プロフィール詳細

プロジェクトを作成

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Dr. Jeya Maheshwari J.に依頼

India

Biotechnology researcher with 10+ years of experience | Expert in Proteomics | Experienced in big data analysis

プロフィール概要

I am a biochemist with a PhD in biotechnology and an advanced diploma in Bioinformatics. I have more than 10+ years of research experience, particularly in the area of human diseases. My core expertise lies in the use of proteomics to understand disease mechanisms and to identify predictive and prognostic markers, which would help predict a disease onset or progression. I had employed these approaches in two major eye diseases and identified and validated prognostic markers for diabetic retinopathy and predictive protein markers for fungal keratitis. I have wide microbiological experience and have worked with clinically relevant bacteria (Mycobacterium) and fungi (Aspergillus and Fusarium). I have extraordinary skill in designing, planning and executing research projects and have successfully completed a number of private and govt funded projects. Owing to my bioinformatics training, I am also well versed with big data analysis (RNA-seq and proteomics data). I use R to perform statistical analysis and create visualisations for the data analyzed.

専門分野

• ☆ Molecular Biology
• ☆ Proteomics
• ☆ Big Data Analytics
• ☆ R
• ☆ Scientific Animation & Illustration
• ☆ Technical & Scientific Writing
• ☆ Scientific Proofreading & Editing

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling, Statistical Analysis, Data Visualization, Big Data Analytics, Data Cleaning, Data Insights

職務経験

Scientist

Aravind Medical Research Foundation

2月 2013 - 8月 2022

Research Associate

DSQ Biotech

7月 2000 - 3月 2002

学歴

PhD (School of Biotechnology)

Madurai Kamaraj University

2003 - 2011

Advanced Diploma in Bioinformatics

Madurai Kamaraj University

6月 2002 - 4月 2003

M. Phil in Biochemistry

Madras University

6月 1999 - 5月 2000

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Jeya Maheshwari Jayapal, Lakshmi Prabha Venugopalan, Vishukumar Aimanianda, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Dharmalingam Kuppamuthu (2023). Comparative proteome analysis identifies species-specific signature proteins in Aspergillus pathogens . Applied Microbiology and Biotechnology.

(2022). Multicenter Evaluation of Diagnostic Circulating Biomarkers to Detect Sight-Threatening Diabetic Retinopathy . JAMA ophthalmology.

(2021). Species-Specific Immunological Reactivities Depend on the Cell-Wall Organization of the Two <i>Aspergillus</i>, <i>Aspergillus fumigatus</i> and <i>A. flavus</i> . Frontiers in cellular and infection microbiology.

Wong, S.S.W., Venugopalan, L.P., Beaussart, A., Karnam, A., Mohammed, M.R.S., Jayapal, J.M., Bretagne, S., Bayry, J., Prajna, L., Kuppamuthu, D., et al.(2021). Species-Specific Immunological Reactivities Depend on the Cell-Wall Organization of the Two Aspergillus, Aspergillus fumigatus and A. flavus . Frontiers in Cellular and Infection Microbiology. 11.

Rathinam, S., Daniel, I., Kuppamuthu, D., Jayapal, J.M.(2021). Molecular Mimicry between Betaine Aldehyde Dehydrogenase of Leptospira and Retinal Dehydrogenase 1 of Human Lens: A Potential Trigger for Cataract Formation in Leptospiral Uveitis Patients . Ocular Immunology and Inflammation. 29. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 579-586.

(2020). Differential Interactions of Serum and Bronchoalveolar Lavage Fluid Complement Proteins with Conidia of Airborne Fungal Pathogen Aspergillus fumigatus . Infection and immunity.

(2020). Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear . Frontiers in cellular and infection microbiology.

Shait Mohammed, M.R., Krishnan, S., Amrathlal, R.S., Jayapal, J.M., Namperumalsamy, V.P., Prajna, L., Kuppamuthu, D.(2020). Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear . Frontiers in Cellular and Infection Microbiology. 10.

