プロフィール詳細

プロジェクトを作成

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Dr. Joseph K.に依頼

United States

Biological Scientist | Innovative Stem Cell Research | Research & Data Consultant

プロフィール概要

I am a dedicated and results-driven biomedical scientist with a PhD in Biomedical Sciences, specializing in cell biology and hematopoiesis. My research expertise spans cellular signaling pathways, bone marrow niche dynamics, and the intricate mechanisms governing hematopoietic stem cell function. Throughout my academic and research career, I have contributed to numerous high-impact publications that explored transformative growth factor-beta (TGF-β) signaling, stem/progenitor cell interactions, and translational applications for hematological disorders. With extensive experience in hypothesis-driven research, I have developed a robust skill set in experimental design, complex data analysis, and scientific problem-solving. I excel at synthesizing large datasets, identifying meaningful patterns, and delivering actionable insights. My collaborative approach has enabled me to work effectively across multidisciplinary teams, bridging fundamental biology with clinical applications. Highlights of my career include: - Leading research projects to investigate TGF-β signaling in mesenchymal stromal cells and its implications for hematopoietic niche maintenance. - Publishing first-author and collaborative papers in top-tier journals, contributing to the understanding of hematopoietic niche function under basal and stress conditions. - Utilizing advanced techniques such as RNA sequencing, flow cytometry, microscopy, and bioinformatics for detailed molecular characterization. - Translating research insights into proposals, presentations, and peer-reviewed publications. Beyond technical expertise, I am skilled in project management, scientific communication, and mentoring, which have empowered me to oversee complex projects and foster the growth of junior researchers. My adaptability and attention to detail make me an ideal candidate for consulting roles or short-term projects requiring a nuanced understanding of biomedical research and data interpretation. I am passionate about leveraging my expertise to support companies, research institutions, or startups in advancing their biomedical initiatives through data-driven insights and innovative solutions.

専門分野

• ☆ Microbiology
• ☆ Microbiome Research
• ☆ Biostatistics
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Microarrays
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ Gene Expression Analysis
• ☆ Exome Sequencing
• ☆ Recombinant DNA
• ☆ Plasmid DNA
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Stem Cell Research
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Data Analysis
• ☆ Data Processing
• ☆ Data Exploration
• ☆ Data Collection
• ☆ Statistics
• ☆ Comparative Analysis
• ☆ Regression Analysis
• ☆ Multivariate Analysis
• ☆ Nonlinear Regression
• ☆ Bayesian Statistics
• ☆ Correlation Analysis
• ☆ Study Design
• ☆ Statistical Review
• ☆ Bioinformatics
• ☆ Gene & Protein Expression Analysis
• ☆ Pathogenesis
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Surface Receptors
• ☆ Immunohistochemistry
• ☆ Cytometry
• ☆ Cell Aging
• ☆ Logic
• ☆ R

サービス

• Research
• Consulting

Research Feasibility Study, Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

職務経験

Medical student

Washington University School of Medicine

9月 2022 - 現在

Principal Investigator, F31 Predoctoral Fellow

Washington University School of Medicine - NIH USA

9月 2019 - 8月 2022

学歴

PhD Molecular Genetics

Washington University School of Medicine

6月 2015 - 8月 2022

認定資格

• 認定資格の詳細は未入力です。

出版物

JOURNAL ARTICLE

Sidan Li, Juo-Chin Yao, Karolyn A Oetjen, Joseph R. Krambs, Jun Xia, Jingzhu Zhang, Amy P. Schmidt, Nichole M. Helton, Robert S. Fulton, Sharon E. Heath, et al. (2022). IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function . Blood.

Juo-Chin Yao, Karolyn A. Oetjen, Tianjiao Wang, Haoliang Xu, Grazia Abou-Ezzi, Joseph R. Krambs, Salil Uttarwar, Eric J. Duncavage, Daniel C. Link(2022). TGF-β signaling in myeloproliferative neoplasms contributes to myelofibrosis without disrupting the hematopoietic niche . Journal of Clinical Investigation. American Society for Clinical Investigation

Joseph R. Krambs, Darlene A. Monlish, Feng Gao, Laura G. Schuettpelz, Daniel C. Link (2021). Microbiota Signals Suppress B Lymphopoiesis With Aging in Mice . Frontiers in Immunology.

Joseph Ryan Krambs, Xing-Ming Shi, Grazia Abou Ezzi, Juo-Chin Yao, Daniel C. Link(2020). Canonical signaling by TGF family members in mesenchymal stromal cells is dispensable for hematopoietic niche maintenance under basal and stress conditions . PLOS ONE. 15. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString e0233751. Public Library of Science ({PLoS})

Vaishali Kapoor, Andrea Collins, Kaylan Griffith, Subhajit Ghosh, Nathan Wong, Xiaowei Wang, Grant A. Challen, Joseph Krambs, Dan Link, Dennis E. Hallahan, et al. (2020). Radiation induces iatrogenic immunosuppression by indirectly affecting hematopoiesis in bone marrow . Oncotarget.

Grazia Abou-Ezzi, Teerawit Supakorndej, Jingzhu Zhang, Bryan Anthony, Joseph Krambs, Hamza Celik, Darja Karpova, Clarissa S. Craft, Daniel C. Link (2019). TGF-β Signaling Plays an Essential Role in the Lineage Specification of Mesenchymal Stem/Progenitor Cells in Fetal Bone Marrow . Stem Cell Reports.

Jingzhu Zhang, Teerawit Supakorndej, Joseph R. Krambs, Mahil Rao, Grazia Abou-Ezzi, Rachel Y. Ye, Sidan Li, Kathryn Trinkaus, Daniel C. Link (2019). Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking . Journal of Clinical Investigation.