プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Ismael S.に依頼

Canada

Tumor immunologist with deep expertise in metabolic biochemistry, immunoassays, animal models, and flow cytometry.

プロフィール概要

I obtained my Ph.D. in genetics from Texas A&M University (2002) and received postdoctoral training in pharmacology and toxicology at the Institute of Biotechnology in Houston. I then worked as a scientist and research instructor in the Section of Molecular Hematology at MD Anderson Cancer Center where I led and supported various preclinical and clinical studies on the antileukemic and antitumor effects of various targeted agents, including the various precursors of the recently approved BH3 inhibitor Venetoclax, the MDM-2 inhibitor Nutlin3, peptide and small molecule inhibitors of CXCR4, MEK/ERK inhibitors, and the synthetic triterpenoid CDDO-Me (bardoxolone methyl). I also demonstrated that the Warburg effect in leukemias is supported by increased mitochondrial function (rather than the opposite postulated by Warburg himself) and that inhibition of fatty acid oxidation could sensitize leukemia cells to cell death. In addition, in collaboration with Dr. Frank Marini, we demonstrated the therapeutic efficacy of gene-modified mesenchymal stromal cells in animal models of pancreatic and ovarian cancer. From 2013 until 2015, while receiving additional postdoctoral training in immunotherapy at the BC Cancer Agency, I reported in the prestigious journal Blood that HSV-1 is a potent activator of immune cell function and can be an adjuvant in the setting of bone marrow transplantation for the treatment of leukemia. These findings also support the notion that HSV-1 could be broadly used to potentiate solid tumor immunotherapy. In 2015, I was recruited to the Centre for Drug Research and Development (CDRD) to lead a nascent immunotherapy initiative and eventually became Director of Biologics for CDRD. Our team at CDRD developed several novel anti-tumor biotherapeutics of various formats, including CAR-T, antibody drug-conjugates (ADC), and functional antibodies. In 2019, I assumed the role of Senior Director of R&D for Virogin where I am responsible for overseeing the development of an oncolytic virus pipeline and supporting the clinical translation of the lead program VG-161. I have expertise in tumor immunology, metabolic biochemistry, apoptosis, and signal transduction. I am have designed, conducted, supervised and reported in vitro and in vivo pharmacology and immunotherapy experiments, and have deep expertise in flow cytometry, immunological, and biochemical assays.

専門分野

• ★ Immunotherapy
• ★ Metabolism & Metabolic Disease
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Apoptosis
• ☆ Cell Biology
• ☆ Biologic & Biosimilar Development

サービス

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing, Newswriting

Research Feasibility Study, Fact Checking, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Product Development Formulation

職務経験

Sr. Director R&D

Virogin Biotech Ltd.

2月 2019 - 現在

Director

Centre for Drug Research and Development

10月 2018 - 2月 2019

Head

Centre for Drug Research and Development

3月 2016 - 10月 2018

Immunotherapy Scientist

Centre for Drug Research and Development

3月 2015 - 3月 2016

学歴

Ph.D. (Genetics)

Texas A&M University

9月 1997 - 8月 2002

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Li, Y., Shen, Y., Zhao, R., Samudio, I., Jia, W., Bai, X., Liang, T.(2020). Oncolytic virotherapy in hepato-bilio-pancreatic cancer: The key to breaking the log jam? . Cancer Medicine. 9. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2943-2959.

Samudio, I., Hofs, E., Cho, B., Li, M., Bolduc, K., Bu, L., Liu, G., Lam, V., Rennie, P., Jia, W., et al.(2019). UV Light-inactivated HSV-1 Stimulates Natural Killer Cell-induced Killing of Prostate Cancer Cells . Journal of Immunotherapy. 42. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 162-174.

Holtzman, S.H., Cohen, R., Levin, J.M., Maraganore, J., Albers, J., Aoun, J.E., Audia, J.E., Bailey, M.P., Barrett, P., Bartel, D., et al.(2019). Chinese scientists and US leadership in the life sciences . Nature Biotechnology. 37. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1261-1263.

