プロフィール詳細

プロジェクトを作成

★★★★★

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★★★★★

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Dr. Isolda C.に依頼

Spain

Senior Scientist – Cancer Nanomedicine and Preclinical Drug Development

プロフィール概要

I am a senior biomedical scientist with over 20 years of experience in cancer research, preclinical drug development and nanomedicine. I currently work at the Josep Carreras Leukaemia Research Institute, where my research focuses on the development and preclinical evaluation of targeted anticancer therapies, including nanoparticle-based drug delivery systems. I also serve as Scientific Coordinator of the Nanotoxicology Unit of the NANBIOSIS research infrastructure, where we evaluate the safety and efficacy of nanomaterials and nanomedicines using in vitro and in vivo models. My expertise includes cancer biology, mouse tumor models, nanoparticle-based therapeutics, nanotoxicology and translational preclinical research. I have authored over 75 peer-reviewed publications and hold 8 patents related to anticancer therapies and targeted antitumor nanomedicines. I support biotech companies and research groups in designing and evaluating preclinical strategies for anticancer drug development, including experimental design, model selection and translational development.

専門分野

• ☆ Drug Discovery
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Drug Efficacy Testing
• ☆ Oncology
• ☆ Chemotherapy
• ☆ Precision Medicine
• ☆ Hematology
• ☆ Hematology-Oncology
• ☆ Leukemia & Lymphoma
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Carcinogenesis
• ☆ Pharmaceutical Technology
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ Literature Search
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing

サービス

• Research
• Consulting
• Product Development

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Product Development Product Evaluation, Product Validation, Concept Development

職務経験

Senior Scientist / Group Manager

Josep Carreras Leukaemia Research Institute

5月 2022 - 現在

Researcher

CIBER-BBN

3月 2007 - 現在

Senior postdoctoral scientist

CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine)

3月 2008 - 4月 2022

Postdoctoral Researcher

Sant Pau Research Institute

7月 2004 - 2月 2008

学歴

PhD Genetics

University of Barcelona

9月 1999 - 6月 2004

BSc Biology

University of Barcelona

9月 1993 - 6月 1998

認定資格

• Certification for Laboratory Animal Science and Experimental Animal Handling

  FELASA (Federation of European Laboratory Animal Science Associations)

  3月 2013 - 現在

出版物

JOURNAL ARTICLE

Voltà-Durán, E., Serna, N., Sánchez-García, L., Aviñó, A., Sánchez, J.M., López-Laguna, H., Cano-Garrido, O., Casanova, I., Mangues, R., Eritja, R., et al.(2021). Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles . Acta Biomaterialia. 119. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 312-322.

Sánchez, J.M., López-Laguna, H., Álamo, P., Serna, N., Sánchez-Chardi, A., Nolan, V., Cano-Garrido, O., Casanova, I., Unzueta, U., Vazquez, E., et al.(2020). Artificial Inclusion Bodies for Clinical Development . Advanced Science. 7. (3).

Pallarès, V., Unzueta, U., Falgàs, A., Sánchez-Garciá, L., Serna, N., Gallardo, A., Morris, G.A., Alba-Castellón, L., Álamo, P., Sierra, J., et al.(2020). An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination . Journal of Hematology and Oncology. 13. (1).

Falgàs, A., Pallarès, V., Serna, N., Sánchez-García, L., Sierra, J., Gallardo, A., Alba-Castellón, L., Álamo, P., Unzueta, U., Villaverde, A., et al.(2020). Selective delivery of T22-PE24-H6 to CXCR4⁺ diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model . Theranostics. 10. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5169-5180.

Álamo, P., Pallarès, V., Céspedes, M.V., Falgàs, A., Sanchez, J.M., Serna, N., Sánchez‐garcía, L., Voltà‐duràn, E., Morris, G.A., Sánchez‐chardi, A., et al.(2020). Fluorescent dye labeling changes the biodistribution of tumor‐targeted nanoparticles . Pharmaceutics. 12. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-18.

Falgàs, A., Pallarès, V., Unzueta, U., Céspedes, M.V., Arroyo-Solera, I., Moreno, M.J., Gallardo, A., Mangues, M.A., Sierra, J., Villaverde, A., et al.(2020). A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models . Haematologica. 105. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 741-753.

Céspedes, M.V., Cano-Garrido, O., Álamo, P., Sala, R., Gallardo, A., Serna, N., Falgàs, A., Voltà-Durán, E., Casanova, I., Sánchez-Chardi, A., et al.(2020). Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci . Advanced Materials. 32. (7).

