platforms for bone regeneration and highlight the potential of aptamers in promoting signaling pathways related to bone formation. The novelty of our study lies in elucidating the unique advantages of aptamers in mediating mechanoactivation, presenting a promising avenue for advancing bone regenerative strategies.", keywords = "magnetic nanoparticles, integrin alpha-5, aptamer, mechanotransduction, osteogenesis, bone regeneration", author = "Hadi Hajiali and Michael Rotherham and Haj, {Alicia J. El}", note = "Funding: This research was funded by an ERC Advanced Grant DYNACEUTICS (grant No. 789119). ", year = "2023", month = dec, day = "22", doi = "10.3390/pharmaceutics16010021", language = "English", volume = "16", journal = "Pharmaceutics", issn = "1999-4923", publisher = "Multidisciplinary Digital Publishing Institute (MDPI)", number = "1", } . Pharmaceutics.

Hadi Hajiali, Michael Rotherham, Alicia El Haj (2023). Remote Activation of Mechanotransduction via Integrin Alpha-5 via Aptamer-Conjugated Magnetic Nanoparticles Promotes Osteogenesis . Pharmaceutics.

Hadi Hajiali, Liliang Ouyang, Virginia Llopis-Hernandez, Oana Dobre, Felicity R. A. J. Rose(2021). Review of emerging nanotechnology in bone regeneration: progress, challenges, and perspectives . Nanoscale. 13. (23). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 10266--10280. Royal Society of Chemistry ({RSC})

Hadi Hajiali, Jamie D. Patient, Kate Harris, Bertil Abrahamsson, Christer Tannergren, Lisa J. White, Amir M. Ghaemmaghami, Philip M. Williams, Clive J. Roberts, Felicity R. A. J. Rose(2019). Nanofibrous Scaffolds Support a 3D in vitro Permeability Model of the Human Intestinal Epithelium . Frontiers in Pharmacology. 10. Frontiers Media {SA}

Spinal cord astrocytomas: progresses in experimental and clinical investigations for developing recovery neurobiology-based novel therapies @article{Teng_2019, title={Spinal cord astrocytomas: progresses in experimental and clinical investigations for developing recovery neurobiology-based novel therapies}, volume={311}, ISSN={0014-4886}, url={http://dx.doi.org/10.1016/j.expneurol.2018.09.010}, DOI={10.1016/j.expneurol.2018.09.010}, journal={Experimental Neurology}, publisher={Elsevier BV}, author={Teng, Yang D. and Abd-El-Barr, Muhammad and Wang, Lei and Hajiali, Hadi and Wu, Liqun and Zafonte, Ross D.}, year={2019}, month=jan, pages={135–147} } . Experimental Neurology.

Hadi Hajiali, Jungmok Seo, Jung-Youn Shin, Jeroen Leijten, Oju Jeon, Ayça Bal Öztürk, Jeroen Rouwkema, Yuancheng Li, Su Ryon Shin, Eben Alsberg, et al.(2018). Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three Dimensions . ACS Applied Materials & Interfaces. 10. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 13293--13303. American Chemical Society ({ACS})

H. Hajiali, A. Contestabile, E. Mele, A. Athanassiou(2018). Influence of topography of nanofibrous scaffolds on functionality of engineered neural tissue . Journal of Materials Chemistry B. 6. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 930--939. Royal Society of Chemistry ({RSC})

H. Hajiali, A. Contestabile, E. Mele, A. Athanassiou(2018). Influence of topography of nanofibrous scaffolds on functionality of engineered neural tissue . Journal of Materials Chemistry B. 6. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 930--939. Royal Society of Chemistry ({RSC})

Hadi Hajiali, Susana Guzman-Puyol, José A. Heredia-Guerrero, Luca Ceseracciu, Claudio Canale, Alice Scarpellini, Roberto Cingolani, Ilker S. Bayer, Athanassia Athanassiou, Elisa Mele(2016). Low-Cost and Effective Fabrication of Biocompatible Nanofibers from Silk and Cellulose-Rich Materials . ACS Biomaterials Science & Engineering. 2. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 526--534. American Chemical Society ({ACS})

Hadi Hajiali, Maria Summa, Debora Russo, Andrea Armirotti, Virgilio Brunetti, Rosalia Bertorelli, Athanassia Athanassiou, Elisa Mele(2016). Alginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing . Journal of Materials Chemistry B. 4. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1686--1695. Royal Society of Chemistry ({RSC})

Hajiali Hadi, Contestabile Andrea, Athanassiou Athanassia, Mele Elisa(2016). Migration and differentiation of neural stem cells in novel random and aligned nanofibrous scaffolds . Frontiers in Bioengineering and Biotechnology. 4. Frontiers Media {SA}

Hadi Hajiali, George C. Anyfantis, Elisa Mele, Sergio Marras, Riccardo Carzino, Lara Marini, Evie L. Papadopoulou, Athanassia Athanassiou(2016). Investigation of the electro-spinnability of alginate solutions containing gold precursor HAuCl 4 . Journal of Colloid and Interface Science. 483. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 60--66. Elsevier {BV}

Hadi Hajiali, José A. Heredia-Guerrero, Ioannis Liakos, Athanassia Athanassiou, Elisa Mele(2015). Alginate Nanofibrous Mats with Adjustable Degradation Rate for Regenerative Medicine . Biomacromolecules. 16. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 936--943. American Chemical Society ({ACS})