Kuhlmann, L., Cummins, E., Samudio, I., Kislinger, T.(2018). Cell-surface proteomics for the identification of novel therapeutic targets in cancer . Expert Review of Proteomics. 15. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 259-275.

Tcheng, M., Samudio, I., Lee, E.A., Minden, M.D., Spagnuolo, P.A.(2017). The mitochondria target drug avocatin B synergizes with induction chemotherapeutics to induce leukemia cell death . Leukemia and Lymphoma. 58. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 986-988.

González, M., Samudio, I., Sequeda-Castañeda, L.G., Celis, C., Iglesias, J., Morales, L.(2017). Cytotoxic and antioxidant capacity of extracts from Vaccinium meridionale Swartz (Ericaceae) in transformed leukemic cell lines . Journal of Applied Pharmaceutical Science. 7. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 24-30.

Zeng, Z., Liu, W., Tsao, T., Qiu, Y.H., Zhao, Y., Samudio, I., Sarbassov, D.D., Kornblau, S.M., Baggerly, K.A., Kantarjian, H.M., et al.(2017). High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia . Haematologica. 102. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1537-1548.

Ismael Samudio, Katayoun Rezvani, Hila Shaim, Elyse Hofs, Mor Ngom, Luke Bu, Guoyu Liu, Jason T. C. Lee, Suzan Imren, Vivian Lam, et al.(2016). {UV}-inactivated {HSV}-1 potently activates {NK} cell killing of leukemic cells . Blood. 127. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2575--2586. American Society of Hematology

Velez, J., Pan, R., Lee, J.T.C., Enciso, L., Suarez, M., Duque, J.E., Jaramillo, D., Lopez, C., Morales, L., Bornmann, W., et al.(2016). Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport . Oncotarget. 7. (32). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 51435-51449.

Samudio, I., Rezvani, K., Shaim, H., Hofs, E., Ngom, M., Bu, L., Liu, G., Lee, J.T.C., Imren, S., Lam, V., et al.(2016). UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells . Blood. 127. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2575-2586.

Elisia, I., Nakamura, H., Lam, V., Hofs, E., Cederberg, R., Cait, J., Hughes, M.R., Lee, L., Jia, W., Adomat, H.H., et al.(2016). DMSO represses inflammatory cytokine production from human blood cells and reduces autoimmune arthritis . PLoS ONE. 11. (3).

Ho, V.W., Hofs, E., Elisia, I., Lam, V., Hsu, B.E., Lai, J., Luk, B., Samudio, I., Krystal, G.(2016). All Trans Retinoic Acid, Transforming Growth Factor β and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages . PLoS ONE. 11. (12).

Matre, P., Velez, J., Jacamo, R., Qi, Y., Su, X., Cai, T., Chan, S.M., Lodi, A., Sweeney, S.R., Ma, H., et al.(2016). Inhibiting glutaminase in acute myeloid leukemia: Metabolic dependency of selected AML subtypes . Oncotarget. 7. (48). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 79722-79735.

Ismael Samudio, Marina Konopleva(2015). Targeting leukemia's {\textquotedblleft}fatty tooth{\textquotedblright} . Blood. 126. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1874--1875. American Society of Hematology

Phan, L., Chou, P.-C., Velazquez-Torres, G., Samudio, I., Parreno, K., Huang, Y., Tseng, C., Vu, T., Gully, C., Su, C.-H., et al.(2015). The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming . Nature Communications. 6.

Ríos, D.L., López, C., Álvarez, M.E., Samudio, I.J., Carmona, J.U.(2015). Effects over time of two platelet gel supernatants on growth factor, cytokine and hyaluronan concentrations in normal synovial membrane explants challenged with lipopolysaccharide Pathophysiology of musculoskeletal disorders . BMC Musculoskeletal Disorders. 16. (1).

Samudio, I., Konopleva, M.(2015). Targeting leukemia's fatty tooth . Blood. 126. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1874-1875.