Recasens-Zorzo, C., Cardesa-Salzmann, T., Petazzi, P., Ros-Blanco, L., Esteve-Arenys, A., Clot, G., Guerrero-Hernández, M., Rodríguez, V., Soldini, D., Valera, A., et al.(2019). Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma . Haematologica. 104. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 778-788.

Casanova, I., Unzueta, U., Arroyo-Solera, I., Céspedes, M.V., Villaverde, A., Mangues, R., Vazquez, E.(2019). Protein-driven nanomedicines in oncotherapy . Current Opinion in Pharmacology. 47. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-7.

Pavón, M.A., Arroyo-Solera, I., León, X., Téllez-Gabriel, M., Virós, D., Gallardo, A., Céspedes, M.V., Casanova, I., Lopez-Pousa, A., Barnadas, A., et al.(2019). The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes . Head and Neck. 41. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1830-1845.

Protein-driven nanomedicines in oncotherapy @article{PMID:30685732, Title= {Protein-driven nanomedicines in oncotherapy}, Author= {Casanova, Isolda and Unzueta, Ugutz and Arroyo-Solera, Irene and Céspedes, Maria Virtudes and Villaverde, Antonio and Mangues, Ramon and Vazquez, Esther}, DOI= {10.1016/j.coph.2018.12.004}, Volume= {47}, Month= {August}, Year= {2019}, Journal= {Current opinion in pharmacology}, ISSN= {1471-4892}, Pages= {1—7}, URL= {https://doi.org/10.1016/j.coph.2018.12.004}} . Current opinion in pharmacology.

The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes @article{PMID:30652380, Title= {The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes}, Author= {Pavón, Miguel Angel and Arroyo-Solera, Irene and León, Xavier and Téllez-Gabriel, Marta and Virós, David and Gallardo, Alberto and Céspedes, Maria Virtudes and Casanova, Isolda and Lopez-Pousa, Antonio and Barnadas, Agustí and Quer, Miquel and Mangues, Ramón and Mangues, Ramón}, DOI= {10.1002/hed.25623}, Number= {6}, Volume= {41}, Month= {June}, Year= {2019}, Journal= {Head & neck}, ISSN= {1043-3074}, Pages= {1830—1845}, URL= {https://doi.org/10.1002/hed.25623}} . Head & neck.

Sala, R., Sánchez-García, L., Serna, N., Céspedes, M.V., Casanova, I., Roldán, M., Sánchez-Chardi, A., Unzueta, U., Vázquez, E., Mangues, R., et al.(2019). Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4⁺ colorectal cancer . Acta Biomaterialia. 99. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 426-432.

(2019). A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models . Haematologica.

Arroyo-Solera, I., Pavón, M.Á., León, X., López, M., Gallardo, A., Céspedes, M.V., Casanova, I., Pallarès, V., López-Pousa, A., Mangues, M.A., et al.(2019). Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma . Head and Neck. 41. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 429-439.

Aviñó, A., Unzueta, U., Virtudes Céspedes, M., Casanova, I., Vázquez, E., Villaverde, A., Mangues, R., Eritja, R.(2019). Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy . ChemistryOpen. 8. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 382-387.

(2019). Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci . Advanced materials (Deerfield Beach, Fla.).

Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer @article{PMID:31494293, Title= {Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer}, Author= {Sala, Rita and Sánchez-García, Laura and Serna, Naroa and Céspedes, María Virtudes and Casanova, Isolda and Roldán, Mònica and Sánchez-Chardi, Alejandro and Unzueta, Ugutz and Vázquez, Esther and Mangues, Ramón and Villaverde, Antonio}, DOI= {10.1016/j.actbio.2019.09.002}, Volume= {99}, Month= {November}, Year= {2019}, Journal= {Acta biomaterialia}, ISSN= {1742-7061}, Pages= {426—432}, URL= {https://doi.org/10.1016/j.actbio.2019.09.002}} . Acta biomaterialia.

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma @article{PMID:30548470, Title= {Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma}, Author= {Arroyo-Solera, Irene and Pavón, Miguel Ángel and Pavón, Miguel Ángel and León, Xavier and López, Montserrat and Gallardo, Alberto and Céspedes, María Virtudes and Casanova, Isolda and Pallarès, Víctor and López-Pousa, Antonio and Mangues, María Antonia and Barnadas, Agustí and Quer, Miquel and Mangues, Ramón}, DOI= {10.1002/hed.25437}, Number= {2}, Volume= {41}, Month= {February}, Year= {2019}, Journal= {Head & neck}, ISSN= {1043-3074}, Pages= {429—439}, URL= {https://doi.org/10.1002/hed.25437}} . Head & neck.

