プロフィール詳細

プロジェクトを作成

★★★★★

☆☆☆☆☆

★★★★★

☆☆☆☆☆

Dr. Joe V.に依頼

United States

Biomedical Scientist Specializing in Cardiovascular Research, Cardiac Metabolism & Translational Therapeutics

プロフィール概要

I am a biomedical scientist specializing in cardiovascular research, cardiac metabolism, and translational therapeutic development, with over a decade of experience leading mechanistic, preclinical, and translational studies. My work focuses on understanding how metabolic and molecular pathways influence myocardial injury, remodeling, and recovery and on developing therapeutic strategies that target these processes. Currently, I serve as a Staff Scientist in Cardiothoracic Surgery, where I lead research programs focused on developing novel therapeutics to treat chronic/advanced diseases. My projects span metabolite transport, myocardial salvage in ischemia-reperfusion injury, cardiac microplastic toxicity, and cardiac metabolic remodeling. I also have ongoing collaborations in preclinical large-animal models of myocardial infarction and cardiac arrest, therapeutic testing in ischemia-reperfusion injury, and translational biobanking. My expertise includes: Cardiac metabolism & metabolic transporters Myocardial ischemia-reperfusion injury, cardioprotection & salvage pathways Preclinical model design (murine, swine, ex vivo perfusion, cellular models) Toxicology of microplastics & emerging environmental stressors on the heart Therapeutic development including small molecules, microRNA treatments, and tissue-engineered patches Biobanking, tissue processing, and translational human sample workflows Scientific writing (grant proposals, manuscripts, white papers, regulatory summaries) Data analysis (metabolic assays, imaging, functional data, histology, molecular assays) Across my career, I have worked with clinicians, biotech partners, and interdisciplinary research teams to develop mechanistic insights, guide therapeutic strategy, and design rigorous, high-value experiments. I excel at translating complex biological problems into clear, actionable plans, whether for scientific manuscripts, preclinical trial designs, or early-stage therapeutic development. I welcome collaborations involving study design, experimental strategy, data interpretation, scientific writing, grant development, literature synthesis, translational planning, and mechanistic consultation in cardiovascular and metabolic research.

専門分野

• ☆ Chemical Reagent Development
• ☆ Catalysis
• ☆ Microbiology
• ☆ Microbiome Research
• ☆ Microbiological Assays
• ☆ Biostatistics
• ☆ Zoology
• ☆ Mammalian Biology
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Structural Biology
• ☆ Apoptosis
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Antioxidants
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ Omics
• ☆ Transcriptomics
• ☆ Comparative Genomics
• ☆ Lipidomics
• ☆ Proteomics
• ☆ Metabolomics
• ☆ Genomics
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ Next Generation Sequencing (NGS)
• ☆ DNA Sequencing
• ☆ Protein Sequencing
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ RNA Synthesis
• ☆ RNA Sequencing
• ☆ DNA/Gene Synthesis
• ☆ DNA Damage & Repair
• ☆ Kinases
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Membrane Biology
• ☆ Gene Regulation
• ☆ Histology
• ☆ Biomarker Discovery
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Large Scale Cell Culture
• ☆ Cell Surface Receptors
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Cell Aging
• ☆ Exercise & Fitness
• ☆ Physical Fitness
• ☆ Athletic Training & Coaching
• ☆ Personal Training
• ☆ Bioethics & Medical Ethics
• ☆ Publishing
• ☆ Educational Counseling
• ☆ Academic Testing
• ☆ Higher Education
• ☆ Python
• ☆ SPSS
• ☆ Excel
• ☆ Java
• ☆ SAS
• ☆ R
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Phenotypic Assays
• ☆ Drug Design
• ☆ Medical Devices
• ☆ Medical Device Development
• ☆ Medical Implants
• ☆ Wearable Technology
• ☆ In vitro Diagnostics
• ☆ In vitro Diagnostic Design
• ☆ Biomarker Analysis
• ☆ Lab-on-a-Chip Devices
• ☆ Medical Imaging/Radiology
• ☆ Human Biology
• ☆ Kinesiology & Exercise Science
• ☆ Precision Medicine
• ☆ Endocrinology
• ☆ Diabetes
• ☆ Cardiovascular Disease
• ☆ Interventional Cardiology
• ☆ Cardiovascular Disease Management
• ☆ Clinical Laboratory Science
• ☆ Molecular Pathology
• ☆ Cardiac Surgery
• ☆ Pulmonology/Respiratory Disease
• ☆ Lung Cancer
• ☆ Medical Toxicology
• ☆ Counseling & Mental Health Support
• ☆ Occupational Therapy
• ☆ Electrocardiogram (ECG)
• ☆ Echocardiography
• ☆ DEXA Scan
• ☆ Complementary & Alternative Medicine
• ☆ Traditional Medicine
• ☆ Recreational Therapy
• ☆ Medical Terminology
• ☆ Medical Sciences
• ☆ Connective Tissue
• ☆ Inflammation
• ☆ Metabolism & Metabolic Disease
• ☆ Medical Equipment & Supplies
• ☆ Cardiothoracic Radiology
• ☆ Muscoskeletal Radiology
• ☆ Concept Development
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ User Research
• ☆ Feasibility Studies
• ☆ Technology Scouting
• ☆ Fact Checking
• ☆ Literature Search
• ☆ Gap Analysis
• ☆ Gray Literature Search
• ☆ Medical Writing
• ☆ Medical Content Writing
• ☆ Continuing Medical Education (CME) Materials
• ☆ Healthcare Communications
• ☆ Research Summaries & Abstracts
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Instructional Materials
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ White Papers
• ☆ Case Studies
• ☆ Textbook Content Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Course Content Writing
• ☆ Grant Writing