Ho, V.W., J.Hamilton, M., Dang, N.-H.T., E.Hsu, B., H.Adomat, H., S.Guns, E., Weljie, A., Samudio, I., L.Bennewith, K., Krystal, G.(2014). A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis . Carcinogenesis. 35. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2291-2299.

Velez, J., Enciso, L.J., Suarez, M., Fiegl, M., Grismaldo, A., López, C., Barreto, A., Cardozo, C., Palacios, P., Morales, L., et al.(2014). Platelets promote mitochondrial uncoupling and resistance to apoptosis in leukemia cells: A novel paradigm for the bone marrow microenvironment . Cancer Microenvironment. 7. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 79-90.

Torrente, D., Avila, M.F., Cabezas, R., Morales, L., Gonzalez, J., Samudio, I., Barreto, G.E.(2014). Paracrine factors of human mesenchymal stem cells increase wound closure and reduce reactive oxygen species production in a traumatic brain injury in vitro model . Human and Experimental Toxicology. 33. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 673-684.

Asem Mansour, Yousef Ismael, Hikmat Abdel-Razeq(2013). Limited Benefit Gained From Inferior Vena Cava Filter Insertion In Patients With Advanced-Stage Cancer . Blood. 122. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1147--1147. American Society of Hematology

Ismael Samudio, Marina Konopleva(2013). Asparaginase unveils glutamine-addicted {AML} . Blood. 122. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3398--3400. American Society of Hematology

Ismael Samudio, Polina Matre, Rodrigo Jacamo, Ying Wang, Jing Wang, R Eric Davis, Xiaohua Su, Sonja Schindela, Rachel Newman, Jianhua Hu, et al.(2013). Unraveling The Molecular and Metabolic Basis For Glutamine Addiction In Leukemias . Blood. 122. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 606--606. American Society of Hematology

Samudio, I., Konopleva, M.(2013). Asparaginase unveils glutamine-addicted AML . Blood. 122. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3398-3400.

Nair, V., Pathi, S., Jutooru, I., Sreevalsan, S., Basha, R., Abdelrahim, M., Samudio, I., Safe, S.(2013). Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors . Carcinogenesis. 34. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2870-2879.

Giraldo, C.E., López, C., Álvarez, M.E., Samudio, I.J., Prades, M., Carmona, J.U.(2013). Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel . BMC Veterinary Research. 9.

Dembinski, J.L., Wilson, S.M., Spaeth, E.L., Studeny, M., Zompetta, C., Samudio, I., Roby, K., Andreeff, M., Marini, F.C.(2013). Tumor stroma engraftment of gene-modified mesenchymal stem cells as anti-tumor therapy against ovarian cancer . Cytotherapy. 15. (1).

Vélez, J., Hail, N., Konopleva, M., Zeng, Z., Kojima, K., Samudio, I., Andreeff, M.(2013). Mitochondrial uncoupling and the reprograming of intermediary metabolism in leukemia cells . Frontiers in Oncology. 3 APR.

Zhou, L., Ruvolo, V.R., McQueen, T., Chen, W., Samudio, I.J., Conneely, O., Konopleva, M., Andreeff, M.(2013). HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML . Leukemia. 27. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1358-1368.

Carmona, J.U., López, C., Samudio, I.J.(2013). Autologous Platelet Concentrates as an Adjunctive Treatment for Chronic Laminitis in a Mare with Pituitary Pars Intermedia Dysfunction . Journal of Equine Veterinary Science. 33. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 191-195.

Frolova, O., Samudio, I., Benito, J., Jacamo, R., Kornblau, S.M., Markovic, A., Schober, W., Lu, H., Qiu, Y.H., Buglio, D., et al.(2012). Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment . Cancer Biology and Therapy. 13. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 858-870.

Albarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J., Gonzalo, L., Capani, F., Morales, L., Barreto, G.E.(2012). Effects of natural antioxidants in neurodegenerative disease . Nutritional Neuroscience. 15. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-9.

Duque, J.E., Velez, J., Samudio, I., Lai, E.(2012). Metformin as a Novel Component of Metronomic Chemotherapeutic Use: A Hypothesis . Journal of Experimental and Clinical Medicine. 4. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 140-144.