Díaz, R., Pallarès, V., Cano-Garrido, O., Serna, N., Sánchez-García, L., Falgàs, A., Pesarrodona, M., Unzueta, U., Sánchez-Chardi, A., Sánchez, J.M., et al.(2018). Selective CXCR4⁺ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin . Small. 14. (26).

Céspedes, M.V., Unzueta, U., Aviñó, A., Gallardo, A., Álamo, P., Sala, R., Sánchez-Chardi, A., Casanova, I., Mangues, M.A., Lopez-Pousa, A., et al.(2018). Selective depletion of metastatic stem cells as therapy for human colorectal cancer . EMBO Molecular Medicine. 10. (10).

Sánchez-García, L., Serna, N., Álamo, P., Sala, R., Céspedes, M.V., Roldan, M., Sánchez-Chardi, A., Unzueta, U., Casanova, I., Mangues, R., et al.(2018). Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs . Journal of Controlled Release. 274. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 81-92.

Pallarès, V., Hoyos, M., Chillón, M.C., Barragán, E., Conde, M.I.P., Llop, M., Falgàs, A., Céspedes, M.V., Montesinos, P., Nomdedeu, J.F., et al.(2018). Focal adhesion genes refine the intermediate-risk cytogenetic classification of acute myeloid leukemia . Cancers. 10. (11).

Moreno, M.J., Gallardo, A., Novelli, S., Mozos, A., Arago, M., Pavón, M.Á., Céspedes, M.V., Pallarès, V., Falgàs, A., Alcoceba, M., et al.(2018). CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis . PLoS ONE. 13. (6).

(2018). Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin . Small (Weinheim an der Bergstrasse, Germany).

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs @article{PMID:29408658, Title= {Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs}, Author= {Sánchez-García, Laura and Serna, Naroa and Álamo, Patricia and Sala, Rita and Céspedes, María Virtudes and Roldan, Mònica and Sánchez-Chardi, Alejandro and Unzueta, Ugutz and Casanova, Isolda and Mangues, Ramón and Vázquez, Esther and Villaverde, Antonio}, DOI= {10.1016/j.jconrel.2018.01.031}, Volume= {274}, Month= {March}, Year= {2018}, Journal= {Journal of controlled release : official journal of the Controlled Release Society}, ISSN= {0168-3659}, Pages= {81—92}, URL= {https://doi.org/10.1016/j.jconrel.2018.01.031}} . Journal of controlled release : official journal of the Controlled Release Society.

et al.(2017). NEDD9, an independent good prognostic factor in intermediaterisk acute myeloid leukemia patients . Oncotarget.

Pallarès, V., Hoyos, M., Chillón, M.C., Barragán, E., Conde, M.I.P., Llop, M., Céspedes, M.V., Nomdedeu, J.F., Brunet, S., Sanz, M.Á., et al.(2017). NEDD 9 an independent good prognostic factor in intermediaterisk acute myeloid leukemia patients . Oncotarget. 8. (44). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 76003-76014.

Body, S., Esteve-Arenys, A., Miloudi, H., Recasens-Zorzo, C., Tchakarska, G., Moros, A., Bustany, S., Vidal-Crespo, A., Rodriguez, V., Lavigne, R., et al.(2017). Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells . Scientific Reports. 7. (1).

et al.(2016). Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4(+) colorectal cancer models . Nanomedicine : nanotechnology, biology, and medicine.

(2016). uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy . Oncotarget.

et al.(2016). CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma . Head & neck.

Pavón, M.A., Parreño, M., Téllez-Gabriel, M., León, X., Arroyo-Solera, I., López, M., Céspedes, M.V., Casanova, I., Gallardo, A., López-Pousa, A., et al.(2016). CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma . Head and Neck. 38. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString E1392-E1403.

Céspedes, M.V., Unzueta, U., Álamo, P., Gallardo, A., Sala, R., Casanova, I., Pavón, M.A., Mangues, M.A., Trías, M., López-Pousa, A., et al.(2016). Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4⁺ colorectal cancer models . Nanomedicine: Nanotechnology, Biology, and Medicine. 12. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1987-1996.

Pavón, M.A., Arroyo-Solera, I., Céspedes, M.V., Casanova, I., León, X., Mangues, R.(2016). uPA/uPAR and SERPINE1 in head and neck cancer: Role in tumor resistance, metastasis, prognosis and therapy . Oncotarget. 7. (35). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 57351-57366.

et al.(2015). Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients . Oncotarget.

et al.(2015). CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival . The Journal of pathology.

et al.(2015). Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model . The FASEB Journal.

