プロフィール詳細

プロジェクトを作成

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Dr. Hiba G.に依頼

Israel

Peptide Drug Discovery Scientist | SPPS · Macrocyclic D-Peptides · Molecular Docking | PhD Chemical Biology

プロフィール概要

Hebrew University of Jerusalem, 2023) specializing in therapeutic peptide discovery, chemical protein synthesis, and computational drug design. I currently work as a Postdoctoral Researcher at the Institute of Chemistry, Hebrew University of Jerusalem. My core expertise includes solid-phase peptide synthesis (SPPS), HPLC, MALDI/ESI-MS characterization, macrocyclic peptide design, and molecular docking using HADDOCK, GNINA, and AutoDock Vina. My most recent work produced a first-author publication in Angewandte Chemie International Edition (2025) on MI-RaPID-derived macrocyclic D-amino acid peptide inhibitors of MMP-7, a validated cancer and inflammation target. This work resulted in a PCT patent (PCT/IL2025/xxxxxx) and identified a lead inhibitor with IC₅₀ of 90 nM. I have hands-on experience running the full pipeline from peptide design through synthesis, HPLC purification, mass spectrometry characterization, enzyme kinetics, and computational docking against protein crystal structures. I am available for consulting on peptide synthesis strategy, SPPS troubleshooting, HPLC/MS method development, molecular docking protocols, and grant writing in peptide therapeutics and drug discovery.

専門分野

• ☆ Analytical Chemistry
• ☆ Mass Spectrometry
• ☆ Peptide Synthesis
• ☆ Biochemistry
• ☆ Chemical Biology
• ☆ Drug Discovery
• ☆ Drug Development

サービス

• Writing
• Research
• Product Development

Writing Medical Writing, Non-Medical Regulatory Writing, Technical Writing

Research Scientific and Technical Research

Product Development Formulation, Quality Assurance & Control (QA/QC)

職務経験

PostdoctoralResearcher

Hebrew University of Jerusalem

1月 2024 - 現在

Post Doc

Hebrew University of Jerusalem

1月 2024 - 現在

学歴

MSc in pharmaceutical sciences (Pharmacy)

Al-Quds University

- 現在

BSc in pharmacy (Pharmacy)

Al-Quds University

- 現在

Ph.D

Hebrew University of Jerusalem

10月 2018 - 3月 2024

Ph.D., Chemistry

Hebrew University of Jerusalem

9月 2017 - 3月 2024

Masters (Science)

alquds university

9月 2011 - 6月 2014

Bachelor in Pharmacy

Al-Quds University - The Arab University in Jerusalem - Palestine, State of

9月 2004 - 6月 2009

認定資格

• Professional Development Certificate, Protein Research

  Proteintech Group

  3月 2026 - 現在

• HUJI ASPER Innovation

  Hebrew University of Jerusalem

  12月 2024 - 現在

出版物

JOURNAL ARTICLE

Hiba Ghareeb, Choi Yi Li, Anjana Shenoy, Naama Rotenberg, Julia M. Shifman, Takayuki Katoh, Irit Sagi, Hiroaki Suga, Norman Metanis (2025). Mirror‐Image Random Nonstandard Peptides Integrated Discovery (MI‐RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7 . Angewandte Chemie International Edition.

Hiba Ghareeb, Norman Metanis (2023). Enhancing the gastrointestinal stability of salmon calcitonin through peptide stapling . Chemical Communications.