サービス

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Copywriting, Creative Writing

Research Market Research, User Research, Meta-Research, Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Go-to-Market Strategy Consulting, Digital Strategy Consulting, Healthcare Consulting, Legal Consulting, Operations Consulting, Scientific and Technical Consulting, Financial Consulting, Regulatory Consulting, Manufacturing Consulting

Data & AI Statistical Analysis, Image Processing, Image Analysis, Algorithm Design-Non ML, Algorithm Design-ML, Big Data Analytics, Text Mining & Analytics, Data Mining, Data Cleaning, Data Processing, Data Insights

Product Development Formulation, Deformulation, Stability/Shelf Life Testing, Product Evaluation, Material Sourcing, Manufacturing, Quality Assurance & Control (QA/QC), Product Compliance , Product Launch Support, Packaging Design, Prototyping, Reverse Engineering, Device Fabrication

職務経験

Researcher

University of Utah

6月 2020 - 現在

Reseacher

Michigan State University

6月 2016 - 5月 2020

Exercise Rehabilitator

Atrium Health

5月 2015 - 6月 2016

Researcher

UNC Charlotte

6月 2013 - 5月 2015

学歴

PhD

Michigan State University

6月 2016 - 5月 2020

MS

UNC Charlotte

6月 2013 - 5月 2015

BS

Utah Valley University

1月 2009 - 5月 2012

認定資格

• Registered Clinical Exercise Physiologist

  American College of Sports Medicine

  6月 2015 - 現在

出版物

JOURNAL ARTICLE

Rana Hamouche, Sean M. Tatum, Elizabeth Dranow, J. Alan Maschek, Christos P. Kyriakopoulos, Thirupura S. Shankar, Joseph R. Visker, Jing Ling, Konstantinos Sideris, Craig H. Selzman, et al. (2026). The Role of Sphingolipids in Myocardial Recovery Mediated by Mechanical Unloading and Circulatory Support . JACC: Basic to Translational Science.

Jing Li, Pia Balmaceda, Thuy Ha, Joseph R. Visker, Nicole Maalouf, Eugene Kwan, Guillaume L. Hoareau, Michel Accad, Ravi Ranjan, Craig H. Selzman, et al. (2024). Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs . npj Regenerative Medicine.

Christos P. Kyriakopoulos, Iosif Taleb, Eleni Tseliou, Konstantinos Sideris, Rana Hamouche, Eleni Maneta, Marisca Nelson, Ethan Krauspe, Sean Selko, Joseph R. Visker, et al. (2024). Impact of Diabetes and Glycemia on Cardiac Improvement and Adverse Events Following Mechanical Circulatory Support . Journal of the American Heart Association.

Joseph R. Visker, Eric C. Leszczynski, Austin G. Wellette‐Hunsucker, Ashley C. McPeek, Melissa A. Quinn, Seong Hyun Kim, Jason N. Bazil, David P. Ferguson (2024). Postnatal growth restriction alters myocardial mitochondrial energetics in mice . Experimental Physiology.

Natali Froese, Malgorzata Szaroszyk, Paolo Galuppo, Joseph R. Visker, Christopher Werlein, Mortimer Korf‐Klingebiel, Dominik Berliner, Marc R. Reboll, Rana Hamouche, Simona Gegel, et al. (2024). Hypoxia Attenuates Pressure Overload‐Induced Heart Failure . Journal of the American Heart Association.

Drakos SG, Badolia R, Makaju A, Kyriakopoulos CP, Wever-Pinzon O, Tracy CM, Bakhtina A, Bia R, Parnell T, Taleb I, et al. (2022). Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support . Circulation.

Melissa A. Quinn, Abby E. Pritchard, Joseph R. Visker, Ashley C. McPeek, Ruma Raghuvanshi, Christian Martin H, Austin G. Wellette-Hunsucker, Eric C. Leszczynski, Laura R. McCabe, Karin A. Pfeiffer, et al. (2022). Longitudinal effects of growth restriction on the murine gut microbiome and metabolome . American Journal of Physiology-Endocrinology and Metabolism.

