プロフィール詳細

プロジェクトを作成

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Dr. Javed Akhtar, M.に依頼

China

Consultant Cardiothoracici Surgeon / Biomedical research

プロフィール概要

Javed Akhtar, MD, PhD, is a consultant cardiothoracic surgeon and biomedical researcher with expertise in basic, clinical, and translational research. His interdisciplinary work focuses on esophageal squamous cell carcinoma, particularly tumor plasticity, drug resistance, biomarker discovery, and personalized treatment strategies. His research spans cancer biology, epigenetic regulation, tumor microenvironment, metabolic signaling, and biocomplexity, using computational and systems biology approaches to study interacting biological networks as dynamic systems. He pioneered research on bistable insulin-signaling thresholds in metabolic regulation, providing new insight into insulin resistance and metabolic heterogeneity. He utilizes cutting-edge technologies, including live-cell FRET imaging, CRISPR/Cas9-mediated gene editing, patient-derived models, and zebrafish systems, and integrates these approaches with computational modeling for precise quantitative measurement and prediction in precision medicine. His clinical research includes retrospective and prospective patient studies with long-term follow-up to identify factors influencing treatment response and patient outcomes. His research has been published in peer-reviewed international journals and contributes to translational oncology and metabolic disease research.

専門分野

• ☆ Biostatistics
• ☆ Pharmacovigilance/Drug Safety Monitoring
• ☆ Anesthesiology
• ☆ Dermatology
• ☆ Dermatologic Surgery
• ☆ Skin Cancer
• ☆ Medical Imaging/Radiology
• ☆ Interventional Radiology
• ☆ Nuclear Medicine
• ☆ Primary Care/Family Medicine
• ☆ Human Biology
• ☆ Sleep Medicine
• ☆ Teratology/Birth Defects
• ☆ Orthoptics
• ☆ Ophthalmology
• ☆ Neuro-Ophthalmology
• ☆ Kinesiology & Exercise Science
• ☆ Precision Medicine
• ☆ General Surgery
• ☆ Abortion
• ☆ Gastroenterology & Hepatology
• ☆ Colorectal Cancer
• ☆ Pancreatic Cancer
• ☆ Stomach & Esophageal Cancer
• ☆ Crohn's Disease
• ☆ Hepatitis
• ☆ Irritable Bowel Syndrome (IBS)
• ☆ Liver Cancer
• ☆ Endocrinology
• ☆ Hormone Replacement Therapy
• ☆ Reproductive Medicine
• ☆ Endocrine Surgery
• ☆ Diabetes
• ☆ Neurosurgery
• ☆ Spine Surgery
• ☆ Orthopedic Surgery
• ☆ Plastic Surgery
• ☆ Oral & Maxillofacial Surgery
• ☆ Podiatry
• ☆ Hematology
• ☆ Hematology-Oncology
• ☆ Leukemia & Lymphoma
• ☆ Infectious Disease
• ☆ Antibiotic Resistance Research
• ☆ Antibiotic Stewardship
• ☆ Sexually Transmitted Infections (STI)
• ☆ HIV/AIDS Treatment
• ☆ Tropical Medicine
• ☆ Malaria
• ☆ Dengue
• ☆ Hospice & Palliative Medicine
• ☆ Pain Management
• ☆ Cardiac Surgery
• ☆ Pulmonology/Respiratory Disease
• ☆ Lung Cancer
• ☆ Tuberculosis
• ☆ Severe Acute Respiratory Syndrome (SARS)
• ☆ Respiratory Therapy
• ☆ Influenza
• ☆ Health Technology Assessment
• ☆ E-Health & Telemedicine
• ☆ Dietetics
• ☆ Medical Toxicology
• ☆ Health Informatics
• ☆ Healthcare Administration & Management
• ☆ Hospital & Medical Facility Management
• ☆ Managed Healthcare
• ☆ Medical Practice Management
• ☆ Medical Billing
• ☆ Medical Affairs
• ☆ Healthcare Quality Improvement
• ☆ Magnetic Resonance Imaging (MRI)
• ☆ Medical X-Ray
• ☆ Endoscopy
• ☆ Electrocardiogram (ECG)
• ☆ Echocardiography
• ☆ Computed Tomography (CT)
• ☆ Mammography
• ☆ Positron Emission Tomography (PET)
• ☆ Ultrasound
• ☆ Image-Guided Biopsy
• ☆ DEXA Scan
• ☆ Fluoroscopy
• ☆ Diagnostic Radiology
• ☆ Oral & Maxillofacial Radiology
• ☆ Traditional Medicine
• ☆ Intensive Care Medicine
• ☆ Photodermatology
• ☆ Dermatitis
• ☆ Pediatric Endocrinology
• ☆ School Health Services
• ☆ Hemophilia
• ☆ Photomedicine/Phototherapy
• ☆ Internal Medicine
• ☆ Back & Spine Health
• ☆ Environmental Medicine
• ☆ Geriatric Medicine
• ☆ Military Medicine
• ☆ Perinatology
• ☆ Travel Medicine
• ☆ Pediatric Surgery
• ☆ Trauma Surgery
• ☆ Craniofacial Surgery
• ☆ Vascular Surgery
• ☆ Developmental Disabilities
• ☆ Blindness & Visual Impairment
• ☆ Physical Disabilities
• ☆ Medical Terminology
• ☆ Medical Sciences
• ☆ Connective Tissue
• ☆ Vision Health
• ☆ Inflammation
• ☆ Asthma
• ☆ Metabolism & Metabolic Disease
• ☆ Medical Equipment & Supplies
• ☆ Laparoscopic/Minimally Invasive Surgery
• ☆ Cardiothoracic Radiology
• ☆ Muscoskeletal Radiology
• ☆ Neuroradiology
• ☆ Nuclear Radiology
• ☆ Pediatric Radiology
• ☆ Laser Surgery
• ☆ Healthcare Reimbursement

