プロフィール詳細

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Huaishan W.に依頼

United States

Advancing Cell Therapy for Cancer | T Cell Biology Expert | Immuno-Oncology & Tech Transfer

プロフィール概要

Young entrepreneur specializing in CAR-T cell therapy R&D and advancing pipeline innovations through seamless R&D to Process Development (PD) tech transfer. Ph.D. in Immunology with extensive experience in immunotoxicology, preclinical drug evaluation, and cellular therapy. Expertise in immunoassays, flow cytometry, and immunological safety assessments. Proficient in assay development, including T cell and CAR-T cell culturing, immunophenotyping, cytokine release assays, and in vivo/ex vivo evaluations of drug candidates. Skilled in mouse models, toxicity testing, and immunohistochemistry (IHC). Successfully designed and executed preclinical and mechanistic studies in immuno-oncology (I/O), immunotoxicity, and drug safety, ensuring alignment with regulatory and developmental milestones. Demonstrated strong cross-functional collaboration, data analysis, and communication skills to deliver high-quality scientific insights for decision-making.

専門分野

• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Drug Development
• ☆ Immunotherapy
• ☆ Pharmaceutical Technology

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing

Research Scientific and Technical Research

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Data Processing, Data Insights

Product Development Stability/Shelf Life Testing, Product Evaluation, Product Validation, Quality Assurance & Control (QA/QC), Concept Development, Prototyping

職務経験

Postdoc

University of Pennsylvania

- 現在

Postdoctoral Researcher

University of Pennsylvania

6月 2018 - 現在

Senior Research Scientist

Kite Pharma

6月 2022 - 7月 2025

Postdoctoral Researcher

University of Texas Southwestern Medical School

8月 2017 - 6月 2018

Research Assistant

Peking Union Medical College

8月 2014 - 8月 2017

学歴

Ph.D (Immunology)

Peking Union Medical College

9月 2011 - 7月 2014

Master of Science

Shandong University

9月 2008 - 7月 2011

bachelor

Shandong University

9月 2004 - 7月 2008

認定資格

• 認定資格の詳細は未入力です。

出版物

PREPRINT

Huaishan Wang, Shujing Liu, Prithvi Sinha, Fang Liu, Xiaogang Zhang, Yeye Guo, Beatriz Goncalves, Qiuxiang Zheng, Haiwei Mou, Jingbo Yang, et al. (2025). DR5 CAR-T cells target solid tumors and suppress MDSCs with minimal toxicity .

Huaishan Wang, Divanshu Shukla, Khatuna Gabunia, Shannon E. McGettigan, Prachi R. Patel, Shannon Christensen, Ting-Jia Fan, Decheng Song, Yanping Luo, Yanling Wang, et al. (2025). Data from CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target .

Huaishan Wang, Divanshu Shukla, Khatuna Gabunia, Shannon E. McGettigan, Prachi R. Patel, Shannon Christensen, Ting-Jia Fan, Decheng Song, Yanping Luo, Yanling Wang, et al. (2025). Supplementary Data from CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target .

Huaishan Wang, Divanshu Shukla, Khatuna Gabunia, Shannon E. McGettigan, Prachi R. Patel, Shannon Christensen, Ting-Jia Fan, Decheng Song, Yanping Luo, Yanling Wang, et al. (2025). Supplemental Figure 2 from CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target .

Huaishan Wang, Divanshu Shukla, Khatuna Gabunia, Shannon E. McGettigan, Prachi R. Patel, Shannon Christensen, Ting-Jia Fan, Decheng Song, Yanping Luo, Yanling Wang, et al. (2025). Supplemental Figure 3 from CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target .

Huaishan Wang, Divanshu Shukla, Khatuna Gabunia, Shannon E. McGettigan, Prachi R. Patel, Shannon Christensen, Ting-Jia Fan, Decheng Song, Yanping Luo, Yanling Wang, et al. (2025). Supplemental Figure 1 from CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target .

Huaishan Wang, Divanshu Shukla, Khatuna Gabunia, Shannon E. McGettigan, Prachi R. Patel, Shannon Christensen, Ting-Jia Fan, Decheng Song, Yanping Luo, Yanling Wang, et al. (2025). Supplemental Figure 4 from CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target .

Huaishan Wang, Divanshu Shukla, Khatuna Gabunia, Shannon E. McGettigan, Prachi R. Patel, Shannon Christensen, Ting-Jia Fan, Decheng Song, Yanping Luo, Yanling Wang, et al. (2025). Supplementary Data from CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target .

JOURNAL ARTICLE

Huaishan Wang, Divanshu Shukla, Khatuna Gabunia, Shannon E. McGettigan, Prachi R. Patel, Shannon Christensen, Ting-Jia Fan, Decheng Song, Yanping Luo, Yanling Wang, et al. (2025). CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target . Cancer Immunology Research.