Sutachan, J.J., Casas, Z., Albarracin, S.L., Stab II, B.R., Samudio, I., Gonzalez, J., Morales, L., Barreto, G.E.(2012). Cellular and molecular mechanisms of antioxidants in Parkinson's disease . Nutritional Neuroscience. 15. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 120-126.

Álvarez, M.E., López, C., Giraldo, C.E., Samudio, I., Carmona, J.U.(2011). In vitro bactericidal activity of equine platelet concentrates, platelet poor plasma, and plasma against methicillin-resistant Staphylococcus aureus . Archivos de Medicina Veterinaria. 43. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 155-161.

Jutooru, I., Chadalapaka, G., Abdelrahim, M., Basha, M.R., Samudio, I., Konopleva, M., Andreeff, M., Safe, S.(2011). Methyl 2-cyano-3,12-dioxooleana-1, 9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: Role of microRNA-27a (Molecular Pharmacology (2010) 78, (226-236)) . Molecular Pharmacology. 79. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 336.

Kidd, S., Caldwell, L., Dietrich, M., Samudio, I., Spaeth, E.L., Watson, K., Shi, Y., Abbruzzese, J., Konopleva, M., Andreeff, M., et al.(2010). Mesenchymal stromal cells alone or expressing interferon-β suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment . Cytotherapy. 12. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 615-625.

Duque, J.E., López, C., Cruz, N., Samudio, I.(2010). Antitumor mechanisms of metformin: Signaling, metabolism, immunity and beyond,Mecanismos antitumorales de la metformina: Señalización, metabolismo, inmunidad y más allá . Universitas Scientiarum. 15. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 122-129.

Jutooru, I., Chadalapaka, G., Abdelrahim, M., Basha, M.R., Samudio, I., Konopleva, M., Andreeff, M., Safe, S.(2010). Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: Role of microRNA-27a . Molecular Pharmacology. 78. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 226-236.

Samudio, I., Harmancey, R., Fiegl, M., Kantarjian, H., Konopleva, M., Korchin, B., Kaluarachchi, K., Bornmann, W., Duvvuri, S., Taegtmeyer, H., et al.(2010). Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction . Journal of Clinical Investigation. 120. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 142-156.

Samudio, I.J., Duvvuri, S., Clise-Dwyer, K., Watt, J.C., Mak, D., Kantarjian, H., Yang, D., Ruvolo, V., Borthakur, G.(2010). Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells . Leukemia and Lymphoma. 51. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 911-919.

López, C., Carmona, J.U., Samudio, I.(2010). Use of autologous platelet concentrates as treatment for a scapular fracture and brachial plexus nerve injury produced by a gunshot in a horse,Uso de concentrados autólogos de plaquetas como tratamiento de una fractura escapular y una lesión del plexo braquial producidas por un disparo en un caballo . Archivos de Medicina Veterinaria. 42. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 209-214.

Fiegl, M., Samudio, I., Mnjoyan, Z., Korchin, B., Fritsche, H., Andreeff, M.(2010). Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells . Leukemia. 24. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1364-1367.

Michael Andreeff, Michael Fiegl, Marina Konopleva, Borys Korchin, Kumar Kaluarachchi, William G. Bornmann, Patrick H. Guthrie, Romain Harmancey, Heinrich Taegtmeyer, Ismael J. Samudio(2009). Pharmacological Inhibition of Fatty Acid Oxidation as a Novel Therapeutic Concept for Acute Myeloid Leukemia . Blood. 114. (22). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3779--3779. American Society of Hematology

Zhihong Zeng, Yue Xi Shi, Ismael J. Samudio, Rui-Yu Wang, Xiaoyang Ling, Olga Frolova, Mark Levis, Joshua B. Rubin, Robert R. Negrin, Elihu H. Estey, et al.(2009). Targeting the leukemia microenvironment by {CXCR}4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in {AML} . Blood. 113. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6215--6224. American Society of Hematology

Ismael Samudio, Michael Fiegl, Karen Clise-Dwyer, Jared K. Burks, Zakar Mnjoyan, Michael Andreeff(2009). {CXCR}4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure . Blood. 113. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1504--1512. American Society of Hematology

Zeng, Z., Shi, Y.X., Samudio, I.J., Wang, R.-Y., Ling, X., Frolova, O., Levis, M., Rubin, J.B., Negrin, R.R., Estey, E.H., et al.(2009). Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML . Blood. 113. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6215-6224.

