プロフィール詳細

プロジェクトを作成

★★★★★

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★★★★★

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Dr. Jeff L.に依頼

United States

Biomedical research scientist with 20+ years of experience in the areas of neuroscience and pharmacology.

プロフィール概要

I have performed biomedical research and published papers in peer-reviewed biomedical journals in the areas of Alzheimer's disease, stroke, the blood-brain barrier, and drug delivery.

専門分野

• ☆ Neuroscience
• ☆ Neurochemistry
• ☆ Neuropharmacology
• ☆ Molecular Neuroscience

サービス

• Writing
• Research
• Consulting

Writing Medical Writing, Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Research Assistant Professor

University of Arizona

11月 2016 - 現在

Postdoctoral Associate

University of Wisconsin Madison

1月 2011 - 11月 2016

Research Technician

Banner Sun Health

11月 2000 - 8月 2004

学歴

Neuroscience

University of Arizona

8月 2004 - 12月 2010

B.Sc. Microbiology

Northern Arizona University

8月 2000 - 5月 2004

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Junzhi Yang, Robert D. Betterton, Erica I. Williams, Joshua A. Stanton, Elizabeth S. Reddell, Chidinma E. Ogbonnaya, Emma Dorn, Thomas P. Davis, Jeffrey Lochhead, Patrick Ronaldson (2022). High-Dose Acetaminophen Alters the Integrity of the Blood–Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats . Pharmaceutics.

Jeffrey Lochhead, Thomas P. Davis (2019). Perivascular and Perineural Pathways Involved in Brain Delivery and Distribution of Drugs after Intranasal Administration . Pharmaceutics.

(2019). Distribution of insulin in trigeminal nerve and brain after intranasal administration . Scientific reports.

Kumar, Niyanta N, Lochhead, Jeffrey J, Pizzo, Michelle E, Nehra, Geetika, Boroumand, Sam, Greene, Gretchen, Thorne, Robert G(2018). Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery . Journal of controlled release : official journal of the Controlled Release Society. 286. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 467-484.

Boroumand, Sam, Kumar, Niyanta, Lochhead, Jeffrey, Pizzo, Michelle, Nehra, Geetika, Thorne, Robert G.(2018). Intranasal delivery of antibodies bypasses the blood-brain barrier and results in significantly higher central nervous system levels than systemic administration . Faseb Journal. 32. (1).

Lochhead, Jeffrey J., Ronaldson, Patrick T., Davis, Thomas P.(2017). Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System . Aaps Journal. 19. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 910-920.

Kumar, Niyanta N., Gautam, Mohan, Lochhead, Jeffrey J., Wolak, Daniel J., Ithapu, Vamsi, Singh, Vikas, Thorne, Robert G.(2016). Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery . Scientific Reports. 6.

Lochhead, Jeffrey J., Wolak, Daniel J., Pizzo, Michelle E., Thorne, Robert G.(2015). Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration . Journal of Cerebral Blood Flow and Metabolism. 35. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 371-381.

Lochhead, Jeffrey J., Thorne, Robert G.(2012). Intranasal delivery of biologics to the central nervous system . Advanced Drug Delivery Reviews. 64. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 614-628.

Lochhead, Jeffrey J., McCaffrey, Gwen, Sanchez-Covarrubias, Lucy, Finch, Jessica D., DeMarco, Kristin M., Quigley, Colleen E., Davis, Thomas P., Ronaldson, Patrick T.(2012). Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain . American Journal of Physiology-Heart and Circulatory Physiology. 302. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString H582-H593.

Lochhead, Jeffrey J., McCaffrey, Gwen, Quigley, Colleen E., Finch, Jessica, DeMarco, Kristin M., Nametz, Nicole, Davis, Thomas P.(2011). Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation (vol 30, pg 1625, 2010) . Journal of Cerebral Blood Flow and Metabolism. 31. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 790-791.

Lochhead, Jeffrey J., McCaffrey, Gwen, Quigley, Colleen E., Finch, Jessica, DeMarco, Kristin M., Nametz, Nicole, Davis, Thomas P.(2010). Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation . Journal of Cerebral Blood Flow and Metabolism. 30. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1625-1636.

McCaffrey, Gwen, Willis, Colin L., Staatz, William D., Nametz, Nicole, Quigley, Carolyn A., Hom, Sharon, Lochhead, Jeffrey J., Davis, Thomas P.(2009). Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress . Journal of Neurochemistry. 110. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 58-71.

Sparks, DL, Sabbagh, MN, Connor, DJ, Lopez, J, Launer, LJ, Browne, P, Wasser, D, Johnson-Traver, S, Lochhead, J, Ziolwolski, C(2005). Atorvastatin for the treatment of mild to moderate Alzheimer disease - Preliminary results . Archives of Neurology. 62. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 753-757.

Lochhead, Jeff, Sparks, D Larry, Sabbagh, Marwan N, Connor, Donald J, Lopez, Jean, Launer, Lenore J, Petanceska, Suzana, Browne, Patrick, Wassar, Dawn, Johnson-Traver, Sherry, et al.(2005). Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD . Current Alzheimer research. 2. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 343-53.

Lochhead, Jeff, Sparks, D Larry, Petanceska, Suzana, Sabbagh, Marwan, Connor, Donald, Soares, Holly, Adler, Charles, Lopez, Jean, Ziolkowski, Chuck, Browne, Patrick(2005). Cholesterol, copper and Abeta in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT) . Current Alzheimer research. 2. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 527-39.

Sparks, DL, Sabbagh, MN, Connor, DJ, Launer, LJ, Petanceska, S, Baxter, L, Browne, P, Lopez, J, Wassar, D, Lochhead, J, et al.(2004). Benefits of atorvastatin in subjects with Alzheimer's disease . Circulation. 110. (17). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 813.

Sparks, DL, Connor, D, Lopez, J, Launer, L, Petanceska, S, Baxter, L, Wasser, D, Lochhead, J, Ziolowski, C, Idouraine, A, et al.(2004). Benefit of atorvastatin in the treatment of Alzheimer disease . Neurobiology of Aging. 25. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString S24.

Schreurs, BG, Smith-Bell, CA, Lochhead, J, Sparks, DL(2003). Cholesterol modifies classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response . Behavioral Neuroscience. 117. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1220-1232.

Lochhead, Jeff, Sparks, D. Larry, Horstman, Donna, Wagoner, Tom, Martin, Tim(2002). Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (A beta) in rabbit brain . Journal of Alzheimers Disease. 4. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 523-529.