Huaishan Wang, Yeye Guo, Shujing Liu, Xiaogang Zhang, Xingyue Zhu, Lili Huang, Wenqun Zhong, Lei Guan, Yeqing Chen, Min Xiao, et al. (2025). Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells . Science Advances.

Huaishan Wang, Chao Li, Han Zhang, Kexin Tong, Menghua Cai, Fei Gao, Jia Yang, Yi Xu, Hui Chen, Yu Hu, et al. (2023). Genetic Deletion of Thorase Causes Purkinje Cell Loss and Impaired Motor Coordination Behavior . Cells.

Huaishan Wang, Chao Li, Han Zhang, Kexin Tong, Menghua Cai, Fei Gao, Jia Yang, Yi Xu, Hui Chen, Yu Hu, et al. (2023). Genetic Deletion of Thorase Causes Purkinje Cell Loss and Impaired Motor Coordination Behavior . Cells.

ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson’s Disease-like Behavior <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Cells.

Huaishan Wang, Fei Gao, Han Zhang, Jia Yang, Menghua Cai, Qi Yang, Yi Xu, Hui Chen, Yu Hu, Wei He, et al. (2022). ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson’s Disease-like Behavior . Cells.

Wang, Huaishan, Ou, Lingling, Huang, Hui, Zhou, Zhiyan, Lin, Qiang, Guo, Yeye, Mitchell, Tara, Huang, Alexander C., Karakousis, Giorgos, Schuchter, Lynn, et al. (2022). Preclinical platforms to study therapeutic efficacy of human γδ T cells . Clinical and Translational Medicine.

Wang, Huaishan, Gao, Fei, Zhang, Han, Yang, Jia, Cai, Menghua, Yang, Qi, Xu, Yi, Chen, Hui, Hu, Yu, He, Wei, et al. (2022). ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson's Disease-like Behavior . Cells.

Huaishan Wang, Hui Chen, Shujing Liu, Jie Zhang, Hezhe Lu, Rajasekharan Somasundaram, Robin Choi, Gao Zhang, Lingling Ou, John Scholler, et al. (2021). Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function . Journal for ImmunoTherapy of Cancer.

Zhang H, Wang H, Gao F, Yang J, Xu Y, Fu Y, Cai M, Zhang X, Yang Q, Tong K, et al.(2021). TSPO deficiency accelerates amyloid pathology and neuroinflammation by impairing microglial phagocytosis . Neurobiology of aging.

Huaishan Wang, Lingling Ou, Qin Liu, Jie Zhang, Hezhe Lu, Liangping Luo, Changzheng Shi, Shaoqiang Lin, Liyun Dong, Yeye Guo, et al. (2021). Dichotomous and stable gamma delta T-cell number and function in healthy individuals . Journal for ImmunoTherapy of Cancer.

Wang, Huaishan, Guo, Yeye, Huang, Lili, Ou, Lingling, Zhu, Jinjin, Liu, Shujing, Xu, Xiaowei (2021). Small extracellular vesicles-based cell-free strategies for therapy . MedComm.

Wang, Huaishan, Ou, Lingling, Liu, Qin, Zhang, Jie, Lu, Hezhe, Luo, Liangping, Shi, Changzheng, Lin, Shaoqiang, Dong, Liyun, Guo, Yeye, et al. (2021). Dichotomous and stable gamma delta T-cell number and function in healthy individuals . Journal for ImmunoTherapy of Cancer.

Zhang, J., Wang, H., Gao, F., Yang, J., Fu, Y., He, W. (2021). TSPO knockout promotes amyloid pathology and neuroinflammation by affecting microglia phagocytosis . European Journal of Immunology.

Wang, Huaishan, Chen, Hui, Liu, Shujing, Zhang, Jie, Lu, Hezhe, Somasundaram, Rajasekharan, Choi, Robin, Zhang, Gao, Ou, Lingling, Scholler, John, et al. (2021). Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function . Journal for ImmunoTherapy of Cancer.

Wang, Huaishan, Fu, Yi, Wang, Dongdong, Cai, Menghua, Li, Chao, Zhang, Xue, Chen, Hui, Hu, Yu, Zhang, Xuan, Ying, Mingyao, et al. (2020). TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma . Neuro-Oncology.

Shang, Chao, Yao, Ru-Meng, Guo, Ying, Ding, Zhen-Chun, Sun, Li-Jun, Ran, Yu-Hua, Xue, Rui, Wang, Huai-Shan, Zhang, Jian-Min, Zhang, You-Zhi, et al. (2020). Translocator protein-mediated fast-onset antidepressant-like and memory-enhancing effects in chronically stressed mice . Journal of Psychopharmacology.