Samudio, I., Fiegl, M., Andreeff, M.(2009). Mitochondrial uncoupling and the warburg effect: Molecular basis for the reprogramming of cancer cell metabolism . Cancer Research. 69. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2163-2166.

Fiegl, M., Samudio, I., Clise-Dwyer, K., Burks, J.K., Mnjoyan, Z., Andreeff, M.(2009). CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure . Blood. 113. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1504-1512.

Ismael J. Samudio, Michael Fiegl, Marina Konopleva, Kumar Kaluarachchi, John S. McMurray, Borys Korchin, Karen Clise Dwyer, Romain Harmancey, Patrick Guthrie, Heinrich Taegtmeyer, et al.(2008). Targeting Anaplerotic Pathways That Support Fatty Acid Metabolism as a Therapeutic Strategy for Hematological Malignancies: The Achilles' Heel of the Warburg Effect . Blood. 112. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1631--1631. American Society of Hematology

Konopleva, M., Watt, J., Contractor, R., Tsao, T., Harris, D., Estrov, Z., Bornmann, W., Kantarjian, H., Viallet, J., Samudio, I., et al.(2008). Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (Obatoclax) . Cancer Research. 68. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3413-3420.

Samudio, I., Kurinna, S., Ruvolo, P., Korchin, B., Kantarjian, H., Beran, M., Dunner Jr., K., Kondo, S., Andreeff, M., Konopleva, M.(2008). Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana- 1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells . Molecular Cancer Therapeutics. 7. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1130-1139.

Samudio, I., Fiegl, M., McQueen, T., Clise-Dwyer, K., Andreeff, M.(2008). The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation . Cancer Research. 68. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5198-5205.

Kojima, K., Shimanuki, M., Shikami, M., Samudio, I.J., Ruvolo, V., Corn, P., Hanaoka, N., Konopleva, M., Andreeff, M., Nakakuma, H.(2008). The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML . Leukemia. 22. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1728-1736.

Hong, J., Samudio, I., Chintharlapalli, S., Safe, S.(2008). 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines . Molecular Carcinogenesis. 47. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 492-507.

Ismael Samudio, Zhihong Zeng, Michael Andreeff, Marina Konopleva(2007). Synergistic Induction of Apoptosis by Simultaneous Disruption of the Bcl-2 and {mTOR}/Akt Pathways in Acute Myeloid Leukemia . Blood. 110. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1588--1588. American Society of Hematology

Ismael Samudio, Michael Andreeff, Martin Dietrich, Paul Corn, Sergej Konoplev, Marina Konopleva(2007). The Hypoxic Microenvironment in Acute Myelogenous Leukemia: Critical Role of {CXCR}4 in the Induction of {HIF}-1$\upalpha$ . Blood. 110. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1819--1819. American Society of Hematology

Zeng, Z., Sarbassov, D.D., Samudio, I.J., Yee, K.W.L., Munsell, M.F., Jackson, C.E., Giles, F.J., Sabatini, D.M., Andreeff, M., Konopleva, M.(2007). Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML . Blood. 109. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3509-3512.

Kojima, K., Konopleva, M., Samudio, I.J., Ruvolo, V., Andreeff, M.(2007). Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells . Cancer Research. 67. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3210-3219.

