プロフィール詳細

プロジェクトを作成

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Dr. Jingjing Y.に依頼

United States

Pharmaceutical and Biotech Expert; 8 Years Industry Experience (AstraZeneca, Eli Lilly, Biogen)

プロフィール概要

PhD Chemist | Oligonucleotide & Biologics DMPK Expert | Bioanalysis & Process Development Leader Accomplished pharmaceutical scientist with 8+ years in drug discovery & development at AstraZeneca, Eli Lilly, and Biogen. Specialized in: Oligonucleotide Therapeutics: Leading DMPK (Drug Metabolism & Pharmacokinetics) projects from preclinical to clinical stages. Bioanalysis: Method development/validation for small molecules, Oligonucleotides, biologics, and gene therapies (LC-MS, hybrid LBA/LC-MS). Process Development: Optimizing synthetic and analytical workflows to accelerate CMC (Chemistry, Manufacturing, Controls) and regulatory submissions (FDA/EMA). Cross-functional Leadership: Bridging DMPK, CMC, and preclinical teams to advance complex therapeutics (oligos, gene therapies, biologics). Core Skills: Oligonucleotide chemistry, DMPK, Bioanalysis, PK/PD modeling, high-resolution MS, regulatory strategy, synthetic route optimization, analytical QC.

専門分野

• ☆ Drug Discovery
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Biologic & Biosimilar Development
• ☆ Bioanalytical Testing
• ☆ Preclinical ADME/PK/PD
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Investigational New Drug (IND) Application Consulting
• ☆ Bioavailability
• ☆ Gene Therapy

サービス

• Writing
• Consulting

Writing Technical Writing

Consulting Business Strategy Consulting, Go-to-Market Strategy Consulting, Healthcare Consulting, Scientific and Technical Consulting, Regulatory Consulting

職務経験

AstraZeneca (Sweden)

- 現在

Senior Scientist

AstraZeneca

2月 2021 - 現在

Scientist

Eli Lilly

4月 2020 - 2月 2021

Analytical Scientist

Medpace

4月 2019 - 4月 2020

Scientist

Biogen

4月 2018 - 4月 2019

学歴

PhD Chemistry

Worcester Polytechnic Institute

8月 2012 - 10月 2017

Masters of Science

Nankai University

9月 2007 - 6月 2010

Bachelors, Chemistry

Nankai University

9月 2002 - 6月 2006

認定資格

• PhD Degree

  Worcester Polytechnic Institute

  10月 2017 - 現在

出版物

JOURNAL ARTICLE

Lovrić J, Yan J, Li X, Karlsborn T, Bood M, Dahlén A, Hilgendorf C, Bhatt DK(2025). In Vitro Structure-Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases . Pharmacology research & perspectives.

et al., Bhattacharya C, Sandinge AS, Bragg RA, Heijer M, Yan J, Andersson LC, Jurva U, Pelay-Gimeno M, Vaes WHJ, de Ligt RAF(2023). Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, following Administration of an Oral Radiolabeled Microtracer Dose in Humans . Drug metabolism and disposition: the biological fate of chemicals.

MOF Decomposition and Introduction of Repairable Defects Using a Photodegradable Strut @article{Yan_2019, title={MOF Decomposition and Introduction of Repairable Defects Using a Photodegradable Strut}, volume={25}, ISSN={1521-3765}, url={http://dx.doi.org/10.1002/chem.201901213}, DOI={10.1002/chem.201901213}, number={35}, journal={Chemistry – A European Journal}, publisher={Wiley}, author={Yan, Jingjing and MacDonald, John C. and Maag, Alex R. and Coudert, François‐Xavier and Burdette, Shawn C.}, year={2019}, month=may, pages={8393–8400} } . Chemistry – A European Journal.

Jingjing Yan, Alexander D. Carl, Alex R. Maag, John C. MacDonald, Peter Müller, Ronald Grimm, Shawn Burdette(2019). Detection of adsorbates on emissive MOF surfaces with X-ray photoelectron spectroscopy . Dalton Transactions. 48. (14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4520–4529. Royal Society of Chemistry (RSC)

Emissive Azobenzenes Delivered on a Silver Coordination Polymer @article{Yan_2018, title={Emissive Azobenzenes Delivered on a Silver Coordination Polymer}, volume={57}, ISSN={1520-510X}, url={http://dx.doi.org/10.1021/acs.inorgchem.8b02845}, DOI={10.1021/acs.inorgchem.8b02845}, number={23}, journal={Inorganic Chemistry}, publisher={American Chemical Society (ACS)}, author={Yan, Jingjing and Wilbraham, Liam and Basa, Prem N. and Schüttel, Mischa and MacDonald, John C. and Ciofini, Ilaria and Coudert, François-Xavier and Burdette, Shawn C.}, year={2018}, month=nov, pages={15009–15022} } . Inorganic Chemistry.

Jingjing Yan, Yong Guo, Azza Altawashi, Basem Moosa, Sébastien Lecommandoux, Niveen M. Khashab(2012). Experimental and theoretical evaluation of nanodiamonds as pH triggered drug carriers . New Journal of Chemistry. 36. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1479. Royal Society of Chemistry (RSC)