プロフィール詳細

プロジェクトを作成

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Harshita T.に依頼

India

Competent Researcher with more than 7+ experience in Computer Aided Drug Discovery (CADD).

プロフィール概要

I am a passionate researcher (PhD) with experience in early phase in silico drug discovery. I have been parts of many institutional projects covering many disease areas such as cancer, sickle cell and infectious disease. My areas of expertise include structure and ligand based discovery techniques such as molecular docking, Pharmacophore mapping , molecular dynamics, QSAR, AI/ML based modelling of data etc. Present position: Computational Chemist Project: Target identification and in silico drug repurposing for neuroinflammation using network pharmacology. Funding source: Indian Council of Medical Research (DELHI) Education: PhD CSIR-Indian Institute of Integrative Medicine Jammu MS Pharmacoinformatics - National Institute of Pharmaceutical Education and Research Kolkata B.Pharm - Kumaun University: Nainital, Uttarakhand. Software used: Schrodinger , PyRx, OCHEM Languages: Python, Bash Data Science: numpy, scipy, pandas, Biopython, scikit-learn I am available to Assist with scientific project writing and editing and proofreading. Assist in Computer aided drug discovery. Literature search in biomedical, pharmaceutical and life sciences using various literature databases.

専門分野

• ★ Molecular Modeling
• ★ Chemoinformatics
• ★ Artificial Intelligence
• ★ Pharmacy
• ☆ Computational Chemistry
• ☆ Computational Biology
• ☆ Neuroscience
• ☆ Neuropharmacology
• ☆ Data Analysis
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Drug Design
• ☆ Combinatorial Chemistry
• ☆ Structure-Activity Relationship (SAR) Studies

サービス

• Writing
• Research
• Data & AI

Writing Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research

Data & AI Predictive Modeling, Statistical Analysis, Data Cleaning, Data Processing

職務経験

SENIOR RESEARCH FELLOW

Indian Institute of Integrative Medicine CSIR

8月 2019 - 現在

Senior Research Fellow

CSIR-IIIM

8月 2019 - 3月 2023

PROJECT ASSISTANT-II

Indian Institute of Integrative Medicine

9月 2015 - 8月 2019

学歴

MS Pharma

National Institute of Pharmaceutical Education and Research Kolkata:

8月 2013 - 6月 2015

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Diksha Raina and Farrah Gul Khan and Harshita Tiwari and Payare L. Sangwan and Amit Nargotra and Vinod Kumar and Inshad Ali Khan and Saurabh Saran(2022). Boswellic acids, as novel inhibitor targeting peptidoglycan biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) in Escherichia coli . Archives of Microbiology. 204. (8). Springer Science and Business Media {LLC}

Davinder Singh and Tenzen Yodun and Gulshan Kumar and Javeed Ahmad Tali and Harshita Tiwari and Jasvinder Singh and Amit Nargotra and Abhilash Samykutty and Shashank Singh and Ravi Shankar(2022). Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity . Bioorganic Chemistry. 125. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 105882. Elsevier {BV}

Ravi S. Manhas and Harshita Tiwari and Mateen Noor and Ajaz Ahmed and Jyoti Vishwakarma and Raja B. M. Tripathi and Ravishankar Ramachandran and Sreedhar Madishetti and Debaraj Mukherjee and Asha Chaubey and Amit Nargotra(2022). Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation . Molecular Diversity. Springer Science and Business Media {LLC}

Poonam Khandelwal and Harshita Tiwari and Venu Sharma and Deepak Mali and Pooja Vyas and Barkha Darra Wadhwani(2022). Study of potent CDK7 inhibitor secondary metabolites from Tecomella undulata . Natural Product Research. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--5. Informa {UK} Limited

Harshita Tiwari and Amit Kumar and Manas Ranjan Barik and Harjot Kaur and Shubham Mahajan and Monu Kumar Shukla and Monika Gupta and Govind Yadav and Amit Nargotra(2022). Repositioning the Existing Drugs for Neuroinflammation: A Fusion of Computational Approach and Biological Validation to Counter the Parkinson's Disease Progression . SSRN Electronic Journal. Elsevier {BV}

Harshita Tiwari and Diksha Raina and Monika Gupta and Manas Ranjan Barik and Inshad Ali Khan and Farrah Khan and Amit Nargotra(2021). Identification of novel MurA inhibitors using in silico approach, their validation and elucidation of mode of inhibition . Journal of Biomolecular Structure and Dynamics. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1--12. Informa {UK} Limited

Umar Gani and Priyanka Sharma and Harshita Tiwari and Abhishek Kumar Nautiyal and Maridul Kundan and Mir Abdul Wajid and Ravi Kesari and Amit Nargotra and Prashant Misra(2021). Comprehensive genome-wide identification, characterization, and expression profiling of MATE gene family in Nicotiana tabacum . Gene. 783. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 145554. Elsevier {BV}

Diksha Raina and Harshita Tiwari and Smriti Sharma and Deepika and Praveen Kumar Chinthakindi and Amit Nargotra and Payare L. Sangwan and Kandasamy Eniyan and Urmi Bajpai and Ram A. Vishwakarma and Farrah Gul Khan and Saurabh Saran and Inshad Ali Khan(2021). Screening of compound library identifies novel inhibitors against the MurA enzyme of Escherichia coli . Applied Microbiology and Biotechnology. 105. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3611--3623. Springer Science and Business Media {LLC}

(2020). Discovery of a new donepezil-like acetylcholinesterase inhibitor for targeting Alzheimer's disease: computational studies with biological validation. J Chem Inf Model.

Dar, M.I., Mahajan, P., Jan, S., Jain, S.K., Tiwari, H., Sandey, J., Bharate, S., Nargotra, A., Syed, S.H.(2019). Rottlerin is a pan phosphodiesterase inhibitor and can induce neurodifferentiation in IMR-32 human neuroblastoma cells . European Journal of Pharmacology. 857.

Khajuria, V., Gupta, S., Sharma, N., Tiwari, H., Bhardwaj, S., Dutt, P., Satti, N., Nargotra, A., Bhagat, A., Ahmed, Z.(2018). Kaempferol-3-o-β-D-glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model . International Immunopharmacology. 57. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 62-71.

Ahmad, B., Banerjee, A., Tiwari, H., Jana, S., Bose, S., Chakrabarti, S.(2018). Structural and functional characterization of the Vindoline biosynthesis pathway enzymes of Catharanthus roseus . Journal of Molecular Modeling. 24. (3).

CONFERENCE ABSTRACT

Tiwari, H., Barik, M. R., & Nargotra, A. (2020, February). Application of Computer-Aided Drug Design for Lead Identification and Drug Repurposing. In Proceedings of International Conference on Drug Discovery (ICDD) .

BOOK CHAPTER

(2019). In Silico Drug Design Methods for Drug Repurposing, In: Roy - In Silico Drug Design . Elsevier Products & Solutions Services.