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Business & Legal Writing, Creative Writing, Newswriting, Audio Transcription, General Proofreading & Editing, Translation

Research Market Research, User Research, Meta-Research, Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Business Strategy Consulting, Go-to-Market Strategy Consulting, Digital Strategy Consulting, Healthcare Consulting, Operations Consulting, Scientific and Technical Consulting, Financial Consulting, Regulatory Consulting, Manufacturing Consulting

Data & AI Predictive Modeling, Statistical Analysis, Image Processing, Image Analysis, Algorithm Design-Non ML, Algorithm Design-ML, Data Visualization, Big Data Analytics, Text Mining & Analytics, Data Mining, Data Cleaning, Data Processing, Data Insights

Product Development Formulation, Recipe Development, Deformulation, Stability/Shelf Life Testing, Product Evaluation, Material Sourcing, Product Validation, Manufacturing, Quality Assurance & Control (QA/QC), Product Compliance , Concept Development, Product Launch Support, Packaging Design, Prototyping, Reverse Engineering, Device Fabrication

職務経験

Research Associate

Chinese University of Hong Kong, Shenzhen

7月 2024 - 現在

Research Fellow

Chinese University of Hong Kong, Shenzhen

7月 2023 - 7月 2024

Senior Research Scholar

Southern University of Science and Technology

11月 2021 - 5月 2023

Research Assistant Professor (RAP)

Southern University of Science and Technology

11月 2019 - 11月 2021

Postdoctoral Fellow

Southern University of Science and Technology

12月 2017 - 10月 2021

学歴

Ph.D (Cardiothoracic Surgery)

Shandong University

9月 2008 - 7月 2015

MBBS (Clinical Medicine )

Shandong University

3月 2003 - 7月 2008

認定資格

• n/a

  n/a

  1月 2026 - 現在

出版物

JOURNAL ARTICLE

Javed Akhtar, Muhammad Imran, Jiahe Wang, Gang Ma, Guanyu Wang (2025). Live-cell Förster resonance energy transfer imaging of metabolically regulated Akt activation dynamics in HepG2 cells . Journal of Visualized Experiments.

Javed Akhtar, Muhammad Imran, Guanyu Wang (2024). Protocol for live-cell Förster resonance energy transfer imaging to reveal the bistable insulin response of single C2C12-derived myotubes . STAR Protocols.

Javed Akhtar, Muhammad Imran, Guanyu Wang (2023). CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells . International Journal of Molecular Sciences.

Yukun Han, Javed Akhtar, Guozhen Liu, Chenzhong Li, Guanyu Wang (2023). Early warning and diagnosis of liver cancer based on dynamic network biomarker and deep learning . Computational and Structural Biotechnology Journal.

Javed Akhtar, Yukun Han, Shangchen Han, Weiping Lin, Chenyu Cao, Ruowen Ge, Isaac Adeyemi Babarinde, Qingzhao Jia, Yueyang Yuan, Guangming Chen, et al. (2022). Bistable insulin response: The win-win solution for glycemic control . iScience.

Jiashun Mao, Javed Akhtar, Xiao Zhang, Liang Sun, Shenghui Guan, Xinyu Li, Guangming Chen, Jiaxin Liu, Hyeon-Nae Jeon, Min Sung Kim, et al. (2021). Comprehensive strategies of machine-learning-based quantitative structure-activity relationship models . iScience.