Quinn MA, Pritchard AE, Visker JR, McPeek AC, Raghuvanshi R, Martin H C, Wellette-Hunsucker AG, Leszczynski EC, McCabe LR, Pfeiffer KA, et al. (2022). Longitudinal effects of growth restriction on the murine gut microbiome and metabolome . American journal of physiology. Endocrinology and metabolism.

Joseph Visker, Sankarankutty AC, Greiner J, Bragard J, Visker JR, Shankar TS, Kyriakopoulos CP, Drakos SG, Sachse FB (2021). Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction . Frontiers in physiology.

Joseph Visker, Ferguson DP, Leszczynski EC, McPeek AC, Pendergrast LA, Visker JR, Triplett AN (2021). Physical Activity Engagement Worsens Health Outcomes and Limits Exercise Capacity in Growth-restricted Mice . Medicine and science in sports and exercise.

Joseph R. Visker, Lawrence J. Dangott, Eric C. Leszczynski, David P. Ferguson (2020). Postnatal Growth Restriction in Mice Alters Cardiac Protein Composition and Leads to Functional Impairment in Adulthood . International Journal of Molecular Sciences.

Joseph R. Visker, Lawrence J. Dangott, Eric C. Leszczynski, David P. Ferguson (2020). Postnatal Growth Restriction in Mice Alters Cardiac Protein Composition and Leads to Functional Impairment in Adulthood . International Journal of Molecular Sciences.

Joseph Visker, Felzer-Kim IT, Visker JR, Ferguson DP, Hauck JL (2020). Infant blood lipids: a systematic review of predictive value and influential factors . Expert review of cardiovascular therapy.

Joseph Visker, Leszczynski EC, Visker JR, Ferguson DP (2019). The Effect of Growth Restriction on Voluntary Physical Activity Engagement in Mice . Medicine and science in sports and exercise.

Joseph Visker, Leszczynski EC, Kuenze C, Brazier B, Visker J, Ferguson DP (2019). The Effect of ACL Reconstruction on Involved and Contralateral Limb Vastus Lateralis Morphology and Histology: A Pilot Study . The journal of knee surgery.

Joseph Visker, Pendergrast LA, Leszczynski EC, Visker JR, Triplett AN, Ferguson DP (2019). Early life undernutrition reduces maximum treadmill running capacity in adulthood in mice . Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

J. R. Visker, D. P. Ferguson (2018). Postnatal undernutrition in mice causes cardiac arrhythmogenesis which is exacerbated when pharmacologically stressed . Journal of Developmental Origins of Health and Disease.

Visker JR, Ferguson DP (2018). Postnatal undernutrition in mice causes cardiac arrhythmogenesis which is exacerbated when pharmacologically stressed . Journal of developmental origins of health and disease.

PREPRINT

Thirupura S. Shankar, Marco Marchetti, Harini Srinivasan, Joseph R. Visker, Rana Hamouche, Ezra Johnson, James Jeong, Ioannis Kyriakoulis, Jing Ling, Konstantinos Sideris, et al. (2025). Extracellular matrix and cytoskeletal reverse remodeling pathways are key drivers of myocardial recovery following left ventricular assist device therapy .

Joseph R. Visker, Eleni Tseliou, Christos P. Kyriakopoulos, Rana Hamouche, Michael Yin, Jing Ling, Thirupura S. Shankar, Eugene Kwan, Luis Cedeno-Rosaria, Jesse N. Velasco-Silva, et al. (2025). Peroxisome proliferator-activated receptor gamma (PPARG)-mediated myocardial salvage in acute myocardial infarction managed with left ventricular unloading and coronary reperfusion .

Ahmad A. Cluntun, Joseph R. Visker, Jesse N. Velasco-Silva, Marisa J. Lang, Luis Cedeño-Rosario, Thirupura S. Shankar, Rana Hamouche, Jing Ling, Ji Eon Kim, Ashish G. Toshniwal, et al. (2024). Direct mitochondrial import of lactate supports resilient carbohydrate oxidation .

Joseph R. Visker, Ben J. Brintz, Christos P. Kyriakopoulos, Yanni Hillas, Iosif Taleb, Rachit Badolia, Thirupura S. Shankar, Junedh M. Amrute, Jing Ling, Rana Hamouche, et al. (2024). Integrating molecular and clinical variables to predict myocardial recovery .

Joseph R. Visker, Ahmad A. Cluntun, Jesse N. Velasco-Silva, David R. Eberhardt, Thirupura S. Shankar, Rana Hamouche, Jing Ling, Hyoin Kwak, Yanni Hillas, Ian Aist, et al. (2024). Enhancing mitochondrial pyruvate metabolism ameliorates myocardial ischemic reperfusion injury .

Stavros Drakos, Thirupura Sundari Shankar, Joseph Visker, Junedh Amrute, Georgiy Polishchuk, Ty Lunde, Jing Ling, Peter Ferrin, Rana Hamouche, Dominik Feigle, et al. (2023). Adipocyte Enhancer Binding Protein 1 (AEBP1) Inhibition as a Potential Anti-Fibrotic Therapy in Heart Failure .