Ismael Samudio, Olga Frolova, Daniela Buglio, Teresa McQueen, Hagop Kantarjian, Mary A. Weiser, Michael Andreeff, Marina Konopleva(2006). Relationship between {mTOR}-Mediated Upregulation of Glycolysis and Chemosensitivity of {ALL} Blasts . Blood. 108. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1833--1833. American Society of Hematology

Ismael Samudio, Martin Dietrich, Paul Corn, Dajun Yang, Gautam Borthakur(2006). Novel Small Molecule {MDM}2 Inhibitor {MI}-63 Induces p53-Dependent Apoptosis in {AML} Cell Lines . Blood. 108. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2596--2596. American Society of Hematology

Vanderlaag, K., Samudio, I., Burghardt, R., Barhoumi, R., Safe, S.(2006). Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3′-indolyl)methane (DIM) and 5,5′-dibromoDIM . Cancer Letters. 236. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 198-212.

Abdelrahim, M., Newman, K., Vanderlaag, K., Samudio, I., Safe, S.(2006). 3,3′-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5 . Carcinogenesis. 27. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 717-728.

Zeng, Z., Samudio, I.J., Munsell, M., An, J., Huang, Z., Estey, E., Andreeff, M., Konopleva, M.(2006). Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias . Molecular Cancer Therapeutics. 5. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3113-3121.

Samudio, I., Konopleva, M., Pelicano, H., Huang, P., Frolova, O., Bornmann, W., Ying, Y., Evans, R., Contractor, R., Andreeff, M.(2006). A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: Direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis . Molecular Pharmacology. 69. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1182-1193.

Konopleva, M., Contractor, R., Tsao, T., Samudio, I., Ruvolo, P.P., Kitada, S., Deng, X., Zhai, D., Shi, Y.-X., Sneed, T., et al.(2006). Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia . Cancer Cell. 10. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 375-388.

Zeng, Z., Samudio, I.J., Zhang, W., Estrov, Z., Pelicano, H., Harris, D., Frolova, O., Hail Jr., N., Chen, W., Kornblau, S.M., et al.(2006). Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia . Cancer Research. 66. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3737-3746.

Kojima, K., Konopleva, M., Samudio, I.J., Schober, W.D., Bornmann, W.G., Andreeff, M.(2006). Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML . Cell Cycle. 5. (23). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2778-2786.

Ismael Samudio, Rooha Contractor, Marina Konopleva, Hagop Kantarjian, Michael Andreeff(2005). Inhibition of Bcl-2 Signaling by Small Molecule {BH}3 Inhibitor {GX}15-070 as a Novel Therapeutic Strategy in {AML} . Blood. 106. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3372--3372. American Society of Hematology

Ismael Samudio, Michael Andreeff, Rooha Contractor, Peter P. Ruvolo, Xingming Deng, Yue-Xi Shi, Teresa McQueen, Rui-Yu Wang, Wendy Schober, Xiaoyang Ling, et al.(2005). Mechanisms of Apoptosis Induction by {BH}3 Inhibitor {ABT}-737 in {AML} . Blood. 106. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 244--244. American Society of Hematology

Ismael Samudio, Marina Konopleva, Stephen Safe, Michael Andreeff(2005). Guggulsterones Induce Apoptosis and Differentiation in {AML}: Identification of Isomer-Specific Antileukemic Activities of the Pregnanedienedione Structure . Blood. 106. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4466--4466. American Society of Hematology

Ismael Samudio, Marina Konopleva, Helene Pelicano, Peng Huang, Olga Frolova, William Bornmann, Yun-ming Ying, Randall Evans, Michael Andreeff(2005). A Novel Mechanism of Action of Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate ({CDDO}-Me): Direct Permeabilization of the Inner Mitochondrial Membrane To Inhibit Electron Transport and Induce Apoptosis . Blood. 106. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4462--4462. American Society of Hematology

Ismael Samudio, Daniela Buglio, Marina Konopleva, Teresa McQueen, Kristine R. Broglio, Vivian Ruvolo, Rooha Contractor, Wenjing Chen, Hagop Kantarjian, Michael Andreeff, et al.(2005). Relationship between m-{TOR}-Mediated Upregulation of Glycolysis, Chemoresistance, and Prognosis in Patients with {ALL} . Blood. 106. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 12--12. American Society of Hematology

Contractor, R., Samudio, I.J., Estrov, Z., Harris, D., McCubrey, J.A., Safe, S.H., Andreeff, M., Konopleva, M., Contractor, R., Samudio, I.J., et al.(2005). A novel ring-substituted diindolylmethane, 1,1-bis[3′-(5- methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia . Cancer Research. 65. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2890-2898.