Huaishan Wang, Jianmin Zhang, Jia Yang, Omar Sherbini, Matthew J Keuss, George KE Umanah, Emily Ling-Lin Pai, Zhikai Chi, Kaisa MA Paldanius, Wei He, et al. (2019). The AAA + ATPase Thorase is neuroprotective against ischemic injury . Journal of Cerebral Blood Flow & Metabolism.

Qin, Hui-Di, Shi, Yan-Qiu, Liu, Zhao-Hua, Li, Zhong-Gang, Wang, Huai-Shan, Wang, Hong, Liu, Zhao-Ping (2019). Effect of chlorogenic acid on mast cell-dependent anaphylactic reaction (vol 10, pg 1135, 2010) . International Immunopharmacology.

Wang, Huaishan, Zhu, Yuli, Zhang, Siya, Li, Zinan, Li, Zhen, Hu, Yu, Chen, Hui, Zhang, Xuan, Cui, Lianxian, Zhang, Jianmin, et al. (2019). miR-125b-5p and miR-99a-5p downregulate human γδ T-cell activation and cytotoxicity . Cellular and Molecular Immunology.

Huaishan Wang, Yuli Zhu, Siya Zhang, Zinan Li, Zhen Li, Yu Hu, Hui Chen, Xuan Zhang, Lianxian Cui, Jianmin Zhang, et al.(2018). miR-125b-5p and miR-99a-5p downregulate human γδ T-cell activation and cytotoxicity . Cellular and Molecular Immunology. Springer Nature

Wang, Huaishan, Li, Zinan, Zhang, Siya, Wan, Ying, Cai, Menghua, Wang, Weiqing, Zhu, Yuli, Li, Zhen, Hu, Yu, Chen, Hui, et al. (2018). Microrna-146a Overexpression impairs the Positive selection during T cell Development . Frontiers in Immunology.

Wang, Huaishan, Dong, Peng, Ju, Xiangwu, Yan, Yiwu, Zhang, Siya, Cai, Menghua, Chen, Hui, Hu, Yu, Cui, Lianxian, Zhang, Jianmin, et al. (2018). γδ T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection . Frontiers in Immunology.

Wang, Huaishan, Gao, Fei, Yang, Jia, Wang, Dongdong, Li, Chao, Fu, Yi, He, Wei, Zhang, Jianmin (2017). Mitophagy in Parkinson's Disease: Pathogenic and Therapeutic Implications . Frontiers in Neurology.

Wang, Huaishan, Zhai, Kangle, Xue, Yingchao, Yang, Jia, Yang, Qi, Fu, Yi, Hu, Yu, Liu, Fang, Wang, Weiqing, Cui, Lianxian, et al. (2016). Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile . Plos One.

Wang, Huaishan, Zhang, Jianmin, Sherbini, Omar, Pai, Emily Ling-lin, Kang, Sung-Ung, Kwon, Ji-Sun, Yang, Jia, He, Wei, Wang, Hong, Eacker, Stephen M., et al. (2016). High-Content Genome-Wide RNAi Screen Reveals <i>CCR3</i> as a Key Mediator of Neuronal Cell Death . eNeuro.

Wang, Huaishan, Wang, Weiqing, Gao, Zhiqiang, Li, Taisheng, He, Wei, Lv, Wei, Zhang, Jianmin (2016). Transcriptome Analysis Reveals Distinct Gene Expression Profiles in Eosinophilic and Noneosinophilic Chronic Rhinosinusitis with Nasal Polyps . Scientific Reports.

Wang, Huaishan, Zhu, Yuli, Xu, Yi, Hu, Yu, Chen, Hui, Cui, Lianxian, Zhang, Jianmin, He, Wei (2016). Human γδ T Cells Augment Antigen Presentation in <i>Listeria Monocytogenes</i> Infection . Molecular Medicine.

Wang, Huaishan, Wang, Hong, Liu, Zhaoping (2011). Agents that induce pseudo-allergic reaction . Drug Discoveries & Therapeutics.

Wang, Huaishan, Li, Zhonggang, Gao, Yan, Liu, Zhaoping (2010). A rat model of Shuang Huang Lian injection-induced anaphylaxis . Asian Pacific Journal of Allergy and Immunology.

Qin, Hui-Di, Shi, Yan-Qiu, Liu, Zhao-Hua, Li, Zhong-Gang, Wang, Huai-Shang, Wang, Hong, Liu, Zhao-Ping (2010). Effect of Chlorogenic acid on mast cell-dependent anaphylactic reaction . International Immunopharmacology.

Wang, Huaishan, Cheng, Fang, Shi, Yanqiu, Li, Zhonggang, Qin, Huidi, Liu, Zhaoping (2010). Hypotensive response in rats and toxicological mechanisms induced by shuanghuanglian, an herbal extract mixture . Drug Discoveries & Therapeutics.

The AAA+ ATPase Thorase is Neuroprotective Against Ischemic Injury. Journal of Cerebral Blood Flow and Metabolism.