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プロフィール詳細
プロジェクトを作成
★★★★★
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Julie M.に依頼
Denmark

Freelance Scientist & Data Analyst | Experienced in R & Excel | Inflammation, Mitochondria & Pain research specialist

プロフィール概要
専門分野
サービス
Writing Creative Writing, Translation
Research Meta-Research, Scientific and Technical Research, Systematic Literature Review
Data & AI Statistical Analysis, Data Visualization, Data Insights
職務経験

Research Assistant

Aarhus Universitet

8月 2024 - 現在

DVIP-teacher, Student Teacher

Aarhus University

10月 2023 - 現在

Teaching Assistant

Aarhus University

10月 2023 - 5月 2024

Research Assistant

Research Unit for Molecular Medicine

6月 2022 - 2月 2023

学歴

Msc. in Molecular Medicine

Aarhus University

9月 2022 - 6月 2024

Molecular Medicine

Aarhus University

8月 2019 - 7月 2022

認定資格
  • A/D animal handling course

    Aarhus University

    4月 2023 - 現在

出版物
JOURNAL ARTICLE
Julie Mie Mølgaard Bentzen, Peter Kolind Brask-Thomsen, Maiken Krogsbæk, Xiaoli Hu, Jens Randel Nyengaard, Sandra Sif Gylfadottir, Pall Karlsson, Nanna Brix Finnerup, Rikke Katrine Jentoft Olsen, Zahra Nochi (2026). Dermal fibroblast mitochondrial profiles in painful diabetic neuropathy . Diabetologia.
Dermal fibroblast mitochondrial profiles in painful diabetic neuropathy @article{458360b5b7eb4c4f97895309efc57cb7, title = "Dermal fibroblast mitochondrial profiles in painful diabetic neuropathy", abstract = "AIMS/HYPOTHESIS: Dermal fibroblasts have emerged as potential contributors to chronic pain, yet their role in diabetic polyneuropathy (DPN) and neuropathic pain remains poorly defined. Mitochondrial dysfunction and low-grade inflammation have been implicated in different pain conditions, but whether fibroblast mitochondrial health and cytokine secretion contribute to painful DPN is unknown.METHODS: We conducted an integrated cellular and molecular profiling of dermal fibroblasts and skin biopsies from 30 participants, grouped into control participants (n=5), diabetes without DPN (n=7), pain-free DPN (n=7) and painful DPN (n=11). Fibroblast cultures (n=24) were evaluated for morphology, growth rate, phenotype, inflammatory mediator secretion and mitochondrial function. Immunohistochemistry of skin biopsies was used to assess fibroblast density, mitochondrial markers and immune cell infiltration.RESULTS: Fibroblast morphology and proliferation did not differ significantly between groups. Flow cytometric profiling revealed no significant differences in fibroblast subtype distributions across groups. Inflammatory mediator secretion was limited. Mitochondrial mass, membrane potential, reactive oxygen species production and bioenergetic parameters were not different across groups. Skin biopsy analyses confirmed comparable fibroblast density and mitochondrial profiles across groups, regardless of neuropathy or pain. Notably, dermal macrophage infiltration was significantly elevated in the painful DPN group (mean \textasciitilde{}8\%; ANOVA p=0.02; painful DPN vs control participants p=0.02; painful DPN vs pain-free DPN p=0.07), consistent with prior findings from the same cohort, while Langerhans cell area fraction did not differ between groups.CONCLUSIONS/INTERPRETATION: Fibroblasts from participants with painful DPN did not differ in inflammatory and mitochondrial profiles compared with those from pain-free DPN. However, persistent dermal macrophage infiltration in painful DPN suggests a stable immune-activated microenvironment, potentially contributing to pain maintenance. Our results suggest that immune-related, rather than fibroblast-intrinsic, mechanisms could play a role in sustaining neuropathic pain in painful DPN.", keywords = "Bioenergetics, Cytokine secretion, Dermal fibroblasts, Diabetic polyneuropathy, Fibroblast phenotyping, Immunohistochemistry, Macrophage infiltration, Mitochondrial function, Neuropathic pain, Skin biopsy", author = "Bentzen, \{Julie Mie M{\o}lgaard\} and Brask-Thomsen, \{Peter Kolind\} and Maiken Krogsb{\ae}k and Xiaoli Hu and Nyengaard, \{Jens Randel\} and Gylfadottir, \{Sandra Sif\} and Pall Karlsson and Finnerup, \{Nanna Brix\} and Olsen, \{Rikke Katrine Jentoft\} and Zahra Nochi", note = "{\textcopyright} 2026. The Author(s).", year = "2026", month = jan, day = "26", doi = "10.1007/s00125-025-06660-8", language = "English", journal = "Diabetologia", issn = "0012-186X", publisher = "Springer Science+Business Media", } . Diabetologia.
CONFERENCE PAPER
(2023). PNS Abstracts 2023 . Journal of the Peripheral Nervous System.