I. Liakos, L. Rizzello, H. Hajiali, V. Brunetti, R. Carzino, P. P. Pompa, A. Athanassiou, E. Mele(2015). Fibrous wound dressings encapsulating essential oils as natural antimicrobial agents . Journal of Materials Chemistry B. 3. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1583--1589. Royal Society of Chemistry ({RSC})

Hadi Hajiali, Ilaria Romano, Elisa Mele, José A. Heredia-Guerrero, Luca Ceseracciu, Luca Goldoni, Lara Marini, Athanassia Athanassiou(2015). Photo-polymerisable electrospun fibres of N-methacrylate glycol chitosan for biomedical applications . RSC Advances. 5. (31). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 24723--24728. Royal Society of Chemistry ({RSC})

Hadi Hajiali, S. Karbasi, M. Hosseinalipour, H. R. Rezaie(2013). Effects of bioglass nanoparticles on bioactivity and mechanical property of poly(3-hydroxybutirate) scaffolds. Scientia Iranica. 20. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2306--2313.

Hadi Hajiali, Mohammad Hosseinalipour, Saeed Karbasi, Mohammad Ali Shokrgozar(2012). The Influence of Bioglass Nanoparticles on the Biodegradation and Biocompatibility of Poly (3-Hydroxybutyrate) Scaffolds . The International Journal of Artificial Organs. 35. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1015--1024. {SAGE} Publications

Hadi Hajiali, Mohammad Hosseinalipour, Saeed Karbasi, Mohammad Ali Shokrgozar(2012). The influence of bioglass nanoparticles on the biodegradation and biocompatibility of poly (3-hydroxybutyrate) scaffolds . The International Journal of Artificial Organs. 35. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1015--1024. {SAGE} Publications

Hadi Hajiali, Shahgasempour, Mohammad Reza Naimi-Jamal, Peirovi(2011). Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering . International Journal of Nanomedicine. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2133. Dove Medical Press Ltd.

Hadi Hajiali, Saeed Karbasi, Mohammad Hosseinalipour, Hamid Reza Rezaie(2010). Preparation of a novel biodegradable nanocomposite scaffold based on poly (3-hydroxybutyrate)/bioglass nanoparticles for bone tissue engineering . Journal of Materials Science: Materials in Medicine. 21. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2125--2132. Springer Nature

CONFERENCE ABSTRACT

Comparison of magnetic nanoparticle activation of mechanotransduction via antibody and aptamer @conference{8b34372ab13749d9ab7fd1cabb0a2562, title = "Comparison of magnetic nanoparticle activation of mechanotransduction via antibody and aptamer", author = "Hadi Hajiali and {El Haj}, Alicia", year = "2023", month = mar, day = "31", language = "English", note = "Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Meeting 2023 ; Conference date: 28-03-2023 Through 31-03-2023", }. Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Meeting 2023, Manchester, United Kingdom, 28/03/23.

Comparison of magnetic nanoparticle activation of mechanotransduction via antibody and aptamer @conference{cebf815fb0c44b97ad28a31ae0f3d1c7, title = "Comparison of magnetic nanoparticle activation of mechanotransduction via antibody and aptamer", author = "Hadi Hajiali and {El Haj}, Alicia", year = "2022", month = jun, day = "15", language = "English", note = "Joint TCES // CDT Conference 2022 ; Conference date: 13-06-2022 Through 15-06-2022", }. Joint TCES // CDT Conference 2022, Birmingham, United Kingdom, 13/06/22.

OTHER

Adenosine release from microparticles for bone regeneration @article{0676d518cf044887b67953c308015c90, title = "Adenosine release from microparticles for bone regeneration", author = "Hadi Hajiali and Manuel Salmeron-Sanchez and {J Dalby}, Matthew and Felicity Rose", year = "2022", month = apr, day = "4", doi = "10.1089/ten.tea.2022.29025.abstracts", language = "English", volume = "28", pages = "S389--S390", journal = "Tissue Engineering Part A", issn = "1937-3341", publisher = "Mary Ann Liebert", number = "S1", note = "6th world congress of the Tissue Engineering and Regenerative Medicine International Society, TERMIS2021 ; Conference date: 15-11-2021 Through 19-11-2021", } . Tissue Engineering Part A.

Hadi Hajiali(2022). Enabling Technologies and Biomaterials. (Chair in the section) TCES/CDT, June 13-15, 2022 Birmingham, UK.

H. Hajiali, M. Hosseinalipour, S. Karbasi, H. R. Rezaie(2010). Mechanical Property of Poly (3-hydroxybutyrate)/Bioglass Nanocomposite Scaffolds for Bone Tissue Engineering . 6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010 Singapore. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1238--1241. Springer Berlin Heidelberg

CONFERENCE PAPER

Hadi Hajiali, Felicity Rose(2020). Tuning adenosine release from biodegradable microparticles for bone regeneration. World Biomaterials Congress 2020, December 11-15, 2020 Virtual.

Hadi Hajiali, Felicity Rose(2019). Tuning adenosine release from biodegradable microspheres for bone regeneration. TCES-UKSB, June 11-13, 2019 Nottingham, UK.

Hadi Hajiali(2018). Encapsulation of adenosine into biodegradable microspheres for bone regeneration. TCES, July 2-4, 2018 Keele, UK.