Huan Xu, Bing Liu, Zhen Xiao, Meiling Zhou, Lin Ge, Fan Jia, Yanling Liu, Hongshan Jin, Xiuliang Zhu, Jian Gao, et al. (2021). Computational and Experimental Studies Reveal That Thymoquinone Blocks the Entry of Coronaviruses Into In Vitro Cells . Infectious Diseases and Therapy.

Shuai Wang, Javed Akhtar, Zhou Wang (2015). Anti-STMN1 therapy improves sensitivity to antimicrotubule drugs in esophageal squamous cell carcinoma . Tumor Biology.

RAEES HABIB, JAVED AKHTAR, MOHAMMAD TAQI, CHE YU, CHUNQING ZHANG (2015). Lentiviral vector-mediated survivin shRNA delivery in gastric cancer cell lines significantly inhibits cell proliferation and tumor growth . Oncology Reports.

Che Yu, Wei Xin, Junhui Zhen, Yi Liu, Akhtar Javed, Rong Wang, Qiang Wan (2015). Human antigen R mediated post-transcriptional regulation of epithelial-mesenchymal transition related genes in diabetic nephropathy . Journal of Diabetes.

Dr.JAVED AKHTAR MD,PhD (2015). [病人源性移植瘤模型的研究现况] Review on patient-derived tumor xenograft model. Chin J Cancer Prev Treat.

Dr.JAVED AKHTAR MD,PhD (2015). [沉默 Stathmin 基因增强食管鳞癌细胞对紫杉醇敏感度的实验[J]. 肿瘤 防治研究] Stathmin Silencing Increases Sensitivity of Esophageal Squamous Cell Carcinoma Cells to Paclitaxel[J]. Cancer Research on Prevention and Treatment.

Javed Akhtar, Zhou Wang, Che Yu, Zhi Ping Zhang (2014). Effectiveness of local injection of lentivirus‐delivered stathmin1 and stathmin1 <scp>shRNA</scp> in human gastric cancer xenograft mouse . Journal of Gastroenterology and Hepatology.

Javed Akhtar, Zhou Wang, Che Yu, Zhi Ping Zhang (2014). Effectiveness of local injection of lentivirus‐delivered stathmin1 and stathmin1 <scp>shRNA</scp> in human gastric cancer xenograft mouse . Journal of Gastroenterology and Hepatology.

Javed Akhtar, Zhou Wang, Che Yu, Zhi Ping Zhang (2014). Effectiveness of local injection of lentivirus-delivered stathmin1 and stathmin1 shRNA in human gastric cancer xenograft mouse . Journal of Gastroenterology and Hepatology.

Akhtar J, Wang Z, Jiang WP, Bi MM, Zhang ZP (2014). Stathmin overexpression identifies high risk for lymphatic metastatic recurrence in pN0 esophageal squamous cell carcinoma patients . Journal of gastroenterology and hepatology.

Yu Che, Liu Yi, Javed Akhtar, Chen Bing, Zhang Ruiyu, Wan Qiang, Wang Rong (2014). AngiotensinII induces HuR shuttling by post-transcriptional regulated CyclinD1 in human mesangial cells . Molecular Biology Reports.

Javed Akhtar, Zhou Wang, Che Yu, Zhi Ping Zhang, Ming Ming Bi (2014). STMN-1 Gene: A Predictor of Survival in Stage IIA Esophageal Squamous Cell Carcinoma After Ivor-Lewis Esophagectomy? . Annals of Surgical Oncology.

Yu Che, Chen Bing, Javed Akhtar, Zhao Tingting, Yu Kezhou, Wang Rong (2013). Lanthanum carbonate prevents accelerated medial calcification in uremic rats: role of osteoclast-like activity . Journal of Translational Medicine.

Javed Akhtar, Zhou Wang, Zhi Ping Zhang, Ming Ming Bi (2013). Lentiviral-mediated RNA interference targeting stathmin1 gene in human gastric cancer cells inhibits proliferation in vitro and tumor growth in vivo . Journal of Translational Medicine.

Che Yu, Bing Chen, TingTing Zhao, Rong Wang, Javed Akhtar, HaiPing Wang, Hong Zhang (2013). High phosphate feeding induced arterial medial calcification in uremic rats: Roles of Lanthanum carbonate on protecting vasculature . Life Sciences.

Shuai Wang, Hong Liu, Javed Akhtar, Hua-Xia Chen, Zhou Wang (2013). Alteration of Runt-related Transcription Factor 3 Gene Expression and Biologic Behavior of Esophageal Carcinoma TE-1 Cells after 5-Azacytidine Intervention . Asian Pacific Journal of Cancer Prevention.