Alamo, P., Gallardo, A., Di Nicolantonio, F., Pavón, M.A., Casanova, I., Trias, M., Mangues, M.A., Lopez-Pousa, A., Villaverde, A., Vázquez, E., et al.(2015). Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model . FASEB Journal. 29. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 464-476.

De La Torre, C., Casanova, I., Acosta, G., Coll, C., Moreno, M.J., Albericio, F., Aznar, E., Mangues, R., Royo, M., Sancenón, F., et al.(2015). Gated mesoporous silica nanoparticles using a double-role circular peptide for the controlled and target-preferential release of doxorubicin in CXCR4-expresing lymphoma cells . Advanced Functional Materials. 25. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 687-695.

Moreno, M.J., Bosch, R., Dieguez-Gonzalez, R., Novelli, S., Mozos, A., Gallardo, A., Pavón, M.Á., Céspedes, M.V., Grañena, A., Alcoceba, M., et al.(2015). CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival . Journal of Pathology. 235. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 445-455.

Pavón, M.A., Arroyo-Solera, I., Téllez-Gabriel, M., León, X., Virós, D., López, M., Gallardo, A., Céspedes, M.V., Casanova, I., López-Pousa, A., et al.(2015). Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients . Oncotarget. 6. (30). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 29016-29033.

et al.(2014). Focal adhesion protein expression in human diffuse large B-cell lymphoma . Histopathology.

et al.(2014). In vivo architectonic stability of fully de novo designed protein-only nanoparticles . ACS nano.

et al.(2014). Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models . Disease models & mechanisms.

Alamo, P., Gallardo, A., Pavón, M.A., Casanova, I., Trias, M., Mangues, M.A., Vázquez, E., Villaverde, A., Mangues, R., Céspedes, M.V.(2014). Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models . DMM Disease Models and Mechanisms. 7. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 387-396.

Céspedes, M.V., Unzueta, U., Tatkiewicz, W., Sánchez-Chardi, A., Conchillo-Solé, O., Álamo, P., Xu, Z., Casanova, I., Corchero, J.L., Pesarrodona, M., et al.(2014). In vivo architectonic stability of fully de novo designed protein-only nanoparticles . ACS Nano. 8. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4166-4176.

Bosch, R., Dieguez-Gonzalez, R., Moreno, M.J., Gallardo, A., Novelli, S., Espinosa, I., Céspedes, M.V., Pavón, M.A., Briones, J., Grañena, A., et al.(2014). Focal adhesion protein expression in human diffuse large B-cell lymphoma . Histopathology. 65. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 119-131.

et al.(2013). High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma . Cancer medicine.

Bosch R, Moreno MJ, Dieguez-Gonzalez R, Céspedes MV, Gallardo A, Trias M, Grañena A, Sierra J, Casanova I, Mangues R, Haematologica, 2013, vol. 98, no. 8, pp. 1242-1249 .

Bosch, R., Moreno, M.J., Dieguez-Gonzalez, R., Céspedes, M.V., Gallardo, A., Trias, M., Grañena, A., Sierra, J., Casanova, I., Mangues, R.(2013). A novel orally available inhibitor of focal adhesion signaling increases survival in a xenograft model of diffuse large B-cell lymphoma with central nervous system involvement . Haematologica. 98. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1242-1249.

Téllez-Gabriel, M., Arroyo-Solera, I., León, X., Gallardo, A., López, M., Céspedes, M.V., Casanova, I., López-Pousa, A., Quer, M., Mangues, M.A., et al.(2013). High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma . Cancer Medicine. 2. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 950-963.

et al.(2012). Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma . Carcinogenesis.

Bosch R, Moreno MJ, Dieguez-Gonzalez R, Céspedes MV, Gallardo A, Nomdedeu J, Pavón MA, Espinosa I, Mangues MA, Sierra J, Casanova I, Mangues R, Clinical & experimental metastasis, 2012, vol. 29, no. 4, pp. 339-347 .

Bosch, R., Moreno, M.J., Dieguez-Gonzalez, R., Céspedes, M.V., Gallardo, A., Nomdedeu, J., Pavón, M.Á., Espinosa, I., Mangues, M.A., Sierra, J., et al.(2012). Subcutaneous passage increases cell aggressiveness in a xenograft model of diffuse large B cell lymphoma . Clinical and Experimental Metastasis. 29. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 339-347.

Unzueta U, Céspedes MV, Ferrer-Miralles N, Casanova I, Cedano J, Corchero JL, Domingo-Espín J, Villaverde A, Mangues R, Vázquez E, International journal of nanomedicine, 2012, vol. 7, pp. 4533-4544 .

