プロフィール詳細

プロジェクトを作成

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Dr. Isaline R.に依頼

Italy

Translational Oncology Scientist | Renal Cancer, VHL Disease & Metabolic Reprogramming

プロフィール概要

Translational oncology scientist with over 20 years of experience in renal cancer, cystic kidney diseases, and von Hippel–Lindau (VHL) disease. I specialize in tumor heterogeneity, microenvironmental biology, and metabolic reprogramming as drivers of disease progression and therapeutic resistance. I support research teams and biotech projects by translating complex biological data into actionable experimental strategies, including study design, mechanistic interpretation, and hypothesis development for preclinical oncology research. My expertise includes integrating molecular biology, organ culture systems, and clinical oncology data to guide translational research decisions and prioritize experimentally testable hypotheses. I have contributed to high-impact publications, including Nature Medicine, and have experience in competitive research programs (PNRR, AIRC) and patentable metabolic targeting strategies.

専門分野

• ☆ Biochemistry
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Omics
• ☆ Transcriptomics
• ☆ Metabolomics
• ☆ Gene Expression Analysis
• ☆ Cell Biology
• ☆ Cell-Based Assays

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing General Proofreading & Editing, Translation

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Data Visualization, Data Mining

職務経験

Staff Scientist

Ospedale San Raffaele

6月 2019 - 現在

Ospedale San Raffaele

3月 2019 - 現在

Senior Post-Doc

Ospedale San Raffaele

1月 2013 - 2月 2019

Post-Doctoral Fellow

Ospedale San Raffaele

7月 2009 - 12月 2012

Post-Doctoral Fellow

Ospedale San Raffaele

7月 2004 - 6月 2008

学歴

PhD

UPMC

9月 2000 - 6月 2004

Ph.D in Life Sciences

Université Pierre et Marie Curie

9月 2000 - 6月 2004

2nd year M. Sc in Molecular and Cellular Genetics

Université Pierre et Marie Curie

9月 1999 - 6月 2000

1rst year Msc in Biochemistry

Université Pierre et Marie Curie

9月 1998 - 6月 1999

Bsc in Biology

Université Pierre et Marie Curie

9月 1994 - 6月 1998

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Musso G, Fallara G, Rosiello G, Martini A, Re C, Cei F, Basile G, Cignoli D, Colandrea G, Rowe I, et al.(2023). Differential Prognostic Value of Extrarenal Involvement in Patients With Non-Metastatic Renal Cell Cancer . Clinical genitourinary cancer.

Capitanio U, Freschi M, Rosiello G, Fallara G, Musso G, Cei F, Basile G, Rowe I, Canibus D, Lucianò R, et al.(2022). Case of the Month from San Raffaele Hospital, Milan, Italy: paraneoplastic presentation of small renal masses . BJU international.

Salonia A, Pontillo M, Capogrosso P, Pozzi E, Ferrara AM, Cotelessa A, Belladelli F, Corsini C, Gregori S, Rowe I, et al.(2022). Testosterone in males with COVID-19: a 12-month cohort study . Andrology.

Larcher A, Belladelli F, Fallara G, Rowe I, Capitanio U, Marandino L, Raggi D, Capitanio JF, Bailo M, Lattanzio R, et al.(2022). Multidisciplinary management of patients diagnosed with von Hippel-Lindau disease: A practical review of the literature for clinicians . Asian journal of urology.

Cignoli D, Fallara G, Aleotti F, Larcher A, Rosiello G, Rowe I, Basile G, Colandrea G, Martini A, De Cobelli F, et al.(2022). Pancreatic metastases after surgery for renal cell carcinoma: survival and pathways of progression . World journal of urology.

Capitanio U, Fallara G, Raggi D, Nocera L, Larcher A, Belladelli F, Rowe I, Briganti A, Salonia A, Karakiewicz P, et al.(2022). Pembrolizumab in advanced renal cell carcinoma: a meta-analysis providing level 1a evidence . Current problems in cancer.

Larcher A, Rowe I, Belladelli F, Fallara G, Raggi D, Necchi A, Montorsi F, Capitanio U, Salonia A, OSR VHL Program(2022). Von Hippel-Lindau disease-associated renal cell carcinoma: a call to action . Current opinion in urology.

Salonia A, Pontillo M, Capogrosso P, Gregori S, Carenzi C, Ferrara AM, Rowe I, Boeri L, Larcher A, Ramirez GA, et al.(2021). Testosterone in males with COVID-19: A 7-month cohort study . Andrology.

Salonia A, Pontillo M, Capogrosso P, Gregori S, Tassara M, Boeri L, Carenzi C, Abbate C, Cignoli D, Ferrara AM, et al.(2021). Severely low testosterone in males with COVID-19: A case-control study . Andrology.

Capitanio U, Rosiello G, Erdem S, Rowe I, Kara O, Roussel E, Campi R, Klatte T, Kriegmair MC, Sibona M, et al.(2021). Clinical, surgical, pathological and follow-up features of kidney cancer patients with Von Hippel-Lindau syndrome: novel insights from a large consortium . World journal of urology.

(2018). Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways . Communications biology.

(2015). 2-Deoxy-d-Glucose Ameliorates PKD Progression . Journal of the American Society of Nephrology : JASN.

(2014). Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures . Biochemical and biophysical research communications.

(2014). Defective metabolism in polycystic kidney disease: potential for therapy and open questions . Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

(2013). Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy . Nature medicine.

(2013). Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis . Nature communications.

(2010). Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals . PloS one.

(2009). A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus . PloS one.

(2009). Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1 . Molecular and cellular biology.

(2007). Caspase-9 regulates apoptosis/proliferation balance during metamorphic brain remodeling in Xenopus . Proceedings of the National Academy of Sciences of the United States of America.

(2005). Apoptosis of tail muscle during amphibian metamorphosis involves a caspase 9-dependent mechanism . Developmental dynamics : an official publication of the American Association of Anatomists.

(2002). Autonomous regulation of muscle fibre fate during metamorphosis in Xenopus tropicalis . Developmental dynamics : an official publication of the American Association of Anatomists.