Kojima, K., Konopleva, M., Samudio, I.J., Shikami, M., Cabreira-Hansen, M., McQueen, T., Ruvolo, V., Tsao, T., Zeng, Z., Vassilev, L.T., et al.(2005). MDM2 antagonists induce p53-dependent apoptosis in AML: Implications for leukemia therapy . Blood. 106. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3150-3159.

Chintharlapalli, S., Papineni, S., Konopleva, M., Andreef, M., Samudio, I., Safe, S.(2005). 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor γ-dependent and -independent pathways . Molecular Pharmacology. 68. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 119-128.

Calabrò, P., Samudio, I., Safe, S.H., Willerson, J.T., Yeh, E.T.H.(2005). Inhibition of tumor-necrosis-factor-α induced endothelial cell activation by a new class of PPAR-γ agonists: An in vitro study showing receptor-independent effects . Journal of Vascular Research. 42. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 509-516.

Samudio, I., Konopleva, M., Safe, S., McQueen, T., Andreeff, M.(2005). Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: Identification of isomer-specific antileukemic activities of the pregnadienedione structure . Molecular Cancer Therapeutics. 4. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1982-1992.

Samudio, I., Konopleva, M., Hail Jr., N., Shi, Y.-X., McQueen, T., Hsu, T., Evans, R., Honda, T., Gribble, G.W., Sporn, M., et al.(2005). 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer . Journal of Biological Chemistry. 280. (43). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 36273-36282.

Rooha Contractor, Ismael J. Samudio, Zeev Estrov, David Harris, James A. McCubrey, Stephen H. Safe, Michael Andreeff, Marina Konopleva(2004). A Novel Ring-Substituted Diindolylmethane 1,1-bis [3$\prime$-(5-methoxyindolyl)]-1-(p-t-butylphenyl) Methane Abrogates {ERK} Activation and Induces Apoptosis in Acute Myeloid Leukemia ({AML}) . Blood. 104. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3399--3399. American Society of Hematology

Ismael Samudio, Masato Shikami, Marina Konopleva, Koyu Hoshino, Guillermo Garcia-Manero, Kensuke Kojima, Twee Tsao, Teresa McQueen, Michael Andreeff(2004). {ARTS}, a Pro-Apoptotic Mitochondrial Septin-Like Protein That Binds to {XIAP}, Is Silenced in Acute Lymphoblastic and Primitive Acute Myeloblastic Leukemia Cells . Blood. 104. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3378--3378. American Society of Hematology

Calabro, P., Samudio, I., Willerson, J.T., Yeh, E.T.H.(2004). Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways . Circulation. 110. (21). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3335-3340.

Hong, J., Samudio, I., Liu, S., Abdelrahim, M., Safe, S.(2004). Peroxisome proliferator-activated receptor γ-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins . Endocrinology. 145. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5774-5785.

Chintharlapalli, S., Smith III, R., Samudio, I., Zhang, W., Safe, S.(2004). 1,1-Bis(3′-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor γ-mediated growth inhibition, transactivation, and differeatiation markers in colon cancer cells . Cancer Research. 64. (17). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5994-6001.

Stoner, M., Wormke, M., Saville, B., Samudio, I., Qin, C., Abdelrahim, M., Safe, S.(2004). Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor α and SP proteins . Oncogene. 23. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1052-1063.

Qin, C., Samudio, I., Ngwenya, S., Safe, S.(2004). Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways . Molecular Carcinogenesis. 40. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 160-170.

Qin, C., Morrow, D., Stewart, J., Spencer, K., Porter, W., Smith, R., Phillips, T., Abdelrahim, M., Samudio, I., Safe, S.(2004). A new class of peroxisome proliferator-activated receptor γ (PPARγ) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl) methanes . Molecular Cancer Therapeutics. 3. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 247-259.