Unzueta, U., Céspedes, M.V., Ferrer-Miralles, N., Casanova, I., Cedano, J., Corchero, J.L., Domingo-Espín, J., Villaverde, A., Mangues, R., Vázquez, E.(2012). Intracellular CXCR4⁺ cell targeting with T22-empowered protein-only nanoparticles . International Journal of Nanomedicine. 7. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4533-4544.

Pavón, M.A., Parreño, M., Téllez-Gabriel, M., Sancho, F.J., López, M., Céspedes, M.V., Casanova, I., Lopez-Pousa, A., Mangues, M.A., Quer, M., et al.(2012). Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma . Carcinogenesis. 33. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1707-1716.

Bosch R, Dieguez-Gonzalez R, Céspedes MV, Parreño M, Pavón MÁ, Grañena A, Sierra J, Mangues R, Casanova I, Blood, 2011, vol. 118, no. 16, pp. 4411-4420 .

Bosch, R., Dieguez-Gonzalez, R., Céspedes, M.V., Parreño, M., Pavón, M.Á., Grañena, A., Sierra, J., Mangues, R., Casanova, I.(2011). A novel inhibitor of focal adhesion signaling induces caspase-independent cell death in diffuse large B-cell lymphoma . Blood. 118. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4411-4420.

Céspedes MV, Larriba MJ, Pavón MA, Alamo P, Casanova I, Parreño M, Feliu A, Sancho FJ, Muñoz A, Mangues R, The American journal of pathology, 2010, vol. 177, no. 4, pp. 2067-2079 .

Céspedes, M.V., Larriba, M.J., Pavón, M.A., Álamo, P., Casanova, I., Parreño, M., Feliu, A., Sancho, F.J., Muñoz, A., Mangues, R.(2010). Site-dependent E-cadherin cleavage and nuclear translocation in a metastatic colorectal cancer model . American Journal of Pathology. 177. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2067-2079.

Pavón MA, Parreño M, León X, Sancho FJ, Céspedes MV, Casanova I, Lopez-Pousa A, Mangues MA, Quer M, Barnadas A, Mangues R, International journal of cancer. Journal international du cancer, 2008, vol. 123, no. 5, pp. 1068-1079 .

Parreño M, Casanova I, Céspedes MV, Vaqué JP, Pavón MA, Leon J, Mangues R, Cancer research, 2008, vol. 68, no. 15, pp. 6313-6323 .

Casanova I, Bosch R, Lasa A, Parreño M, Céspedes MV, Brunet S, Nomdedéu JF, Mangues MA, Sierra J, Mangues R, International journal of cancer. Journal international du cancer, 2008, vol. 123, no. 1, pp. 217-226 .

Casanova, I., Bosch, R., Lasa, A., Parreño, M., Céspedes, M.V., Brunet, S., Nomdedéu, J.F., Mangues, M.A., Sierra, J., Mangues, R.(2008). A celecoxib derivative inhibits focal adhesion signaling and induces caspase-8-dependent apoptosis in human acute myeloid leukemia cells . International Journal of Cancer. 123. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 217-226.

Parreño, M., Casanova, I., Céspedes, M.V., Vaqué, J.P., Pavón, M.A., Leon, J., Mangues, R.(2008). Bobel-24 and derivatives induce caspase-independent death in pancreatic cancer regardless of apoptotic resistance . Cancer Research. 68. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6313-6323.

Pavón, M.A., Parreño, M., León, X., Sancho, F.J., Céspedes, M.V., Casanova, I., Lopez-Pousa, A., Mangues, M.A., Quer, M., Barnadas, A., et al.(2008). Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer . International Journal of Cancer. 123. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1068-1079.

Céspedes MV, Sancho FJ, Guerrero S, Parreño M, Casanova I, Pavón MA, Marcuello E, Trias M, Cascante M, Capellà G, Mangues R, Carcinogenesis, 2006, vol. 27, no. 11, pp. 2190-2200 .

Casanova I, Parreño M, Farré L, Guerrero S, Céspedes MV, Pavon MA, Sancho FJ, Marcuello E, Trias M, Mangues R, International journal of cancer. Journal international du cancer, 2006, vol. 118, no. 10, pp. 2381-2389 .

(2006). Mouse models in oncogenesis and cancer therapy . Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.

Parreño M, Vaqué JP, Casanova I, Frade P, Céspedes MV, Pavón MA, Molins A, Camacho M, Vila L, Nomdedeu JF, Mangues R, León J, Molecular cancer therapeutics, 2006, vol. 5, no. 5, pp. 1166-1175 .

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