プロフィール詳細

プロジェクトを作成

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Dr. Jinseol R.に依頼

South Korea

Preclinical Cell Biology Expert for Early-Stage Drug Discovery | MoA, Assay Design & Data Interpretation

プロフィール概要

I am a PhD Cell Biologist specializing in mechanism-of-action (MoA) studies, cell-based assay development, and early-stage preclinical validation. For biotech startups, I provide lean, fast, data-driven scientific support that strengthens your drug hypothesis, clarifies mechanistic rationale, and helps de-risk your pipeline before costly in vivo or IND-enabling studies. I have 20+ years of experience across academia and industry, including leadership roles as Team Leader, Director, and CTO. I’ve developed 35+ SOPs, authored 50+ due diligence reports, and led mechanistic programs for therapeutic candidates targeting neurodegeneration, inflammation, fibrosis, and arthritis. I help startups: - Validate drug concepts with robust cell-based assays - Generate clear mechanistic rationale for investors - Design MoA studies that fit tight budgets & timelines - Produce data-driven scientific reports for partnerships - Review datasets and identify actionable next steps My goal is to ensure you advance only the most promising drug concepts—with confidence and scientific clarity.

専門分野

• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Neuroscience
• ☆ Neuropharmacology
• ☆ Molecular Neuroscience
• ☆ Neurobiology
• ☆ Cell Culture
• ☆ Primary Cells

サービス

• Writing
• Research
• Consulting

Writing Technical Writing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

職務経験

Chief Technology Officer (CTO)

Biopharma Corp.

3月 2023 - 6月 2025

Director

Biopharma Corp.

3月 2023 - 6月 2025

Team Leader

Aribio

3月 2019 - 2月 2023

Assistant Professor

Keimyung University Dongsan Hospital

3月 2017 - 2月 2019

Research Professor

Gwangju Institute of Science and Technology

1月 2009 - 2月 2017

Postdoctoral Fellow

UCSF

1月 2005 - 10月 2008

学歴

Ph. D (Biological Sciences)

University of Iowa

8月 2000 - 7月 2004

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

(2023). Proteomic analysis of human synovial fluid reveals potential diagnostic biomarkers for ankylosing spondylitis (vol 17, 20, 2020) . CLINICAL PROTEOMICS.

(2022). Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions . ALZHEIMERS RESEARCH & THERAPY.

(2020). Proteomic analysis of human synovial fluid reveals potential diagnostic biomarkers for ankylosing spondylitis . CLINICAL PROTEOMICS.

(2019). SYNOVIAL FLUID PROTEOMICS IN PATIENTS WITH ANKYLOSING SPONDYLITIS . ANNALS OF THE RHEUMATIC DISEASES.

(2018). BATF regulates collagen-induced arthritis by regulating T helper cell differentiation . ARTHRITIS RESEARCH & THERAPY.

(2017). Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes . NATURE COMMUNICATIONS.

(2017). Inhibition of BATF/JUN transcriptional activity protects against osteoarthritic cartilage destruction . ANNALS OF THE RHEUMATIC DISEASES.

(2015). Reciprocal regulation by hypoxia-inducible factor-2α and the NAMPT-NAD<SUP>+</SUP>-SIRT axis in articular chondrocytes is involved in osteoarthritis . OSTEOARTHRITIS AND CARTILAGE.

(2014). Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis . CELL.

(2012). α-Catenin Inhibits β-Catenin-T-cellFactor/Lymphoid Enhancing Factor Transcriptional Activity and Collagen Type II Expression in Articular Chondrocytes through Formation of Gli3R.α-Catenin.β-Catenin Ternary Complex . JOURNAL OF BIOLOGICAL CHEMISTRY.

(2011). Cytokine-like 1 Knock-out Mice (<i>Cytl1</i><SUP>-/-</SUP>) Show Normal Cartilage and Bone Development but Exhibit Augmented Osteoarthritic Cartilage Destruction . JOURNAL OF BIOLOGICAL CHEMISTRY.

(2011). Interleukin-6 Plays an Essential Role in Hypoxia-Inducible Factor 2α-Induced Experimental Osteoarthritic Cartilage Destruction in Mice . ARTHRITIS AND RHEUMATISM.

(2010). α-CATENIN FUNCTIONS AS A NUCLEAR FACTOR TO INHIBIT THE WNT/β-CATENIN SIGNALING IN ARTICULAR CHONDROCYTES . OSTEOARTHRITIS AND CARTILAGE.

(2007). Cables links Robo-bound Abl kinase to N-cadherin-bound β-catenin to mediate Slit-induced modulation of adhesion and transcription . NATURE CELL BIOLOGY.