Khan, S., Abdelrahim, M., Samudio, I., Safe, S.(2003). Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17β-estradiol in breast cancer cells . Endocrinology. 144. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2325-2335.

Saville, B., Poukka, H., Wormke, M., Jänne, O.A., Palvimo, J.J., Stoner, M., Samudio, I., Safe, S.(2002). Cooperative coactivation of estrogen receptor α in ZR-75 human breast cancer cells by SNURF and TATA-binding protein . Journal of Biological Chemistry. 277. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2485-2497.

Abdelrahim, M., Samudio, I., Smith 3rd., R., Burghardt, R., Safe, S.(2002). Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells . The Journal of biological chemistry. 277. (32). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 28815-28822.

Qin, C., Nguyen, T., Stewart, J., Samudio, I., Burghardt, R., Safe, S.(2002). Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor κB/CCAAT-binding transcription factor-1 complex . Molecular Endocrinology. 16. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1793-1809.

Castro-Rivera, E., Samudio, I., Safe, S.(2001). Estrogen Regulation of Cyclin D1 Gene Expression in ZR-75 Breast Cancer Cells Involves Multiple Enhancer Elements . Journal of Biological Chemistry. 276. (33). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 30853-30861.

Samudio, I., Vyhlidal, C., Wang, F., Stoner, M., Chen, I., Kladde, M., Barhoumi, R., Burghardt, R., Safe, S.(2001). Transcriptional activation of deoxyribonucleic acid polymerase α gene expression in MCF-7 cells by 17β-estradiol . Endocrinology. 142. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1000-1008.

Wang, F., Samudio, I., Safe, S.(2001). Transcriptional activation of cathepsin D gene expression by 17β-estradiol: Mechanism of aryl hydrocarbon receptor-mediated inhibition . Molecular and Cellular Endocrinology. 172. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 91-103.

Stoner, M., Wang, F., Wormke, M., Nguyen, T., Samudio, I., Vyhlidal, C., Marme, D., Finkenzeller, G., Safe, S.(2000). Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor α and Sp3 proteins . Journal of Biological Chemistry. 275. (30). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 22769-22779.

Xie, W., Duan, R., Chen, I., Samudio, I., Safe, S.(2000). Transcriptional activation of thymidylate synthase by 17β-estradiol in MCF-7 human breast cancer cells . Endocrinology. 141. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2439-2449.

Safe, S., Wormke, M., Samudio, I.(2000). Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells . Journal of Mammary Gland Biology and Neoplasia. 5. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 295-306.

Vyhlidal, C., Samudio, I., Kladde, M.P., Safe, S.(2000). Transcriptional activation of transforming growth factor α by estradiol: Requirement for both a GC-rich site and an estrogen response element half-site . Journal of Molecular Endocrinology. 24. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 329-338.

Duan, R., Porter, W., Samudio, I., Vyhlidal, C., Kladde, M., Safe, S.(1999). Transcriptional activation of c-fos protooncogene by 17β-Estradiol: Mechanism of aryl hydrocarbon receptor-mediated inhibition . Molecular Endocrinology. 13. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1511-1521.

Dong, L., Wang, W., Wang, F., Stoner, M., Reed, J.C., Harigai, M., Samudio, I., Kladde, M.P., Vyhlidalll, C., Safe, S.(1999). Mechanisms of transcriptional activation of bcl-2 gene expression by 17β-estradiol in breast cancer cells . Journal of Biological Chemistry. 274. (45). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 32099-32107.

BOOK CHAPTER

Samudio, I., Vélez, J.(2015). Molecular and biochemical basis for the reprogramming of intermediary metabolism in leukemia cells . Targeted Therapy of Acute Myeloid Leukemi. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 725-733.

BOOK

Samudio, I., Konopleva, M., Carter, B., Andreeff, M.(2010). Apoptosis in leukemias: Regulation and therapeutic targeting . Cancer Treatment and Research. 145. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 197-217.