プロフィール詳細

プロジェクトを作成

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Dr. Jessica T.に依頼

United States

Expertise in molecular biology and structural biology

プロフィール概要

I am a structural biologist with 12 years of experience in the laboratory as an X-ray crystallographer. I am a chemist by training and have expertise in the field of peptide synthesis. I have experience with scientific publishing, figure-making, illustration, teaching, and consulting.

専門分野

• ★ Biochemistry
• ★ Structural Biology
• ★ Technical & Scientific Writing
• ☆ Analytical Chemistry
• ☆ Crystallography
• ☆ X-Ray Crystallography
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Computational Chemistry
• ☆ Peptide Synthesis
• ☆ Computational Biology
• ☆ Microbiology
• ☆ Virology
• ☆ Molecular Virology
• ☆ Biophysics
• ☆ Biotechnology & Bioengineering
• ☆ Chemical Biology
• ☆ Science Outreach
• ☆ Science Education
• ☆ Drug Discovery
• ☆ Medicinal Chemistry
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Infectious Disease
• ☆ Viral Diseases
• ☆ COVID-19
• ☆ Pulmonology/Respiratory Disease
• ☆ Influenza
• ☆ Scientific Animation & Illustration
• ☆ Medical Illustration
• ☆ Science Communication
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Data Processing

職務経験

Scientific and technical writing, consulting

Freelancer

4月 2022 - 現在

Postdoctoral Researcher

University of California, San Francisco

4月 2020 - 4月 2022

Marie Curie postdoctoral fellow

Trinity College Dublin

1月 2019 - 3月 2020

学歴

PhD (Chemistry and Chemical Biology)

University of California San Francisco

8月 2011 - 9月 2018

(Chemistry)

University of Pennsylvania

7月 2010 - 6月 2011

BA (Chemistry)

Swarthmore College

8月 2006 - 6月 2010

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Jessica L. Thomaston, Marley L. Samways, Athina Konstantinidi, Chunlong Ma, Yanmei Hu, Hannah E. Bruce Macdonald, Jun Wang, Jonathan W. Essex, William F. DeGrado, Antonios Kolocouris (2021). Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity . Biochemistry.

Jessica L. Thomaston, Athina Konstantinidi, Lijun Liu, George Lambrinidis, Jingquan Tan, Martin Caffrey, Jun Wang, William F. Degrado, Antonios Kolocouris (2020). X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance . Biochemistry.

Jessica L. Thomaston, Yibing Wu, Nicholas Polizzi, Lijun Liu, Jun Wang, William F. DeGrado (2019). X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case . Journal of the American Chemical Society.

Marco Mravic, Jessica L. Thomaston, Maxwell Tucker, Paige E. Solomon, Lijun Liu, William F. DeGrado (2019). Packing of apolar side chains enables accurate design of highly stable membrane proteins . Science.

Jessica L. Thomaston, Nicholas F. Polizzi, Athina Konstantinidi, Jun Wang, Antonios Kolocouris, William F. DeGrado (2018). Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters . Journal of the American Chemical Society.

Huong T. Kratochvil, Jessica L. Thomaston, Feng Gai, William F. DeGrado(2018). Proton Stabilization and Conduction Pathway in the Matrix Protein M2 . Biophysical Journal. 114. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 240a--241a. Elsevier {BV}

Jessica L. Thomaston, William F. DeGrado(2018). X-Ray Crystal Structures of the Influenza a M2 Proton Channel Bound to Amantadine, Rimantadine, and Inhibiting Compounds . Biophysical Journal. 114. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 204a. Elsevier {BV}

Thomaston, J.L., Woldeyes, R.A., Nakane, T., Yamashita, A., Tanaka, T., Koiwai, K., Brewster, A.S., Barad, B.A., Chen, Y., Lemmin, T., et al.(2017). XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction . Proceedings of the National Academy of Sciences of the United States of America. 114. (51). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 13357-13362.

