プロフィール詳細

プロジェクトを作成

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★★★★★

☆☆☆☆☆

Dr. Joaquim G.に依頼

Spain

Microscopy Facility Manager - Basic Research / 15+ years mentoring PhD students anf master's, Peer reviewer/author.

プロフィール概要

Creative problem-solver with clinical and research laboratory experience, mentoring PhD students, writing grants and manuscripts, preparing presentations and troubleshooting technical issues in the lab environment. Intensive investigative credentials in Developmental Biology, rare diseases and cancer identifying genes, signaling pathways and morphogenetic processes by using cellular and animal models combined with genomic, proteomic, imaging and bioinformatic tools. Strong background in embryonic phenotypic screen, gene mapping and advanced microscopy techniques.

専門分野

• ☆ Developmental Biology
• ☆ Embryology
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Apoptosis
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Gene Expression Analysis
• ☆ Mutagenesis
• ☆ Plasmid DNA
• ☆ Neuroscience
• ☆ Histology
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Literature Search
• ☆ Presentation Design
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ Science Communication
• ☆ Scientific Proofreading & Editing
• ☆ Language Translation
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing, Technical Writing

Research User Research, Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Image Processing, Image Analysis

職務経験

Researcher and Manager of Advanced Microscopy Unit

Josep Carreras Leukaemia Research Institute

4月 2023 - 現在

Research Assistant - Research Associate

Centro Nacional de Investigaciones Cardiovasculares (CNIC)

1月 2015 - 1月 2023

Postdoctoral Researcher

Memorial Sloan Kettering Cancer Center

6月 2008 - 1月 2015

学歴

PhD in Biology

Universitat de Barcelona

3月 2002 - 3月 2007

認定資格

• Profesor Contratado Doctor

  ANECA

  3月 2022 - 現在

出版物

JOURNAL ARTICLE

Grego-Bessa, Joaquim, Piotr Kobialka, Judith Llena Sopena, Nerea Deleyto-Seldas, Munar-Gelabert M, Dengra JA, Pilar Villacampa, Albinyà-Pedrós A, Laia Muixi, Jorge Andrade, et al. (2023). PI3K-C2β limits mTORC1 signaling and angiogenic growth . Science signaling.

Joaquim Grego-Bessa, Paula Gómez-Apiñaniz, Belén Prados, Manuel José Gómez, Donal MacGrogan, José Luis de la Pompa (2023). Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development . Circulation Research.

Joaquim Grego-Bessa, Marcos Siguero-Álvarez, Alejandro Salguero-Jiménez, Jorge de la Barrera, Donal MacGrogan, Belén Prados, Fernando Sánchez-Sáez, Rebeca Piñeiro-Sabarís, Natalia Felipe-Medina, Carlos Torroja, et al. (2023). A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve . Circulation.

Grego-Bessa, Joaquim, Tamara Gonzalez-Costa, Jose Luis de la Pompa(2022). En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos . Journal of Visualized Experiments. (185). {MyJove} Corporation

Joaquim Grego-Bessa, Antonio Cuevas-Navarro, Laura Rodriguez-Muñoz, Alice Cheng, Katherine A Rauen, Anatoly Urisman, Frank McCormick, Gerardo Jimenez, Pau Castel(2022). Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs . eLife. 11. {eLife} Sciences Publications, Ltd

Rebeca Torregrosa-Carrión, Rebeca Piñeiro-Sabarís, Marcos Siguero-Álvarez, Joaquím Grego-Bessa, Luis Luna-Zurita, Vitor Samuel Fernandes, Donal MacGrogan, Didier Y. R. Stainier, José Luis de la Pompa(2021). Adhesion G protein–coupled receptor Gpr126/Adgrg6 is essential for placental development . Science Advances. 7. (46). American Association for the Advancement of Science ({AAAS})

Joaquim Grego-Bessa, Paula Llabata, Manuel Torres-Diz, Antonio Gomez, Laureano Tomas-Daza, Octavio A. Romero, Pere Llinas-Arias, Alfonso Valencia, Manel Esteller, Biola M. Javierre, et al.(2021). MAX mutant small-cell lung cancers exhibit impaired activities of MGA-dependent noncanonical polycomb repressive complex . Proceedings of the National Academy of Sciences. 118. (37). Proceedings of the National Academy of Sciences

Joaquim Grego-Bessa, Jasmine C. Wong, Pedro A. Perez-Mancera, Tannie Q. Huang, Jangkyung Kim, Maria del pilar Alzamora, Scott C. Kogan, Amnon Sharir, Susan H. Keefe, Carolina E. Morales, et al.(2020). KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice . JCI Insight. American Society for Clinical Investigation

Joaquim Grego-Bessa, Stanislao Igor Travisano, Vera Lucia Oliveira, Belén Prados, Rebeca Piñeiro-Sabarís, Vanesa Bou, Manuel J Gómez, Fátima Sánchez-Cabo, Donal MacGrogan, José Luis de la Pompa(2019). Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade . eLife. 8. {eLife} Sciences Publications, Ltd

Salguero-Jiménez, A., Grego-Bessa, J., D'Amato, G., Jiménez-Borreguero, L. J., de la Pompa, J. L.(2018). Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function . PLoS One. 13. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e0203100.