Wong, S.S.W., Daniel, I., Gangneux, J.-P., Jayapal, J.M., Guegan, H., Delli&#232;re, S., Lalitha, P., Shende, R., Madan, T., Bayry, J., et al.(2020). Differential interactions of serum and bronchoalveolar lavage fluid complement proteins with conidia of airborne fungal pathogen aspergillus fumigatus . Infection and Immunity. 88. (9).

(2019). Molecular Mimicry between Betaine Aldehyde Dehydrogenase of <i>Leptospira</i> and Retinal Dehydrogenase 1 of Human Lens: A Potential Trigger for Cataract Formation in Leptospiral Uveitis Patients . Ocular immunology and inflammation.

(2019). Quantitative profiling of tear proteome reveals down regulation of zinc alpha-2 glycoprotein in Aspergillus flavus keratitis patients . Experimental eye research.

(2019). Dataset for the spore surface proteome and hydrophobin A/RodA proteoforms of A.flavus . Data in brief.

Shait Mohammed, M.R., Balamurgan, M.K., Amrathlal, R.S., Kannan, P., Jayapal, J.M., Namperumalsamy, V.P., Prajna, L., Dharmalingam, K.(2019). Dataset for the spore surface proteome and hydrophobin A/RodA proteoforms of A.flavus . Data in Brief. 23.

Shait Mohammed, M.R., Balamurugan, M., Amrathlal, R.S., Kannan, P., Jayapal, J.M., Namperumalsamy, V.P., Prajna, L., Kuppamuthu, D.(2019). Identification of the proteoforms of surface localized Rod A of Aspergillus flavus and determination of the mechanism of proteoform generation . Journal of Proteomics. 193. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 62-70.

(2018). Identification of the proteoforms of surface localized Rod A of Aspergillus flavus and determination of the mechanism of proteoform generation . Journal of proteomics.

Kandhavelu, J., Demonte, N.L., Namperumalsamy, V.P., Prajna, L., Thangavel, C., Jayapal, J.M., Kuppamuthu, D.(2017). Aspergillus flavus induced alterations in tear protein profile reveal pathogen-induced host response to fungal infection . Journal of Proteomics. 152. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 13-21.

(2016). Data set of <i>Aspergillus flavus</i> induced alterations in tear proteome: Understanding the pathogen-induced host response to fungal infection . Data in brief.

(2016). Aspergillus flavus induced alterations in tear protein profile reveal pathogen-induced host response to fungal infection . Journal of proteomics.

Kandhavelu, J., Demonte, N.L., Namperumalsamy, V.P., Prajna, L., Thangavel, C., Jayapal, J.M., Kuppamuthu, D.(2016). Data set of Aspergillus flavus induced alterations in tear proteome: Understanding the pathogen-induced host response to fungal infection . Data in Brief. 9. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 888-894.

Selvam, R.M., Nithya, R., Devi, P.N., Shree, R.S.B., Nila, M.V., Demonte, N.L., Thangavel, C., Maheshwari, J.J., Lalitha, P., Prajna, N.V., et al.(2015). Exoproteome of Aspergillus flavus corneal isolates and saprophytes: Identification of proteoforms of an oversecreted alkaline protease . Journal of Proteomics. 115. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 23-35.

(2014). Data set for the mass spectrometry based exoproteome analysis of Aspergillus flavus isolates . Data in brief.

Maheshwari, J.J., Dharmalingam, K.(2013). Protective role of Mycobacterium leprae small heat-shock protein in heterologous hosts, Escherichia coli and Mycobacterium smegmatis, grown under stress . Journal of Medical Microbiology. 62. (PART7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 959-967.

Lini, N., Rehna, E.A.A., Shiburaj, S., Maheshwari, J.J., Shankernarayan, N.P., Dharmalingam, K.(2008). Functional characterization of a small heat shock protein from Mycobacterium leprae . BMC Microbiology. 8.