Jessica L. Thomaston, William F. DeGrado(2016). Crystal structure of the drug-resistant S31N influenza M2 proton channel . Protein Science. 25. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1551--1554. Wiley-Blackwell

Jessica Thomaston, Elizabeth L. Baxter, Laura Aguila, Roberto Alonso-Mori, Christopher O. Barnes, Christopher A. Bonagura, Winnie Brehmer, Axel T. Brunger, Guillermo Calero, Tom T. Caradoc-Davies, et al.(2016). High-density grids for efficient data collection from multiple crystals . Acta Crystallographica Section D Structural Biology. 72. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2--11. International Union of Crystallography ({IUCr})

Baxter, E.L., Aguila, L., Alonso-Mori, R., Barnes, C.O., Bonagura, C.A., Brehmer, W., Brunger, A.T., Calero, G., Caradoc-Davies, T.T., Chatterjee, R., et al.(2016). High-density grids for efficient data collection from multiple crystals . Acta Crystallographica Section D: Structural Biology. 72. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2-11.

Jessica L. Thomaston, Mercedes Alfonso-Prieto, Rahel A. Woldeyes, James S. Fraser, Michael L. Klein, Giacomo Fiorin, William F. DeGrado(2015). High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction . Proceedings of the National Academy of Sciences. 112. (46). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 14260--14265. Proceedings of the National Academy of Sciences

Jessica Thomaston, Shenstone Huang, Bryan Green, Megan Thompson, Richard Chen, William F. DeGrado, Kathleen P. Howard(2015). C-terminal juxtamembrane region of full-length M2 protein forms a membrane surface associated amphipathic helix . Protein Science. 24. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 426--429. Wiley-Blackwell

Jessica L. Thomaston, Phuong A. Nguyen, Emily C. Brown, Mary Alice Upshur, Jun Wang, William F. DeGrado, Kathleen P. Howard(2012). Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling . Protein Science. 22. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 65--73. Wiley-Blackwell

Jessica Thomaston, Kathleen Howard(2010). Site-Directed Spin-Label EPR Studies Report on Drug-Induced Conformational Change of Influenza a M2 Protein . Biophysical Journal. 98. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 48a. Elsevier {BV}

OTHER

J.L. Thomaston, R.A. Woldeyes, J.S. Fraser, W.F. DeGrado(2017). XFEL structure of influenza A M2 wild type TM domain at low pH in the lipidic cubic phase at room temperature . Protein Data Bank, Rutgers University

J.L. Thomaston, R.A. Woldeyes, J.S. Fraser, W.F. DeGrado(2017). XFEL structure of influenza A M2 wild type TM domain at high pH in the lipidic cubic phase at room temperature . Protein Data Bank, Rutgers University

J.L. Thomaston, R.A. Woldeyes, J.S. Fraser, W.F. DeGrado(2017). XFEL structure of influenza A M2 wild type TM domain at intermediate pH in the lipidic cubic phase at room temperature . Protein Data Bank, Rutgers University

J.L. Thomaston, W.F. DeGrado(2016). Influenza A M2 transmembrane domain drug-resistant S31N mutant at pH 8.0 . Protein Data Bank, Rutgers University

J.L. Thomaston(2015). Influenza A M2 wild type TM domain at high pH in the lipidic cubic phase under cryo diffraction conditions . Protein Data Bank, Rutgers University

J.L. Thomaston, W.F. DeGrado(2015). Influenza A M2 wild type TM domain at high pH in the lipidic cubic phase under room temperature diffraction conditions . Protein Data Bank, Rutgers University

J.L. Thomaston, W.F. DeGrado(2015). Influenza A M2 wild type TM domain at low pH in the lipidic cubic phase under cryo diffraction conditions . Protein Data Bank, Rutgers University

J.L. Thomaston, W.F. DeGrado(2015). Influenza A M2 wild type TM domain at low pH in the lipidic cubic phase under room temperature diffraction conditions . Protein Data Bank, Rutgers University