Joaquim Grego-Bessa, Alba Azagra, Lidia Román-González, Olga Collazo, Javier Rodríguez-Ubreva, Virginia G. de Yébenes, Bruna Barneda-Zahonero, Jairo Rodríguez, Manuel Castro de Moura, Irene Fernández-Duran, et al.(2016). In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development . Journal of Experimental Medicine. 213. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2591--2601. Rockefeller University Press

Castel, P., Carmona, F. J., Grego-Bessa, J., Berger, M. F., Viale, A., Anderson, K. V., Bague, S., Scaltriti, M., Antonescu, C. R., Baselga, E., et al.(2016). Somatic PIK3CA mutations as a driver of sporadic venous malformations . Sci Transl Med. 8. (332). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 332ra42.

Grego-Bessa, J., Bloomekatz, J., Castel, P., Omelchenko, T., Baselga, J., Anderson, K. V.(2016). The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium . Elife. 5.

Grego-Bessa, J., Hildebrand, J., Anderson, K. V.(2015). Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains . Development.

VanDusen, N. J., Casanovas, J., Vincentz, J. W., Firulli, B. A., Osterwalder, M., Lopez-Rios, J., Zeller, R., Zhou, B., Grego-Bessa, J., De La Pompa, J. L., et al.(2014). Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium . Cell Rep. 9. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2071-83.

Omelchenko, T., Rabadan, M. A., Hernández-Martínez, R., Grego-Bessa, J., Anderson, K. V., Hall, A.(2014). β-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo . Genes Dev. 28. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2764-77.

Grego-Bessa, Joaquim, Mahaffey, James P., Liem, Karel F., Jr., Anderson, Kathryn V.(2013). Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo . Development. 140. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1262-1271.

Grego-Bessa, Joaquim, Bloomekatz, Joshua, Migeotte, Isabelle, Anderson, Kathryn V.(2012). Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo . Developmental Biology. 364. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 192-201.

Grego-Bessa, Joaquim, Migeotte, Isabelle, Anderson, Kathryn V.(2011). Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo . Development. 138. (14). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3011-3020.

Grego-Bessa, Joaquim, Luna-Zurita, Luis, Prados, Belen, Luxan, Guillermo, del Monte, Gonzalo, Benguria, Alberto, Adams, Ralf H., Maria Perez-Pomares, Jose, Luis de la Pompa, Jose(2010). Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation . Journal of Clinical Investigation. 120. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3493-3507.

Del Monte, G, Grego-Bessa, J, Gonzalez-Rajal, A, Bolos, V, De La Pompa, JL(2007). Monitoring Notch1 activity in development: Evidence for a feedback regulatory loop . Developmental Dynamics. 236. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2594-2614.

Bolos, V, Grego-Bessa, J, de la Pompa, JL(2007). Notch signaling in development and cancer . Endocrine Reviews. 28. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 339-363.

Grego-Bessa, J, Luna-Zurita, L, del Monte, G, Bolos, V, Melgar, P, Arandilla, A, Garratt, AN, Zang, H, Mukouyama, YS, Chen, HY, et al.(2007). Notch signaling is essential for ventricular chamber development . Developmental Cell. 12. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 415-429.

Grego-Bessa, J, Diez, J, Timmerman, L, de la Pompa, JL(2004). Notch and epithelial-mesenchyme transition in development and tumor progression - Another turn of the screw . Cell Cycle. 3. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 718-721.

Timmerman, LA, Grego-Bessa, J, Raya, A, Bertran, E, Perez-Pomares, JM, Diez, J, Aranda, S, Palomo, S, McCormick, F, Izpisua-Belmonte, JC, et al.(2004). Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation . Genes & Development. 18. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 99-115.

Raya, A, Kawakami, Y, Rodriguez-Esteban, C, Buscher, D, Koth, CM, Itoh, T, Morita, M, Raya, RM, Dubova, I, Bessa, JG, et al.(2003). Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos . Genes & Development. 17. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1213-1218.